#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41832	uniprotkb:P39940	intact:EBI-3692|uniprotkb:O13450|uniprotkb:D6W0S3|ensemblfungi:YNL271C	intact:EBI-16219|ensemblfungi:YER125W|uniprotkb:D3DM31	psi-mi:bni1_yeast(display_long)|uniprotkb:PPF3(gene name synonym)|uniprotkb:SHE5(gene name synonym)|uniprotkb:BNI1(gene name)|psi-mi:BNI1(display_short)|uniprotkb:YNL271C(locus name)|uniprotkb:N0646(orf name)|uniprotkb:Synthetic lethal 39(gene name synonym)|uniprotkb:Sensitive to high expression protein 5(gene name synonym)|uniprotkb:Pointed projection formation protein 3(gene name synonym)	psi-mi:rsp5_yeast(display_long)|uniprotkb:RSP5(gene name)|psi-mi:RSP5(display_short)|uniprotkb:MDP1(gene name synonym)|uniprotkb:NPI1(gene name synonym)|uniprotkb:YER125W(locus name)|uniprotkb:SYGP-ORF41(orf name)|uniprotkb:Reverses SPT-phenotype protein 5(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase RSP5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kono et al. (2012)	pubmed:22727045|imex:IM-17629	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6260446|imex:IM-17629-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014128.2|sgd:S000005215|dip:DIP-974N|ensemblfungi:YNL271C(gene)|ensemblfungi:YNL271C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000133"(polarisome)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032153"(cell division site)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045010"(actin nucleation)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070649"(formin-nucleated actin cable assembly)|go:"GO:1903475"(mitotic actomyosin contractile ring assembly)|go:"GO:1903827"|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|rcsb pdb:1UX4|rcsb pdb:1UX5|rcsb pdb:1Y64	ensemblfungi:YER125W(gene)|ensemblfungi:YER125W_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0010794"(regulation of dolichol biosynthetic process)|go:"GO:0010795"(regulation of ubiquinone biosynthetic process)|go:"GO:0010796"(regulation of multivesicular body size)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0019220"(regulation of phosphate metabolic process)|go:"GO:0030479"(actin cortical patch)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032443"(regulation of ergosterol biosynthetic process)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034517"(ribophagy)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042493"|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:2000203"(regulation of ribosomal large subunit export from nucleus)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000235"(regulation of tRNA processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:2000238"(regulation of tRNA export from nucleus)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:3OLM|rcsb pdb:4LCD|rcsb pdb:5HPL|reactome:R-SCE-1169408|reactome:R-SCE-8948751|reactome:R-SCE-9013406|reactome:R-SCE-983168|sgd:S000000927|refseq:NP_011051.3|dip:DIP-2238N|mint:P39940	-	crc64:0C5A9D5280A5858F	crc64:6F1836384479E70F	figure legend:Figs. 5A-C|comment:Binding not observed in pkc1-/- cells. Mutation of three consensus WW-binding motifs abolishes the interaction between Bni1-642-13myc and the Rsp5-WW domain.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/01	2014/10/16	rogid:aS6XG+rT9RfN7DLRaqtiNywyVro559292	rogid:IoFCQz3aNFApg/LSyc6Si4dsDc0559292	intact-crc:CA06A24FBC19F365|rigid:WDkl8EGCmwx5KjwXUt8bTWXp2K4	false	sufficient binding region:1-642|myc tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:229..229-420..420(IPR001202)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24583	uniprotkb:P06780	intact:EBI-9860|ensemblfungi:YBL105C|uniprotkb:D6VPP8	intact:EBI-15121|uniprotkb:D6W4G6|ensemblfungi:YPR165W	psi-mi:kpc1_yeast(display_long)|uniprotkb:PKC1(gene name)|psi-mi:PKC1(display_short)|uniprotkb:HPO2(gene name synonym)|uniprotkb:STT1(gene name synonym)|uniprotkb:YBL105C(locus name)|uniprotkb:YBL0807(orf name)	psi-mi:rho1_yeast(display_long)|uniprotkb:RHO1(gene name)|psi-mi:RHO1(display_short)|uniprotkb:YPR165W(locus name)|uniprotkb:P9325.3(orf name)|uniprotkb:Rho-type GTPase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kono et al. (2012)	pubmed:22727045|imex:IM-17629	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6260428|imex:IM-17629-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009445.2|sgd:S000000201|ensemblfungi:YBL105C(gene)|ensemblfungi:YBL105C_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032165"(prospore septin filament array)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060211"("regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060237"(regulation of fungal-type cell wall organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037312|interpro:IPR037778|reactome:R-SCE-114508|reactome:R-SCE-114516|reactome:R-SCE-1169091|reactome:R-SCE-1489509|reactome:R-SCE-202424|reactome:R-SCE-2029485|reactome:R-SCE-2179392|reactome:R-SCE-2871837|reactome:R-SCE-399997|reactome:R-SCE-4419969|reactome:R-SCE-5218921|reactome:R-SCE-5607764|reactome:R-SCE-5625740|reactome:R-SCE-5668599|reactome:R-SCE-6798695|reactome:R-SCE-76005|reactome:R-SCE-8980692|reactome:R-SCE-9013026|reactome:R-SCE-9634635|dip:DIP-1516N|mint:P24583	refseq:NP_015491.1|sgd:S000006369|reactome:R-SCE-6798695|reactome:R-SCE-8980692|reactome:R-SCE-9013026|reactome:R-SCE-9013405|reactome:R-SCE-9035034|reactome:R-SCE-9696264|reactome:R-SCE-9696270|reactome:R-SCE-9696273|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043332"(mating projection tip)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0060237"(regulation of fungal-type cell wall organization)|go:"GO:0071944"(cell periphery)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090334"("regulation of cell wall (1->3)-beta-D-glucan biosynthetic process")|go:"GO:1903395"(regulation of secondary cell septum biogenesis)|go:"GO:1903501"(positive regulation of mitotic actomyosin contractile ring assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:3A58|reactome:R-SCE-198203|reactome:R-SCE-392451|reactome:R-SCE-416482|reactome:R-SCE-5625740|ensemblfungi:YPR165W(gene)|ensemblfungi:YPR165W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000148"(1,3-beta-D-glucan synthase complex)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010008"(endosome membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|dip:DIP-1040N|mint:P06780	-	crc64:8200EC2A2C6E649E	crc64:630B17E9E34CFE75	figure legend:Supp. Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/08/01	2014/10/16	rogid:ajnsIv2ZUh0GzDRqYAJTKsbr7hg559292	rogid:DHzmbB2VfZP/fwD9FzdTnXOc8aA559292	intact-crc:2EC80B645535A818|rigid:dpBmD/prh3AtxT9MlXRoTt6haHA	false	green fluorescent protein tag:?-?|sufficient binding region:1..1-288..288	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)