#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0AAW9	uniprotkb:P31224	intact:EBI-6313593|ensemblbacteria:AAC73849|ensemblbacteria:BAA35426|uniprotkb:P75759	intact:EBI-551006|uniprotkb:Q2MBW5|ensemblbacteria:AAC73564|ensemblbacteria:BAE76241	psi-mi:acrz_ecoli(display_long)|uniprotkb:acrZ(gene name)|psi-mi:acrZ(display_short)|uniprotkb:AcrAB-TolC multidrug efflux pump accessory protein AcrZ(gene name synonym)|uniprotkb:Acridine resistance protein Z(gene name synonym)|uniprotkb:ybhT(gene name synonym)|uniprotkb:JW5102(locus name)|uniprotkb:b0762(locus name)	psi-mi:acrb_ecoli(display_long)|uniprotkb:acrB(gene name)|psi-mi:acrB(display_short)|uniprotkb:acrE(gene name synonym)|uniprotkb:b0462(locus name)|uniprotkb:JW0451(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrB(gene name synonym)|uniprotkb:Acridine resistance protein B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hobbs et al. (2012)	imex:IM-17898|pubmed:23010927	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6313605|imex:IM-17898-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000891515.1|ensemblbacteria:AAC73849(transcript)|ensemblbacteria:b0762(gene)|ensemblbacteria:BAA35426(gene)|ensemblbacteria:BAA35426(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR019702|rcsb pdb:4C48|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:6SGR|refseq:NP_415283.1|dip:DIP-11423N	refseq:NP_414995.1|refseq:WP_001132469.1|dip:DIP-9049N|ensemblbacteria:AAC73564(transcript)|ensemblbacteria:b0462(gene)|ensemblbacteria:BAE76241(gene)|ensemblbacteria:BAE76241(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1990281"(efflux pump complex)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR004764(Hydrophobe/amphiphile efflux-1 HAE1)|interpro:IPR027463|rcsb pdb:1IWG|rcsb pdb:1OY6|rcsb pdb:1OY8|rcsb pdb:1OY9|rcsb pdb:1OYD|rcsb pdb:1OYE|rcsb pdb:1T9T|rcsb pdb:1T9U|rcsb pdb:1T9V|rcsb pdb:1T9W|rcsb pdb:1T9X|rcsb pdb:1T9Y|rcsb pdb:2DHH|rcsb pdb:2DR6|rcsb pdb:2DRD|rcsb pdb:2GIF|rcsb pdb:2HQC|rcsb pdb:2HQD|rcsb pdb:2HQF|rcsb pdb:2HQG|rcsb pdb:2HRT|rcsb pdb:2I6W|rcsb pdb:2J8S|rcsb pdb:2RDD|rcsb pdb:2W1B|rcsb pdb:3AOA|rcsb pdb:3AOB|rcsb pdb:3AOC|rcsb pdb:3AOD|rcsb pdb:3D9B|rcsb pdb:3NOC|rcsb pdb:3NOG|rcsb pdb:3W9H|rcsb pdb:4C48|rcsb pdb:4CDI|rcsb pdb:4DX5|rcsb pdb:4DX6|rcsb pdb:4DX7|rcsb pdb:4K7Q|rcsb pdb:4U8V|rcsb pdb:4U8Y|rcsb pdb:4U95|rcsb pdb:4U96|rcsb pdb:4ZIT|rcsb pdb:4ZIV|rcsb pdb:4ZIW|rcsb pdb:4ZJL|rcsb pdb:4ZJO|rcsb pdb:4ZJQ|rcsb pdb:4ZLJ|rcsb pdb:4ZLL|rcsb pdb:4ZLN|rcsb pdb:5EN5|rcsb pdb:5ENO|rcsb pdb:5ENP|rcsb pdb:5ENQ|rcsb pdb:5ENR|rcsb pdb:5ENS|rcsb pdb:5ENT|rcsb