#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UI95 uniprotkb:Q9UBZ9 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-7353917|intact:MINT-140323|uniprotkb:Q53SI7|uniprotkb:O95941|uniprotkb:Q9NUP2|uniprotkb:Q9C0J4|ensembl:ENSP00000258428 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev1_human(display_long)|uniprotkb:REV1(gene name)|psi-mi:REV1(display_short)|uniprotkb:REV1L(gene name synonym)|uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym)|uniprotkb:Alpha integrin-binding protein 80(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985644|mint:MINT-8385442|imex:IM-26445-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385446(identity) refseq:NP_001308383.1|refseq:NP_001308384.1|refseq:NP_001308387.1|refseq:NP_001308388.1|refseq:NP_001308389.1|refseq:NP_001032961.1|refseq:NP_057400.1|ensembl:ENSG00000135945(gene)|ensembl:ENST00000258428(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0009411"(response to UV)|go:"GO:0017125"(deoxycytidyl transferase activity)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR001357(BRCT)|interpro:IPR012112(DNA repair protein, Rev1)|interpro:IPR017961|interpro:IPR025527|interpro:IPR031991|interpro:IPR036420|interpro:IPR036775|interpro:IPR038401|interpro:IPR043128|interpro:IPR043502|rcsb pdb:2EBW|rcsb pdb:2LSI|rcsb pdb:2LSK|rcsb pdb:2LSY|rcsb pdb:2N1G|rcsb pdb:3GQC|rcsb pdb:3VU7|rcsb pdb:4BA9|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5VZM|rcsb pdb:6ASR|rcsb pdb:6AXD|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|mint:MINT-8385444(identity) - - comment:mint|comment:homomint|function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents comment:homomint|comment:mint|figure legend:f1 f3a f3b f2 f3d f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:nqlZzaFe/OYk+xqMSxqvMxPULXI9606 intact-crc:261BAEA5E0015A8F|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1158-1251(MINT-8385448) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:O60673 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-2871302|uniprotkb:O43214|uniprotkb:Q5TC33|intact:EBI-28974373|ensembl:ENSP00000351697|ensembl:ENSP00000357792 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev3l_human(display_long)|uniprotkb:REV3L(gene name)|psi-mi:REV3L(display_short)|uniprotkb:POLZ(gene name synonym)|uniprotkb:REV3(gene name synonym)|uniprotkb:Protein reversionless 3-like(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985644|mint:MINT-8385442|imex:IM-26445-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385446(identity) refseq:NP_001273360.1|refseq:NP_001273361.1|ensembl:ENSP00000351697|ensembl:ENSP00000357792|ensembl:ENST00000435970|ensembl:ENSP00000402003|refseq:NP_002903.3|ensembl:ENSG00000009413(gene)|ensembl:ENST00000358835(transcript)|ensembl:ENST00000368802(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|reactome:R-HSA-5655862|reactome:R-HSA-5656121|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR030559|interpro:IPR032757|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5O8K|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6EKM|rcsb pdb:6KEA|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|mint:MINT-8385445(identity) - - - comment:homomint|comment:mint|figure legend:f1 f3a f3b f2 f3d f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:6lX9oCcC9HRO89EjXBoZ4sfk5HU9606 intact-crc:261BAEA5E0015A8F|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1847-1898(MINT-8385453) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:Q9Y253 