#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30750	uniprotkb:P30750	intact:EBI-541886|uniprotkb:P77517|uniprotkb:Q47615|ensemblbacteria:AAC73310|ensemblbacteria:BAA77876	intact:EBI-541886|uniprotkb:P77517|uniprotkb:Q47615|ensemblbacteria:AAC73310|ensemblbacteria:BAA77876	psi-mi:metn_ecoli(display_long)|uniprotkb:metN(gene name)|psi-mi:metN(display_short)|uniprotkb:abc(gene name synonym)|uniprotkb:b0199(locus name)|uniprotkb:JW0195(locus name)	psi-mi:metn_ecoli(display_long)|uniprotkb:metN(gene name)|psi-mi:metN(display_short)|uniprotkb:abc(gene name synonym)|uniprotkb:b0199(locus name)|uniprotkb:JW0195(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Kadaba et al. (2008)	imex:IM-21434|pubmed:18621668	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8771551|imex:IM-21434-4|wwpdb:3dhx	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC73310(transcript)|ensemblbacteria:b0199(gene)|ensemblbacteria:BAA77876(gene)|ensemblbacteria:BAA77876(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008152"(metabolic process)|go:"GO:0009276"(Gram-negative-bacterium-type cell wall)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0033232"(ABC-type D-methionine transporter activity)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012692(D-methionine ABC transporter, ATP-binding)|interpro:IPR017871|interpro:IPR018449|interpro:IPR026253|interpro:IPR041701|rcsb pdb:3DHW|rcsb pdb:3DHX|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|interpro:IPR027417|refseq:NP_414741.1|refseq:WP_000594006.1|dip:DIP-9027N	ensemblbacteria:AAC73310(transcript)|ensemblbacteria:b0199(gene)|ensemblbacteria:BAA77876(gene)|ensemblbacteria:BAA77876(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008152"(metabolic process)|go:"GO:0009276"(Gram-negative-bacterium-type cell wall)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0033232"(ABC-type D-methionine transporter activity)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012692(D-methionine ABC transporter, ATP-binding)|interpro:IPR017871|interpro:IPR018449|interpro:IPR026253|interpro:IPR041701|rcsb pdb:3DHW|rcsb pdb:3DHX|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|interpro:IPR027417|refseq:NP_414741.1|refseq:WP_000594006.1|dip:DIP-9027N	-	-	-	figure legend:Fig. 3b, Table S2|3d-resolution:2.1 A|3d-r-factors:R = 0.19; Rwork = 0.19; Rfree = 0.24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/24	2014/10/16	rogid:0TYcrL7Ur4qZaSr137r0VzrwI6c83333	rogid:0TYcrL7Ur4qZaSr137r0VzrwI6c83333	intact-crc:93D2F34666250C6F|rigid:wl8Lwr9aTCJOaEWEvamLtO2RziY	false	his tag:c-c|sufficient binding region:246-343	his tag:c-c|sufficient binding region:246-343	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30750	uniprotkb:P31547	intact:EBI-541886|uniprotkb:P77517|uniprotkb:Q47615|ensemblbacteria:AAC73310|ensemblbacteria:BAA77876	intact:EBI-8769561|ensemblbacteria:AAC73309|ensemblbacteria:BAA77875	psi-mi:metn_ecoli(display_long)|uniprotkb:metN(gene name)|psi-mi:metN(display_short)|uniprotkb:abc(gene name synonym)|uniprotkb:b0199(locus name)|uniprotkb:JW0195(locus name)	psi-mi:meti_ecoli(display_long)|uniprotkb:metI(gene name)|psi-mi:metI(display_short)|uniprotkb:yaeE(gene name synonym)|uniprotkb:b0198(locus name)|uniprotkb:JW0194(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Kadaba et al. (2008)	imex:IM-21434|pubmed:18621668	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8769943|imex:IM-21434-1|wwpdb:3dhw	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC73310(transcript)|ensemblbacteria:b0199(gene)|ensemblbacteria:BAA77876(gene)|ensemblbacteria:BAA77876(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008152"(metabolic process)|go:"GO:0009276"(Gram-negative-bacterium-type cell wall)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0033232"(ABC-type D-methionine transporter activity)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012692(D-methionine ABC transporter, ATP-binding)|interpro:IPR017871|interpro:IPR018449|interpro:IPR026253|interpro:IPR041701|rcsb pdb:3DHW|rcsb pdb:3DHX|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|interpro:IPR027417|refseq:NP_414741.1|refseq:WP_000594006.1|dip:DIP-9027N	ensemblbacteria:AAC73309(transcript)|ensemblbacteria:b0198(gene)|ensemblbacteria:BAA77875(gene)|ensemblbacteria:BAA77875(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:3DHW|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|refseq:WP_001294600.1|refseq:NP_414740.1|dip:DIP-11198N	-	-	-	figure legend:Fig. 1,  Table S1.