#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49024 uniprotkb:P12003-1 intact:EBI-2896280 intact:EBI-6138078|ensembl:ENSGALP00000048583 psi-mi:paxi_chick(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:p12003-1(display_long)|uniprotkb:Vinculin(isoform synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)|uniprotkb:VINC1(gene name synonym)|uniprotkb:Metavinculin(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (1996) pubmed:8922390|imex:IM-18803 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6138076|imex:IM-18803-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0017166"(vinculin binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|rcsb pdb:4R32|go:"GO:0005925"(focal adhesion)|refseq:NP_990315.1|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49024 intact:EBI-1039563(isoform-parent)|ensembl:ENSGALG00000005079(gene)|ensembl:ENSGALT00000061988(transcript) - - crc64:6F585201260BA47F figure legend:Fig 1B, 2A, 3A, 4A.|comment:"This entry demonstrates paxillin interacting with vinculun (isoform 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/24 2014/10/16 rogid:gFcb1txdr5lCKvDMcZnyDVkcSbg9031 rogid:7pjVJ/hVjJ330ElcLAQKHP/WGaQ9031 intact-crc:0A9C4DCF2BCB3A50|rigid:8vl+/9aNf74y6zdaqicowhnkzRA false mutation decreasing interaction:146-147|necessary binding region:143-164|glutathione s tranferase tag:?-?|mutation decreasing interaction:151-151 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P49024 uniprotkb:P12003-2 intact:EBI-2896280 intact:EBI-6138096|ensembl:ENSGALP00000008131 psi-mi:paxi_chick(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:p12003-2(display_long)|uniprotkb:Metavinculin(isoform synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)|uniprotkb:VINC1(gene name synonym)|uniprotkb:Metavinculin(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (1996) pubmed:8922390|imex:IM-18803 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6138094|imex:IM-18803-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0017166"(vinculin binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|rcsb pdb:4R32|go:"GO:0005925"(focal adhesion)|refseq:NP_990315.1|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49024 intact:EBI-1039563(isoform-parent)|ensembl:ENSGALG00000005079(gene)|ensembl:ENSGALT00000008145(transcript) - - - figure legend:Fig 1B, 2A, 3A, 4A.|comment:"This entry demonstrates paxillin interacting with metavinculin (vinculin isoform 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/24 2014/10/16 rogid:gFcb1txdr5lCKvDMcZnyDVkcSbg9031 rogid:94z6CivjYryFIKVVE4dRTbssflA9031 intact-crc:5D446C6B15C6214D|rigid:N+FnsflqyijkoiznmcEtpa4qYEI false mutation disrupting interaction:146-147|mutation disrupting interaction:151-151|glutathione s tranferase tag:?-?|necessary binding region:143-164 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P49024 uniprotkb:Q00944 intact:EBI-2896280 intact:EBI-2896409|ensembl:ENSGALP00000044406 psi-mi:paxi_chick(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (1996) pubmed:8922390|imex:IM-18803 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6138112|imex:IM-18803-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0017166"(vinculin binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|rcsb pdb:4R32|go:"GO:0005925"(focal adhesion)|refseq:NP_990315.1|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49024 ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1 - - - figure legend:Fig 1C, 2B, 3B, 4B.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/24 2014/10/16 rogid:gFcb1txdr5lCKvDMcZnyDVkcSbg9031 rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031 intact-crc:3F7E9E96FEF82648|rigid:OhoV9GRK7g6SQcA6WwO0S5tPGiA false sufficient binding region:266-313|mutation decreasing interaction:146-147|sufficient binding region:143-164|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P49024 uniprotkb:Q92063 intact:EBI-2896280 intact:EBI-6138134 psi-mi:paxi_chick(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:q92063_chick(display_long)|uniprotkb:FRNK(gene name)|psi-mi:FRNK(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (1996) pubmed:8922390|imex:IM-18803 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6138132|imex:IM-18803-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0017166"(vinculin binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|rcsb pdb:4R32|go:"GO:0005925"(focal adhesion)|refseq:NP_990315.1|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49024 interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR036137|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0007172"(signal complex assembly) - - - figure legend:Fig 1D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/24 2014/10/16 rogid:gFcb1txdr5lCKvDMcZnyDVkcSbg9031 rogid:epTPqCYG0YrZnYQ9KIJnMrGCB+k9031 intact-crc:708D1876D84DCDB4|rigid:xBwie5v0QqYlMgMzrcdJ1+h3/8U false necessary binding region:143-218|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)