#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5MNZ9	uniprotkb:O94817	intact:EBI-720689|uniprotkb:Q8IXM5|uniprotkb:Q9NWF8|ensembl:ENSP00000262139	intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107	psi-mi:wipi1_human(display_long)|uniprotkb:WD40 repeat protein interacting with phosphoinositides of 49 kDa(gene name synonym)|uniprotkb:Atg18 protein homolog(gene name synonym)|uniprotkb:WIPI1(gene name)|psi-mi:WIPI1(display_short)|uniprotkb:WIPI49(gene name synonym)	psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gaugel et al. (2012)	pubmed:23088497|imex:IM-21838	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6391026|imex:IM-21838-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060453.3|refseq:NP_001307701.1|ensembl:ENSG00000070540(gene)|ensembl:ENST00000262139(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010008"(endosome membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0048203"(vesicle targeting, trans-Golgi to endosome)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032909|interpro:IPR036322|reactome:R-HSA-1632852|reactome:R-HSA-381038	reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N	go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:fig. 4|expression level:U2OS cells transiently express GFP-WIPI-1 or GFP-tagged mutant WIPI-1 variants|comment:the following mutations on WIPI1 did not nullify the ability to localize at autophagosomal membranes-Asn23, Gln24, Asp25, Glu64, Arg107, Arg110, Arg112, Gly198, Glu224, Phe225, Ser250, Ser335, Gly336|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2012/11/14	2014/10/16	rogid:0iEJwMV1yagtSWHMXbw7+EKc3pk9606	rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606	intact-crc:DF63BAC97ED6BBD9|rigid:AYF7gh7xvmLfK7hwXIVezrZKSp8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
chebi:"CHEBI:16851"	uniprotkb:Q5MNZ9	intact:EBI-1257121	intact:EBI-720689|uniprotkb:Q8IXM5|uniprotkb:Q9NWF8|ensembl:ENSP00000262139	psi-mi:1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate(display_short)|psi-mi:"CHEBI:16851"(display_long)	psi-mi:wipi1_human(display_long)|uniprotkb:WD40 repeat protein interacting with phosphoinositides of 49 kDa(gene name synonym)|uniprotkb:Atg18 protein homolog(gene name synonym)|uniprotkb:WIPI1(gene name)|psi-mi:WIPI1(display_short)|uniprotkb:WIPI49(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Gaugel et al. (2012)	pubmed:23088497|imex:IM-21838	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-9251086|imex:IM-21838-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060453.3|refseq:NP_001307701.1|ensembl:ENSG00000070540(gene)|ensembl:ENST00000262139(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010008"(endosome membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0048203"(vesicle targeting, trans-Golgi to endosome)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032909|interpro:IPR036322|reactome:R-HSA-1632852|reactome:R-HSA-381038	go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:figs.  6, 8|expression level:U2OS cells transiently express GFP-WIPI-1 or GFP-tagged mutant WIPI-1 variants|comment:the following mutations on WIPI1 did not nullify the ability to localize at autophagosomal membranes-Asn23, Gln24, Asp25, Glu64, Arg107, Arg110, Arg112, Gly198, Glu224, Phe225, Ser250, Ser335, Gly336|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/14	2014/10/16	-	rogid:0iEJwMV1yagtSWHMXbw7+EKc3pk9606	intact-crc:4AC221529E217F30	false	-	green fluorescent protein tag:?-?|mutation disrupting interaction strength:226-227	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:17283"	uniprotkb:Q5MNZ9	intact:EBI-1257113	intact:EBI-720689|uniprotkb:Q8IXM5|uniprotkb:Q9NWF8|ensembl:ENSP00000262139	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wipi1_human(display_long)|uniprotkb:WD40 repeat protein interacting with phosphoinositides of 49 kDa(gene name synonym)|uniprotkb:Atg18 protein homolog(gene name synonym)|uniprotkb:WIPI1(gene name)|psi-mi:WIPI1(display_short)|uniprotkb:WIPI49(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Gaugel et al. (2012)	pubmed:23088497|imex:IM-21838	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-9251045|imex:IM-21838-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060453.3|refseq:NP_001307701.1|ensembl:ENSG00000070540(gene)|ensembl:ENST00000262139(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010008"(endosome membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0048203"(vesicle targeting, trans-Golgi to endosome)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032909|interpro:IPR036322|reactome:R-HSA-1632852|reactome:R-HSA-381038	go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:figs.  6, 7|expression level:U2OS cells transiently express GFP-WIPI-1 or GFP-tagged mutant WIPI-1 variants|comment:the following mutations on WIPI1 did not nullify the ability to localize at autophagosomal membranes-Asn23, Gln24, Asp25, Glu64, Arg107, Arg110, Arg112, Gly198, Glu224, Phe225, Ser250, Ser335, Gly336|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/14	2014/10/16	-	rogid:0iEJwMV1yagtSWHMXbw7+EKc3pk9606	intact-crc:F2DC6F1520913004	false	-	mutation disrupting interaction strength:112-112|green fluorescent protein tag:?-?|mutation disrupting interaction strength:226-227|mutation disrupting interaction strength:185-185|mutation decreasing interaction strength:203-203|mutation decreasing interaction strength:205-205|mutation decreasing interaction strength:208-208|mutation decreasing interaction strength:209-209|mutation disrupting interaction strength:212-212|mutation decreasing interaction strength:226-226|mutation decreasing interaction strength:227-227|mutation decreasing interaction strength:228-228|mutation decreasing interaction strength:251-251|mutation decreasing interaction strength:255-255|mutation decreasing interaction strength:257-257	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)