pdb:5JMN|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:5YIL|rcsb pdb:6BAJ|rcsb pdb:6CSX|rcsb pdb:6Q4N|rcsb pdb:6Q4O|rcsb pdb:6Q4P|rcsb pdb:6SGR|rcsb pdb:6SGS|rcsb pdb:6SGT|rcsb pdb:6SGU|rcsb pdb:6ZO5|rcsb pdb:6ZO6|rcsb pdb:6ZO7|rcsb pdb:6ZO8|rcsb pdb:6ZO9|rcsb pdb:6ZOA|rcsb pdb:6ZOB|rcsb pdb:6ZOC|rcsb pdb:6ZOD|rcsb pdb:6ZOE|rcsb pdb:6ZOF|rcsb pdb:6ZOG|rcsb pdb:6ZOH	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/10/09	2014/10/16	rogid:USyC6XSr0G1GBmSanW0dQ9wP2VI83333	rogid:c4g5xahCoi9NOgjxyZoC8WzQpnc83333	intact-crc:9EBECCAFA9BF1868|rigid:VvFzG/sWQSpzO+tAgL4zOuO3Ph8	false	tandem tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P0AAW9	uniprotkb:P0AE06	intact:EBI-6313593|ensemblbacteria:AAC73849|ensemblbacteria:BAA35426|uniprotkb:P75759	intact:EBI-875601|uniprotkb:P31223|uniprotkb:Q2MBW4|ensemblbacteria:AAC73565|ensemblbacteria:BAE76242	psi-mi:acrz_ecoli(display_long)|uniprotkb:acrZ(gene name)|psi-mi:acrZ(display_short)|uniprotkb:AcrAB-TolC multidrug efflux pump accessory protein AcrZ(gene name synonym)|uniprotkb:Acridine resistance protein Z(gene name synonym)|uniprotkb:ybhT(gene name synonym)|uniprotkb:JW5102(locus name)|uniprotkb:b0762(locus name)	psi-mi:acra_ecoli(display_long)|uniprotkb:acrA(gene name)|psi-mi:acrA(display_short)|uniprotkb:lir(gene name synonym)|uniprotkb:mtcA(gene name synonym)|uniprotkb:b0463(locus name)|uniprotkb:JW0452(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrA(gene name synonym)|uniprotkb:Acridine resistance protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hobbs et al. (2012)	imex:IM-17898|pubmed:23010927	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6313605|imex:IM-17898-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000891515.1|ensemblbacteria:AAC73849(transcript)|ensemblbacteria:b0762(gene)|ensemblbacteria:BAA35426(gene)|ensemblbacteria:BAA35426(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR019702|rcsb pdb:4C48|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:6SGR|refseq:NP_415283.1|dip:DIP-11423N	refseq:NP_414996.1|refseq:WP_001295324.1|dip:DIP-29039N|ensemblbacteria:AAC73565(transcript)|ensemblbacteria:b0463(gene)|ensemblbacteria:BAE76242(gene)|ensemblbacteria:BAE76242(transcript)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990281"(efflux pump complex)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR032317|interpro:IPR043602|rcsb pdb:2F1M|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S	-	-	crc64:5B81DD5BC2B0A077	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/10/09	2014/10/16	rogid:USyC6XSr0G1GBmSanW0dQ9wP2VI83333	