#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95684	uniprotkb:P29279	intact:EBI-1266334|uniprotkb:Q49AI0|uniprotkb:Q5R3F6|uniprotkb:Q96EW1|uniprotkb:A8K1D1|uniprotkb:B2R705|ensembl:ENSP00000355812	intact:EBI-2835375|uniprotkb:Q9UDL6|uniprotkb:Q96QX2|uniprotkb:Q96A79|uniprotkb:Q6LCY0|uniprotkb:E1P578|ensembl:ENSP00000356954	psi-mi:cep43_human(display_long)|uniprotkb:CEP43(gene name)|psi-mi:CEP43(display_short)|uniprotkb:FGFR1 oncogene partner(gene name synonym)|uniprotkb:FGFR1OP(gene name synonym)|uniprotkb:FOP(gene name synonym)	psi-mi:ccn2_human(display_long)|uniprotkb:CCN2(gene name)|psi-mi:CCN2(display_short)|uniprotkb:CTGF(gene name synonym)|uniprotkb:Cellular communication network factor 2(gene name synonym)|uniprotkb:Connective tissue growth factor(gene name synonym)|uniprotkb:HCS24(gene name synonym)|uniprotkb:Hypertrophic chondrocyte-specific protein 24(gene name synonym)|uniprotkb:IGFBP8(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 8(gene name synonym)	psi-mi:"MI:0089"(protein array)	Aoyama et al. (2012)	mint:d-12-01264r1|pubmed:23142580|mint:MINT-8400166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8157592|mint:MINT-8400171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008976.1|refseq:NP_919410.1|ensembl:ENSG00000213066(gene)|ensembl:ENST00000366847(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR018993|rcsb pdb:2D68|reactome:R-HSA-1839117|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5655302|reactome:R-HSA-8854518|mint:MINT-8400174(identity)	go:"GO:0001525"(angiogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016477"(cell migration)|go:"GO:0001503"(ossification)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034059"(response to anoxia)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|reactome:R-HSA-2032785|reactome:R-HSA-8951671|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|ensembl:ENSG00000118523(gene)|ensembl:ENST00000367976(transcript)|go:"GO:0001502"(cartilage condensation)|refseq:NP_001892.1|mint:MINT-8400173(identity)	-	-	-	figure legend:f1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:AcqOicx3UulQVfNzo6X0XyfExcc9606	rogid:49UlrN4n3y1PYiOptu1l0KPco+89606	intact-crc:494712A0A5493D24|rigid:Xp3dhL2KzySQk4dUCBnXNdFzTkg	false	-	his tag:?-?(MINT-8400176)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P21802	uniprotkb:P29279	intact:EBI-1028658|uniprotkb:P18443|uniprotkb:Q01742|uniprotkb:Q12922|uniprotkb:Q14300|uniprotkb:Q14301|uniprotkb:Q14302|uniprotkb:Q14303|uniprotkb:Q14304|uniprotkb:Q14305|uniprotkb:Q14672|uniprotkb:Q14718|uniprotkb:Q14719|uniprotkb:Q86YI4|uniprotkb:Q96KL9|uniprotkb:Q96KM0|uniprotkb:Q96KM1|uniprotkb:Q96KM2|uniprotkb:Q9NZU2|uniprotkb:Q9NZU3|uniprotkb:Q9UD01|uniprotkb:Q9UD02|uniprotkb:Q9UIH3|uniprotkb:Q9UIH4|uniprotkb:Q9UIH5|uniprotkb:Q9UIH6|uniprotkb:Q9UIH7|uniprotkb:Q9UIH8|uniprotkb:Q9UM87|uniprotkb:Q9UMC6|uniprotkb:Q9UNS7|uniprotkb:Q9UQH7|uniprotkb:Q9UQH8|uniprotkb:Q9UQH9|uniprotkb:Q9UQI0|uniprotkb:Q1KHY5|ensembl:ENSP00000351276|uniprotkb:B4DFC2|uniprotkb:E7EVR6|uniprotkb:E9PCR0|uniprotkb:Q8IXC7	intact:EBI-2835375|uniprotkb:Q9UDL6|uniprotkb:Q96QX2|uniprotkb:Q96A79|uniprotkb:Q6LCY0|uniprotkb:E1P578|ensembl:ENSP00000356954	psi-mi:fgfr2_human(display_long)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:K-sam(gene name synonym)	psi-mi:ccn2_human(display_long)|uniprotkb:CCN2(gene name)|psi-mi:CCN2(display_short)|uniprotkb:CTGF(gene name synonym)|uniprotkb:Cellular communication network factor 2(gene name synonym)|uniprotkb:Connective tissue growth factor(gene name synonym)|uniprotkb:HCS24(gene name synonym)|uniprotkb:Hypertrophic chondrocyte-specific protein 24(gene name synonym)|uniprotkb:IGFBP8(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 8(gene name synonym)	psi-mi:"MI:0089"(protein array)	Aoyama et al. (2012)	mint:d-12-01264r1|pubmed:23142580|mint:MINT-8400166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8157633|mint:MINT-8400183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000132.3|refseq:NP_001138385.1|refseq:NP_001138386.1|refseq:NP_001138387.1|refseq:NP_001138388.1|refseq:NP_001138389.1|refseq:NP_001138390.1|refseq:NP_001138391.1|refseq:NP_075259.4|ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030901"(midbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0035265"(organ growth)|go:"GO:0035602"(fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell)|go:"GO:0035603"(fibroblast growth factor receptor signaling pathway involved in hemopoiesis)|go:"GO:0035604"(fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060174"(limb bud formation)|go:"GO:0060348"(bone development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060512"(prostate gland morphogenesis)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0060595"(fibroblast growth factor receptor signaling pathway involved in mammary gland specification)|go:"GO:0060601"(lateral