#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P60709	uniprotkb:Q9NQ11	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377433|imex:IM-17891-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:0173980EB73BC4C7|rigid:gBs4B4OAdcwqM1so79d9VeuUiUc	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P60468	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377222|imex:IM-17891-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:106FA2643C140FB3|rigid:bI/7FAEuC8oOKIqnkWxQJvty/30	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15084	uniprotkb:Q9NQ11	intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377208|imex:IM-17891-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:411bo7TdfeCtMvUqyBb7bofi5To9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:0B2A23B7AC5FB97E|rigid:q+1kw5wb1jTYDbWAt9lLnjw9Hrg	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q9Y284	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309120|ensembl:ENSP00000468969|uniprotkb:B2R4T8|uniprotkb:Q9BVI3	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:aster_human(display_long)|uniprotkb:WDR83OS(gene name)|psi-mi:WDR83OS(display_short)|uniprotkb:WD repeat domain 83 opposite strand(gene name synonym)|uniprotkb:WDR83 opposite strand(gene name synonym)|uniprotkb:CGI-140(orf name)|uniprotkb:My006(orf name)|uniprotkb:PTD008(orf name)|uniprotkb:C19orf56(gene name synonym)|uniprotkb:Protein associated with the ER translocon of 10kDa(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377615|imex:IM-17891-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000105583(gene)|ensembl:ENST00000596731(transcript)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR005351(Protein of unknown function UPF0139)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|refseq:NP_057229.1|refseq:XP_016882353.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:Bk6ngJZ1hogLSRAmH6XH+pU+0709606	intact-crc:C870EFE71EBE1278|rigid:mBgXWnRnsKC5cn8RXISbwArG53Y	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P61962	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377535|imex:IM-17891-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:8ABA0D241E94319A|rigid:NVKxDNzjp3ic2WQia/0+4j/HpQM	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q86Z02	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-692891|uniprotkb:A6NJ34|uniprotkb:O75125|uniprotkb:Q8IYD7|uniprotkb:Q8NDN5|uniprotkb:Q8NEB6|uniprotkb:Q8TBZ1|uniprotkb:Q5SQL4|uniprotkb:Q5SQL2|uniprotkb:Q5SQL5|ensembl:ENSP00000358571|ensembl:ENSP00000407442	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:hipk1_human(display_long)|uniprotkb:MYAK(gene name synonym)|uniprotkb:NBAK2(gene name synonym)|uniprotkb:Nuclear body-associated kinase 2(gene name synonym)|uniprotkb:HIPK1(gene name)|psi-mi:HIPK1(display_short)|uniprotkb:KIAA0630(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377479|imex:IM-17891-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_689909.2|refseq:NP_852003.1|refseq:NP_938009.1|refseq:NP_938010.1|refseq:XP_005270669.1|refseq:XP_005270670.1|ensembl:ENSG00000163349(gene)|ensembl:ENST00000369558(transcript)|ensembl:ENST00000426820(transcript)|go:"GO:0001654"(eye development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-2032785|reactome:R-HSA-5578768|reactome:R-HSA-6804756	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:IB2SjhD7slQ5TxJEdeuZ4c/fGLE9606	intact-crc:3E90E9673E6BA067|rigid:kFavQhbnXTte21KQk9Jvj2twfq0	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:O75581	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377417|imex:IM-17891-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:AECA8BA9325FADA7|rigid:EwPlppTWrh2UvY2fGbp2bA/stVQ	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P13598	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-2806056|ensembl:ENSP00000464665|uniprotkb:Q14600|ensembl:ENSP00000388666|ensembl:ENSP00000392634|ensembl:ENSP00000415283|ensembl:ENSP00000462579	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:icam2_human(display_long)|uniprotkb:ICAM2(gene name)|psi-mi:ICAM2(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377320|imex:IM-17891-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENST00000412356(transcript)|ensembl:ENST00000418105(transcript)|ensembl:ENST00000449662(transcript)|ensembl:ENST00000579687(transcript)|ensembl:ENST00000579788(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015653(Intercellular adhesion molecule 2)|interpro:IPR036179|rcsb pdb:1ZXQ|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-5621575|refseq:NP_000864.2|refseq:NP_001093256.1|refseq:NP_001093257.1|refseq:NP_001093258.1|refseq:NP_001093259.1|ensembl:ENSG00000108622(gene)	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:46FxUe9wv2WIelobimN/4k+qSS89606	intact-crc:8BD6060BD865275E|rigid:2SfxwxdMUbx0w+8Lcxx+7sLij8U	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q99679	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309069|ensembl:ENSP00000482287|uniprotkb:B2R8W9|uniprotkb:Q6NXU2	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:gpr21_human(display_long)|uniprotkb:GPR21(gene name)|psi-mi:GPR21(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377575|imex:IM-17891-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000188394(gene)|ensembl:ENST00000616002(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_005285.1|refseq:XP_005251990.