#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q01973 uniprotkb:Q14149 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-2556145|uniprotkb:Q9UEZ2|uniprotkb:A8KA92|ensembl:ENSP00000383333 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:morc3_human(display_long)|uniprotkb:KIAA0136(gene name synonym)|uniprotkb:ZCWCC3(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)|uniprotkb:MORC3(gene name)|psi-mi:MORC3(display_short)|uniprotkb:NXP2(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397122|imex:IM-18118-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_056173.1|ensembl:ENSG00000159256(gene)|ensembl:ENST00000400485(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:4QQ4|rcsb pdb:5SVI|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:6O1E|rcsb pdb:6O5W - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-697)|taxid:9606(Homo sapiens) - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:Le9NRwTLr01G+tQNUAxFzEkGjfs9606 intact-crc:4B824E7883D44D63|rigid:U7Dzh0+kMRvTXpy8QGnc83nsbuU false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:P19474 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397122|imex:IM-18118-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like) - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-697)|taxid:9606(Homo sapiens) - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 intact-crc:4B824E7883D44D63|rigid:U7Dzh0+kMRvTXpy8QGnc83nsbuU false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q86TI0 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-1644036|uniprotkb:Q96K82|uniprotkb:Q9UPP4|uniprotkb:B7Z3D9|uniprotkb:E9PGH8|ensembl:ENSP00000261439 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd1_human(display_long)|uniprotkb:TBC1D1(gene name)|psi-mi:TBC1D1(display_short)|uniprotkb:KIAA1108(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397122|imex:IM-18118-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055988.2|refseq:NP_001240841.1|ensembl:ENSG00000065882(gene)|ensembl:ENST00000261439(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:Q86TI0|rcsb pdb:3QYE|reactome:R-HSA-1445148 - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-697)|taxid:9606(Homo sapiens) - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:+tRzQ4X+dhS4c3md7N2TaJdHIWY9606 intact-crc:4B824E7883D44D63|rigid:U7Dzh0+kMRvTXpy8QGnc83nsbuU false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q14149 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-2556145|uniprotkb:Q9UEZ2|uniprotkb:A8KA92|ensembl:ENSP00000383333 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:morc3_human(display_long)|uniprotkb:KIAA0136(gene name synonym)|uniprotkb:ZCWCC3(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)|uniprotkb:MORC3(gene name)|psi-mi:MORC3(display_short)|uniprotkb:NXP2(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397206|imex:IM-18118-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_056173.1|ensembl:ENSG00000159256(gene)|ensembl:ENST00000400485(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:4QQ4|rcsb pdb:5SVI|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:6O1E|rcsb pdb:6O5W - - - figure legend:S6A/B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:Le9NRwTLr01G+tQNUAxFzEkGjfs9606 intact-crc:544A2EDB25A7B32D|rigid:BBDxpDiHoA4Igvn3TZf5hwECGbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01973 uniprotkb:O60343 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-522028|uniprotkb:A7E2X8|uniprotkb:B4DU25|uniprotkb:B4E235|uniprotkb:B6ETN8|uniprotkb:B6ETN9|uniprotkb:Q68D14|uniprotkb:Q5W0B9|ensembl:ENSP00000366863 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd4_human(display_long)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:TBC1D4(gene name)|psi-mi:TBC1D4(display_short)|uniprotkb:KIAA0603(gene name synonym)|uniprotkb:AS160(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397206|imex:IM-18118-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055647.2|ensembl:ENSG00000136111(gene)|ensembl:ENST00000377636(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|refseq:NP_001273587.1|refseq:NP_001273588.1|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:O60343|rcsb pdb:3QYB|rcsb pdb:7NIX|reactome:R-HSA-1445148 - - - figure legend:S6A/B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:AfptaRNss/0wnCrivoxs2PgxNOM9606 intact-crc:544A2EDB25A7B32D|rigid:BBDxpDiHoA4Igvn3TZf5hwECGbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01973 uniprotkb:O60343 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-522028|uniprotkb:A7E2X8|uniprotkb:B4DU25|uniprotkb:B4E235|uniprotkb:B6ETN8|uniprotkb:B6ETN9|uniprotkb:Q68D14|uniprotkb:Q5W0B9|ensembl:ENSP00000366863 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd4_human(display_long)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:TBC1D4(gene name)|psi-mi:TBC1D4(display_short)|uniprotkb:KIAA0603(gene name synonym)|uniprotkb:AS160(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397085|imex:IM-18118-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055647.2|ensembl:ENSG00000136111(gene)|ensembl:ENST00000377636(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|refseq:NP_001273587.1|refseq:NP_001273588.1|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:O60343|rcsb pdb:3QYB|rcsb pdb:7NIX|reactome:R-HSA-1445148 - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kasumi-2)|taxid:9606("Human Kasumi-2 ALL cell line (B cell precursor)") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:AfptaRNss/0wnCrivoxs2PgxNOM9606 intact-crc:C64645CDA70EE909|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q86TI0 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-1644036|uniprotkb:Q96K82|uniprotkb:Q9UPP4|uniprotkb:B7Z3D9|uniprotkb:E9PGH8|ensembl:ENSP00000261439 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd1_human(display_long)|uniprotkb:TBC1D1(gene name)|psi-mi:TBC1D1(display_short)|uniprotkb:KIAA1108(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397085|imex:IM-18118-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055988.2|refseq:NP_001240841.1|ensembl:ENSG00000065882(gene)|ensembl:ENST00000261439(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:Q86TI0|rcsb