|3d-resolution:3.7 A|3d-r-factors:R = 0.31; Rwork = 0.31; Rfree = 0.35|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/24	2014/10/16	rogid:0TYcrL7Ur4qZaSr137r0VzrwI6c83333	rogid:Gfb6AuQvYoj/R2rfn+tAlfnC9LU83333	intact-crc:11AE5B54B827AC4F|rigid:Hw4dID7OaiQAcziGT1YK5NuSbD0	false	his tag:n-n	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:P31547	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-8769561|ensemblbacteria:AAC73309|ensemblbacteria:BAA77875	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:meti_ecoli(display_long)|uniprotkb:metI(gene name)|psi-mi:metI(display_short)|uniprotkb:yaeE(gene name synonym)|uniprotkb:b0198(locus name)|uniprotkb:JW0194(locus name)	psi-mi:"MI:0880"(atpase assay)	Kadaba et al. (2008)	imex:IM-21434|pubmed:18621668	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8771597|imex:IM-21434-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensemblbacteria:AAC73309(transcript)|ensemblbacteria:b0198(gene)|ensemblbacteria:BAA77875(gene)|ensemblbacteria:BAA77875(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:3DHW|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|refseq:WP_001294600.1|refseq:NP_414740.1|dip:DIP-11198N	go:"GO:0006200"(obsolete ATP catabolic process)|go:"GO:0016887"(ATP hydrolysis activity)	-	-	figure legend:Fig.s 4, S3|antagonist:"L-methionine & L-selenomethionine (concentration-dependent)"|comment:"The MetN-C2 construct (aa 247-343 + 6xHis) showed a L-methionine-concentration-independent reduction of ATPase activity of ~50%."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/24	2014/10/16	-	rogid:Gfb6AuQvYoj/R2rfn+tAlfnC9LU83333	intact-crc:1BEB7E0655CE0B6B	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:P30750	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-541886|uniprotkb:P77517|uniprotkb:Q47615|ensemblbacteria:AAC73310|ensemblbacteria:BAA77876	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:metn_ecoli(display_long)|uniprotkb:metN(gene name)|psi-mi:metN(display_short)|uniprotkb:abc(gene name synonym)|uniprotkb:b0199(locus name)|uniprotkb:JW0195(locus name)	psi-mi:"MI:0880"(atpase assay)	Kadaba et al. (2008)	imex:IM-21434|pubmed:18621668	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8771597|imex:IM-21434-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensemblbacteria:AAC73310(transcript)|ensemblbacteria:b0199(gene)|ensemblbacteria:BAA77876(gene)|ensemblbacteria:BAA77876(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008152"(metabolic process)|go:"GO:0009276"(Gram-negative-bacterium-type cell wall)|go:"GO:0015191"(L-methionine transmembrane transporter activity)|go:"GO:0033232"(ABC-type D-methionine transporter activity)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0048473"(D-methionine transport)|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012692(D-methionine ABC transporter, ATP-binding)|interpro:IPR017871|interpro:IPR018449|interpro:IPR026253|interpro:IPR041701|rcsb pdb:3DHW|rcsb pdb:3DHX|rcsb pdb:3TUI|rcsb pdb:3TUJ|rcsb pdb:3TUZ|rcsb pdb:6CVL|interpro:IPR027417|refseq:NP_414741.1|refseq:WP_000594006.1|dip:DIP-9027N	go:"GO:0006200"(obsolete ATP catabolic process)|go:"GO:0016887"(ATP hydrolysis activity)	-	-	figure legend:Fig.s 4, S3|antagonist:"L-methionine & L-selenomethionine (concentration-dependent)"|comment:"The MetN-C2 construct (aa 247-343 + 6xHis) showed a L-methionine-concentration-independent reduction of ATPase activity of ~50%."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/24	2014/10/16	-	rogid:0TYcrL7Ur4qZaSr137r0VzrwI6c83333	intact-crc:1BEB7E0655CE0B6B	false	-	his tag:?-?|mutation disrupting interaction:166-166|necessary binding region:246-343	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)