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:sbKSn+COEEXA7RBDLA+iWBdO60I9606	intact-crc:29F349788A781939|rigid:02GCFeKJ3ttnnM3PTfgXpKndwFI	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q04671	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6308983|uniprotkb:Q15211|uniprotkb:Q15212|uniprotkb:Q96EN1|uniprotkb:Q9UMI5|ensembl:ENSP00000346659	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:p_human(display_long)|uniprotkb:P(gene name synonym)|uniprotkb:Melanocyte-specific transporter protein(gene name synonym)|uniprotkb:Pink-eyed dilution protein homolog(gene name synonym)|uniprotkb:OCA2(gene name)|psi-mi:OCA2(display_short)|uniprotkb:D15S12(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377543|imex:IM-17891-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_001287913.1|refseq:NP_000266.2|ensembl:ENSG00000104044(gene)|ensembl:ENST00000354638(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005302"(L-tyrosine transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007286"(spermatid development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042438"(melanin biosynthetic process)|interpro:IPR004680(Divalent ion symporter)|reactome:R-HSA-5662702	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:F21yrICziBgbtLNSW3vlWyZuZ/s9606	intact-crc:A54E86FF47DEBE61|rigid:5Q3HyuEVVYSfS0HDBVA/RaILnTE	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06055	uniprotkb:Q9NQ11	intact:EBI-3912136|uniprotkb:B3KQQ6|ensembl:ENSP00000340315|ensembl:ENSP00000377878|ensembl:ENSP00000447317|ensembl:ENSP00000448801	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:at5g2_human(display_long)|uniprotkb:ATP5MC2(gene name)|psi-mi:ATP5MC2(display_short)|uniprotkb:ATP synthase lipid-binding protein(gene name synonym)|uniprotkb:ATP synthase membrane subunit c locus 2(gene name synonym)|uniprotkb:ATP synthase proteolipid P2(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit C2"(gene name synonym)|uniprotkb:ATP5G2(gene name synonym)|uniprotkb:ATPase protein 9(gene name synonym)|uniprotkb:ATPase subunit c(gene name synonym)|uniprotkb:PSEC0033(orf name)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377451|imex:IM-17891-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002031.1|refseq:NP_005167.2|ensembl:ENSG00000135390(gene)|ensembl:ENST00000338662(transcript)|ensembl:ENST00000394349(transcript)|ensembl:ENST00000552242(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|interpro:IPR000454(ATPase, F0 complex, subunit C)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR020537|interpro:IPR035921|interpro:IPR038662|mint:Q06055|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENST00000549164(transcript)|refseq:NP_001317198.1|refseq:XP_016874949.1|refseq:XP_016874950.1	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:4ZhP9IXjOV0f7aZYk2/ReIVZsDk9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:EE413260865971F8|rigid:nsno9tBuhiwDxOI4Bx1OZ3L+2Gc	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O60238	uniprotkb:Q9NQ11	intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377441|imex:IM-17891-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:EDD0CB7006C06565|rigid:mNLgxUWLDYPLoLkbDpQf59+XtPk	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q9UBN7	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377425|imex:IM-17891-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	intact-crc:8143D8AE0865C56D|rigid:4WJAHSPWvwKdG89rtXjfkbFipVI	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P63027	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-520113|uniprotkb:P19065|ensembl:ENSP00000314214|uniprotkb:Q9BUC2	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:vamp2_human(display_long)|uniprotkb:Synaptobrevin-2(gene name synonym)|uniprotkb:VAMP2(gene name)|psi-mi:VAMP2(display_short)|uniprotkb:SYB2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377246|imex:IM-17891-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_055047.2|ensembl:ENSG00000220205(gene)|ensembl:ENST00000316509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043621"(protein self-association)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63027|rcsb pdb:3FIE|rcsb pdb:3FII|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|reactome:R-HSA-1445148|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-199992|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-264876|reactome:R-HSA-422356|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-449836|reactome:R-HSA-5250955|reactome:R-HSA-5250958|reactome:R-HSA-5250981|reactome:R-HSA-5250982|reactome:R-HSA-5250989|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-888590|reactome:R-HSA-9609523|reactome:R-HSA-9662360|dip:DIP-39072N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:uuuJXsI5sr7fzjxuBhSYDHJZp9M9606	intact-crc:0BFB2D5099ECF441|rigid:wcs/1Sc6YLK55o7MO+AkXipbBz0	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P25929	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-372227|uniprotkb:B2R6H5|ensembl:ENSP00000354652	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:npy1r_human(display_long)|uniprotkb:NPY1R(gene name)|psi-mi:NPY1R(display_short)|uniprotkb:NPYR(gene name