#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28026	uniprotkb:A6NFA1	intact:EBI-6257743	intact:EBI-6257471|ensembl:ENSP00000476820|uniprotkb:I6U4Y0	psi-mi:wnt8_xenla(display_long)|uniprotkb:wnt8(gene name)|psi-mi:wnt8(display_short)	psi-mi:tiki2_human(display_long)|uniprotkb:HKAT(gene name synonym)|uniprotkb:Heart, kidney and adipose-enriched transmembrane protein homolog(gene name synonym)|uniprotkb:TRABD2B(gene name)|psi-mi:TRABD2B(display_short)|uniprotkb:TIKI2(gene name synonym)|uniprotkb:TRAB domain-containing protein 2B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6257737|imex:IM-17383-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000578"(embryonic axis specification)|go:"GO:0002020"(protease binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000044"(negative regulation of cardiac cell fate specification)|interpro:IPR034312|rcsb pdb:4F0A|interpro:IPR005817(Wnt superfamily)|interpro:IPR013301(Wnt-8 protein)|interpro:IPR018161|refseq:NP_001081637.1|interpro:IPR043158	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:1904808"(positive regulation of protein oxidation)|interpro:IPR002816(Pheromone shutdown-related, TraB)|interpro:IPR040230|ensembl:ENSG00000269113(gene)|ensembl:ENST00000606738(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:NP_001181915.1	go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. FIg. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:i5DWY4D0O89KF0BJ91mXYV/TlcU8355	rogid:eEvi/y1zoB81Elmk7VPxcirxhpo9606	intact-crc:2555FBEFCD9F9948|rigid:5CNnLiE376FcAGTT1dvn3NYmYzI	false	myc tag:?-?	flag tag:c-c|sufficient binding region:20..20-494..494|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49893	uniprotkb:A6NFA1	intact:EBI-6258101|uniprotkb:Q5U5D9	intact:EBI-6257471|ensembl:ENSP00000476820|uniprotkb:I6U4Y0	psi-mi:wn11b_xenla(display_long)|uniprotkb:wnt11b(gene name)|psi-mi:wnt11b(display_short)|uniprotkb:wnt-11(gene name synonym)|uniprotkb:wnt11(gene name synonym)|uniprotkb:Protein Wnt-11(gene name synonym)	psi-mi:tiki2_human(display_long)|uniprotkb:HKAT(gene name synonym)|uniprotkb:Heart, kidney and adipose-enriched transmembrane protein homolog(gene name synonym)|uniprotkb:TRABD2B(gene name)|psi-mi:TRABD2B(display_short)|uniprotkb:TIKI2(gene name synonym)|uniprotkb:TRAB domain-containing protein 2B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258088|imex:IM-17383-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001755"(neural crest cell migration)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019838"(growth factor binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048793"(pronephros development)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060914"(heart formation)|go:"GO:0061101"(neuroendocrine cell differentiation)|go:"GO:0062009"(secondary palate development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|refseq:NP_001084327.1|interpro:IPR005817(Wnt superfamily)|interpro:IPR018161|interpro:IPR043158	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:1904808"(positive regulation of protein oxidation)|interpro:IPR002816(Pheromone shutdown-related, TraB)|interpro:IPR040230|ensembl:ENSG00000269113(gene)|ensembl:ENST00000606738(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:NP_001181915.1	go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. FIg. 6G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:54KibofrzBS1n95TEYcN+RjCb3A8355	rogid:eEvi/y1zoB81Elmk7VPxcirxhpo9606	intact-crc:55F1F6B740AF2E56|rigid:rE6f0yYueqANYJH5NZgx+hKmySM	false	myc tag:?-?	sufficient binding region:20..20-494..494|his tag:c-c|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27467	uniprotkb:A6NFA1	intact:EBI-2899665|ensembl:ENSMUSP00000010044	intact:EBI-6257471|ensembl:ENSP00000476820|uniprotkb:I6U4Y0	psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym)	psi-mi:tiki2_human(display_long)|uniprotkb:HKAT(gene name synonym)|uniprotkb:Heart, kidney and adipose-enriched transmembrane protein homolog(gene name synonym)|uniprotkb:TRABD2B(gene name)|psi-mi:TRABD2B(display_short)|uniprotkb:TIKI2(gene name synonym)|uniprotkb:TRAB domain-containing protein 2B(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6257467|imex:IM-17383-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:1904808"(positive regulation of protein oxidation)|interpro:IPR002816(Pheromone shutdown-related, TraB)|interpro:IPR040230|ensembl:ENSG00000269113(gene)|ensembl:ENST00000606738(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:NP_001181915.1	go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 5O, 5P, 5Q, 5R Supp. FIgs. 7A- 7E|antagonist:"1,10-phenanthroline, (a divalent metal chelator), EDTA  (a divalent metal chelator), Ni2+, Cu2+, Zn2+,"|agonist:Co2+, Mn2+|comment:"Cleavage of HA-Wnt3a became obvious at 2 hr and exhibited preference for neutral to slightly basic pH (pH 7–9).  TIKI2N was insensitive  to Bestatin, an aminopeptidase inhibitor, and to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases. This suggests Tiki is probably a Co2+- or Mn2+-dependent metalloprotease."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090	rogid:eEvi/y1zoB81Elmk7VPxcirxhpo9606	intact-crc:50847811E3B3192F|rigid:d0rF5kueUCaxkiB+4gI/EkOrJzk	false	ha tag:?-?	