#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01019	uniprotkb:Q10714	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-115736|uniprotkb:A4V0P3|uniprotkb:Q27572|uniprotkb:Q9NKE4|uniprotkb:Q9TX66|ensemblmetazoa:FBpp0080129|ensemblmetazoa:FBpp0080130|ensemblmetazoa:FBpp0310259|uniprotkb:Q9VJV3	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:ace_drome(display_long)|uniprotkb:Ance(gene name)|psi-mi:Ance(display_short)|uniprotkb:Race(gene name synonym)|uniprotkb:CG8827(orf name)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Akif et al. (2012)	pubmed:23082758|mint:MINT-8400253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095597|mint:MINT-8400258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-8400261(identity)	ensemblmetazoa:FBgn0012037(gene)|ensemblmetazoa:FBtr0080552(transcript)|ensemblmetazoa:FBtr0080553(transcript)|ensemblmetazoa:FBtr0343667(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007291"(sperm individualization)|rcsb pdb:1J38|rcsb pdb:2X8Y|rcsb pdb:2X8Z|rcsb pdb:2X90|rcsb pdb:2X91|rcsb pdb:2X92|rcsb pdb:2X93|rcsb pdb:2X94|go:"GO:0007552"(metamorphosis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|rcsb pdb:2X95|rcsb pdb:2X96|rcsb pdb:2X97|rcsb pdb:2XHM|rcsb pdb:3ZQZ|rcsb pdb:4AA1|rcsb pdb:4AA2|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0032504"(multicellular organism reproduction)|rcsb pdb:4ASQ|go:"GO:0046872"(metal ion binding)|rcsb pdb:4ASR|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|rcsb pdb:4CA7|rcsb pdb:4CA8|rcsb pdb:5A2R|reactome:R-DME-2022377|rcsb pdb:1J36|rcsb pdb:1J37|refseq:NP_001285915.1|refseq:NP_477046.1|refseq:NP_723852.1|flybase:FBgn0012037|mint:MINT-8400260(identity)	-	-	-	comment:mint|figure legend:t1 t2 t3 f1 f2a f3a f3b	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:9fhRnoqgyGvBdM/zJm7V4bX7dNs7227	intact-crc:48694DC8E97E316E|rigid:3SraxAt+bme3mxfO+lt61v6nmEM	false	binding-associated region:34-41(MINT-8400266)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01021	uniprotkb:Q10714	intact:EBI-8095641|intact:MINT-8400351|uniprotkb:Q9PT52	intact:EBI-115736|uniprotkb:A4V0P3|uniprotkb:Q27572|uniprotkb:Q9NKE4|uniprotkb:Q9TX66|ensemblmetazoa:FBpp0080129|ensemblmetazoa:FBpp0080130|ensemblmetazoa:FBpp0310259|uniprotkb:Q9VJV3	psi-mi:bnp_globl(display_long)|uniprotkb:Angiotensin-converting enzyme inhibitor(gene name synonym)|uniprotkb:BPP-CNP homolog(gene name synonym)	psi-mi:ace_drome(display_long)|uniprotkb:Ance(gene name)|psi-mi:Ance(display_short)|uniprotkb:Race(gene name synonym)|uniprotkb:CG8827(orf name)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Akif et al. (2012)	pubmed:23082758|mint:MINT-8400253	taxid:242054(mamushi)|taxid:242054(Gloydius blomhoffii)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095656|mint:MINT-8400340	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030480|interpro:IPR000663(Natriuretic peptide)|rcsb pdb:4AA2|rcsb pdb:4APJ|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0042311"(vasodilation)|go:"GO:0090729"(toxin activity)|mint:MINT-8400361(identity)	ensemblmetazoa:FBgn0012037(gene)|ensemblmetazoa:FBtr0080552(transcript)|ensemblmetazoa:FBtr0080553(transcript)|ensemblmetazoa:FBtr0343667(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007291"(sperm individualization)|rcsb pdb:1J38|rcsb pdb:2X8Y|rcsb pdb:2X8Z|rcsb pdb:2X90|rcsb pdb:2X91|rcsb pdb:2X92|rcsb pdb:2X93|rcsb