synonym)|uniprotkb:NPYY1(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377401|imex:IM-17891-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:XP_011530312.1|refseq:NP_000900.1|refseq:XP_005263088.1|ensembl:ENSG00000164128(gene)|ensembl:ENST00000296533(transcript)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2F1U|rcsb pdb:2IIL|rcsb pdb:5ZBQ|reactome:R-HSA-375276|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:Znnr1wafoTgjDhpe9OWZ1aBOa/s9606	intact-crc:30DF90DFFA798BA7|rigid:Y98CY8ps60GAkJPBg/BE1QyUbeo	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q12907	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-3915406|uniprotkb:Q53HH1|ensembl:ENSP00000303366	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:lman2_human(display_long)|uniprotkb:LMAN2(gene name)|psi-mi:LMAN2(display_short)|uniprotkb:C5orf8(gene name synonym)|uniprotkb:Glycoprotein GP36b(gene name synonym)|uniprotkb:Lectin mannose-binding 2(gene name synonym)|uniprotkb:Vesicular integral-membrane protein 36(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377200|imex:IM-17891-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_006807.1|ensembl:ENSG00000169223(gene)|ensembl:ENST00000303127(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035664|mint:Q12907|reactome:R-HSA-204005|reactome:R-HSA-5694530	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:goqUZGW9/lvVMWDAZS9csH3TqWY9606	intact-crc:95A6191A7BE89764|rigid:tH2LDBwA0w7LDP/70m25N2JvHyE	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q9NPA0	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309137|ensembl:ENSP00000256545|uniprotkb:B2RC00|uniprotkb:Q96ED5	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:emc7_human(display_long)|uniprotkb:EMC7(gene name)|psi-mi:EMC7(display_short)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:C15orf24(gene name synonym)|uniprotkb:HT022(orf name)|uniprotkb:UNQ905/PRO1926(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377607|imex:IM-17891-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000134153(gene)|ensembl:ENST00000256545(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR019008|interpro:IPR039163|rcsb pdb:1B0G|rcsb pdb:1LP9|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2UWE|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|refseq:NP_064539.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:XBg97fKNpvbssNf6YFewsWDmiBE9606	intact-crc:BFBB92C04D77E0E2|rigid:UOxVE663krR/APYg+enBi7/wtRk	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P11142	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377286|imex:IM-17891-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:51FA319DFE0BF145|rigid:WTOikBnt5O6Eyood2qkUSMAeOcY	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BWH2	uniprotkb:Q9NQ11	intact:EBI-714482|ensembl:ENSP00000358510|uniprotkb:Q9H2I6|uniprotkb:Q8NHX8|uniprotkb:B2R7W5|uniprotkb:D3DWY5	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:fund2_human(display_long)|uniprotkb:HCC3(orf name)|uniprotkb:PD03104(orf name)|uniprotkb:FUNDC2(gene name)|psi-mi:FUNDC2(display_short)|uniprotkb:HCBP6(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 6(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 3 protein(gene name synonym)|uniprotkb:DC44(orf name)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377471|imex:IM-17891-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165775(gene)|ensembl:ENST00000369498(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|refseq:NP_076423.2	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:oAN8aj9JpmBS5+YUfdh8Keehk3E9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:224832B197996011|rigid:5nVxSFiC+3CB30Eak9vM1S1dKns	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q15005	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-1043352|uniprotkb:Q15507|uniprotkb:Q3KQT0|uniprotkb:Q641R4|uniprotkb:Q6FG65|uniprotkb:Q6IRX0|ensembl:ENSP00000263672|uniprotkb:Q6P1P4|uniprotkb:Q96HU9	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:spcs2_human(display_long)|uniprotkb:Microsomal signal peptidase 25 kDa subunit(gene name synonym)|uniprotkb:SPCS2(gene name)|psi-mi:SPCS2(display_short)|uniprotkb:KIAA0102(gene name synonym)|uniprotkb:SPC25(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377183|imex:IM-17891-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000118363(gene)|ensembl:ENST00000263672(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009582(Microsomal signal peptidase 25 kDa subunit)|mint:Q15005|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085|refseq:NP_055567.2|dip:DIP-47276N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:3POhDKvg+aoZiz2XRTC+m77XTAw9606	intact-crc:B0AEF6D1477DFB10|rigid:O5cfXFHNHJqUxqz0sgLFNzNvrmE	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q2M2I8	uniprotkb:Q9NQ11	intact:EBI-1383433|uniprotkb:Q4ZFZ3|uniprotkb:Q53RX6|uniprotkb:Q9UPV4|ensembl:ENSP00000386456	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:aak1_human(display_long)|uniprotkb:AAK1(gene name)|psi-mi:AAK1(display_short)|uniprotkb:KIAA1048(gene name synonym)|uniprotkb:Adaptor-associated kinase 1(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377254|imex:IM-17891-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055726.3|ensembl:ENSG00000115977(gene)|ensembl:ENST00000409085(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0061024"(membrane organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:4WSQ|rcsb pdb:5L4Q|rcsb pdb:5TE0|reactome:R-HSA-8856825|reactome:R-HSA-8856828	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:RorQ1U6bmiSsmR0TWsyvrF+rkL89606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:7D9817FE7A5C98AE|rigid:9eAXQfPSyIegLa5GcyUvQeBsogI	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q9UBU6	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309101|intact:EBI-28967558|ensembl:ENSP00000259963|uniprotkb:B2R725	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:fa8a1_human(display_long)|uniprotkb:FAM8A1(gene name)|psi-mi:FAM8A1(display_short)|uniprotkb:AHCP(gene name synonym)|uniprotkb:Autosomal highly conserved protein(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377591|imex:IM-17891-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSP00000259963|ensembl:ENSG00000137414(gene)|ensembl:ENST00000259963(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|interpro:IPR010432(RDD)|interpro:IPR039871|refseq:NP_057339.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:0HV6qye10bMGdnt9CiGztIacrHM9606	intact-crc:8C42DC9335F977B6|rigid:03vKJhzoGHpv8TkPhWZwDAebIQ8	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O14976	uniprotkb:Q9NQ11	intact:EBI-714707|uniprotkb:Q9BVY6|uniprotkb:Q5U4P5|intact:EBI-28970318|ensembl:ENSP00000314499	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:gak_human(display_long)|uniprotkb:GAK(gene name)|psi-mi:GAK(display_short)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377262|imex:IM-17891-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314499|ensembl:ENST00000511163|ensembl:ENSP00000421361|refseq:NP_005246.2|refseq:NP_001305063.1|ensembl:ENSG00000178950(gene)|ensembl:ENST00000314167(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|rcsb pdb:4C57|rcsb pdb:4C58|rcsb pdb:4C59|rcsb pdb:4O38|rcsb pdb:4Y8D|rcsb pdb:5Y7Z|rcsb pdb:5Y80|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0072318"(clathrin coat disassembly)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:+CTVzAL9y1B3+JIg6PHsj8QXIjE9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:8A84429DE34FFC20|rigid:evh8qLEZfoPOBL50nWh7upj1mpE	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q6SJ93	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309082|ensembl:ENSP00000341565|ensembl:ENSP00000483456|uniprotkb:B4E2G2|uniprotkb:Q6P661	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:f111b_human(display_long)|uniprotkb:FAM111B(gene name)|psi-mi:FAM111B(display_short)|uniprotkb:CANP(gene name synonym)|uniprotkb:Cancer-associated nucleoprotein(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377583|imex:IM-17891-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000189057(gene)|ensembl:ENST00000343597(transcript)|ensembl:ENST00000620384(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0008233"(peptidase activity)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|refseq:NP_001136175.1|refseq:NP_001136176.1|refseq:NP_945185.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:HifGkflX4mJWwgk12ZT6xY6LhKk9606	intact-crc:A8F73B7F0760D41C|rigid:7rlSAt406uOABs32aFDCr+YeNDQ	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q8N2K1	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-2340110|uniprotkb:Q96T84|uniprotkb:Q96N26|uniprotkb:Q504T9|uniprotkb:A8MYC7|ensembl:ENSP00000305826|ensembl:ENSP00000353653	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:ub2j2_human(display_long)|uniprotkb:UBE2J2(gene name)|psi-mi:UBE2J2(display_short)|uniprotkb:NCUBE2(gene name synonym)|uniprotkb:Non-canonical ubiquitin-conjugating enzyme 2(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme J2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377230|imex:IM-17891-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:XP_011538915.1|refseq:XP_011538916.1|refseq:XP_006710396.1|refseq:NP_477515.2|refseq:NP_919440.1|refseq:NP_919296.1|refseq:XP_005244775.1|refseq:XP_005244776.1|ensembl:ENSG00000160087(gene)|ensembl:ENST00000349431(transcript)|ensembl:ENST00000360466(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2F4W|reactome:R-HSA-8866654|reactome:R-HSA-9609523|reactome:R-HSA-983168	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:wsZGIUcE5bEjsim+d4Ur3DDOJWs9606	intact-crc:CE7EE240EA2ED2DB|rigid:Tr2DEBVFSfjIjnlpOYRcFpmZD9M	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NV79	uniprotkb:Q9NQ11	intact:EBI-6309018|ensembl:ENSP00000307854|ensembl:ENSP00000482166|ensembl:ENSP00000486510|uniprotkb:E1P5H3|uniprotkb:Q8IW60|uniprotkb:Q9H4K2	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:pcmd2_human(display_long)|uniprotkb:PCMTD2(gene name)|psi-mi:PCMTD2(display_short)|uniprotkb:C20orf36(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377551|imex:IM-17891-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203880(gene)|ensembl:ENSG00000280663(gene)|ensembl:ENST00000308824(transcript)|ensembl:ENST00000615818(transcript)|ensembl:ENST00000627415(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|refseq:NP_001098395.1|refseq:NP_060727.2	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:+xp9xRMObwVcGrqZ9huvyIokOXQ9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:2AB1FF42F4C7E461|rigid:68jR43ndheA9kbuoRJbaWZ6XOPA	