#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CGZ2	uniprotkb:O35889	intact:EBI-6654103|ensembl:ENSRNOP00000043877|ensembl:ENSRNOP00000072590	intact:EBI-6654073|uniprotkb:O35890	psi-mi:adip_rat(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654101|imex:IM-20796-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|ensembl:ENSRNOG00000015425(gene)|ensembl:ENSRNOT00000041186(transcript)|ensembl:ENSRNOT00000084034(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|refseq:XP_006233516.1|refseq:XP_006233517.1|refseq:NP_783187.1|rgd:708490	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	-	-	-	figure legend:"Text reference (p4106)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:S8nsc0eueTB3CPB6hL8TUF5xjY410116	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	intact-crc:6B7A5FD41A257047|rigid:1Nsq/9rGjPNwqP1ZLrwey2nxOpc	false	-	sufficient binding region:511-981(IPR002710)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VC66	uniprotkb:Q9Z1P2	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	intact:EBI-920286|ensembl:ENSRNOP00000069598	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:actn1_rat(display_long)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654258|imex:IM-20796-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	rgd:70907|refseq:NP_112267.1|ensembl:ENSRNOG00000056756(gene)|ensembl:ENSRNOT00000088795(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9Z1P2|reactome:R-RNO-114608|reactome:R-RNO-446388|reactome:R-RNO-9013405|reactome:R-RNO-9013418|reactome:R-RNO-9035034	-	-	-	figure legend:"Text reference (p 4108)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	rogid:e8zdF7HOx12sx9WE9oJe6tk9br810116	intact-crc:52376DFF86ACC1E5|rigid:Qehg0jKa5JhjzCqkc+K8TKbu9xA	false	sufficient binding region:152-436	sufficient binding region:406-892	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35889	uniprotkb:Q8CGZ2	intact:EBI-6654073|uniprotkb:O35890	intact:EBI-6654103|ensembl:ENSRNOP00000043877|ensembl:ENSRNOP00000072590	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_rat(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654134|imex:IM-20796-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|ensembl:ENSRNOG00000015425(gene)|ensembl:ENSRNOT00000041186(transcript)|ensembl:ENSRNOT00000084034(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|refseq:XP_006233516.1|refseq:XP_006233517.1|refseq:NP_783187.1|rgd:708490	-	-	-	figure legend:Fig 2A, 2B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	rogid:S8nsc0eueTB3CPB6hL8TUF5xjY410116	intact-crc:9F559C54995DFCA4|rigid:1Nsq/9rGjPNwqP1ZLrwey2nxOpc	false	sufficient binding region:511-981(IPR002710)	sufficient binding region:159-613	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35889	uniprotkb:Q8VC66	intact:EBI-6654073|uniprotkb:O35890	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654147|imex:IM-20796-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 2A, 2B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:E907521F19B35256|rigid:ebEsHmT2FP+hlmuKyNJw7Jd8O20	false	sufficient binding region:511-981(IPR002710)	sufficient binding region:339-480	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VC66	uniprotkb:Q9Z1P2	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	intact:EBI-920286|ensembl:ENSRNOP00000069598	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:actn1_rat(display_long)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654267|imex:IM-20796-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	rgd:70907|refseq:NP_112267.1|ensembl:ENSRNOG00000056756(gene)|ensembl:ENSRNOT00000088795(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9Z1P2|reactome:R-RNO-114608|reactome:R-RNO-446388|reactome:R-RNO-9013405|reactome:R-RNO-9013418|reactome:R-RNO-9035034	-	-	-	figure legend:Fig 2A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	rogid:e8zdF7HOx12sx9WE9oJe6tk9br810116	intact-crc:C6EA66260E5C1070|rigid:Qehg0jKa5JhjzCqkc+K8TKbu9xA	false	sufficient binding region:1-226	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32492	uniprotkb:P38272	intact:EBI-11681|ensemblfungi:YAL029C|uniprotkb:D6VPI9	intact:EBI-21600|uniprotkb:D6VQC7|ensemblfungi:YBR130C	psi-mi:myo4_yeast(display_long)|uniprotkb:MYO4(gene name)|psi-mi:MYO4(display_short)|uniprotkb:SHE1(gene name synonym)|uniprotkb:YAL029C(locus name)|uniprotkb:FUN22(orf name)|uniprotkb:SWI5-dependent HO expression protein 1(gene name synonym)	psi-mi:she3_yeast(display_long)|uniprotkb:YBR1005(orf name)|uniprotkb:YBR130C(locus name)|uniprotkb:SHE3(gene name)|psi-mi:SHE3(display_short)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654355|imex:IM-20796-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007015"(actin filament organization)|go:"GO:0007533"(mating type switching)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002710(Dilute)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR036961|rcsb pdb:3MMI|rcsb pdb:4LL6|rcsb