sprouting from an epithelium)|go:"GO:0060615"(mammary gland bud formation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060667"(branch elongation involved in salivary gland morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060688"(regulation of morphogenesis of a branching structure)|go:"GO:0060915"(mesenchymal cell differentiation involved in lung development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|mint:P21802|rcsb pdb:1DJS|rcsb pdb:1E0O|rcsb pdb:1EV2|rcsb pdb:1GJO|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:1NUN|rcsb pdb:1OEC|rcsb pdb:1WVZ|rcsb pdb:2FDB|rcsb pdb:2PSQ|rcsb pdb:2PVF|rcsb pdb:2PVY|rcsb pdb:2PWL|rcsb pdb:2PY3|rcsb pdb:2PZ5|rcsb pdb:2PZP|rcsb pdb:2PZR|rcsb pdb:2Q0B|rcsb pdb:3B2T|rcsb pdb:3CAF|rcsb pdb:3CLY|rcsb pdb:3CU1|rcsb pdb:3DAR|rcsb pdb:3EUU|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3RI1|rcsb pdb:4J23|rcsb pdb:4J95|rcsb pdb:4J96|rcsb pdb:4J97|rcsb pdb:4J98|rcsb pdb:4J99|rcsb pdb:4WV1|rcsb pdb:5EG3|rcsb pdb:5UGL|rcsb pdb:5UGX|rcsb pdb:5UHN|rcsb pdb:5UI0|rcsb pdb:6AGX|rcsb pdb:6LVK|rcsb pdb:6LVL|rcsb pdb:6V6Q|rcsb pdb:7KIA|rcsb pdb:7KIE|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190375|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853333|reactome:R-HSA-190377|reactome:R-HSA-2023837|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|refseq:NP_001307583.1|refseq:NP_001307587.1|refseq:NP_075418.1|dip:DIP-3788N|mint:MINT-8400185(identity)	go:"GO:0001525"(angiogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016477"(cell migration)|go:"GO:0001503"(ossification)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034059"(response to anoxia)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|reactome:R-HSA-2032785|reactome:R-HSA-8951671|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|ensembl:ENSG00000118523(gene)|ensembl:ENST00000367976(transcript)|go:"GO:0001502"(cartilage condensation)|refseq:NP_001892.1|mint:MINT-8400187(identity)	-	-	-	figure legend:f1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rogid:49UlrN4n3y1PYiOptu1l0KPco+89606	intact-crc:6A673D2D61702A65|rigid:NdSOIgyOxPYNX0pQ+A7cVDuywGU	false	-	his tag:?-?(MINT-8400188)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P22607	uniprotkb:P29279	intact:EBI-348399|ensembl:ENSP00000414914|uniprotkb:Q14308|uniprotkb:Q16294|uniprotkb:Q16608|uniprotkb:D3DVP9|uniprotkb:D3DVQ0|uniprotkb:Q59FL9	intact:EBI-2835375|uniprotkb:Q9UDL6|uniprotkb:Q96QX2|uniprotkb:Q96A79|uniprotkb:Q6LCY0|uniprotkb:E1P578|ensembl:ENSP00000356954	psi-mi:fgfr3_human(display_long)|uniprotkb:FGFR3(gene name)|psi-mi:FGFR3(display_short)|uniprotkb:JTK4(gene name synonym)	psi-mi:ccn2_human(display_long)|uniprotkb:CCN2(gene name)|psi-mi:CCN2(display_short)|uniprotkb:CTGF(gene name synonym)|uniprotkb:Cellular communication network factor 2(gene name synonym)|uniprotkb:Connective tissue growth factor(gene name synonym)|uniprotkb:HCS24(gene name synonym)|uniprotkb:Hypertrophic chondrocyte-specific protein 24(gene name synonym)|uniprotkb:IGFBP8(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 8(gene name synonym)	psi-mi:"MI:0089"(protein array)	Aoyama et al. (2012)	mint:d-12-01264r1|pubmed:23142580|mint:MINT-8400166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8157674|mint:MINT-8400193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000133.1|refseq:NP_001156685.1|refseq:NP_075254.1|ensembl:ENSG00000068078(gene)|ensembl:ENST00000440486(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030282"(bone mineralization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070977"(bone maturation)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|rcsb pdb:1RY7|rcsb pdb:2LZL|rcsb pdb:4K33|rcsb pdb:6LVM|rcsb pdb:6PNX|rcsb pdb:7DHL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839130|reactome:R-HSA-2033514|reactome:R-HSA-2033515|reactome:R-HSA-2219530|reactome:R-HSA-5654227|reactome:R-HSA-5654704|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654732|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|dip:DIP-4016N|mint:MINT-8400195(identity)	go:"GO:0001525"(angiogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016477"(cell migration)|go:"GO:0001503"(ossification)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034059"(response to anoxia)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|reactome:R-HSA-2032785|reactome:R-HSA-8951671|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|ensembl:ENSG00000118523(gene)|ensembl:ENST00000367976(transcript)|go:"GO:0001502"(cartilage condensation)|refseq:NP_001892.1|mint:MINT-8400197(identity)	-	-	-	figure legend:f1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:5yOR7/EmXO7Wff9yKMSdZuWjIKU9606	rogid:49UlrN4n3y1PYiOptu1l0KPco+89606	intact-crc:2D44C09C2AC3D73F|rigid:zETVq0Ol9wQgM9FZtZwjJ8ie09k	false	-	his tag:?-?(MINT-8400198)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)