pdb:3QYE|reactome:R-HSA-1445148 - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kasumi-2)|taxid:9606("Human Kasumi-2 ALL cell line (B cell precursor)") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:+tRzQ4X+dhS4c3md7N2TaJdHIWY9606 intact-crc:C64645CDA70EE909|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q14149 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-2556145|uniprotkb:Q9UEZ2|uniprotkb:A8KA92|ensembl:ENSP00000383333 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:morc3_human(display_long)|uniprotkb:KIAA0136(gene name synonym)|uniprotkb:ZCWCC3(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)|uniprotkb:MORC3(gene name)|psi-mi:MORC3(display_short)|uniprotkb:NXP2(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397085|imex:IM-18118-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_056173.1|ensembl:ENSG00000159256(gene)|ensembl:ENST00000400485(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:4QQ4|rcsb pdb:5SVI|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:6O1E|rcsb pdb:6O5W - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kasumi-2)|taxid:9606("Human Kasumi-2 ALL cell line (B cell precursor)") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:Le9NRwTLr01G+tQNUAxFzEkGjfs9606 intact-crc:C64645CDA70EE909|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:P19474 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397085|imex:IM-18118-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like) - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kasumi-2)|taxid:9606("Human Kasumi-2 ALL cell line (B cell precursor)") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 intact-crc:C64645CDA70EE909|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q14149 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-2556145|uniprotkb:Q9UEZ2|uniprotkb:A8KA92|ensembl:ENSP00000383333 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:morc3_human(display_long)|uniprotkb:KIAA0136(gene name synonym)|uniprotkb:ZCWCC3(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)|uniprotkb:MORC3(gene name)|psi-mi:MORC3(display_short)|uniprotkb:NXP2(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397148|imex:IM-18118-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_056173.1|ensembl:ENSG00000159256(gene)|ensembl:ENST00000400485(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:4QQ4|rcsb pdb:5SVI|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:6O1E|rcsb pdb:6O5W - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:Le9NRwTLr01G+tQNUAxFzEkGjfs9606 intact-crc:293BF659992A6694|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:O60343 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-522028|uniprotkb:A7E2X8|uniprotkb:B4DU25|uniprotkb:B4E235|uniprotkb:B6ETN8|uniprotkb:B6ETN9|uniprotkb:Q68D14|uniprotkb:Q5W0B9|ensembl:ENSP00000366863 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd4_human(display_long)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:TBC1D4(gene name)|psi-mi:TBC1D4(display_short)|uniprotkb:KIAA0603(gene name synonym)|uniprotkb:AS160(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397148|imex:IM-18118-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055647.2|ensembl:ENSG00000136111(gene)|ensembl:ENST00000377636(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|refseq:NP_001273587.1|refseq:NP_001273588.1|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:O60343|rcsb pdb:3QYB|rcsb pdb:7NIX|reactome:R-HSA-1445148 - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:AfptaRNss/0wnCrivoxs2PgxNOM9606 intact-crc:293BF659992A6694|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:Q86TI0 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-1644036|uniprotkb:Q96K82|uniprotkb:Q9UPP4|uniprotkb:B7Z3D9|uniprotkb:E9PGH8|ensembl:ENSP00000261439 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:tbcd1_human(display_long)|uniprotkb:TBC1D1(gene name)|psi-mi:TBC1D1(display_short)|uniprotkb:KIAA1108(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397148|imex:IM-18118-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_055988.2|refseq:NP_001240841.1|ensembl:ENSG00000065882(gene)|ensembl:ENST00000261439(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:Q86TI0|rcsb pdb:3QYE|reactome:R-HSA-1445148 - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:+tRzQ4X+dhS4c3md7N2TaJdHIWY9606 intact-crc:293BF659992A6694|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01973 uniprotkb:P19474 intact:EBI-6082337|uniprotkb:Q5VVX6|uniprotkb:Q92776|uniprotkb:Q66K77|ensembl:ENSP00000360120 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 psi-mi:ror1_human(display_long)|uniprotkb:ROR1(gene name)|psi-mi:ROR1(display_short)|uniprotkb:NTRKR1(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 1(gene name synonym) psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bicocca et al. (2012) imex:IM-18118|pubmed:23153538 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6397148|imex:IM-18118-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005003.2|refseq:NP_001077061.1|dip:DIP-29734N|ensembl:ENSG00000185483(gene)|ensembl:ENST00000371079(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0048839"(inner ear development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000001(Kringle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016247(Tyrosine-protein kinase transmembrane receptor ROR)|interpro:IPR018056|interpro:IPR020067|interpro:IPR036179|interpro:IPR036790|interpro:IPR038178|mint:Q01973|rcsb pdb:5Z55|rcsb pdb:6BA5|rcsb pdb:6BAN|rcsb pdb:6TU9|reactome:R-HSA-5140745 refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like) - - - figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rch-acv)|taxid:9606("Human RCH-ACV cALL(B cell precursor) cell line") - 2012/11/22 2014/10/16 rogid:6IEe1PDlBcnHoo9bQbH/zomeJh49606 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 intact-crc:293BF659992A6694|rigid:2MOlzYVPJWWDBJjnP9rhll0i4NQ false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)