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-2827270|uniprotkb:Q9BX13|uniprotkb:Q96BC4|uniprotkb:Q7L8E3|ensembl:ENSP00000361310 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:polh_human(display_long)|uniprotkb:POLH(gene name)|psi-mi:POLH(display_short)|uniprotkb:RAD30(gene name synonym)|uniprotkb:RAD30A(gene name synonym)|uniprotkb:XPV(gene name synonym)|uniprotkb:RAD30 homolog A(gene name synonym)|uniprotkb:Xeroderma pigmentosum variant type protein(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985733|mint:MINT-8385495|imex:IM-26445-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385505(identity) refseq:NP_001278899.1|refseq:NP_006493.1|rcsb pdb:5KFG|rcsb pdb:5KFH|rcsb pdb:5KFI|rcsb pdb:5KFJ|rcsb pdb:5KFK|rcsb pdb:5KFL|rcsb pdb:5KFM|rcsb pdb:5KFN|rcsb pdb:5KFO|rcsb pdb:5KFP|rcsb pdb:5KFQ|rcsb pdb:5KFR|rcsb pdb:5KFS|rcsb pdb:5KFT|rcsb pdb:5KFU|rcsb pdb:5KFV|rcsb pdb:5KFW|rcsb pdb:5KFX|rcsb pdb:5KFY|rcsb pdb:5KFZ|rcsb pdb:5KG0|rcsb pdb:5KG1|rcsb pdb:5KG2|rcsb pdb:5KG3|rcsb pdb:5KG4|rcsb pdb:5KG5|rcsb pdb:5KG6|rcsb pdb:5KG7|rcsb pdb:5L1I|rcsb pdb:5L1J|ensembl:ENSG00000170734(gene)|ensembl:ENST00000372236(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0009314"(response to radiation)|go:"GO:0010225"(response to UV-C)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071494"(cellular response to UV-C)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR041298|interpro:IPR043128|interpro:IPR043502|mint:Q9Y253|rcsb pdb:2I5O|rcsb pdb:2LSK|rcsb pdb:3JAA|rcsb pdb:3MR2|rcsb pdb:3MR3|rcsb pdb:3MR5|rcsb pdb:3MR6|rcsb pdb:3SI8|rcsb pdb:3TQ1|rcsb pdb:3WUP|rcsb pdb:4DL2|rcsb pdb:4DL3|rcsb pdb:4DL4|rcsb pdb:4DL5|rcsb pdb:4DL6|rcsb pdb:4DL7|rcsb pdb:4ECQ|rcsb pdb:4ECR|rcsb pdb:4ECS|rcsb pdb:4ECT|rcsb pdb:4ECU|rcsb pdb:4ECV|rcsb pdb:4ECW|rcsb pdb:4ECX|rcsb pdb:4ECY|rcsb pdb:4ECZ|rcsb pdb:4ED0|rcsb pdb:4ED1|rcsb pdb:4ED2|rcsb pdb:4ED3|rcsb pdb:4ED6|rcsb pdb:4ED7|rcsb pdb:4ED8|rcsb pdb:4EEY|rcsb pdb:4J9K|rcsb pdb:4J9L|rcsb pdb:4J9M|rcsb pdb:4J9N|rcsb pdb:4J9O|rcsb pdb:4J9P|rcsb pdb:4J9Q|rcsb pdb:4J9R|rcsb pdb:4J9S|rcsb pdb:4O3Q|rcsb pdb:4O3R|rcsb pdb:4O3S|rcsb pdb:4Q8E|rcsb pdb:4Q8F|rcsb pdb:4RNM|rcsb pdb:4RNN|rcsb pdb:4RNO|rcsb pdb:4RU9|rcsb pdb:4YP3|rcsb pdb:4YQW|rcsb pdb:4YR0|rcsb pdb:4YR2|rcsb pdb:4YR3|rcsb pdb:5DG7|rcsb pdb:5DG8|rcsb pdb:5DG9|rcsb pdb:5DGA|rcsb pdb:5DGB|rcsb pdb:5DLF|rcsb pdb:5DLG|rcsb pdb:5DQG|rcsb pdb:5DQH|rcsb pdb:5DQI|rcsb pdb:5EWE|rcsb pdb:5EWF|rcsb pdb:4O3N|rcsb pdb:4O3O|rcsb pdb:5EWG|rcsb pdb:4O3P|rcsb pdb:5F9L|rcsb pdb:5F9N|rcsb pdb:5JUM|rcsb pdb:5KFA|rcsb pdb:5KFB|rcsb pdb:5KFC|rcsb pdb:5KFD|rcsb pdb:5KFE|rcsb pdb:5KFF|rcsb pdb:5L1K|rcsb pdb:5L1L|rcsb pdb:5L9X|rcsb pdb:6D0M|rcsb pdb:6D0Z|rcsb pdb:6M7O|rcsb pdb:6M7P|rcsb pdb:6M7T|rcsb pdb:6M7U|rcsb pdb:6M7V|rcsb pdb:6MP3|rcsb pdb:6MQ8|rcsb pdb:6MXO|rcsb pdb:6PL7|rcsb pdb:6PL8|rcsb pdb:6PLC|rcsb pdb:6PZ3|rcsb pdb:6Q02|rcsb pdb:6UI2|rcsb pdb:6UQI|rcsb pdb:6V5K|rcsb pdb:6W5X|rcsb pdb:6WK6|rcsb pdb:7M7L|rcsb pdb:7M7M|rcsb pdb:7M7N|rcsb pdb:7M7O|rcsb pdb:7M7P|rcsb pdb:7M7Q|rcsb pdb:7M7R|rcsb pdb:7M7S|rcsb pdb:7M7T|rcsb pdb:7M7U|rcsb pdb:7M7Y|rcsb pdb:7M7Z|rcsb pdb:7M80|rcsb pdb:7M81|rcsb pdb:7M82|rcsb pdb:7M83|rcsb pdb:7M84|rcsb pdb:7M85|rcsb pdb:7M86|rcsb pdb:7M87|rcsb pdb:7M88|rcsb pdb:7M89|rcsb pdb:7M8A|rcsb pdb:7M8B|rcsb pdb:7M8C|rcsb pdb:7M8D|reactome:R-HSA-110320|reactome:R-HSA-5656169|reactome:R-HSA-5685942|mint:MINT-8385507(identity) - - - comment:homomint|comment:mint|figure legend:f1 f3a f3b f2 f3d f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:gFWYJTkZiTzfwV5JtH5qdtNpaN09606 