#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32745	uniprotkb:P30874	intact:EBI-6266935|ensembl:ENSP00000480971|ensembl:ENSP00000481325|uniprotkb:A8K550|uniprotkb:Q53ZR7	intact:EBI-6266898|ensembl:ENSP00000350198|uniprotkb:A8K3Y0|uniprotkb:Q4VBP0|uniprotkb:Q96GE0|uniprotkb:Q96TF2|uniprotkb:Q9BWH1|uniprotkb:B2R9P7	psi-mi:ssr3_human(display_long)|uniprotkb:SSTR3(gene name)|psi-mi:SSTR3(display_short)|uniprotkb:SSR-28(gene name synonym)	psi-mi:ssr2_human(display_long)|uniprotkb:SSTR2(gene name)|psi-mi:SSTR2(display_short)|uniprotkb:SRIF-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	War et al. (2012)	pubmed:22651821|imex:IM-17676	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6266896|imex:IM-17676-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000278195(gene)|ensembl:ENST00000610913(transcript)|ensembl:ENST00000617123(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060170"(ciliary membrane)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001856(Somatostatin receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32745|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-5620922|refseq:XP_011528651.1|refseq:XP_005261778.1|refseq:NP_001042.1|refseq:XP_006724374.1|refseq:NP_001265616.1|refseq:XP_016884412.1|refseq:XP_016884413.1	go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030432"(peristalsis)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR002074(Somatostatin receptor, type 2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|mint:P30874|ensembl:ENSG00000180616(gene)|ensembl:ENST00000357585(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0006937"(regulation of muscle contraction)|refseq:NP_001041.1	go:"GO:0016020"(membrane)	-	-	figure legend:fig. 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/08/14	2014/10/16	rogid:qSna7iphTpLgG05n7OyhDpvYX4A9606	rogid:AhlurWDwC9NS3Qv0qz4Th/4FT589606	intact-crc:E038E7D3EC36F82F|rigid:VE6J+jPebHAQLMxuR2OD0pJ15Us	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32745	uniprotkb:P30874	intact:EBI-6266935|ensembl:ENSP00000480971|ensembl:ENSP00000481325|uniprotkb:A8K550|uniprotkb:Q53ZR7	intact:EBI-6266898|ensembl:ENSP00000350198|uniprotkb:A8K3Y0|uniprotkb:Q4VBP0|uniprotkb:Q96GE0|uniprotkb:Q96TF2|uniprotkb:Q9BWH1|uniprotkb:B2R9P7	psi-mi:ssr3_human(display_long)|uniprotkb:SSTR3(gene name)|psi-mi:SSTR3(display_short)|uniprotkb:SSR-28(gene name synonym)	psi-mi:ssr2_human(display_long)|uniprotkb:SSTR2(gene name)|psi-mi:SSTR2(display_short)|uniprotkb:SRIF-1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	War et al. (2012)	pubmed:22651821|imex:IM-17676	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6266977|imex:IM-17676-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000278195(gene)|ensembl:ENST00000610913(transcript)|ensembl:ENST00000617123(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060170"(ciliary membrane)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001856(Somatostatin receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32745|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-5620922|refseq:XP_011528651.1|refseq:XP_005261778.1|refseq:NP_001042.1|refseq:XP_006724374.1|refseq:NP_001265616.1|refseq:XP_016884412.1|refseq:XP_016884413.1	go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030432"(peristalsis)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR002074(Somatostatin receptor, type 2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|mint:P30874|ensembl:ENSG00000180616(gene)|ensembl:ENST00000357585(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0006937"(regulation of muscle contraction)|refseq:NP_001041.1	-	-	-	figure legend:fig. 1b|antagonist:"SST (Somatostatin), SSTR2-specific agonist L-779976 and SSTR3-specific agonist L-796778 - or in combination."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/08/14	2014/10/16	rogid:qSna7iphTpLgG05n7OyhDpvYX4A9606	rogid:AhlurWDwC9NS3Qv0qz4Th/4FT589606	intact-crc:A4AA9E62B503A4E4|rigid:VE6J+jPebHAQLMxuR2OD0pJ15Us	false	ha tag:n-n	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P30874	uniprotkb:P32745	intact:EBI-6266898|ensembl:ENSP00000350198|uniprotkb:A8K3Y0|uniprotkb:Q4VBP0|uniprotkb:Q96GE0|uniprotkb:Q96TF2|uniprotkb:Q9BWH1|uniprotkb:B2R9P7	intact:EBI-6266935|ensembl:ENSP00000480971|ensembl:ENSP00000481325|uniprotkb:A8K550|uniprotkb:Q53ZR7	psi-mi:ssr2_human(display_long)|uniprotkb:SSTR2(gene name)|psi-mi:SSTR2(display_short)|uniprotkb:SRIF-1(gene name synonym)	psi-mi:ssr3_human(display_long)|uniprotkb:SSTR3(gene name)|psi-mi:SSTR3(display_short)|uniprotkb:SSR-28(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	War et al. (2012)	pubmed:22651821|imex:IM-17676	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6266988|imex:IM-17676-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030432"(peristalsis)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR002074(Somatostatin receptor, type 2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|mint:P30874|ensembl:ENSG00000180616(gene)|ensembl:ENST00000357585(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0006937"(regulation of muscle contraction)|refseq:NP_001041.1	ensembl:ENSG00000278195(gene)|ensembl:ENST00000610913(transcript)|ensembl:ENST00000617123(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060170"(ciliary membrane)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001856(Somatostatin receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32745|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-5620922|refseq:XP_011528651.1|refseq:XP_005261778.1|refseq:NP_001042.1|refseq:XP_006724374.1|refseq:NP_001265616.1|refseq:XP_016884412.1|refseq:XP_016884413.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:fig.2|comment:SSTR2 and SSTR3 display colocalization at the cell surface and internalize upon treatment with SST, L-779976  and L-796778.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/08/14	2014/10/16	rogid:AhlurWDwC9NS3Qv0qz4Th/4FT589606	rogid:qSna7iphTpLgG05n7OyhDpvYX4A9606	intact-crc:F450495C4FEAA0B6|rigid:VE6J+jPebHAQLMxuR2OD0pJ15Us	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)