#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P28905 uniprotkb:P28632 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464431|imex:IM-18575-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:7FEFFC359B28AA88 - figure legend:Fig. 2b|complex-properties:chi-psi complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2012/12/17 2014/10/16 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:B24599FD0921AFE4|rigid:Mq1IZXIavCXTUGkZ6MWMwGW8Qx8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06710 uniprotkb:P28905 intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464444|imex:IM-18575-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) - crc64:7FEFFC359B28AA88 figure legend:Fig. 6, Table II|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.8x10^-9(molar) 2012/12/17 2014/10/16 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:2F0342FDB8E91C75|rigid:6eygg40CctdSrJFPP1XvK5dPiGg false - - 4 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06710 uniprotkb:P28632 intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464444|imex:IM-18575-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) - - figure legend:Fig. 6, Table II|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.8x10^-9(molar) 2012/12/17 2014/10/16 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:2F0342FDB8E91C75|rigid:6eygg40CctdSrJFPP1XvK5dPiGg false - - 4 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P06710-1 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-6464728 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464466|imex:IM-18575-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG intact:EBI-549140(isoform-parent) go:"GO:0043846"(DNA polymerase III, clamp loader complex) - isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)." figure legend:Fig. 7|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:45D8570C9A26E6D3|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P28630 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464466|imex:IM-18575-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF go:"GO:0043846"(DNA polymerase III, clamp loader complex) - crc64:87239A678FE16BE2 figure legend:Fig. 7|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 intact-crc:45D8570C9A26E6D3|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P28905 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464466|imex:IM-18575-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) - crc64:7FEFFC359B28AA88 figure legend:Fig. 7|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:45D8570C9A26E6D3|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P28632 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464466|imex:IM-18575-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) - - figure legend:Fig. 7|complex-properties:'tau' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:45D8570C9A26E6D3|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P28630 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464474|imex:IM-18575-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF go:"GO:0043846"(DNA polymerase III, clamp loader complex) - crc64:87239A678FE16BE2 figure legend:Fig. 7|complex-properties:'gamma' complex without chi & psi, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 intact-crc:95DB7218C3184958|rigid:BKqB83gB/pa0PCKfIZ5XWvKGr84 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28631 uniprotkb:P06710-1 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 intact:EBI-6464728 psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464474|imex:IM-18575-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG intact:EBI-549140(isoform-parent) go:"GO:0043846"(DNA polymerase III, clamp loader complex) - isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)." figure legend:Fig. 7|complex-properties:'gamma' complex without chi & psi, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/17 2014/10/16 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:95DB7218C3184958|rigid:BKqB83gB/pa0PCKfIZ5XWvKGr84 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06710-2 uniprotkb:P28905 intact:EBI-2604194 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464458|imex:IM-18575-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-549140(isoform-parent) refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." crc64:7FEFFC359B28AA88 figure legend:Table II|complex-properties:'gamma' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.5x10^-9(molar) 2012/12/17 2015/06/09 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:7E56EC8BB8659270|rigid:OpROIQkxuKisps6wqxAqWHxHWRw false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06710-2 uniprotkb:P28632 intact:EBI-2604194 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Olson et al. (1995) pubmed:7494000|imex:IM-18575 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6464458|imex:IM-18575-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-549140(isoform-parent) refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." - figure legend:Table II|complex-properties:'gamma' complex, part of DNA Polymerase III complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.5x10^-9(molar) 2012/12/17 2015/06/09 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:7E56EC8BB8659270|rigid:OpROIQkxuKisps6wqxAqWHxHWRw false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)