#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O35550 uniprotkb:O95259 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991537|mint:MINT-8385714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8385717(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8385716(identity) - comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A - figure legend:f1|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/10 2014/10/16 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:DB2F28760582D7DC|rigid:oz4s3iEI8KP26k77yMEmVScI9L8 false binding-associated region:280-644(MINT-8385743)|fusion protein:?-?(MINT-8385725) fusion protein:?-?(MINT-8385719)|binding-associated region:478-963(MINT-8385722) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63472 uniprotkb:O95259 intact:EBI-7991592|intact:MINT-8386100|ensembl:ENSRNOP00000005209|ensembl:ENSRNOP00000068394 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:kcnh1_rat(display_long)|uniprotkb:Kcnh1(gene name)|psi-mi:Kcnh1(display_short)|uniprotkb:Eag(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991588|mint:MINT-8385729 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:68398|refseq:NP_113930.1|refseq:XP_006250553.1|ensembl:ENSRNOG00000003841(gene)|ensembl:ENSRNOT00000005209(transcript)|ensembl:ENSRNOT00000077014(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5K7L|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-RNO-1296072|mint:MINT-8386119(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8385731(identity) - comment:mint - figure legend:f1|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/10 2014/10/16 rogid:zAYVr6xejavV+8ij4NUSR3obIeM10116 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:74866056339CD147|rigid:2ndHwXTYrltjck/ESrBE17YKpAQ false fusion protein:?-?(MINT-8386120)|binding-associated region:?-?(MINT-8386123) fusion protein:?-?(MINT-8385734)|binding-associated region:478-963(MINT-8385732) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35550 uniprotkb:O35550 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991640|mint:MINT-8386143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8386151(identity) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8386145(identity) - comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A figure legend:f1|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/10 2014/10/16 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 intact-crc:6AC398067F5A6FFD|rigid:M5V/GKHa8lR0054o+4V+2npLupI false binding-associated region:280-644(MINT-8386160)|fusion protein:?-?(MINT-8386154) fusion protein:?-?(MINT-8386148) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35550 uniprotkb:O95259 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991690|mint:MINT-8386164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8386172(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8386166(identity) - comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A - figure legend:f1|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/10 2014/10/16 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:7DC4987965272B27|rigid:oz4s3iEI8KP26k77yMEmVScI9L8 false fusion protein:?-?(MINT-8386173) fusion protein:?-?(MINT-8386169)|binding-associated region:478-963(MINT-8386167) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63472 uniprotkb:O35550 intact:EBI-7991592|intact:MINT-8386100|ensembl:ENSRNOP00000005209|ensembl:ENSRNOP00000068394 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 psi-mi:kcnh1_rat(display_long)|uniprotkb:Kcnh1(gene name)|psi-mi:Kcnh1(display_short)|uniprotkb:Eag(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym) psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991730|mint:MINT-8386186 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:68398|refseq:NP_113930.1|refseq:XP_006250553.1|ensembl:ENSRNOG00000003841(gene)|ensembl:ENSRNOT00000005209(transcript)|ensembl:ENSRNOT00000077014(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5K7L|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-RNO-1296072|mint:MINT-8386188(identity) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8386189(identity) - comment:mint comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A figure legend:f2a|comment:mint taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2012/07/10 2014/10/16 rogid:zAYVr6xejavV+8ij4NUSR3obIeM10116 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 intact-crc:C9147F434BE27C45|rigid:vyPQchpdchOLX6zlzrneDKEToxk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O35550 uniprotkb:Q63472 intact:EBI-7991542|intact:MINT-4582796|uniprotkb:P70609 intact:EBI-7991592|intact:MINT-8386100|ensembl:ENSRNOP00000005209|ensembl:ENSRNOP00000068394 psi-mi:rabe1_rat(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:kcnh1_rat(display_long)|uniprotkb:Kcnh1(gene name)|psi-mi:Kcnh1(display_short)|uniprotkb:Eag(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991740|mint:MINT-8386196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029880|refseq:NP_061997.1|interpro:IPR018514|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|rgd:708568|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|mint:MINT-8386200(identity) rgd:68398|refseq:NP_113930.1|refseq:XP_006250553.1|ensembl:ENSRNOG00000003841(gene)|ensembl:ENSRNOT00000005209(transcript)|ensembl:ENSRNOT00000077014(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5K7L|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-RNO-1296072|mint:MINT-8386198(identity) - comment:mint|comment:homomint|function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A comment:mint figure legend:f2b|comment:mint taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2012/07/10 2014/10/16 rogid:fjxVD9zaor1dzG8GZdZRdu28gLE10116 rogid:zAYVr6xejavV+8ij4NUSR3obIeM10116 intact-crc:CF1D27EC62CA917F|rigid:vyPQchpdchOLX6zlzrneDKEToxk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60603 uniprotkb:O35551 intact:EBI-7991775|uniprotkb:Q32MR6|uniprotkb:Q3USQ9|intact:UNK-5460726 