intact-crc:E39CEA618864D7CE|rigid:FdCCRTb13ssnTYgNfxljjdtje0I false - binding-associated region:524-539(MINT-8385528) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9UI95 uniprotkb:Q9UBZ9 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-7353917|intact:MINT-140323|uniprotkb:Q53SI7|uniprotkb:O95941|uniprotkb:Q9NUP2|uniprotkb:Q9C0J4|ensembl:ENSP00000258428 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev1_human(display_long)|uniprotkb:REV1(gene name)|psi-mi:REV1(display_short)|uniprotkb:REV1L(gene name synonym)|uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym)|uniprotkb:Alpha integrin-binding protein 80(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985733|mint:MINT-8385495|imex:IM-26445-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385505(identity) refseq:NP_001308383.1|refseq:NP_001308384.1|refseq:NP_001308387.1|refseq:NP_001308388.1|refseq:NP_001308389.1|refseq:NP_001032961.1|refseq:NP_057400.1|ensembl:ENSG00000135945(gene)|ensembl:ENST00000258428(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0009411"(response to UV)|go:"GO:0017125"(deoxycytidyl transferase activity)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR001357(BRCT)|interpro:IPR012112(DNA repair protein, Rev1)|interpro:IPR017961|interpro:IPR025527|interpro:IPR031991|interpro:IPR036420|interpro:IPR036775|interpro:IPR038401|interpro:IPR043128|interpro:IPR043502|rcsb pdb:2EBW|rcsb pdb:2LSI|rcsb pdb:2LSK|rcsb pdb:2LSY|rcsb pdb:2N1G|rcsb pdb:3GQC|rcsb pdb:3VU7|rcsb pdb:4BA9|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5VZM|rcsb pdb:6ASR|rcsb pdb:6AXD|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|mint:MINT-8385497(identity) - - comment:mint|comment:homomint|function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents comment:homomint|comment:mint|figure legend:f1 f3a f3b f2 f3d f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:nqlZzaFe/OYk+xqMSxqvMxPULXI9606 intact-crc:E39CEA618864D7CE|rigid:FdCCRTb13ssnTYgNfxljjdtje0I false - binding-associated region:1158-1251(MINT-8385498) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:O60673 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-2871302|uniprotkb:O43214|uniprotkb:Q5TC33|intact:EBI-28974373|ensembl:ENSP00000351697|ensembl:ENSP00000357792 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev3l_human(display_long)|uniprotkb:REV3L(gene name)|psi-mi:REV3L(display_short)|uniprotkb:POLZ(gene name synonym)|uniprotkb:REV3(gene name synonym)|uniprotkb:Protein reversionless 3-like(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985733|mint:MINT-8385495|imex:IM-26445-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385505(identity) refseq:NP_001273360.1|refseq:NP_001273361.1|ensembl:ENSP00000351697|ensembl:ENSP00000357792|ensembl:ENST00000435970|ensembl:ENSP00000402003|refseq:NP_002903.3|ensembl:ENSG00000009413(gene)|ensembl:ENST00000358835(transcript)|ensembl:ENST00000368802(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|reactome:R-HSA-5655862|reactome:R-HSA-5656121|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR030559|interpro:IPR032757|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5O8K|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6EKM|rcsb pdb:6KEA|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|mint:MINT-8385501(identity) - - - comment:homomint|comment:mint|figure legend:f1 f3a f3b f2 f3d f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:6lX9oCcC9HRO89EjXBoZ4sfk5HU9606 