#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24627	uniprotkb:Q9WU74	intact:EBI-8076910|uniprotkb:Q9MZY3|uniprotkb:Q29629|uniprotkb:Q6LEC7|uniprotkb:Q1JQC9|intact:UNK-6028871|ensembl:ENSBTAP00000001704	intact:EBI-8076872|uniprotkb:Q497B9|intact:UNK-5559263|uniprotkb:Q9WU76|uniprotkb:Q9WU75|ensembl:ENSRNOP00000041379	psi-mi:trfl_bovin(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)	psi-mi:lsr_rat(display_long)|uniprotkb:Lsr(gene name)|psi-mi:Lsr(display_short)|uniprotkb:Lisch7(gene name synonym)|uniprotkb:Lipolysis-stimulated remnant receptor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Ahmad et al. (2012)	mint:fj-12-0475.r1|pubmed:23050782|mint:MINT-8396086	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8076904|mint:MINT-8396091	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_851341.1|refseq:XP_015315141.1|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051673"(membrane disruption in another organism)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1900229"(negative regulation of single-species biofilm formation in or on host organism)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000308"("negative regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042581"(specific granule)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044793"(negative regulation by host of viral process)|ensembl:ENSBTAG00000001292(gene)|ensembl:ENSBTAT00000001704(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|rcsb pdb:3TOD|rcsb pdb:3TTR|rcsb pdb:3TUS|rcsb pdb:3U72|rcsb pdb:3U8Q|rcsb pdb:3UGW|rcsb pdb:3UK4|rcsb pdb:3USD|rcsb pdb:3V5A|rcsb pdb:3VDF|rcsb pdb:4DIG|rcsb pdb:4DXU|rcsb pdb:4FIM|rcsb pdb:4FJP|rcsb pdb:4FOR|rcsb pdb:4G2Z|rcsb pdb:4G77|rcsb pdb:4G8H|rcsb pdb:4GRK|rcsb pdb:4N6P|rcsb pdb:4NED|rcsb pdb:4OQO|rcsb pdb:5CRY|rcsb pdb:5HBC|rcsb pdb:7ENU|rcsb pdb:7EQU|rcsb pdb:7EV0|rcsb pdb:7EVQ|reactome:R-BTA-6798695|reactome:R-BTA-6799990|reactome:R-BTA-6803157|rcsb pdb:3TAJ|interpro:IPR018195|interpro:IPR030684|mint:P24627|rcsb pdb:1BLF|rcsb pdb:1LFC|rcsb pdb:1NKX|rcsb pdb:1SDX|rcsb pdb:1Y58|rcsb pdb:2ALU|rcsb pdb:2AYS|rcsb pdb:2B65|rcsb pdb:2DOJ|rcsb pdb:2DP8|rcsb pdb:2DQV|rcsb pdb:2DS9|rcsb pdb:2DSF|rcsb pdb:2DVC|rcsb pdb:2DWA|rcsb pdb:2DWH|rcsb pdb:2DWI|rcsb pdb:2DWJ|rcsb pdb:2DXR|rcsb pdb:2DXY|rcsb pdb:2DYX|rcsb pdb:2E0S|rcsb pdb:2E1S|rcsb pdb:2FA7|rcsb pdb:2G93|rcsb pdb:2H4I|rcsb pdb:2HCA|rcsb pdb:2MD1|rcsb pdb:2MD2|rcsb pdb:2MD3|rcsb pdb:2MD4|rcsb pdb:2NUV|rcsb pdb:2NWJ|rcsb pdb:2O1L|rcsb pdb:2O51|rcsb pdb:2OCU|rcsb pdb:2P1S|rcsb pdb:2PX1|rcsb pdb:2Q8J|rcsb pdb:2QJE|rcsb pdb:2R71|rcsb pdb:2R9J|rcsb pdb:2ZMB|rcsb pdb:3CFL|rcsb pdb:3CI8|rcsb pdb:3CRB|rcsb pdb:3E9X|rcsb pdb:3IAZ|rcsb pdb:3IB0|rcsb pdb:3IB1|rcsb pdb:3IB2|rcsb pdb:3K0V|rcsb pdb:3KJ7|rcsb pdb:3MJN|rcsb pdb:3O97|rcsb pdb:3RGY|rcsb pdb:3SDF|mint:MINT-8396093(identity)	rgd:69236|refseq:NP_116005.1|refseq:XP_006228906.1|refseq:XP_006228907.1|ensembl:ENSRNOG00000021053(gene)|ensembl:ENSRNOT00000044678(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0042627"(chylomicron)|go:"GO:0060856"(establishment of blood-brain barrier)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061689"(tricellular tight junction)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:1904274"(tricellular tight junction assembly)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008664(LISCH7)|interpro:IPR036179|mint:MINT-8396196(identity)	-	comment:mint|function:"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate"|function:The lactotransferrin peptidase S60 domain 1 functions as a serine protease that cuts arginine rich regions. This function contributes to the antimicrobial activity|comment:homomint|function:Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa|function:Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria	comment:mint|comment:homomint|function:Probable role in the clearance of triglyceride-rich lipoprotein from plasma. