#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2B5	uniprotkb:P27958-PRO_0000037570	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	intact:EBI-6904269	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pavio et al. (2003)	pubmed:12610133|imex:IM-26049	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8699609|imex:IM-26049-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	intact:EBI-706378(chain-parent)	-	-	chain-seq-start:384|chain-seq-end:746	figure legend:Fig. 1D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2013/08/27	2014/10/16	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	intact-crc:4470EFD36750A975|rigid:xR8tc/40wwLIxAd2LZiUJkR9zq4	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27958-PRO_0000037570	uniprotkb:Q9Z2B5	intact:EBI-6904269	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pavio et al. (2003)	pubmed:12610133|imex:IM-26049	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8699559|imex:IM-26049-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-706378(chain-parent)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	chain-seq-start:384|chain-seq-end:746	-	figure legend:Fig. 1B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2017/09/02	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	intact-crc:41C7A208A3703B4D|rigid:xR8tc/40wwLIxAd2LZiUJkR9zq4	false	glutathione s tranferase tag:?-?	35s radiolabel:35-35	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P27958-PRO_0000037570	uniprotkb:P19525	intact:EBI-6904269	intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pavio et al. (2003)	pubmed:12610133|imex:IM-26049	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8699539|imex:IM-26049-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-706378(chain-parent)	refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1	-	chain-seq-start:384|chain-seq-end:746	-	figure legend:Fig. 1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2017/09/02	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606	intact-crc:019D1048FB5DA509|rigid:2oeBcujKQkW4TJecb6bgngBO7Wc	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9Z2B5	uniprotkb:P27958-PRO_0000037570	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	intact:EBI-6904269	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pavio et al. (2003)	pubmed:12610133|imex:IM-26049	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8699549|imex:IM-26049-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	intact:EBI-706378(chain-parent)	-	-	chain-seq-start:384|chain-seq-end:746	figure legend:Fig. 1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2017/09/02	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	intact-crc:9064EC18D90DEA01|rigid:xR8tc/40wwLIxAd2LZiUJkR9zq4	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9Z2B5	uniprotkb:P27958-PRO_0000037570	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	intact:EBI-6904269	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:"MI:0096"(pull down)	Pavio et al. (2003)	pubmed:12610133|imex:IM-26049	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8699583|imex:IM-26049-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	intact:EBI-706378(chain-parent)	go:"GO:0033673"(negative regulation of kinase activity)	-	chain-seq-start:384|chain-seq-end:746	figure legend:Fig. 1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2017/09/02	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	intact-crc:735A89AF59C052DA|rigid:xR8tc/40wwLIxAd2LZiUJkR9zq4	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)