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NRP0	uniprotkb:Q9NQ11	intact:EBI-1044658|uniprotkb:B2R5H1|ensembl:ENSP00000354676|uniprotkb:A8MYS2|uniprotkb:Q9P075|uniprotkb:Q9P1R4|uniprotkb:D6RH22	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:ostc_human(display_long)|uniprotkb:DC2(orf name)|uniprotkb:HDCMD45P(orf name)|uniprotkb:HSPC307(orf name)|uniprotkb:Hydrophobic protein HSF-28(gene name synonym)|uniprotkb:OSTC(gene name)|psi-mi:OSTC(display_short)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377505|imex:IM-17891-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067050.1|ensembl:ENSG00000198856(gene)|ensembl:ENST00000361564(transcript)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|interpro:IPR021149|interpro:IPR042416|mint:Q9NRP0|rcsb pdb:6S7O|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|refseq:NP_001254746.1|refseq:NP_001254747.1	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:7hCT4erjmVblwj7wzSb2af+yLu09606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:9BC591AB200A2957|rigid:/Kcd+Rq/OoXR+wZNRvDzoyyU/1I	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14318	uniprotkb:Q9NQ11	intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377270|imex:IM-17891-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:CpZqwry5szPluwNMwWXshCIMUvY9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:862768F9CD5DC767|rigid:AbvzANxDoULWhJi07oABfgEpYuI	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P61073	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377294|imex:IM-17891-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	intact-crc:786C11B87AF3FB62|rigid:d1L7vfX/kJTWK4PC4gy+EL32BA4	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95070	uniprotkb:Q9NQ11	intact:EBI-2799703|uniprotkb:Q9BVD0|uniprotkb:A6NM00|uniprotkb:Q96G83|ensembl:ENSP00000366098	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:yif1a_human(display_long)|uniprotkb:54TM(gene name synonym)|uniprotkb:HYIF1P(gene name synonym)|uniprotkb:YIF1(gene name synonym)|uniprotkb:54TMp(gene name synonym)|uniprotkb:YIP1-interacting factor homolog A(gene name synonym)|uniprotkb:YIF1A(gene name)|psi-mi:YIF1A(display_short)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377238|imex:IM-17891-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065203.2|ensembl:ENSG00000174851(gene)|ensembl:ENST00000376901(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005578(Hrf1)|mint:O95070|reactome:R-HSA-381038	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:udkO5o876pUyTxBnhOchiirpW0U9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:AEF1E81170B789A3|rigid:j3zUfaLnrmMmVO+JBMJlJdgR1ZM	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9NQ11	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377495|imex:IM-17891-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2018/07/05	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:790C670C2E02364E|rigid:aPBJ+P4eQO8Yez1buoga6bNIJHU	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P25106	uniprotkb:Q9NQ11	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377302|imex:IM-17891-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:8F502527DA425E12|rigid:xHjtofj2v1tmEPBAGxwHDNmjnTA	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU8	uniprotkb:Q9NQ11	intact:EBI-2371956|ensembl:ENSP00000335808|ensembl:ENSP00000374098|ensembl:ENSP00000456211|ensembl:ENSP00000457740|ensembl:ENSP00000457850	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:pip30_human(display_long)|uniprotkb:PSME3IP1(gene name)|psi-mi:PSME3IP1(display_short)|uniprotkb:C16orf94(gene name synonym)|uniprotkb:FAM192A(gene name synonym)|uniprotkb:NEFA-interacting nuclear protein NIP30(gene name synonym)|uniprotkb:NIP30(gene name synonym)|uniprotkb:PA28G-interacting protein(gene name synonym)|uniprotkb:PIP30(gene name synonym)|uniprotkb:CDA018(orf name)|uniprotkb:CDA10(orf name)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377599|imex:IM-17891-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521645.1|refseq:NP_079222.1|refseq:XP_005256217.1|refseq:XP_005256220.1|refseq:XP_005256221.1|refseq:XP_005256222.1|refseq:XP_016879171.1|refseq:XP_016879172.1|refseq:XP_016879173.1|refseq:XP_016879174.1|refseq:XP_016879175.1|refseq:XP_016879176.1|refseq:XP_016879177.1|refseq:XP_016879178.1|refseq:XP_016879179.1|refseq:XP_016879180.1|refseq:XP_016879181.1|refseq:XP_016879182.1|refseq:XP_016879183.1|refseq:XP_016879184.1|refseq:XP_016879185.1|refseq:XP_016879186.1|refseq:XP_016879187.1|refseq:XP_016879188.1|refseq:XP_016879189.1|refseq:XP_016879190.1|refseq:XP_016879191.1|refseq:XP_016879192.1|refseq:XP_016879193.1|ensembl:ENSG00000172775(gene)|ensembl:ENST00000309137(transcript)|ensembl:ENST00000389447(transcript)|ensembl:ENST00000564108(transcript)|ensembl:ENST00000567439(transcript)|ensembl:ENST00000569266(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|interpro:IPR019331|interpro:IPR039845|mint:Q9GZU8	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:L6twOcOqRARWRz4Em7oxxyLGsL09606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:98154F65F78F559D|rigid:+Hl1B4T+RWRAmb3v3Wk/7UxIWqM	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:P02452	