rogid:SAeFuPoeyyXFuBiQN5ZAQH5f5W883333	intact-crc:9EBECCAFA9BF1868|rigid:VvFzG/sWQSpzO+tAgL4zOuO3Ph8	false	tandem tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P0AAW9	uniprotkb:P31224	intact:EBI-6313593|ensemblbacteria:AAC73849|ensemblbacteria:BAA35426|uniprotkb:P75759	intact:EBI-551006|uniprotkb:Q2MBW5|ensemblbacteria:AAC73564|ensemblbacteria:BAE76241	psi-mi:acrz_ecoli(display_long)|uniprotkb:acrZ(gene name)|psi-mi:acrZ(display_short)|uniprotkb:AcrAB-TolC multidrug efflux pump accessory protein AcrZ(gene name synonym)|uniprotkb:Acridine resistance protein Z(gene name synonym)|uniprotkb:ybhT(gene name synonym)|uniprotkb:JW5102(locus name)|uniprotkb:b0762(locus name)	psi-mi:acrb_ecoli(display_long)|uniprotkb:acrB(gene name)|psi-mi:acrB(display_short)|uniprotkb:acrE(gene name synonym)|uniprotkb:b0462(locus name)|uniprotkb:JW0451(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrB(gene name synonym)|uniprotkb:Acridine resistance protein B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hobbs et al. (2012)	imex:IM-17898|pubmed:23010927	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6349258|imex:IM-17898-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000891515.1|ensemblbacteria:AAC73849(transcript)|ensemblbacteria:b0762(gene)|ensemblbacteria:BAA35426(gene)|ensemblbacteria:BAA35426(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR019702|rcsb pdb:4C48|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:6SGR|refseq:NP_415283.1|dip:DIP-11423N	refseq:NP_414995.1|refseq:WP_001132469.1|dip:DIP-9049N|ensemblbacteria:AAC73564(transcript)|ensemblbacteria:b0462(gene)|ensemblbacteria:BAE76241(gene)|ensemblbacteria:BAE76241(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1990281"(efflux pump complex)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR004764(Hydrophobe/amphiphile efflux-1 HAE1)|interpro:IPR027463|rcsb pdb:1IWG|rcsb pdb:1OY6|rcsb pdb:1OY8|rcsb pdb:1OY9|rcsb pdb:1OYD|rcsb pdb:1OYE|rcsb pdb:1T9T|rcsb pdb:1T9U|rcsb pdb:1T9V|rcsb pdb:1T9W|rcsb pdb:1T9X|rcsb pdb:1T9Y|rcsb pdb:2DHH|rcsb pdb:2DR6|rcsb pdb:2DRD|rcsb pdb:2GIF|rcsb pdb:2HQC|rcsb pdb:2HQD|rcsb pdb:2HQF|rcsb pdb:2HQG|rcsb pdb:2HRT|rcsb pdb:2I6W|rcsb pdb:2J8S|rcsb pdb:2RDD|rcsb pdb:2W1B|rcsb pdb:3AOA|rcsb pdb:3AOB|rcsb pdb:3AOC|rcsb pdb:3AOD|rcsb pdb:3D9B|rcsb pdb:3NOC|rcsb pdb:3NOG|rcsb pdb:3W9H|rcsb pdb:4C48|rcsb pdb:4CDI|rcsb pdb:4DX5|rcsb pdb:4DX6|rcsb pdb:4DX7|rcsb pdb:4K7Q|rcsb pdb:4U8V|rcsb pdb:4U8Y|rcsb pdb:4U95|rcsb pdb:4U96|rcsb pdb:4ZIT|rcsb pdb:4ZIV|rcsb pdb:4ZIW|rcsb pdb:4ZJL|rcsb pdb:4ZJO|rcsb pdb:4ZJQ|rcsb pdb:4ZLJ|rcsb