#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06239	uniprotkb:P29350	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lorenz et al. (1994)	mint:MINT-7028063|pubmed:8114715	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8641068|mint:MINT-8310748	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-8310759(identity)|uniprotkb:P06239(original identifier)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-8310749(identity)|uniprotkb:P29350(original identifier)	-	-	-	comment:homomint|comment:mint|figure legend:F6 F7|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/13	2014/10/16	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	intact-crc:EDC4D1A082FF6ACD|rigid:Z7ZnTogzYLe+5tiK9FViiBMxrpQ	false	-	phosphorylated residue:564-564(MINT-8310757)|binding-associated region:558-570(MINT-8310752)|mutation decreasing interaction:564-564(MINT-8310754)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:P29350	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lorenz et al. (1994)	mint:MINT-7028063|pubmed:8114715	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8641035|mint:MINT-8310738	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-8310745(identity)|uniprotkb:P06239(original identifier)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-8310739(identity)|uniprotkb:P29350(original identifier)	-	-	-	comment:homomint|comment:mint|figure legend:F4, F5|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/13	2014/10/16	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	intact-crc:CD439CCC85C774B4|rigid:Z7ZnTogzYLe+5tiK9FViiBMxrpQ	false	-	binding-associated region:495-595(MINT-8310742)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:P29350	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lorenz et al. (1994)	mint:MINT-7028063|pubmed:8114715	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8641116|mint:MINT-8310776	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-8310787(identity)|uniprotkb:P06239(original identifier)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-8310777(identity)|uniprotkb:P29350(original identifier)	-	-	-	comment:homomint|comment:mint|figure legend:F6 F7|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/13	2014/10/16	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	intact-crc:21C866900BAC0437|rigid:Z7ZnTogzYLe+5tiK9FViiBMxrpQ	false	-	mutation decreasing interaction:541-541(MINT-8310782)|phosphorylated residue:541-541(MINT-8310785)|binding-associated region:535-547(MINT-8310780)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06239	uniprotkb:P29350	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lorenz et al. (1994)	mint:MINT-7028063|pubmed:8114715	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8641092|mint:MINT-8310762	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-8310773(identity)|uniprotkb:P06239(original identifier)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-8310763(identity)|uniprotkb:P29350(original identifier)	-	-	-	comment:homomint|comment:mint|figure legend:F6 F7|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/13	2014/10/16	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	intact-crc:EE59F48C0876DF75|rigid:Z7ZnTogzYLe+5tiK9FViiBMxrpQ	false	-	binding-associated region:530-542(MINT-8310766)|phosphorylated residue:536-536(MINT-8310771)|mutation decreasing interaction:536-536(MINT-8310768)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)