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-982999|uniprotkb:O76045|uniprotkb:P78441|uniprotkb:Q13896|uniprotkb:Q13902|uniprotkb:Q13903|uniprotkb:Q14037|uniprotkb:Q14992|uniprotkb:Q15176|uniprotkb:Q15201|uniprotkb:Q16050|uniprotkb:Q59F64|uniprotkb:Q7KZ30|uniprotkb:Q7KZ34|uniprotkb:Q8IVI5|ensembl:ENSP00000225964|uniprotkb:Q8N473|uniprotkb:Q9UML6|uniprotkb:Q9UMM7	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:co1a1_human(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:COL1A1(gene name)|psi-mi:COL1A1(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377567|imex:IM-17891-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_000079.2|ensembl:ENSG00000108821(gene)|ensembl:ENST00000225964(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P02452|rcsb pdb:1Q7D|rcsb pdb:2LLP|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:5CTD|rcsb pdb:5CTI|rcsb pdb:5CVA|rcsb pdb:5CVB|rcsb pdb:5K31|rcsb pdb:5OU8|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|rcsb pdb:5OU9|rcsb pdb:7E7B|rcsb pdb:7E7D|reactome:R-HSA-114604|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-198933|reactome:R-HSA-2022090|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-430116|reactome:R-HSA-75892|reactome:R-HSA-76009|reactome:R-HSA-8874081|reactome:R-HSA-8940973|reactome:R-HSA-8948216|dip:DIP-36077N	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:x83+B64Cl9zkAVeZ9RCo0BukkwU9606	intact-crc:E3DD8C4B816B3FEF|rigid:wqKErBKzxnB4KjNHbVp/7HckM0Q	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q86VZ2	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-996170|uniprotkb:Q9NUL4|uniprotkb:B2RCM9|ensembl:ENSP00000330381	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:wdr5b_human(display_long)|uniprotkb:WDR5B(gene name)|psi-mi:WDR5B(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377523|imex:IM-17891-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_061942.2|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|ensembl:ENSG00000196981(gene)|ensembl:ENST00000330689(transcript)|go:"GO:0042393"(histone binding)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:EGB0u746KFgYLQx2wVU/jlEV/Sg9606	intact-crc:F79C7286CF14148C|rigid:+6ajmpwExOuTze8HtpAowTppdnU	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ11	uniprotkb:Q8WWM9	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-6309037|ensembl:ENSP00000293230|uniprotkb:Q541Y7|uniprotkb:Q8N2X5	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:cygb_human(display_long)|uniprotkb:CYGB(gene name)|psi-mi:CYGB(display_short)|uniprotkb:STAP(gene name synonym)|uniprotkb:Histoglobin(gene name synonym)|uniprotkb:Stellate cell activation-associated protein(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377559|imex:IM-17891-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	ensembl:ENSG00000161544(gene)|ensembl:ENST00000293230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004096"(catalase activity)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0015671"(oxygen transport)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047888"(fatty acid peroxidase activity)|go:"GO:2000490"(negative regulation of hepatic stellate cell activation)|interpro:IPR000971(Globin, subset)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|interpro:IPR013314(Globin, lamprey/hagfish type)|rcsb pdb:1UMO|rcsb pdb:1URV|rcsb pdb:1URY|rcsb pdb:1UT0|rcsb pdb:1UX9|rcsb pdb:1V5H|rcsb pdb:2DC3|rcsb pdb:3AG0|rcsb pdb:4B3W|reactome:R-HSA-203615|reactome:R-HSA-8981607|refseq:NP_599030.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:H4Fv+srjdLe7xJIsc44K4LLFHO09606	intact-crc:714F99E9C14799C3|rigid:mwsuqur/M8tXq/lPTtAcJNSDIIo	false	tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZN04	uniprotkb:Q9NQ11	intact:EBI-722315|uniprotkb:Q4G0W1|uniprotkb:Q8IVG2|uniprotkb:Q9H0J0|ensembl:ENSP00000329918	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:mex3b_human(display_long)|uniprotkb:RING finger and KH domain-containing protein 3(gene name synonym)|uniprotkb:RING finger protein 195(gene name synonym)|uniprotkb:MEX3B(gene name)|psi-mi:MEX3B(display_short)|uniprotkb:KIAA2009(gene name synonym)|uniprotkb:RKHD3(gene name synonym)|uniprotkb:RNF195(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377487|imex:IM-17891-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115622.2|ensembl:ENSP00000329918|ensembl:ENST00000558133|ensembl:ENSP00000456938|ensembl:ENSG00000183496(gene)|ensembl:ENST00000329713(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036612	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:O3FbvwW3wC0pspEINKThFYY9ZrU9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:6D13D8CE1EB91968|rigid:5BGjx869yPaUHfJSFiI3nXrIwE4	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8NG11	uniprotkb:Q9NQ11	intact:EBI-6308913|ensembl:ENSP00000361229|ensembl:ENSP00000361231|ensembl:ENSP00000396270|uniprotkb:A6NHE1|uniprotkb:B4DHY6|uniprotkb:D3DWD7|uniprotkb:D3DWD8|uniprotkb:Q567U7|uniprotkb:Q9BU34|uniprotkb:Q9H0U1	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:tsn14_human(display_long)|uniprotkb:TSPAN14(gene name)|psi-mi:TSPAN14(display_short)|uniprotkb:TM4SF14(gene name synonym)|uniprotkb:DC-TM4F2(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 