intact-crc:E39CEA618864D7CE|rigid:FdCCRTb13ssnTYgNfxljjdtje0I false - binding-associated region:1847-1898(MINT-8385502) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBZ9 uniprotkb:Q9Y253 intact:EBI-7353917|intact:MINT-140323|uniprotkb:Q53SI7|uniprotkb:O95941|uniprotkb:Q9NUP2|uniprotkb:Q9C0J4|ensembl:ENSP00000258428 intact:EBI-2827270|uniprotkb:Q9BX13|uniprotkb:Q96BC4|uniprotkb:Q7L8E3|ensembl:ENSP00000361310 psi-mi:rev1_human(display_long)|uniprotkb:REV1(gene name)|psi-mi:REV1(display_short)|uniprotkb:REV1L(gene name synonym)|uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym)|uniprotkb:Alpha integrin-binding protein 80(gene name synonym) psi-mi:polh_human(display_long)|uniprotkb:POLH(gene name)|psi-mi:POLH(display_short)|uniprotkb:RAD30(gene name synonym)|uniprotkb:RAD30A(gene name synonym)|uniprotkb:XPV(gene name synonym)|uniprotkb:RAD30 homolog A(gene name synonym)|uniprotkb:Xeroderma pigmentosum variant type protein(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7985775|mint:MINT-8385863|imex:IM-26445-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001308383.1|refseq:NP_001308384.1|refseq:NP_001308387.1|refseq:NP_001308388.1|refseq:NP_001308389.1|refseq:NP_001032961.1|refseq:NP_057400.1|ensembl:ENSG00000135945(gene)|ensembl:ENST00000258428(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0009411"(response to UV)|go:"GO:0017125"(deoxycytidyl transferase activity)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR001357(BRCT)|interpro:IPR012112(DNA repair protein, Rev1)|interpro:IPR017961|interpro:IPR025527|interpro:IPR031991|interpro:IPR036420|interpro:IPR036775|interpro:IPR038401|interpro:IPR043128|interpro:IPR043502|rcsb pdb:2EBW|rcsb pdb:2LSI|rcsb pdb:2LSK|rcsb pdb:2LSY|rcsb pdb:2N1G|rcsb pdb:3GQC|rcsb pdb:3VU7|rcsb pdb:4BA9|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5VZM|rcsb pdb:6ASR|rcsb pdb:6AXD|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|mint:MINT-8385865(identity) refseq:NP_001278899.1|refseq:NP_006493.1|rcsb pdb:5KFG|rcsb pdb:5KFH|rcsb pdb:5KFI|rcsb pdb:5KFJ|rcsb pdb:5KFK|rcsb pdb:5KFL|rcsb pdb:5KFM|rcsb pdb:5KFN|rcsb pdb:5KFO|rcsb pdb:5KFP|rcsb pdb:5KFQ|rcsb pdb:5KFR|rcsb pdb:5KFS|rcsb pdb:5KFT|rcsb pdb:5KFU|rcsb pdb:5KFV|rcsb pdb:5KFW|rcsb pdb:5KFX|rcsb pdb:5KFY|rcsb pdb:5KFZ|rcsb pdb:5KG0|rcsb pdb:5KG1|rcsb pdb:5KG2|rcsb pdb:5KG3|rcsb pdb:5KG4|rcsb pdb:5KG5|rcsb pdb:5KG6|rcsb pdb:5KG7|rcsb pdb:5L1I|rcsb pdb:5L1J|ensembl:ENSG00000170734(gene)|ensembl:ENST00000372236(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0009314"(response to radiation)|go:"GO:0010225"(response to UV-C)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071494"(cellular response to UV-C)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR041298|interpro:IPR043128|interpro:IPR043502|mint:Q9Y253|rcsb pdb:2I5O|rcsb pdb:2LSK|rcsb pdb:3JAA|rcsb pdb:3MR2|rcsb pdb:3MR3|rcsb pdb:3MR5|rcsb pdb:3MR6|rcsb pdb:3SI8|rcsb pdb:3TQ1|rcsb pdb:3WUP|rcsb pdb:4DL2|rcsb pdb:4DL3|rcsb pdb:4DL4|rcsb pdb:4DL5|rcsb pdb:4DL6|rcsb pdb:4DL7|rcsb pdb:4ECQ|rcsb pdb:4ECR|rcsb pdb:4ECS|rcsb pdb:4ECT|rcsb pdb:4ECU|rcsb pdb:4ECV|rcsb pdb:4ECW|rcsb pdb:4ECX|rcsb pdb:4ECY|rcsb pdb:4ECZ|rcsb pdb:4ED0|rcsb pdb:4ED1|rcsb pdb:4ED2|rcsb pdb:4ED3|rcsb pdb:4ED6|rcsb pdb:4ED7|rcsb pdb:4ED8|rcsb pdb:4EEY|rcsb pdb:4J9K|rcsb pdb:4J9L|rcsb pdb:4J9M|rcsb pdb:4J9N|rcsb pdb:4J9O|rcsb pdb:4J9P|rcsb pdb:4J9Q|rcsb pdb:4J9R|rcsb pdb:4J9S|rcsb pdb:4O3Q|rcsb pdb:4O3R|rcsb pdb:4O3S|rcsb pdb:4Q8E|rcsb pdb:4Q8F|rcsb pdb:4RNM|rcsb pdb:4RNN|rcsb pdb:4RNO|rcsb pdb:4RU9|rcsb pdb:4YP3|rcsb