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells	figure legend:f5a|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/02	2014/10/16	rogid:/pv90AdDFP/It+VFiEQPRtnRNtU9913	rogid:1ClDHImHhu+2LAJt75HamOU8T4E10116	intact-crc:91EE4BF7135179A3|rigid:vWRiPEEBNHvcWCGg1N0tQachW5o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24627	uniprotkb:Q99KG5	intact:EBI-8076910|uniprotkb:Q9MZY3|uniprotkb:Q29629|uniprotkb:Q6LEC7|uniprotkb:Q1JQC9|intact:UNK-6028871|ensembl:ENSBTAP00000001704	intact:EBI-8077034|uniprotkb:Q6U816|uniprotkb:Q61149|intact:UNK-5536706|uniprotkb:Q61148|uniprotkb:Q3UIQ9|uniprotkb:Q3TJE7|ensembl:ENSMUSP00000001279|ensembl:ENSMUSP00000146120	psi-mi:trfl_bovin(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)	psi-mi:lsr_mouse(display_long)|uniprotkb:Lsr(gene name)|psi-mi:Lsr(display_short)|uniprotkb:Lisch7(gene name synonym)|uniprotkb:Liver-specific bHLH-Zip transcription factor(gene name synonym)|uniprotkb:Lipolysis-stimulated receptor(gene name synonym)|uniprotkb:Liver-specific gene on mouse chromosome 7 protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ahmad et al. (2012)	mint:fj-12-0475.r1|pubmed:23050782|mint:MINT-8396086	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8077028|mint:MINT-8396236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_851341.1|refseq:XP_015315141.1|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051673"(membrane disruption in another organism)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1900229"(negative regulation of single-species biofilm formation in or on host organism)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000308"("negative regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042581"(specific granule)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044793"(negative regulation by host of viral process)|ensembl:ENSBTAG00000001292(gene)|ensembl:ENSBTAT00000001704(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|rcsb pdb:3TOD|rcsb pdb:3TTR|rcsb pdb:3TUS|rcsb pdb:3U72|rcsb pdb:3U8Q|rcsb pdb:3UGW|rcsb pdb:3UK4|rcsb pdb:3USD|rcsb pdb:3V5A|rcsb pdb:3VDF|rcsb pdb:4DIG|rcsb pdb:4DXU|rcsb pdb:4FIM|rcsb pdb:4FJP|rcsb pdb:4FOR|rcsb pdb:4G2Z|rcsb pdb:4G77|rcsb pdb:4G8H|rcsb pdb:4GRK|rcsb pdb:4N6P|rcsb pdb:4NED|rcsb pdb:4OQO|rcsb pdb:5CRY|rcsb pdb:5HBC|rcsb pdb:7ENU|rcsb pdb:7EQU|rcsb pdb:7EV0|rcsb pdb:7EVQ|reactome:R-BTA-6798695|reactome:R-BTA-6799990|reactome:R-BTA-6803157|rcsb pdb:3TAJ|interpro:IPR018195|interpro:IPR030684|mint:P24627|rcsb pdb:1BLF|rcsb pdb:1LFC|rcsb pdb:1NKX|rcsb pdb:1SDX|rcsb pdb:1Y58|rcsb pdb:2ALU|rcsb pdb:2AYS|rcsb pdb:2B65|rcsb pdb:2DOJ|rcsb pdb:2DP8|rcsb pdb:2DQV|rcsb pdb:2DS9|rcsb pdb:2DSF|rcsb pdb:2DVC|rcsb pdb:2DWA|rcsb pdb:2DWH|rcsb pdb:2DWI|rcsb pdb:2DWJ|rcsb pdb:2DXR|rcsb pdb:2DXY|rcsb pdb:2DYX|rcsb pdb:2E0S|rcsb pdb:2E1S|rcsb pdb:2FA7|rcsb pdb:2G93|rcsb pdb:2H4I|rcsb pdb:2HCA|rcsb pdb:2MD1|rcsb pdb:2MD2|rcsb pdb:2MD3|rcsb pdb:2MD4|rcsb pdb:2NUV|rcsb pdb:2NWJ|rcsb pdb:2O1L|rcsb pdb:2O51|rcsb pdb:2OCU|rcsb pdb:2P1S|rcsb pdb:2PX1|rcsb pdb:2Q8J|rcsb pdb:2QJE|rcsb pdb:2R71|rcsb pdb:2R9J|rcsb pdb:2ZMB|rcsb pdb:3CFL|rcsb pdb:3CI8|rcsb pdb:3CRB|rcsb pdb:3E9X|rcsb pdb:3IAZ|rcsb pdb:3IB0|rcsb pdb:3IB1|rcsb pdb:3IB2|rcsb pdb:3K0V|rcsb pdb:3KJ7|rcsb pdb:3MJN|rcsb pdb:3O97|rcsb pdb:3RGY|rcsb pdb:3SDF|mint:MINT-8396238(identity)	refseq:NP_001157656.1|refseq:NP_001157657.1|refseq:NP_059101.1|ensembl:ENSMUSG00000001247(gene)|ensembl:ENSMUST00000001279(transcript)|ensembl:ENSMUST00000205961(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0042627"(chylomicron)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0060856"(establishment of blood-brain barrier)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061689"(tricellular tight junction)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:1904274"(tricellular tight junction assembly)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008664(LISCH7)|interpro:IPR036179|mint:MINT-8396240(identity)	-	comment:mint|function:"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate"|function:The lactotransferrin peptidase S60 domain 1 functions as a serine protease that cuts arginine rich regions. This function contributes to the antimicrobial activity|comment:homomint|function:Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa|function:Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria	comment:mint|comment:homomint|function:Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells	figure legend:f3|comment:homomint|comment:mint	taxid:10090(mouse-hepa1-6)|taxid:10090(Mus musculus)	-	2012/10/02	2014/10/16	rogid:/pv90AdDFP/It+VFiEQPRtnRNtU9913	rogid:QJgx6EbqrlzaNElEzUqNhiCol6A10090	intact-crc:31C2392A5266DC9C|rigid:TWj1NA6QFkly/duqvJQWHqFxSFw	false	tag:?-?(MINT-8396247)	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)