pdb:4LL8|reactome:R-SCE-190873|reactome:R-SCE-9013419|reactome:R-SCE-9013425|ensemblfungi:YAL029C(gene)|ensemblfungi:YAL029C_mRNA(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005933"(cellular bud)|go:"GO:0005934"(cellular bud tip)|refseq:NP_009373.1|sgd:S000000027|mint:P32492|dip:DIP-5761N	sgd:S000000334|refseq:NP_009688.3|mint:P38272|dip:DIP-2037N|ensemblfungi:YBR130C(gene)|ensemblfungi:YBR130C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0007533"(mating type switching)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051028"(mRNA transport)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR031398|rcsb pdb:4LL7|rcsb pdb:4LL8|rcsb pdb:4WNL|rcsb pdb:5M0I|rcsb pdb:5M0J	-	crc64:E79C0FE72B041E95	crc64:590404D2E140BB7A	figure legend:Fig 2B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:jxx/cStiu7zpcGFLmoTedhHVZcY559292	rogid:HmP1/ozLaDCRVBA9eJ10x7CYNjI559292	intact-crc:A9EC1D276F0A3BDA|rigid:eeZUdGg1c631m7Ik/dqUfpLlR5g	false	sufficient binding region:920-1471(IPR002710)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35889	uniprotkb:Q8VC66	intact:EBI-6654073|uniprotkb:O35890	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654167|imex:IM-20796-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 3A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/04/26	2014/10/16	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:316BE11790D1098C|rigid:ebEsHmT2FP+hlmuKyNJw7Jd8O20	false	t7 tag:n-n|sufficient binding region:606-983	flag tag:n-n|sufficient binding region:339-615	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12814	uniprotkb:Q8VC66	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654276|imex:IM-20796-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 8A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/04/26	2014/10/16	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:74ECE27D2330A319|rigid:GMnicfQY2VBLRboVTSWRP+FwUvA	false	ha tag:n-n|sufficient binding region:406-892	sufficient binding region:152-436|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:F1PSU6	uniprotkb:Q8VC66	intact:EBI-6654181|ensembl:ENSCAFP00000001228	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:f1psu6_canlf(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654192|imex:IM-20796-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00000000860(gene)|ensembl:ENSCAFT00000001341(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0050839"(cell adhesion molecule binding)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|refseq:XP_013968665.1	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 3B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/26	2020/01/08	rogid:A1bmRq4cuWPnUaEb6RtAcRRbGMo9615	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:0BF73C478B5A68B0|rigid:zcjdnnAqhkZ5axO+DWsNB3rI254	false	-	maltose binding protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35889	uniprotkb:Q8VC66	intact:EBI-6654073|uniprotkb:O35890	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654207|imex:IM-20796-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 3C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/26	2014/10/16	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:E1CC6B6F10A1ADD0|rigid:ebEsHmT2FP+hlmuKyNJw7Jd8O20	false	glutathione s tranferase tag:?-?|sufficient binding region:606-983(IPR002710)	maltose binding protein tag:?-?|sufficient binding region:121-436	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12814	uniprotkb:Q8VC66	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654310|imex:IM-20796-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:Fig 8C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/26	2014/10/16	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:441B93FB26046E14|rigid:GMnicfQY2VBLRboVTSWRP+FwUvA	false	sufficient binding region:406-892|glutathione s tranferase tag:?-?	maltose binding protein tag:?-?|sufficient binding region:152-436	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:F1PSU6	uniprotkb:F1PAA2	intact:EBI-6654181|ensembl:ENSCAFP00000001228	intact:EBI-6654233|ensembl:ENSCAFP00000030115	psi-mi:f1psu6_canlf(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)	psi-mi:f1paa2_canlf(display_long)|uniprotkb:SSX2IP(gene name)|psi-mi:SSX2IP(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654231|imex:IM-20796-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00000000860(gene)|ensembl:ENSCAFT00000001341(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0050839"(cell adhesion molecule binding)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|refseq:XP_013968665.1	refseq:XP_005622056.1|ensembl:ENSCAFG00000020304(gene)|ensembl:ENSCAFT00000032340(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0031252"(cell leading edge)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0032991"(protein-containing complex)	-	-	-	figure legend:Fig 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2013/04/26	2020/01/08	rogid:A1bmRq4cuWPnUaEb6RtAcRRbGMo9615	rogid:tRpmXN8GEL9Tb3RblOqnzVqKxOU9615	