pdb:4YQW|rcsb pdb:4YR0|rcsb pdb:4YR2|rcsb pdb:4YR3|rcsb pdb:5DG7|rcsb pdb:5DG8|rcsb pdb:5DG9|rcsb pdb:5DGA|rcsb pdb:5DGB|rcsb pdb:5DLF|rcsb pdb:5DLG|rcsb pdb:5DQG|rcsb pdb:5DQH|rcsb pdb:5DQI|rcsb pdb:5EWE|rcsb pdb:5EWF|rcsb pdb:4O3N|rcsb pdb:4O3O|rcsb pdb:5EWG|rcsb pdb:4O3P|rcsb pdb:5F9L|rcsb pdb:5F9N|rcsb pdb:5JUM|rcsb pdb:5KFA|rcsb pdb:5KFB|rcsb pdb:5KFC|rcsb pdb:5KFD|rcsb pdb:5KFE|rcsb pdb:5KFF|rcsb pdb:5L1K|rcsb pdb:5L1L|rcsb pdb:5L9X|rcsb pdb:6D0M|rcsb pdb:6D0Z|rcsb pdb:6M7O|rcsb pdb:6M7P|rcsb pdb:6M7T|rcsb pdb:6M7U|rcsb pdb:6M7V|rcsb pdb:6MP3|rcsb pdb:6MQ8|rcsb pdb:6MXO|rcsb pdb:6PL7|rcsb pdb:6PL8|rcsb pdb:6PLC|rcsb pdb:6PZ3|rcsb pdb:6Q02|rcsb pdb:6UI2|rcsb pdb:6UQI|rcsb pdb:6V5K|rcsb pdb:6W5X|rcsb pdb:6WK6|rcsb pdb:7M7L|rcsb pdb:7M7M|rcsb pdb:7M7N|rcsb pdb:7M7O|rcsb pdb:7M7P|rcsb pdb:7M7Q|rcsb pdb:7M7R|rcsb pdb:7M7S|rcsb pdb:7M7T|rcsb pdb:7M7U|rcsb pdb:7M7Y|rcsb pdb:7M7Z|rcsb pdb:7M80|rcsb pdb:7M81|rcsb pdb:7M82|rcsb pdb:7M83|rcsb pdb:7M84|rcsb pdb:7M85|rcsb pdb:7M86|rcsb pdb:7M87|rcsb pdb:7M88|rcsb pdb:7M89|rcsb pdb:7M8A|rcsb pdb:7M8B|rcsb pdb:7M8C|rcsb pdb:7M8D|reactome:R-HSA-110320|reactome:R-HSA-5656169|reactome:R-HSA-5685942|mint:MINT-8385875(identity) - comment:mint|comment:homomint|function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents - comment:homomint|comment:mint|figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2014/10/16 rogid:nqlZzaFe/OYk+xqMSxqvMxPULXI9606 rogid:gFWYJTkZiTzfwV5JtH5qdtNpaN09606 intact-crc:425650C38798E680|rigid:imBTBeZSBOs8g/WNcESr/U7MlPY false binding-associated region:1158-1251(MINT-8385866) binding-associated region:524-539(MINT-8385876) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9UI95 uniprotkb:Q9UBZ9 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-7353917|intact:MINT-140323|uniprotkb:Q53SI7|uniprotkb:O95941|uniprotkb:Q9NUP2|uniprotkb:Q9C0J4|ensembl:ENSP00000258428 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev1_human(display_long)|uniprotkb:REV1(gene name)|psi-mi:REV1(display_short)|uniprotkb:REV1L(gene name synonym)|uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym)|uniprotkb:Alpha integrin-binding protein 80(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985813|mint:MINT-8385803|imex:IM-26445-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385813(identity) refseq:NP_001308383.1|refseq:NP_001308384.1|refseq:NP_001308387.1|refseq:NP_001308388.1|refseq:NP_001308389.1|refseq:NP_001032961.1|refseq:NP_057400.1|ensembl:ENSG00000135945(gene)|ensembl:ENST00000258428(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0009411"(response to UV)|go:"GO:0017125"(deoxycytidyl transferase activity)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR001357(BRCT)|interpro:IPR012112(DNA repair protein, Rev1)|interpro:IPR017961|interpro:IPR025527|interpro:IPR031991|interpro:IPR036420|interpro:IPR036775|interpro:IPR038401|interpro:IPR043128|interpro:IPR043502|rcsb pdb:2EBW|rcsb pdb:2LSI|rcsb pdb:2LSK|rcsb pdb:2LSY|rcsb pdb:2N1G|rcsb pdb:3GQC|rcsb pdb:3VU7|rcsb pdb:4BA9|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5VZM|rcsb pdb:6ASR|rcsb pdb:6AXD|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|mint:MINT-8385805(identity) - - comment:mint|comment:homomint|function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents figure legend:sf1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-6(molar) 2012/07/09 2014/10/16 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:nqlZzaFe/OYk+xqMSxqvMxPULXI9606 