pdb:4ZLL|rcsb pdb:4ZLN|rcsb pdb:5EN5|rcsb pdb:5ENO|rcsb pdb:5ENP|rcsb pdb:5ENQ|rcsb pdb:5ENR|rcsb pdb:5ENS|rcsb pdb:5ENT|rcsb pdb:5JMN|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:5YIL|rcsb pdb:6BAJ|rcsb pdb:6CSX|rcsb pdb:6Q4N|rcsb pdb:6Q4O|rcsb pdb:6Q4P|rcsb pdb:6SGR|rcsb pdb:6SGS|rcsb pdb:6SGT|rcsb pdb:6SGU|rcsb pdb:6ZO5|rcsb pdb:6ZO6|rcsb pdb:6ZO7|rcsb pdb:6ZO8|rcsb pdb:6ZO9|rcsb pdb:6ZOA|rcsb pdb:6ZOB|rcsb pdb:6ZOC|rcsb pdb:6ZOD|rcsb pdb:6ZOE|rcsb pdb:6ZOF|rcsb pdb:6ZOG|rcsb pdb:6ZOH	-	-	-	figure legend:Figure 3A|comment:AcrZ–SPA was retained by AcrB–His6 on Ni2+-NTA resin in the absence of both AcrA and TolC|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/10/09	2014/10/16	rogid:USyC6XSr0G1GBmSanW0dQ9wP2VI83333	rogid:c4g5xahCoi9NOgjxyZoC8WzQpnc83333	intact-crc:67983D8E0A1F7A84|rigid:xOnxhNM3ca7iy50W0sJlAeQUxCo	false	tandem tag:c-c|mutation disrupting interaction:30-30	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P31224	uniprotkb:P0AAW9	intact:EBI-551006|uniprotkb:Q2MBW5|ensemblbacteria:AAC73564|ensemblbacteria:BAE76241	intact:EBI-6313593|ensemblbacteria:AAC73849|ensemblbacteria:BAA35426|uniprotkb:P75759	psi-mi:acrb_ecoli(display_long)|uniprotkb:acrB(gene name)|psi-mi:acrB(display_short)|uniprotkb:acrE(gene name synonym)|uniprotkb:b0462(locus name)|uniprotkb:JW0451(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrB(gene name synonym)|uniprotkb:Acridine resistance protein B(gene name synonym)	psi-mi:acrz_ecoli(display_long)|uniprotkb:acrZ(gene name)|psi-mi:acrZ(display_short)|uniprotkb:AcrAB-TolC multidrug efflux pump accessory protein AcrZ(gene name synonym)|uniprotkb:Acridine resistance protein Z(gene name synonym)|uniprotkb:ybhT(gene name synonym)|uniprotkb:JW5102(locus name)|uniprotkb:b0762(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Hobbs et al. (2012)	imex:IM-17898|pubmed:23010927	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6349403|imex:IM-17898-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414995.1|refseq:WP_001132469.1|dip:DIP-9049N|ensemblbacteria:AAC73564(transcript)|ensemblbacteria:b0462(gene)|ensemblbacteria:BAE76241(gene)|ensemblbacteria:BAE76241(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1990281"(efflux pump complex)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR004764(Hydrophobe/amphiphile efflux-1 HAE1)|interpro:IPR027463|rcsb pdb:1IWG|rcsb pdb:1OY6|rcsb pdb:1OY8|rcsb pdb:1OY9|rcsb pdb:1OYD|rcsb pdb:1OYE|rcsb pdb:1T9T|rcsb pdb:1T9U|rcsb pdb:1T9V|rcsb pdb:1T9W|rcsb pdb:1T9X|rcsb pdb:1T9Y|rcsb pdb:2DHH|rcsb pdb:2DR6|rcsb pdb:2DRD|rcsb pdb:2GIF|rcsb pdb:2HQC|rcsb