#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11716	uniprotkb:P28652	intact:EBI-6477441	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:ryr1_rabit(display_long)|uniprotkb:RYR1(gene name)|psi-mi:RYR1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sharma et al. (2012)	pubmed:22913516|mint:MINT-8391287	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8036778|mint:MINT-8391302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:2BCX|rcsb pdb:2XOA|rcsb pdb:3HSM|rcsb pdb:3ILA|rcsb pdb:3J8H|rcsb pdb:3RQR|rcsb pdb:4ERT|rcsb pdb:4ESU|rcsb pdb:4ETT|go:"GO:0035381"(ATP-gated ion channel activity)|rcsb pdb:4ETU|rcsb pdb:4I0Y|rcsb pdb:4I1E|go:"GO:0042802"(identical protein binding)|rcsb pdb:4I2S|rcsb pdb:4I37|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|rcsb pdb:4I3N|rcsb pdb:4I6I|rcsb pdb:4I7I|rcsb pdb:4I8M|rcsb pdb:4I96|rcsb pdb:4P9J|rcsb pdb:4UWA|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:4UWE|rcsb pdb:5C30|rcsb pdb:5GKY|rcsb pdb:5GKZ|rcsb pdb:5GL0|rcsb pdb:5GL1|rcsb pdb:5J8V|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6FG3|rcsb pdb:6FOO|rcsb pdb:6M2W|rcsb pdb:6WOT|rcsb pdb:7CF9|refseq:NP_001095188.1|dip:DIP-41872N|mint:MINT-8391304(identity)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N|mint:MINT-8391305(identity)	-	-	-	comment:mint|figure legend:t1 st2	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/20	2014/10/16	rogid:QUlch7kTlopwGM10g+OXd4rODXo9986	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	intact-crc:5D84673505BD8646|rigid:XvDOzKgYZCq9Zgc51faUPu7tz3w	false	his tag:?-?(MINT-8391308)|binding-associated region:2273-2940(MINT-8391311)	binding-associated region:76-105(MINT-8391315)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P28652	uniprotkb:P11716	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-6477441	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:ryr1_rabit(display_long)|uniprotkb:RYR1(gene name)|psi-mi:RYR1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sharma et al. (2012)	pubmed:22913516|mint:MINT-8391287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8036797|mint:MINT-8391357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N|mint:MINT-8391365(identity)	go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:2BCX|rcsb pdb:2XOA|rcsb pdb:3HSM|rcsb pdb:3ILA|rcsb pdb:3J8H|rcsb pdb:3RQR|rcsb pdb:4ERT|rcsb pdb:4ESU|rcsb pdb:4ETT|go:"GO:0035381"(ATP-gated ion channel activity)|rcsb pdb:4ETU|rcsb pdb:4I0Y|rcsb pdb:4I1E|go:"GO:0042802"(identical protein binding)|rcsb pdb:4I2S|rcsb pdb:4I37|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|rcsb pdb:4I3N|rcsb pdb:4I6I|rcsb pdb:4I7I|rcsb pdb:4I8M|rcsb pdb:4I96|rcsb pdb:4P9J|rcsb pdb:4UWA|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:4UWE|rcsb pdb:5C30|rcsb pdb:5GKY|rcsb pdb:5GKZ|rcsb pdb:5GL0|rcsb pdb:5GL1|rcsb pdb:5J8V|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6FG3|rcsb pdb:6FOO|rcsb pdb:6M2W|rcsb pdb:6WOT|rcsb pdb:7CF9|refseq:NP_001095188.1|dip:DIP-41872N|mint:MINT-8391359(identity)	-	-	-	figure legend:f6c|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/20	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:QUlch7kTlopwGM10g+OXd4rODXo9986	intact-crc:BDF0B3BC07D70F41|rigid:XvDOzKgYZCq9Zgc51faUPu7tz3w	false	v5 tag:?-?