#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:H2KZB2	uniprotkb:Q03565	intact:EBI-6258914|ensemblmetazoa:Y55F3BR.8a.1|uniprotkb:Q5W7E5	intact:EBI-2535603|uniprotkb:Q9BMU1|ensemblmetazoa:B0464.7.1	psi-mi:ankl2_caeel(display_long)|uniprotkb:lem-4(gene name)|psi-mi:lem-4(display_short)|uniprotkb:LEM domain-containing protein 4-like(gene name synonym)|uniprotkb:lem-4l(gene name synonym)|uniprotkb:Y55F3BR.8(orf name)	psi-mi:baf1_caeel(display_long)|uniprotkb:baf-1(gene name)|psi-mi:baf-1(display_short)|uniprotkb:B0464.7(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258976|imex:IM-17628-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:WBGene00021945(gene)|ensemblmetazoa:Y55F3BR.8a.1(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|reactome:R-CEL-2995383|wormbase:Y55F3BR.8a|wormbase:Y55F3BR.8b|interpro:IPR002110(Ankyrin)|refseq:NP_001023514.1|refseq:NP_001023515.1|interpro:IPR035007|interpro:IPR036770	ensemblmetazoa:B0464.7.1(transcript)|ensemblmetazoa:WBGene00000235(gene)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010165"(response to X-ray)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051276"(chromosome organization)|refseq:NP_499085.1|wormbase:B0464.7|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617	go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, Supp. Fig. 4A, 4B|comment:Addition of either human ANKLE2 aa 59–938 or C. elegans LEM-4L aa 257–600 strongly inhibited BAF-1 phosphorylation by VRK-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:ESvlBhfWI2e7qk1AeObnMw3fcn06239	rogid:HfXvaGjU///qebHwPnaYBMyvfAo6239	intact-crc:E27E0ACB77F2A055|rigid:uA0FoghFb7+UbpZq4jMqFiLL7bo	false	his tag:?-?|sufficient binding region:257-600	zz tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:H2KZB2	uniprotkb:Q19848	intact:EBI-6258914|ensemblmetazoa:Y55F3BR.8a.1|uniprotkb:Q5W7E5	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	psi-mi:ankl2_caeel(display_long)|uniprotkb:lem-4(gene name)|psi-mi:lem-4(display_short)|uniprotkb:LEM domain-containing protein 4-like(gene name synonym)|uniprotkb:lem-4l(gene name synonym)|uniprotkb:Y55F3BR.8(orf name)	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258976|imex:IM-17628-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:WBGene00021945(gene)|ensemblmetazoa:Y55F3BR.8a.1(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|reactome:R-CEL-2995383|wormbase:Y55F3BR.8a|wormbase:Y55F3BR.8b|interpro:IPR002110(Ankyrin)|refseq:NP_001023514.1|refseq:NP_001023515.1|interpro:IPR035007|interpro:IPR036770	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, Supp. Fig. 4A, 4B|comment:Addition of either human ANKLE2 aa 59–938 or C. elegans LEM-4L aa 257–600 strongly inhibited BAF-1 phosphorylation by VRK-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:ESvlBhfWI2e7qk1AeObnMw3fcn06239	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	intact-crc:E27E0ACB77F2A055|rigid:uA0FoghFb7+UbpZq4jMqFiLL7bo	false	his tag:?-?|sufficient binding region:257-600	glutathione s tranferase tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q19848	-	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	-	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258966|imex:IM-17628-4	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	-	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	-	intact-crc:9FC2BFDE0A495D69	false	his tag:?-?|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q03565	uniprotkb:Q19848	intact:EBI-2535603|uniprotkb:Q9BMU1|ensemblmetazoa:B0464.7.1	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	psi-mi:baf1_caeel(display_long)|uniprotkb:baf-1(gene name)|psi-mi:baf-1(display_short)|uniprotkb:B0464.7(orf name)	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258951|imex:IM-17628-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:B0464.7.1(transcript)|ensemblmetazoa:WBGene00000235(gene)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010165"(response to X-ray)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051276"(chromosome organization)|refseq:NP_499085.1|wormbase:B0464.7|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, 5E, Supp. Fig. 4A|comment:Addition of either human ANKLE2 aa 59–938 or C. elegans LEM-4L aa 257–600 strongly inhibited BAF-1 phosphorylation by VRK-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:HfXvaGjU///qebHwPnaYBMyvfAo6239	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	intact-crc:88986ED4C3FB01D8|rigid:8Ww3Z3X84AfGzWHeygNBcwn/iJo	false	his tag:?-?|zz tag:?-?	his tag:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q86XL3	uniprotkb:Q03565	intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686	intact:EBI-2535603|uniprotkb:Q9BMU1|ensemblmetazoa:B0464.7.1	psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym)	psi-mi:baf1_caeel(display_long)|uniprotkb:baf-1(gene name)|psi-mi:baf-1(display_short)|uniprotkb:B0464.7(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258997|imex:IM-17628-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408	ensemblmetazoa:B0464.7.1(transcript)|ensemblmetazoa:WBGene00000235(gene)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010165"(response to X-ray)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051276"(chromosome organization)|refseq:NP_499085.1|wormbase:B0464.7|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617	go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, Supp. Fig. 4A|comment:Addition of either human ANKLE2 aa 59–938 or C. elegans LEM-4L aa 257–600 strongly inhibited BAF-1 phosphorylation by VRK-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606	rogid:HfXvaGjU///qebHwPnaYBMyvfAo6239	intact-crc:97CF214E2A379C2F|rigid:YLvXiU1FB3wyvP3iVZD42Pcb54o	false	his tag:?