pdb:2HQD|rcsb pdb:2HQF|rcsb pdb:2HQG|rcsb pdb:2HRT|rcsb pdb:2I6W|rcsb pdb:2J8S|rcsb pdb:2RDD|rcsb pdb:2W1B|rcsb pdb:3AOA|rcsb pdb:3AOB|rcsb pdb:3AOC|rcsb pdb:3AOD|rcsb pdb:3D9B|rcsb pdb:3NOC|rcsb pdb:3NOG|rcsb pdb:3W9H|rcsb pdb:4C48|rcsb pdb:4CDI|rcsb pdb:4DX5|rcsb pdb:4DX6|rcsb pdb:4DX7|rcsb pdb:4K7Q|rcsb pdb:4U8V|rcsb pdb:4U8Y|rcsb pdb:4U95|rcsb pdb:4U96|rcsb pdb:4ZIT|rcsb pdb:4ZIV|rcsb pdb:4ZIW|rcsb pdb:4ZJL|rcsb pdb:4ZJO|rcsb pdb:4ZJQ|rcsb pdb:4ZLJ|rcsb pdb:4ZLL|rcsb pdb:4ZLN|rcsb pdb:5EN5|rcsb pdb:5ENO|rcsb pdb:5ENP|rcsb pdb:5ENQ|rcsb pdb:5ENR|rcsb pdb:5ENS|rcsb pdb:5ENT|rcsb pdb:5JMN|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:5YIL|rcsb pdb:6BAJ|rcsb pdb:6CSX|rcsb pdb:6Q4N|rcsb pdb:6Q4O|rcsb pdb:6Q4P|rcsb pdb:6SGR|rcsb pdb:6SGS|rcsb pdb:6SGT|rcsb pdb:6SGU|rcsb pdb:6ZO5|rcsb pdb:6ZO6|rcsb pdb:6ZO7|rcsb pdb:6ZO8|rcsb pdb:6ZO9|rcsb pdb:6ZOA|rcsb pdb:6ZOB|rcsb pdb:6ZOC|rcsb pdb:6ZOD|rcsb pdb:6ZOE|rcsb pdb:6ZOF|rcsb pdb:6ZOG|rcsb pdb:6ZOH	refseq:WP_000891515.1|ensemblbacteria:AAC73849(transcript)|ensemblbacteria:b0762(gene)|ensemblbacteria:BAA35426(gene)|ensemblbacteria:BAA35426(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR019702|rcsb pdb:4C48|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:6SGR|refseq:NP_415283.1|dip:DIP-11423N	-	-	-	figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/10/09	2014/10/16	rogid:c4g5xahCoi9NOgjxyZoC8WzQpnc83333	rogid:USyC6XSr0G1GBmSanW0dQ9wP2VI83333	intact-crc:A5980248A8679841|rigid:xOnxhNM3ca7iy50W0sJlAeQUxCo	false	fusion protein:n-n	mutation disrupting interaction:30-30|fusion protein:c-c	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P0AAW9	uniprotkb:P31224	intact:EBI-6313593|ensemblbacteria:AAC73849|ensemblbacteria:BAA35426|uniprotkb:P75759	intact:EBI-551006|uniprotkb:Q2MBW5|ensemblbacteria:AAC73564|ensemblbacteria:BAE76241	psi-mi:acrz_ecoli(display_long)|uniprotkb:acrZ(gene name)|psi-mi:acrZ(display_short)|uniprotkb:AcrAB-TolC multidrug efflux pump accessory protein AcrZ(gene name synonym)|uniprotkb:Acridine resistance protein Z(gene name synonym)|uniprotkb:ybhT(gene name synonym)|uniprotkb:JW5102(locus name)|uniprotkb:b0762(locus name)	psi-mi:acrb_ecoli(display_long)|uniprotkb:acrB(gene name)|psi-mi:acrB(display_short)|uniprotkb:acrE(gene name synonym)|uniprotkb:b0462(locus name)|uniprotkb:JW0451(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrB(gene name synonym)|uniprotkb:Acridine resistance protein B(gene name synonym)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Hobbs et al. (2012)	imex:IM-17898|pubmed:23010927	