#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:H7BX60 uniprotkb:Q9D7K2 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258509|ensembl:ENSMUSP00000021130 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ten1l_mouse(display_long)|uniprotkb:Ten1(gene name)|psi-mi:Ten1(display_short)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258474|imex:IM-17623-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020778(gene)|ensembl:ENSMUST00000021130(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_081383.1 - - - figure legend:Supp. Fig. 5B|comment:Flag-tagged Ctc1 and Ten1 also transfected into cells but not shown in complex by western blot|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:JLgYwRVgilaEBFfee/oClj0bfzI10090 intact-crc:657D12375B451F6A|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q5SUQ9 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258474|imex:IM-17623-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Supp. Fig. 5B|comment:Flag-tagged Ctc1 and Ten1 also transfected into cells but not shown in complex by western blot|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:657D12375B451F6A|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q8K2X3 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258474|imex:IM-17623-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 - - - figure legend:Supp. Fig. 5B|comment:Flag-tagged Ctc1 and Ten1 also transfected into cells but not shown in complex by western blot|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:657D12375B451F6A|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q5EE38 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258623|imex:IM-17623-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N - - - figure legend:Supp. Fig. 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 intact-crc:22FE0C6FD96ADFA2|rigid:lGCmyELwmSz+iQHYD4adBMrQAVU false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q5SUQ9 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258590|imex:IM-17623-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Supp. Fig. 5E, 5F, 5H, 5I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:9E2882603D3CBEAF|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false necessary binding region:300-350|mutation disrupting interaction strength:638-640,329-329,332-332|myc tag:?-?|mutation decreasing interaction strength:638-640|mutation decreasing interaction strength:329-329,332-332 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q8K2X3 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258590|imex:IM-17623-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 - - - figure legend:Supp. Fig. 5E, 5F, 5H, 5I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:9E2882603D3CBEAF|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false necessary binding region:300-350|mutation disrupting interaction strength:638-640,329-329,332-332|myc tag:?-?|mutation decreasing interaction strength:638-640|mutation decreasing interaction strength:329-329,332-332 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8K2X3 uniprotkb:H7BX60 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 intact:EBI-6258290|ensembl:ENSMUSP00000084089 psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258305|imex:IM-17623-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 - - - figure legend:Fig. 5A, Supp. Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 intact-crc:3B8C50732F4538AF|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false flag tag:?-? mutation disrupting interaction strength:332-332,329-329,638-640|mutation decreasing interaction strength:329-329,332-332|myc tag:?-?|mutation decreasing interaction strength:638-640 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8K2X3 uniprotkb:Q5SUQ9 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258305|imex:IM-17623-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Fig. 5A, Supp. Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:3B8C50732F4538AF|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false flag tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q5SUQ9 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258564|imex:IM-17623-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Fig. 5A, Supp. Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:26B30D95698C5435|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false mutation disrupting interaction strength:332-332,638-640,329-329|myc tag:?-?|mutation decreasing interaction strength:638-640|mutation decreasing interaction strength:329-329,332-332 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q8K2X3 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258564|imex:IM-17623-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 - - - figure legend:Fig. 5A, Supp. Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:26B30D95698C5435|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false mutation disrupting interaction strength:332-332,638-640,329-329|myc tag:?-?|mutation decreasing interaction strength:638-640|mutation decreasing interaction strength:329-329,332-332 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q9D7K2 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258509|ensembl:ENSMUSP00000021130 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ten1l_mouse(display_long)|uniprotkb:Ten1(gene name)|psi-mi:Ten1(display_short)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258564|imex:IM-17623-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020778(gene)|ensembl:ENSMUST00000021130(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_081383.1 - - - figure legend:Fig. 5A, Supp. Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:JLgYwRVgilaEBFfee/oClj0bfzI10090 intact-crc:26B30D95698C5435|rigid:V0VM1J9ebHKuMaqBRDZ1c3rQVM0 false mutation disrupting interaction strength:332-332,638-640,329-329|myc tag:?-?|mutation decreasing interaction strength:638-640|mutation decreasing interaction strength:329-329,332-332 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q8K2X3 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258407|imex:IM-17623-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 - - - figure legend:Supp. Figs. 5A, 5C|comment:Flag-tagged Ctc1 and Ten1 also transfected into cells but not shown in complex by western blot|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:8B702A0BD183510A|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:H7BX60 uniprotkb:Q5SUQ9 intact:EBI-6258290|ensembl:ENSMUSP00000084089 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:h7bx60_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2012) pubmed:22748632|imex:IM-17623 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6258407|imex:IM-17623-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000086876(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_011244947.1|refseq:XP_011244948.1|refseq:XP_006525041.1|refseq:NP_082646.1 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Supp. Figs. 5A, 5C|comment:Flag-tagged Ctc1 and Ten1 also transfected into cells but not shown in complex by western blot|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/31 2014/10/16 rogid:vBy+focCVntO9+2M3Yfzr3q52yY10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:8B702A0BD183510A|rigid:nxLOPk5SF9Y3H0gNa5NKdFIL5nA false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)