#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23804	uniprotkb:P47962	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-773940|uniprotkb:Q9CR19|ensembl:ENSMUSP00000080854	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:rl5_mouse(display_long)|uniprotkb:Rpl5(gene name)|psi-mi:Rpl5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bywater et al. (2012)	pubmed:22789538|imex:IM-17409	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6248397|imex:IM-17409-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_058676.1|ensembl:ENSMUSG00000058558(gene)|ensembl:ENSMUST00000082223(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905017"(positive regulation of isoleucine-tRNA ligase activity)|go:"GO:1905020"(positive regulation of methionine-tRNA ligase activity)|go:"GO:1905023"(positive regulation of threonine-tRNA ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P47962|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig 4F|agonist:CX-5461 - a Pol1 transcription inhibitor.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lymphoma)|taxid:10090(Mus musculus)	-	2012/07/17	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:29DmVSczDJV/5gL/nPYYBBEdo9o10090	intact-crc:6751DF955E78CD49|rigid:M2Owi6Y9+nBdwENOKqtkftOObrU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23804	uniprotkb:Q9CXW4	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-1548890|uniprotkb:Q3TPE3|uniprotkb:Q6ZWY0|ensembl:ENSMUSP00000099595	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:rl11_mouse(display_long)|uniprotkb:Rpl11(gene name)|psi-mi:Rpl11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bywater et al. (2012)	pubmed:22789538|imex:IM-17409	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6248397|imex:IM-17409-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_080195.1|ensembl:ENSMUSG00000059291(gene)|ensembl:ENSMUST00000102536(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006605"(protein targeting)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045202"(synapse)|go:"GO:0050821"(protein stabilization)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR020929|interpro:IPR022803|interpro:IPR031309|interpro:IPR031310|mint:Q9CXW4|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig 4F|agonist:CX-5461 - a Pol1 transcription inhibitor.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lymphoma)|taxid:10090(Mus musculus)	-	2012/07/17	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q10090	intact-crc:6751DF955E78CD49|rigid:M2Owi6Y9+nBdwENOKqtkftOObrU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)