14(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377361|imex:IM-17891-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108219(gene)|ensembl:ENST00000372156(transcript)|ensembl:ENST00000372158(transcript)|ensembl:ENST00000429989(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0051604"(protein maturation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|reactome:R-HSA-6798695|reactome:R-HSA-977225|refseq:XP_011538524.1|refseq:NP_001121781.1|refseq:NP_112189.2|refseq:XP_006718055.1|refseq:XP_016872196.1|refseq:XP_016872197.1|refseq:XP_016872198.1|refseq:XP_016872199.1|refseq:XP_016872200.1	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:p98wAgcN6Kkk6NnV0cuzOT4yufc9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:9EEB18DBDBDB4CB9|rigid:wBI2nFbT6Y+rZVrLdtSP9o8cwps	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P32239	uniprotkb:Q9NQ11	intact:EBI-1753137|uniprotkb:A8K7P9|uniprotkb:O75824|uniprotkb:Q16144|uniprotkb:Q92492|uniprotkb:Q96LC6|uniprotkb:Q9NYK7|uniprotkb:Q9UBV1|ensembl:ENSP00000335544	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:gasr_human(display_long)|uniprotkb:CCKBR(gene name)|psi-mi:CCKBR(display_short)|uniprotkb:CCKRB(gene name synonym)|uniprotkb:Cholecystokinin-2 receptor(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377353|imex:IM-17891-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_795344.1|refseq:XP_005253267.1|refseq:NP_001304958.1|refseq:XP_016874005.1|dip:DIP-229N|go:"GO:0031741"(type B gastrin/cholecystokinin receptor binding)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0045851"(pH reduction)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000314(Gastrin receptor)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32239|rcsb pdb:1L4T|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-881907|go:"GO:0017046"(peptide hormone binding)|ensembl:ENSG00000110148(gene)|ensembl:ENST00000334619(transcript)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015054"(gastrin receptor activity)|go:"GO:0016021"(integral component of membrane)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:wmvdbFzpde5hkgKlLrXxAJdZd8s9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:651B7F2D95D5140D|rigid:X9KA5XF7UylKtHQnxqWL+FF3S9o	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UN67	uniprotkb:Q9NQ11	intact:EBI-6308942|ensembl:ENSP00000239446|uniprotkb:Q96T99	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:pcdba_human(display_long)|uniprotkb:PCDHB10(gene name)|psi-mi:PCDHB10(display_short)|uniprotkb:UNQ1906/PRO4352(orf name)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377345|imex:IM-17891-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120324(gene)|ensembl:ENST00000239446(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045202"(synapse)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR032455|refseq:NP_061753.1	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:eDBO6rRJdTj1TzDUyXxX+iDJywo9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:135F126A65234AE3|rigid:6ABM27t5pu8nVcr8GCPu73AqD3Y	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BT88	uniprotkb:Q9NQ11	intact:EBI-751770|uniprotkb:Q14998|uniprotkb:Q68CT5|uniprotkb:Q8IXU3|uniprotkb:Q96SU2|uniprotkb:Q5W0D4|ensembl:ENSP00000357307	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:syt11_human(display_long)|uniprotkb:Synaptotagmin XI(gene name synonym)|uniprotkb:SYT11(gene name)|psi-mi:SYT11(display_short)|uniprotkb:KIAA0080(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377278|imex:IM-17891-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689493.3|ensembl:ENSG00000132718(gene)|ensembl:ENST00000368324(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006914"(autophagy)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1900243"(negative regulation of synaptic vesicle endocytosis)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905154"(negative regulation of membrane invagination)|go:"GO:1905162"(regulation of phagosome maturation)|go:"GO:1905171"(positive regulation of protein localization to phagocytic vesicle)|go:"GO:1905469"(negative regulation of clathrin-coated pit assembly)|go:"GO:1990927"(calcium ion regulated lysosome exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028699|interpro:IPR035892|reactome:R-HSA-8856825|reactome:R-HSA-8856828	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:+unyxZC+Tuj9r8wtvicjY+Yig+I9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:1A93BB70804DFD71|rigid:YFNSROyGoWmfWQYF2eSxT+jGmPw	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P25116	uniprotkb:Q9NQ11	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377409|imex:IM-17891-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Table S1, fig 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/02	2014/10/16	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:C336BAF6F6526572|rigid:xiycn8cTXrzSkCzkybAoH8Gv16Q	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11142	uniprotkb:Q9NQ11	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377665|imex:IM-17891-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:8370851160CB16C0|rigid:WTOikBnt5O6Eyood2qkUSMAeOcY	false	enhanced green fluorescent protein tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NQ11	uniprotkb:Q2M2I8	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-1383433|uniprotkb:Q4ZFZ3|uniprotkb:Q53RX6|uniprotkb:Q9UPV4|ensembl:ENSP00000386456	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:aak1_human(display_long)|uniprotkb:AAK1(gene name)|psi-mi:AAK1(display_short)|uniprotkb:KIAA1048(gene name synonym)|uniprotkb:Adaptor-associated kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377649|imex:IM-17891-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_055726.3|ensembl:ENSG00000115977(gene)|ensembl:ENST00000409085(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0061024"(membrane organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:4WSQ|rcsb pdb:5L4Q|rcsb pdb:5TE0|reactome:R-HSA-8856825|reactome:R-HSA-8856828	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:RorQ1U6bmiSsmR0TWsyvrF+rkL89606	intact-crc:BC89B3B04E0F52EE|rigid:9eAXQfPSyIegLa5GcyUvQeBsogI	false	v5 tag:?