intact-crc:DC18E3D9265DA882|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1158-1251(MINT-8385806) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:O60673 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-2871302|uniprotkb:O43214|uniprotkb:Q5TC33|intact:EBI-28974373|ensembl:ENSP00000351697|ensembl:ENSP00000357792 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev3l_human(display_long)|uniprotkb:REV3L(gene name)|psi-mi:REV3L(display_short)|uniprotkb:POLZ(gene name synonym)|uniprotkb:REV3(gene name synonym)|uniprotkb:Protein reversionless 3-like(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985813|mint:MINT-8385803|imex:IM-26445-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385813(identity) refseq:NP_001273360.1|refseq:NP_001273361.1|ensembl:ENSP00000351697|ensembl:ENSP00000357792|ensembl:ENST00000435970|ensembl:ENSP00000402003|refseq:NP_002903.3|ensembl:ENSG00000009413(gene)|ensembl:ENST00000358835(transcript)|ensembl:ENST00000368802(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|reactome:R-HSA-5655862|reactome:R-HSA-5656121|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR030559|interpro:IPR032757|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5O8K|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6EKM|rcsb pdb:6KEA|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|mint:MINT-8385809(identity) - - - figure legend:sf1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-6(molar) 2012/07/09 2014/10/16 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:6lX9oCcC9HRO89EjXBoZ4sfk5HU9606 intact-crc:DC18E3D9265DA882|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1847-1898(MINT-8385810) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60673 uniprotkb:Q9UI95 intact:EBI-2871302|uniprotkb:O43214|uniprotkb:Q5TC33|intact:EBI-28974373|ensembl:ENSP00000351697|ensembl:ENSP00000357792 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 psi-mi:rev3l_human(display_long)|uniprotkb:REV3L(gene name)|psi-mi:REV3L(display_short)|uniprotkb:POLZ(gene name synonym)|uniprotkb:REV3(gene name synonym)|uniprotkb:Protein reversionless 3-like(gene name synonym) psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7985895|mint:MINT-8385849|imex:IM-26445-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273360.1|refseq:NP_001273361.1|ensembl:ENSP00000351697|ensembl:ENSP00000357792|ensembl:ENST00000435970|ensembl:ENSP00000402003|refseq:NP_002903.3|ensembl:ENSG00000009413(gene)|ensembl:ENST00000358835(transcript)|ensembl:ENST00000368802(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|reactome:R-HSA-5655862|reactome:R-HSA-5656121|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR030559|interpro:IPR032757|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5O8K|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6EKM|rcsb pdb:6KEA|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|mint:MINT-8385855(identity) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385859(identity) - - - figure legend:sf1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2018/06/20 rogid:6lX9oCcC9HRO89EjXBoZ4sfk5HU9606 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 intact-crc:7C44281A387D573F|rigid:GNJ/aiDFnTET5uAqM6xHvlTcBwE false binding-associated region:1847-1898(MINT-8385856) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:Q9UBZ9 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-7353917|intact:MINT-140323|uniprotkb:Q53SI7|uniprotkb:O95941|uniprotkb:Q9NUP2|uniprotkb:Q9C0J4|ensembl:ENSP00000258428 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev1_human(display_long)|uniprotkb:REV1(gene