#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99NH2	uniprotkb:Q02956	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Iden et al. (2012)	imex:IM-17774|pubmed:22975380	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6299679|imex:IM-17774-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	go:"GO:0005923"(bicellular tight junction)	-	-	figure legend:3B|comment:aPKC was strikingly mislocalized to the cytoplasm in Par3-deficient epidermis and tumors.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2012/09/18	2014/10/16	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	intact-crc:2955F086E9B319E2|rigid:6bUDG4Q5TNtsd4tk2I0bCDEoMBw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q02956	uniprotkb:Q99NH2	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Iden et al. (2012)	imex:IM-17774|pubmed:22975380	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6303079|imex:IM-17774-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	go:"GO:0005923"(bicellular tight junction)	-	-	figure legend:3C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-keratinocyte)|taxid:10090(Mouse Keratinocyte)	-	2012/09/18	2014/10/16	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	intact-crc:A7B54382ACC5B244|rigid:6bUDG4Q5TNtsd4tk2I0bCDEoMBw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)