intact:EBI-4286397|uniprotkb:A1L322|uniprotkb:Q99L08|uniprotkb:Q9CRP3|uniprotkb:Q9EQF9|uniprotkb:Q9JI94|uniprotkb:Q5QNU3|ensembl:ENSMUSP00000075619 psi-mi:kcnh1_mouse(display_long)|uniprotkb:Kcnh1(gene name)|psi-mi:Kcnh1(display_short)|uniprotkb:Eag(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:rabe1_mouse(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rab5ep(gene name synonym)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7991806|mint:MINT-8386206 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5HIT|interpro:IPR005821(Ion transport)|interpro:IPR001610(PAC motif)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:4F8A|rcsb pdb:4HOI|refseq:NP_034730.1|interpro:IPR018490|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|rcsb pdb:4LLO|interpro:IPR030170|interpro:IPR035965|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-MMU-1296072|mint:MINT-8386208(identity) refseq:NP_062273.2|refseq:NP_001278070.1|refseq:NP_001278071.1|refseq:NP_001278072.1|ensembl:ENSMUSG00000020817(gene)|ensembl:ENSMUST00000076270(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|mint:O35551|mint:MINT-8386210(identity) - function:"Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts"|comment:mint|comment:homomint - figure legend:f2b|comment:homomint|comment:mint taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2012/07/10 2016/11/30 rogid:0FpRUrAr6sNADXyDzqn5bcWDZaA10090 rogid:aheuMgAZ4SH4NEHk3VzjzwX+UG010090 intact-crc:75E981229AC2982C|rigid:YR//IPU/48CeI2gNnUwWxC926GM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15276 uniprotkb:O95259 intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7991852|mint:MINT-8387131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|mint:MINT-8387133(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8387134(identity) go:"GO:0005769"(early endosome) - - figure legend:f3|comment:homomint|comment:mint taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/07/10 2014/10/16 rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:4D28E4A8B79D33F3|rigid:mPg+4iyEKskzLhFLubj9liLMpOE false fusion protein:?-?(MINT-8387137) cyan fluorescent protein tag:?-?(MINT-8387142) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P18067 uniprotkb:O95259 intact:EBI-7991906|intact:MINT-8387239|ensembl:ENSCAFP00040042399|ensembl:ENSCAFP00030022348 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:rab7a_canlf(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7991934|mint:MINT-8387224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005632072.1|dip:DIP-61531N|refseq:NP_001003316.1|go:"GO:0099638"(endosome to plasma membrane protein transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-CFA-2132295|reactome:R-CFA-6798695|reactome:R-CFA-8854214|reactome:R-CFA-8873719|reactome:R-CFA-8876198|reactome:R-CFA-9013148|reactome:R-CFA-9013149|reactome:R-CFA-9013404|reactome:R-CFA-9013405|reactome:R-CFA-9013407|reactome:R-CFA-9013408|reactome:R-CFA-9035034|ensembl:ENSCAFT00030025595(transcript)|ensembl:ENSCAFT00040048535(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0061724"(lipophagy)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|ensembl:ENSCAFG00030013725(gene)|ensembl:ENSCAFG00040025936(gene)|mint:MINT-8387227(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8387231(identity) go:"GO:0005769"(early endosome) comment:mint - comment:mint|figure legend:f5a f5b f5c taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/07/10 2014/10/16 rogid:lhrQxOcOBkuWk8LHLgoFtxbIK/E9615 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:F6DC4A28D3ED8E56|rigid:rl1/tT+0QMTJCaM1NmCL/fMsxMQ false yellow fluorescent protein tag:?-?(MINT-8387228) cyan fluorescent protein tag:?-?(MINT-8387232) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P62490 uniprotkb:O95259 intact:EBI-2656272|uniprotkb:P24410|uniprotkb:Q9JLX1|ensembl:ENSCAFP00000025408 intact:EBI-2909270|ensembl:ENSP00000271751|uniprotkb:B1AQ26|uniprotkb:O76035|uniprotkb:Q14CL3 psi-mi:rb11a_canlf(display_long)|uniprotkb:RAB11A(gene name)|psi-mi:RAB11A(display_short)|uniprotkb:RAB11(gene name synonym) psi-mi:kcnh1_human(display_long)|uniprotkb:KCNH1(gene name)|psi-mi:KCNH1(display_short)|uniprotkb:EAG(gene name synonym)|uniprotkb:EAG1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv10.1(gene name synonym)|uniprotkb:Ether-a-go-go potassium channel 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ninkovic et al. (2012) pubmed:22841712|mint:MINT-8385709|doi:10.1016/j.febslet.2012.07.055 taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7991888|mint:MINT-8387204 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003276.1|ensembl:ENSCAFG00000017255(gene)|ensembl:ENSCAFT00000027321(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0006887"(exocytosis)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010796"(regulation of multivesicular body size)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030424"(axon)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031489"(myosin V binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032402"(melanosome transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62490|reactome:R-CFA-5620912|reactome:R-CFA-5620916|reactome:R-CFA-8873719|go:"GO:0032465"(regulation of cytokinesis)|mint:MINT-8387206(identity) go:"GO:0030673"(axolemma)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR030170|interpro:IPR035965|rcsb pdb:5J7E|reactome:R-HSA-1296072|ensembl:ENSG00000143473(gene)|ensembl:ENST00000271751(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|refseq:NP_002229.1|refseq:NP_758872.1|mint:MINT-8387207(identity) go:"GO:0005769"(early endosome) - - comment:homomint|comment:mint|figure legend:f5f f5g f5h taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/07/10 2014/10/16 rogid:FjkzGzN2VDTyv94M9vD/EJC2qoU9615 rogid:jDc4JwcX74sosVPIU9k9weg8n3A9606 intact-crc:4C7B9E6303897331|rigid:K3d7NJgipuF0RMVoPLVP02691MY false yellow fluorescent protein tag:?-?(MINT-8387212) cyan fluorescent protein tag:?-?(MINT-8387217) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)