intact-crc:FFE22F46799B69FE|rigid:XIQm/N/lJaiH+yvuQSFWqwZloIE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E2QY08	uniprotkb:F1PAA2	intact:EBI-6654329|ensembl:ENSCAFP00000024335	intact:EBI-6654233|ensembl:ENSCAFP00000030115	psi-mi:e2qy08_canlf(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)	psi-mi:f1paa2_canlf(display_long)|uniprotkb:SSX2IP(gene name)|psi-mi:SSX2IP(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654327|imex:IM-20796-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00000016534(gene)|ensembl:ENSCAFT00000026207(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005884"(actin filament)|go:"GO:0005903"(brush border)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|refseq:XP_853103.1	refseq:XP_005622056.1|ensembl:ENSCAFG00000020304(gene)|ensembl:ENSCAFT00000032340(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0031252"(cell leading edge)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0032991"(protein-containing complex)	-	-	-	figure legend:Fig 8D.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2013/04/26	2014/10/16	rogid:qbLSlBNdX+dLZbhivI3nI1xLErY9615	rogid:tRpmXN8GEL9Tb3RblOqnzVqKxOU9615	intact-crc:07BDEC32349B1B6E|rigid:zqL0otJyVatN2ZkceA1kX+AK9mw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1PSU6	uniprotkb:F1PAA2	intact:EBI-6654181|ensembl:ENSCAFP00000001228	intact:EBI-6654233|ensembl:ENSCAFP00000030115	psi-mi:f1psu6_canlf(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)	psi-mi:f1paa2_canlf(display_long)|uniprotkb:SSX2IP(gene name)|psi-mi:SSX2IP(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654251|imex:IM-20796-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00000000860(gene)|ensembl:ENSCAFT00000001341(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0050839"(cell adhesion molecule binding)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|refseq:XP_013968665.1	refseq:XP_005622056.1|ensembl:ENSCAFG00000020304(gene)|ensembl:ENSCAFT00000032340(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0031252"(cell leading edge)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0032991"(protein-containing complex)	go:"GO:0005911"(cell-cell junction)	-	-	figure legend:Fig 5A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2013/04/26	2020/01/08	rogid:A1bmRq4cuWPnUaEb6RtAcRRbGMo9615	rogid:tRpmXN8GEL9Tb3RblOqnzVqKxOU9615	intact-crc:766D02B747B3EE73|rigid:XIQm/N/lJaiH+yvuQSFWqwZloIE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8VC66	uniprotkb:P12814	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654300|imex:IM-20796-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:Fig 8B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/04/26	2014/10/16	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	intact-crc:1849D4A3D43E3E47|rigid:GMnicfQY2VBLRboVTSWRP+FwUvA	false	sufficient binding region:152-436|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QZQ1	uniprotkb:Q8VC66	intact:EBI-6673595|ensembl:ENSMUSP00000118318	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:afad_mouse(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6673593|imex:IM-20796-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000068036(gene)|ensembl:ENSMUST00000139666(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|interpro:IPR036034|interpro:IPR037977|rcsb pdb:1WLN|rcsb pdb:1WXA|rcsb pdb:3AXA|rcsb pdb:6AMB|reactome:R-MMU-418990|refseq:NP_034936.1|dip:DIP-60737N	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	go:"GO:0005912"(adherens junction)	-	-	figure legend:Fig 5B, 5C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-intestinal_epitheliu)|taxid:10090(Mouse intestinal epithelial cells)	-	2013/04/26	2014/10/16	rogid:gzoTHL3iU/HoLVKFDiPQjJ6cSxk10090	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:2E0DED251C6CF93E|rigid:vkG+vMnOx/D5XizarALdKzU7QXI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O35889	uniprotkb:Q8VC66	intact:EBI-6654073|uniprotkb:O35890	intact:EBI-6654049|ensembl:ENSMUSP00000101759|uniprotkb:Q8BG59|uniprotkb:Q8C7X0|uniprotkb:Q8K2F7	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:adip_mouse(display_long)|uniprotkb:Ssx2ip(gene name)|psi-mi:Ssx2ip(display_short)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Asada et al. (2003)	pubmed:12446711|imex:IM-20796	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6654047|imex:IM-20796-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	ensembl:ENSMUSG00000036825(gene)|ensembl:ENSMUST00000106153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|refseq:XP_006502467.1|refseq:XP_006502468.1|refseq:XP_006502469.1|refseq:NP_001240697.1|refseq:NP_001240698.1|refseq:NP_001240699.1|refseq:NP_620083.1	-	-	-	figure legend:"Text reference (p4106)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/04/26	2014/10/16	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	rogid:0+eECDd6Kqk2eD+BZkrClb0BXXI10090	intact-crc:8D1E8B28E8F32175|rigid:ebEsHmT2FP+hlmuKyNJw7Jd8O20	false	sufficient binding region:511-981(IPR002710)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)