#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P05923 uniprotkb:Q10589 intact:EBI-8178332|intact:MINT-8402293 intact:EBI-2476339|ensembl:ENSP00000252593|intact:EBI-2839059|uniprotkb:A8K4Y4|uniprotkb:Q53G07 psi-mi:vpu_hv1br(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:bst2_human(display_long)|uniprotkb:BST2(gene name)|psi-mi:BST2(display_short)|uniprotkb:Tetherin(gene name synonym)|uniprotkb:HM1.24 antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lv et al. (2013) pubmed:23201263|mint:MINT-8402280 taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8178325|mint:MINT-8402307 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042609"(CD4 receptor binding)|interpro:IPR009032(Vpu protein, cytoplasmic)|interpro:IPR008187(Vpu protein)|go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|mint:MINT-8402309(identity) go:"GO:0005886"(plasma membrane)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR024886|rcsb pdb:2LK9|rcsb pdb:2X7A|rcsb pdb:2XG7|rcsb pdb:3MQ7|rcsb pdb:3MQ9|rcsb pdb:3MQB|rcsb pdb:3MQC|rcsb pdb:3NWH|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0051607"(defense response to virus)|rcsb pdb:6DFF|go:"GO:0070062"(extracellular exosome)|go:"GO:0070665"(positive regulation of leukocyte proliferation)|go:"GO:1901253"(negative regulation of intracellular transport of viral material)|reactome:R-HSA-6798695|reactome:R-HSA-909733|ensembl:ENSG00000130303(gene)|ensembl:ENST00000252593(transcript)|go:"GO:0002737"(negative regulation of plasmacytoid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|refseq:NP_004326.1|dip:DIP-53216N|mint:MINT-8402310(identity) - comment:mint|comment:homomint - figure legend:f2b|comment:homomint|comment:mint taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/11/19 2014/10/16 rogid:psl3R+sAlSBoFB7dpwESW02v2eA11686 rogid:vunnCOscGahFdaeN03pDo/8xW7I9606 intact-crc:5E09B8EC7E22116C|rigid:+8LTK6AbkybFU8PHZS3STgZwnRU false myc tag:?-?(MINT-8402311) binding-associated region:1-160(MINT-8402347)|ha tag:?-?(MINT-8402318) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P05923 uniprotkb:Q10589 intact:EBI-8178332|intact:MINT-8402293 intact:EBI-2476339|ensembl:ENSP00000252593|intact:EBI-2839059|uniprotkb:A8K4Y4|uniprotkb:Q53G07 psi-mi:vpu_hv1br(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:bst2_human(display_long)|uniprotkb:BST2(gene name)|psi-mi:BST2(display_short)|uniprotkb:Tetherin(gene name synonym)|uniprotkb:HM1.24 antigen(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lv et al. (2013) pubmed:23201263|mint:MINT-8402280 taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8178396|mint:MINT-8402326 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042609"(CD4 receptor binding)|interpro:IPR009032(Vpu protein, cytoplasmic)|interpro:IPR008187(Vpu protein)|go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|mint:MINT-8402332(identity) go:"GO:0005886"(plasma membrane)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR024886|rcsb pdb:2LK9|rcsb pdb:2X7A|rcsb pdb:2XG7|rcsb pdb:3MQ7|rcsb pdb:3MQ9|rcsb pdb:3MQB|rcsb pdb:3MQC|rcsb pdb:3NWH|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0051607"(defense response to virus)|rcsb pdb:6DFF|go:"GO:0070062"(extracellular exosome)|go:"GO:0070665"(positive regulation of leukocyte proliferation)|go:"GO:1901253"(negative regulation of intracellular transport of viral material)|reactome:R-HSA-6798695|reactome:R-HSA-909733|ensembl:ENSG00000130303(gene)|ensembl:ENST00000252593(transcript)|go:"GO:0002737"(negative regulation of plasmacytoid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|refseq:NP_004326.1|dip:DIP-53216N|mint:MINT-8402328(identity) go:"GO:0055037"(recycling endosome) comment:mint|comment:homomint - figure legend:f2a|comment:homomint|comment:mint taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/11/19 2014/10/16 rogid:psl3R+sAlSBoFB7dpwESW02v2eA11686 rogid:vunnCOscGahFdaeN03pDo/8xW7I9606 intact-crc:D7558964D533368C|rigid:+8LTK6AbkybFU8PHZS3STgZwnRU false myc tag:?-?(MINT-8402333) binding-associated region:1-160(MINT-8402357)|ha tag:?-?(MINT-8402329) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)