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6349413|imex:IM-17898-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000891515.1|ensemblbacteria:AAC73849(transcript)|ensemblbacteria:b0762(gene)|ensemblbacteria:BAA35426(gene)|ensemblbacteria:BAA35426(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR019702|rcsb pdb:4C48|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:6SGR|refseq:NP_415283.1|dip:DIP-11423N	refseq:NP_414995.1|refseq:WP_001132469.1|dip:DIP-9049N|ensemblbacteria:AAC73564(transcript)|ensemblbacteria:b0462(gene)|ensemblbacteria:BAE76241(gene)|ensemblbacteria:BAE76241(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1990281"(efflux pump complex)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR004764(Hydrophobe/amphiphile efflux-1 HAE1)|interpro:IPR027463|rcsb pdb:1IWG|rcsb pdb:1OY6|rcsb pdb:1OY8|rcsb pdb:1OY9|rcsb pdb:1OYD|rcsb pdb:1OYE|rcsb pdb:1T9T|rcsb pdb:1T9U|rcsb pdb:1T9V|rcsb pdb:1T9W|rcsb pdb:1T9X|rcsb pdb:1T9Y|rcsb pdb:2DHH|rcsb pdb:2DR6|rcsb pdb:2DRD|rcsb pdb:2GIF|rcsb pdb:2HQC|rcsb pdb:2HQD|rcsb pdb:2HQF|rcsb pdb:2HQG|rcsb pdb:2HRT|rcsb pdb:2I6W|rcsb pdb:2J8S|rcsb pdb:2RDD|rcsb pdb:2W1B|rcsb pdb:3AOA|rcsb pdb:3AOB|rcsb pdb:3AOC|rcsb pdb:3AOD|rcsb pdb:3D9B|rcsb pdb:3NOC|rcsb pdb:3NOG|rcsb pdb:3W9H|rcsb pdb:4C48|rcsb pdb:4CDI|rcsb pdb:4DX5|rcsb pdb:4DX6|rcsb pdb:4DX7|rcsb pdb:4K7Q|rcsb pdb:4U8V|rcsb pdb:4U8Y|rcsb pdb:4U95|rcsb pdb:4U96|rcsb pdb:4ZIT|rcsb pdb:4ZIV|rcsb pdb:4ZIW|rcsb pdb:4ZJL|rcsb pdb:4ZJO|rcsb pdb:4ZJQ|rcsb pdb:4ZLJ|rcsb pdb:4ZLL|rcsb pdb:4ZLN|rcsb pdb:5EN5|rcsb pdb:5ENO|rcsb pdb:5ENP|rcsb pdb:5ENQ|rcsb pdb:5ENR|rcsb pdb:5ENS|rcsb pdb:5ENT|rcsb pdb:5JMN|rcsb pdb:5NC5|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:5YIL|rcsb pdb:6BAJ|rcsb pdb:6CSX|rcsb pdb:6Q4N|rcsb pdb:6Q4O|rcsb pdb:6Q4P|rcsb pdb:6SGR|rcsb pdb:6SGS|rcsb pdb:6SGT|rcsb pdb:6SGU|rcsb pdb:6ZO5|rcsb pdb:6ZO6|rcsb pdb:6ZO7|rcsb pdb:6ZO8|rcsb pdb:6ZO9|rcsb pdb:6ZOA|rcsb pdb:6ZOB|rcsb pdb:6ZOC|rcsb pdb:6ZOD|rcsb pdb:6ZOE|rcsb pdb:6ZOF|rcsb pdb:6ZOG|rcsb pdb:6ZOH	-	-	-	figure legend:Figure 4A|comment:"β-galactosidase activity in strains coexpressing AcrZG30R–T18 with T25–AcrBH526Y or AcrZG30R–T18 with T25–AcrBL984P was increased  to 23% (for H526Y) or 37% (for L984P) of wild-type levels"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/10/09	2014/10/16	rogid:USyC6XSr0G1GBmSanW0dQ9wP2VI83333	rogid:c4g5xahCoi9NOgjxyZoC8WzQpnc83333	intact-crc:B0724D1A1AE390CA|rigid:xOnxhNM3ca7iy50W0sJlAeQUxCo	false	mutation:30-30|fusion protein:c-c	fusion protein:n-n|mutation:526-526|mutation:984-984	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)