-?|sufficient binding region:442-938	his tag:?-?|zz tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q86XL3	uniprotkb:Q19848	intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym)	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258997|imex:IM-17628-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	-	figure legend:Fig. 5B, 5D, Supp. Fig. 4A|comment:Addition of either human ANKLE2 aa 59–938 or C. elegans LEM-4L aa 257–600 strongly inhibited BAF-1 phosphorylation by VRK-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	intact-crc:97CF214E2A379C2F|rigid:YLvXiU1FB3wyvP3iVZD42Pcb54o	false	his tag:?-?|sufficient binding region:442-938	his tag:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P63151	uniprotkb:Q86XL3	intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113	intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686	psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6260172|imex:IM-17628-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N	refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408	-	-	-	figure legend:Fig. 6B, Supp. Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:evS6klM2alZXtMthVsshKkrNgiA9606	rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606	intact-crc:0AFA8B263B45DE53|rigid:Obrd5Op/lxBQMbZb14l/CBENgOo	false	-	glutathione s tranferase tag:?-?|sufficient binding region:162-349	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9XTB5	uniprotkb:O01971	intact:EBI-2535391|ensemblmetazoa:W01G7.5.1	intact:EBI-6260308|ensemblmetazoa:M01D7.6.1|ensemblmetazoa:M01D7.6.2	psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name)	psi-mi:emr1_caeel(display_long)|uniprotkb:emr-1(gene name)|psi-mi:emr-1(display_short)|uniprotkb:Ce-emerin(gene name synonym)|uniprotkb:M01D7.6(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6260324|imex:IM-17628-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405	ensemblmetazoa:M01D7.6.1(transcript)|ensemblmetazoa:M01D7.6.2(transcript)|ensemblmetazoa:WBGene00001309(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|refseq:NP_490907.1|wormbase:M01D7.6|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)	go:"GO:0005635"(nuclear envelope)	-	-	figure legend:Supp. figs. 1G, 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo)	-	2012/07/31	2014/10/16	rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239	rogid:mSbqg6bTFsnrz5HtplZA4FZnNdA6239	intact-crc:355CD6A0CB100FB9|rigid:e0Ay4+CvGesw9xm7ab/i3vsLisA	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:H2KZB2	uniprotkb:Q19848	intact:EBI-6258914|ensemblmetazoa:Y55F3BR.8a.1|uniprotkb:Q5W7E5	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	psi-mi:ankl2_caeel(display_long)|uniprotkb:lem-4(gene name)|psi-mi:lem-4(display_short)|uniprotkb:LEM domain-containing protein 4-like(gene name synonym)|uniprotkb:lem-4l(gene name synonym)|uniprotkb:Y55F3BR.8(orf name)	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258913|imex:IM-17628-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:WBGene00021945(gene)|ensemblmetazoa:Y55F3BR.8a.1(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|reactome:R-CEL-2995383|wormbase:Y55F3BR.8a|wormbase:Y55F3BR.8b|interpro:IPR002110(Ankyrin)|refseq:NP_001023514.1|refseq:NP_001023515.1|interpro:IPR035007|interpro:IPR036770	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:ESvlBhfWI2e7qk1AeObnMw3fcn06239	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	intact-crc:410B1569F07879B7|rigid:2dQyWvgPzb9SYuyEa9BQSJqLGgw	false	sufficient binding region:257-600|his tag:?-?	glutathione s tranferase tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q19848	uniprotkb:Q86XL3	intact:EBI-2414048|ensemblmetazoa:F28B12.3.1|ensemblmetazoa:F28B12.3.2	intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686	psi-mi:vrk1_caeel(display_long)|uniprotkb:vrk-1(gene name)|psi-mi:vrk-1(display_short)|uniprotkb:F28B12.3(orf name)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)	psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Asencio et al. (2012)	imex:IM-17628|pubmed:22770216	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258932|imex:IM-17628-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495185.1|wormbase:F28B12.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2995383|reactome:R-CEL-9013405|go:"GO:0106311"|ensemblmetazoa:F28B12.3.1(transcript)|ensemblmetazoa:F28B12.3.2(transcript)|ensemblmetazoa:WBGene00017895(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000785"(chromatin)|go:"GO:0001708"(cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008406"(gonad development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)	refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/31	2014/10/16	rogid:3BgEGMRV4VGmOaim1VxkmnYu91Q6239	rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606	intact-crc:C10654A7CDA19E42|rigid:ceA6pSps1tLgco+8odg+KnqRb90	false	glutathione s tranferase tag:?-?|his tag:?-?	sufficient binding region:59-938|his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)