name)|psi-mi:REV1(display_short)|uniprotkb:REV1L(gene name synonym)|uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym)|uniprotkb:Alpha integrin-binding protein 80(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985866|mint:MINT-8385833|imex:IM-26445-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385844(identity) refseq:NP_001308383.1|refseq:NP_001308384.1|refseq:NP_001308387.1|refseq:NP_001308388.1|refseq:NP_001308389.1|refseq:NP_001032961.1|refseq:NP_057400.1|ensembl:ENSG00000135945(gene)|ensembl:ENST00000258428(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0009411"(response to UV)|go:"GO:0017125"(deoxycytidyl transferase activity)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0070987"(error-free translesion synthesis)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR001357(BRCT)|interpro:IPR012112(DNA repair protein, Rev1)|interpro:IPR017961|interpro:IPR025527|interpro:IPR031991|interpro:IPR036420|interpro:IPR036775|interpro:IPR038401|interpro:IPR043128|interpro:IPR043502|rcsb pdb:2EBW|rcsb pdb:2LSI|rcsb pdb:2LSK|rcsb pdb:2LSY|rcsb pdb:2N1G|rcsb pdb:3GQC|rcsb pdb:3VU7|rcsb pdb:4BA9|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5VZM|rcsb pdb:6ASR|rcsb pdb:6AXD|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|mint:MINT-8385836(identity) - - comment:mint|comment:homomint|function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents figure legend:sf1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2014/10/16 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:nqlZzaFe/OYk+xqMSxqvMxPULXI9606 intact-crc:CD5AC27231321C8D|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1158-1251(MINT-8385837) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UI95 uniprotkb:O60673 intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3 intact:EBI-2871302|uniprotkb:O43214|uniprotkb:Q5TC33|intact:EBI-28974373|ensembl:ENSP00000351697|ensembl:ENSP00000357792 psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym) psi-mi:rev3l_human(display_long)|uniprotkb:REV3L(gene name)|psi-mi:REV3L(display_short)|uniprotkb:POLZ(gene name synonym)|uniprotkb:REV3(gene name synonym)|uniprotkb:Protein reversionless 3-like(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pustovalova et al. (2012) pubmed:22828282|mint:MINT-8385420|imex:IM-26445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7985866|mint:MINT-8385833|imex:IM-26445-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1|mint:MINT-8385844(identity) refseq:NP_001273360.1|refseq:NP_001273361.1|ensembl:ENSP00000351697|ensembl:ENSP00000357792|ensembl:ENST00000435970|ensembl:ENSP00000402003|refseq:NP_002903.3|ensembl:ENSG00000009413(gene)|ensembl:ENST00000358835(transcript)|ensembl:ENST00000368802(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|reactome:R-HSA-5655862|reactome:R-HSA-5656121|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR030559|interpro:IPR032757|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5O8K|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6EKM|rcsb pdb:6KEA|rcsb pdb:6WS0|rcsb pdb:6WS5|reactome:R-HSA-110312|mint:MINT-8385840(identity) - - - figure legend:sf1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/07/09 2014/10/16 rogid:KBeawMhcP3iXUel74pUDl85A/vw9606 rogid:6lX9oCcC9HRO89EjXBoZ4sfk5HU9606 intact-crc:CD5AC27231321C8D|rigid:mEdr3vfxGjkq3xzpcpHsLHRwL7I false - binding-associated region:1847-1898(MINT-8385841) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)