#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02340	uniprotkb:O08586	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Robbins et al. (2012)	pubmed:23123091|mint:MINT-8399238	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8111580|mint:MINT-8399259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-8399263(identity)	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N|mint:MINT-8399261(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f2|comment:mint	taxid:10090(mouse-jb6)|taxid:10090(Mus musculus)	-	2012/10/15	2018/10/11	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	intact-crc:956C4334E86A5594|rigid:DoWbdUsSd2/SsTQp/DoPBu3tx98	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02340	uniprotkb:O08586	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robbins et al. (2012)	pubmed:23123091|mint:MINT-8399238	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8143111|mint:MINT-8399246	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-8399252(identity)	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N|mint:MINT-8399248(identity)	-	-	-	figure legend:f1b f1c|comment:mint	taxid:10090(mouse-jb6)|taxid:10090(Mus musculus)	-	2012/10/15	2018/10/11	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	intact-crc:424148CE0E9212FE|rigid:DoWbdUsSd2/SsTQp/DoPBu3tx98	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08586	uniprotkb:P02340	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robbins et al. (2012)	pubmed:23123091|mint:MINT-8399238	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8143186|mint:MINT-8399297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N|mint:MINT-8399299(identity)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-8399301(identity)	-	-	-	figure legend:f1b f1c|comment:mint	taxid:10090(mouse-jb6)|taxid:10090(Mus musculus)	-	2012/10/15	2018/10/11	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	intact-crc:C5BA9EBF025A8C3A|rigid:DoWbdUsSd2/SsTQp/DoPBu3tx98	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02340	uniprotkb:O08586	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Robbins et al. (2012)	pubmed:23123091|mint:MINT-8399238	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8143262|mint:MINT-8399304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N|mint:MINT-8399308(identity)	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N|mint:MINT-8399306(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f3a|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2018/10/11	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	intact-crc:2245A89D4A834C33|rigid:DoWbdUsSd2/SsTQp/DoPBu3tx98	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)