pdb:2X94|go:"GO:0007552"(metamorphosis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|rcsb pdb:2X95|rcsb pdb:2X96|rcsb pdb:2X97|rcsb pdb:2XHM|rcsb pdb:3ZQZ|rcsb pdb:4AA1|rcsb pdb:4AA2|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0032504"(multicellular organism reproduction)|rcsb pdb:4ASQ|go:"GO:0046872"(metal ion binding)|rcsb pdb:4ASR|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|rcsb pdb:4CA7|rcsb pdb:4CA8|rcsb pdb:5A2R|reactome:R-DME-2022377|rcsb pdb:1J36|rcsb pdb:1J37|refseq:NP_001285915.1|refseq:NP_477046.1|refseq:NP_723852.1|flybase:FBgn0012037|mint:MINT-8400346(identity)	-	comment:mint	-	comment:mint|figure legend:t1 t2 t3 f2d f3e f3f	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:+ri8fHwDFtHCpeYqUaQehTmK2Kk242054	rogid:9fhRnoqgyGvBdM/zJm7V4bX7dNs7227	intact-crc:AB7C7D256B255A36|rigid:OxTiK5o1xl34k795eH5JNvdGBxU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10714	uniprotkb:P01042	intact:EBI-115736|uniprotkb:A4V0P3|uniprotkb:Q27572|uniprotkb:Q9NKE4|uniprotkb:Q9TX66|ensemblmetazoa:FBpp0080129|ensemblmetazoa:FBpp0080130|ensemblmetazoa:FBpp0310259|uniprotkb:Q9VJV3	intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1	psi-mi:ace_drome(display_long)|uniprotkb:Ance(gene name)|psi-mi:Ance(display_short)|uniprotkb:Race(gene name synonym)|uniprotkb:CG8827(orf name)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym)	psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Akif et al. (2012)	pubmed:23082758|mint:MINT-8400253	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095626|mint:MINT-8400271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0012037(gene)|ensemblmetazoa:FBtr0080552(transcript)|ensemblmetazoa:FBtr0080553(transcript)|ensemblmetazoa:FBtr0343667(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007291"(sperm individualization)|rcsb pdb:1J38|rcsb pdb:2X8Y|rcsb pdb:2X8Z|rcsb pdb:2X90|rcsb pdb:2X91|rcsb pdb:2X92|rcsb pdb:2X93|rcsb pdb:2X94|go:"GO:0007552"(metamorphosis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|rcsb pdb:2X95|rcsb pdb:2X96|rcsb pdb:2X97|rcsb pdb:2XHM|rcsb pdb:3ZQZ|rcsb pdb:4AA1|rcsb pdb:4AA2|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0032504"(multicellular organism reproduction)|rcsb pdb:4ASQ|go:"GO:0046872"(metal ion binding)|rcsb pdb:4ASR|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|rcsb pdb:4CA7|rcsb pdb:4CA8|rcsb pdb:5A2R|reactome:R-DME-2022377|rcsb pdb:1J36|rcsb pdb:1J37|refseq:NP_001285915.1|refseq:NP_477046.1|refseq:NP_723852.1|flybase:FBgn0012037|mint:MINT-8400277(identity)	ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-8400273(identity)	-	-	-	comment:mint|figure legend:t1 t2 t3 f1 f2b f3c sf3	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:9fhRnoqgyGvBdM/zJm7V4bX7dNs7227	rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606	intact-crc:7CB13D3A2E589B0C|rigid:lD5GQS4TAaShOu0nE7/zhM9TU/A	false	-	binding-associated region:381-389(MINT-8400332)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01042	uniprotkb:Q10714	intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1	intact:EBI-115736|uniprotkb:A4V0P3|uniprotkb:Q27572|uniprotkb:Q9NKE4|uniprotkb:Q9TX66|ensemblmetazoa:FBpp0080129|ensemblmetazoa:FBpp0080130|ensemblmetazoa:FBpp0310259|uniprotkb:Q9VJV3	psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:ace_drome(display_long)|uniprotkb:Ance(gene name)|psi-mi:Ance(display_short)|uniprotkb:Race(gene name synonym)|uniprotkb:CG8827(orf