flag tag:c-c|his tag:c-c|necessary binding region:223-349|sufficient binding region:20..20-494..494	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A6NFA1	uniprotkb:P22725	intact:EBI-6257471|ensembl:ENSP00000476820|uniprotkb:I6U4Y0	intact:EBI-1570983|ensembl:ENSMUSP00000064878|uniprotkb:Q8BM17|uniprotkb:Q8BMF9|uniprotkb:Q8VCV6	psi-mi:tiki2_human(display_long)|uniprotkb:HKAT(gene name synonym)|uniprotkb:Heart, kidney and adipose-enriched transmembrane protein homolog(gene name synonym)|uniprotkb:TRABD2B(gene name)|psi-mi:TRABD2B(display_short)|uniprotkb:TIKI2(gene name synonym)|uniprotkb:TRAB domain-containing protein 2B(gene name synonym)	psi-mi:wnt5a_mouse(display_long)|uniprotkb:Wnt5a(gene name)|psi-mi:Wnt5a(display_short)|uniprotkb:Wnt-5a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6258031|imex:IM-17383-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:1904808"(positive regulation of protein oxidation)|interpro:IPR002816(Pheromone shutdown-related, TraB)|interpro:IPR040230|ensembl:ENSG00000269113(gene)|ensembl:ENST00000606738(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:NP_001181915.1	go:"GO:0061349"(planar cell polarity pathway involved in cardiac right atrium morphogenesis)|go:"GO:0061350"(planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:0061354"(planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0061348"(planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902379"(chemoattractant activity involved in axon guidance)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0007165"(signal transduction)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0007254"(JNK cascade)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR018161|interpro:IPR026538|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4086398|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:1903827"|go:"GO:1904934"(negative regulation of cell proliferation in midbrain)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|ensembl:ENSMUST00000063465(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|ensembl:ENSMUSG00000021994(gene)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003401"(axis elongation)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005115"(receptor tyrosine kinase-like orphan receptor binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036517"(chemoattraction of serotonergic neuron axon)|go:"GO:0036518"(chemorepulsion of dopaminergic neuron axon)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046546"(development of primary male sexual characteristics)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048806"(genitalia development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048850"(hypophysis morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051885"(positive regulation of timing of anagen)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060026"(convergent extension)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060067"(cervix development)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0060068"(vagina development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060157"(urinary bladder development)|go:"GO:0060324"(face development)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060606"(tube closure)|go:"GO:0060638"(mesenchymal-epithelial cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060775"(planar cell polarity pathway involved in gastrula mediolateral intercalation)|go:"GO:0060809"(mesodermal to mesenchymal transition involved in gastrulation)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061053"(somite development)|go:"GO:0061347"(planar cell polarity pathway involved in outflow tract morphogenesis)|refseq:NP_001243153.1|refseq:NP_033550.2|refseq:XP_006518987.1|refseq:XP_006518988.1|dip:DIP-39893N	go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. FIg. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:eEvi/y1zoB81Elmk7VPxcirxhpo9606	rogid:G9K/LKijd3T0ccGcNchvUn+NHGE10090	intact-crc:7E9544D43E5F8412|rigid:RYrZNkv06aDyizyyN9K0KKeGrzY	false	sufficient binding region:20..20-494..494|flag tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75581	uniprotkb:P56704	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6173035|imex:IM-17383-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Fig. 4L|comment:Interaction not observed in TIKI2-expressing cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	intact-crc:12A09073D0575E83|rigid:kzsoCTnMoL5enbUPXEMZFz885tg	false	sufficient binding region:1-1368|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61091	uniprotkb:P56704	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6173598|imex:IM-17383-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Fig. 4L|comment:Interaction not observed in TIKI2-expressing cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	intact-crc:601A3C3ECB698DAE|rigid:5ytyUEa26TF+YVkEzU6coQvzBYE	false	fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27467	uniprotkb:A6NFA1	intact:EBI-2899665|ensembl:ENSMUSP00000010044	intact:EBI-6257471|ensembl:ENSP00000476820|uniprotkb:I6U4Y0	psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym)	psi-mi:tiki2_human(display_long)|uniprotkb:HKAT(gene name synonym)|uniprotkb:Heart, kidney and adipose-enriched transmembrane protein homolog(gene name synonym)|uniprotkb:TRABD2B(gene name)|psi-mi:TRABD2B(display_short)|uniprotkb:TIKI2(gene name synonym)|uniprotkb:TRAB domain-containing protein 2B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2012)	pubmed:22726442|imex:IM-17383	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6257711|imex:IM-17383-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:1904808"(positive regulation of protein oxidation)|interpro:IPR002816(Pheromone shutdown-related, TraB)|interpro:IPR040230|ensembl:ENSG00000269113(gene)|ensembl:ENST00000606738(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:NP_001181915.1	go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. FIg. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/05	2014/10/16	rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090	rogid:eEvi/y1zoB81Elmk7VPxcirxhpo9606	intact-crc:6386451E0A841C38|rigid:d0rF5kueUCaxkiB+4gI/EkOrJzk	false	-	his tag:c-c|flag tag:c-c|sufficient binding region:20..20-494..494	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)