(MINT-8391366)	binding-associated region:2273-2940(MINT-8391360)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28652	uniprotkb:P11716	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-6477441	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:ryr1_rabit(display_long)|uniprotkb:RYR1(gene name)|psi-mi:RYR1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharma et al. (2012)	pubmed:22913516|mint:MINT-8391287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8036853|mint:MINT-8391321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N|mint:MINT-8391329(identity)	go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:2BCX|rcsb pdb:2XOA|rcsb pdb:3HSM|rcsb pdb:3ILA|rcsb pdb:3J8H|rcsb pdb:3RQR|rcsb pdb:4ERT|rcsb pdb:4ESU|rcsb pdb:4ETT|go:"GO:0035381"(ATP-gated ion channel activity)|rcsb pdb:4ETU|rcsb pdb:4I0Y|rcsb pdb:4I1E|go:"GO:0042802"(identical protein binding)|rcsb pdb:4I2S|rcsb pdb:4I37|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|rcsb pdb:4I3N|rcsb pdb:4I6I|rcsb pdb:4I7I|rcsb pdb:4I8M|rcsb pdb:4I96|rcsb pdb:4P9J|rcsb pdb:4UWA|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:4UWE|rcsb pdb:5C30|rcsb pdb:5GKY|rcsb pdb:5GKZ|rcsb pdb:5GL0|rcsb pdb:5GL1|rcsb pdb:5J8V|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6FG3|rcsb pdb:6FOO|rcsb pdb:6M2W|rcsb pdb:6WOT|rcsb pdb:7CF9|refseq:NP_001095188.1|dip:DIP-41872N|mint:MINT-8391323(identity)	-	-	-	figure legend:f6d|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/08/20	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:QUlch7kTlopwGM10g+OXd4rODXo9986	intact-crc:C6A18BE9F68019B1|rigid:XvDOzKgYZCq9Zgc51faUPu7tz3w	false	v5 tag:?-?(MINT-8391336)	binding-associated region:2273-2940(MINT-8391324)|flag tag:?-?(MINT-8391326)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11716	uniprotkb:P28652	intact:EBI-6477441	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:ryr1_rabit(display_long)|uniprotkb:RYR1(gene name)|psi-mi:RYR1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharma et al. (2012)	pubmed:22913516|mint:MINT-8391287	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8036872|mint:MINT-8391341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:2BCX|rcsb pdb:2XOA|rcsb pdb:3HSM|rcsb pdb:3ILA|rcsb pdb:3J8H|rcsb pdb:3RQR|rcsb pdb:4ERT|rcsb pdb:4ESU|rcsb pdb:4ETT|go:"GO:0035381"(ATP-gated ion channel activity)|rcsb pdb:4ETU|rcsb pdb:4I0Y|rcsb pdb:4I1E|go:"GO:0042802"(identical protein binding)|rcsb pdb:4I2S|rcsb pdb:4I37|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|rcsb pdb:4I3N|rcsb pdb:4I6I|rcsb pdb:4I7I|rcsb pdb:4I8M|rcsb pdb:4I96|rcsb pdb:4P9J|rcsb pdb:4UWA|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:4UWE|rcsb pdb:5C30|rcsb pdb:5GKY|rcsb pdb:5GKZ|rcsb pdb:5GL0|rcsb pdb:5GL1|rcsb pdb:5J8V|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6FG3|rcsb pdb:6FOO|rcsb pdb:6M2W|rcsb pdb:6WOT|rcsb pdb:7CF9|refseq:NP_001095188.1|dip:DIP-41872N|mint:MINT-8391343(identity)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N|mint:MINT-8391349(identity)	-	-	-	figure legend:f6e|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/08/20	2014/10/16	rogid:QUlch7kTlopwGM10g+OXd4rODXo9986	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	intact-crc:06CA8CCB1232578C|rigid:XvDOzKgYZCq9Zgc51faUPu7tz3w	false	binding-associated region:2273-2940(MINT-8391346)|mutation decreasing interaction:2843-2843(MINT-8391375)|flag tag:?-?(MINT-8391344)	v5 tag:?-?(MINT-8391350)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)