name)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Akif et al. (2012)	pubmed:23082758|mint:MINT-8400253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095673|mint:MINT-8400378	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-8400380(identity)	ensemblmetazoa:FBgn0012037(gene)|ensemblmetazoa:FBtr0080552(transcript)|ensemblmetazoa:FBtr0080553(transcript)|ensemblmetazoa:FBtr0343667(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007291"(sperm individualization)|rcsb pdb:1J38|rcsb pdb:2X8Y|rcsb pdb:2X8Z|rcsb pdb:2X90|rcsb pdb:2X91|rcsb pdb:2X92|rcsb pdb:2X93|rcsb pdb:2X94|go:"GO:0007552"(metamorphosis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|rcsb pdb:2X95|rcsb pdb:2X96|rcsb pdb:2X97|rcsb pdb:2XHM|rcsb pdb:3ZQZ|rcsb pdb:4AA1|rcsb pdb:4AA2|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0032504"(multicellular organism reproduction)|rcsb pdb:4ASQ|go:"GO:0046872"(metal ion binding)|rcsb pdb:4ASR|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|rcsb pdb:4CA7|rcsb pdb:4CA8|rcsb pdb:5A2R|reactome:R-DME-2022377|rcsb pdb:1J36|rcsb pdb:1J37|refseq:NP_001285915.1|refseq:NP_477046.1|refseq:NP_723852.1|flybase:FBgn0012037|mint:MINT-8400384(identity)	-	-	-	figure legend:sf2|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606	rogid:9fhRnoqgyGvBdM/zJm7V4bX7dNs7227	intact-crc:8D2DACCBC955A14B|rigid:lD5GQS4TAaShOu0nE7/zhM9TU/A	false	binding-associated region:381-389(MINT-8400381)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:Q10714	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-115736|uniprotkb:A4V0P3|uniprotkb:Q27572|uniprotkb:Q9NKE4|uniprotkb:Q9TX66|ensemblmetazoa:FBpp0080129|ensemblmetazoa:FBpp0080130|ensemblmetazoa:FBpp0310259|uniprotkb:Q9VJV3	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:ace_drome(display_long)|uniprotkb:Ance(gene name)|psi-mi:Ance(display_short)|uniprotkb:Race(gene name synonym)|uniprotkb:CG8827(orf name)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Akif et al. (2012)	pubmed:23082758|mint:MINT-8400253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095744|mint:MINT-8400392	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-8400394(identity)	ensemblmetazoa:FBgn0012037(gene)|ensemblmetazoa:FBtr0080552(transcript)|ensemblmetazoa:FBtr0080553(transcript)|ensemblmetazoa:FBtr0343667(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007291"(sperm individualization)|rcsb pdb:1J38|rcsb pdb:2X8Y|rcsb pdb:2X8Z|rcsb pdb:2X90|rcsb pdb:2X91|rcsb pdb:2X92|rcsb pdb:2X93|rcsb pdb:2X94|go:"GO:0007552"(metamorphosis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|rcsb pdb:2X95|rcsb pdb:2X96|rcsb pdb:2X97|rcsb pdb:2XHM|rcsb pdb:3ZQZ|rcsb pdb:4AA1|rcsb pdb:4AA2|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0032504"(multicellular organism reproduction)|rcsb pdb:4ASQ|go:"GO:0046872"(metal ion binding)|rcsb pdb:4ASR|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|rcsb pdb:4CA7|rcsb pdb:4CA8|rcsb pdb:5A2R|reactome:R-DME-2022377|rcsb pdb:1J36|rcsb pdb:1J37|refseq:NP_001285915.1|refseq:NP_477046.1|refseq:NP_723852.1|flybase:FBgn0012037|mint:MINT-8400398(identity)	-	-	-	figure legend:sf1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/24	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:9fhRnoqgyGvBdM/zJm7V4bX7dNs7227	intact-crc:A02669C5AEFE5880|rigid:3SraxAt+bme3mxfO+lt61v6nmEM	false	binding-associated region:34-43(MINT-8400395)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)