-?	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NQ11	uniprotkb:O95070	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-2799703|uniprotkb:Q9BVD0|uniprotkb:A6NM00|uniprotkb:Q96G83|ensembl:ENSP00000366098	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:yif1a_human(display_long)|uniprotkb:54TM(gene name synonym)|uniprotkb:HYIF1P(gene name synonym)|uniprotkb:YIF1(gene name synonym)|uniprotkb:54TMp(gene name synonym)|uniprotkb:YIP1-interacting factor homolog A(gene name synonym)|uniprotkb:YIF1A(gene name)|psi-mi:YIF1A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377682|imex:IM-17891-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_065203.2|ensembl:ENSG00000174851(gene)|ensembl:ENST00000376901(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005578(Hrf1)|mint:O95070|reactome:R-HSA-381038	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:udkO5o876pUyTxBnhOchiirpW0U9606	intact-crc:D2BE7B7254B65D1F|rigid:j3zUfaLnrmMmVO+JBMJlJdgR1ZM	false	v5 tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BT88	uniprotkb:Q9NQ11	intact:EBI-751770|uniprotkb:Q14998|uniprotkb:Q68CT5|uniprotkb:Q8IXU3|uniprotkb:Q96SU2|uniprotkb:Q5W0D4|ensembl:ENSP00000357307	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:syt11_human(display_long)|uniprotkb:Synaptotagmin XI(gene name synonym)|uniprotkb:SYT11(gene name)|psi-mi:SYT11(display_short)|uniprotkb:KIAA0080(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377657|imex:IM-17891-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689493.3|ensembl:ENSG00000132718(gene)|ensembl:ENST00000368324(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006914"(autophagy)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1900243"(negative regulation of synaptic vesicle endocytosis)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905154"(negative regulation of membrane invagination)|go:"GO:1905162"(regulation of phagosome maturation)|go:"GO:1905171"(positive regulation of protein localization to phagocytic vesicle)|go:"GO:1905469"(negative regulation of clathrin-coated pit assembly)|go:"GO:1990927"(calcium ion regulated lysosome exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028699|interpro:IPR035892|reactome:R-HSA-8856825|reactome:R-HSA-8856828	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:+unyxZC+Tuj9r8wtvicjY+Yig+I9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:B890BE3B15D30368|rigid:YFNSROyGoWmfWQYF2eSxT+jGmPw	false	enhanced green fluorescent protein tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NQ11	uniprotkb:O60238	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377673|imex:IM-17891-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606	intact-crc:4EE3A4F7C0175B53|rigid:mNLgxUWLDYPLoLkbDpQf59+XtPk	false	v5 tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBN7	uniprotkb:Q9NQ11	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6309194|imex:IM-17891-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:247F1BBC29943E46|rigid:4WJAHSPWvwKdG89rtXjfkbFipVI	false	flag tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14976	uniprotkb:Q9NQ11	intact:EBI-714707|uniprotkb:Q9BVY6|uniprotkb:Q5U4P5|intact:EBI-28970318|ensembl:ENSP00000314499	intact:EBI-6308763|ensembl:ENSP00000327214|uniprotkb:O75700|uniprotkb:Q5JXY2|uniprotkb:Q6S9Z9|uniprotkb:Q5JXY1	psi-mi:gak_human(display_long)|uniprotkb:GAK(gene name)|psi-mi:GAK(display_short)	psi-mi:at132_human(display_long)|uniprotkb:ATP13A2(gene name)|psi-mi:ATP13A2(display_short)|uniprotkb:PARK9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Usenovic et al. (2012)	pubmed:22645275|imex:IM-17891	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6377690|imex:IM-17891-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314499|ensembl:ENST00000511163|ensembl:ENSP00000421361|refseq:NP_005246.2|refseq:NP_001305063.1|ensembl:ENSG00000178950(gene)|ensembl:ENST00000314167(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|rcsb pdb:4C57|rcsb pdb:4C58|rcsb pdb:4C59|rcsb pdb:4O38|rcsb pdb:4Y8D|rcsb pdb:5Y7Z|rcsb pdb:5Y80|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0072318"(clathrin coat disassembly)	ensembl:ENSG00000159363(gene)|ensembl:ENST00000326735(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005776"(autophagosome)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0015417"(ABC-type polyamine transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016243"(regulation of autophagosome size)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030003"(cellular cation homeostasis)|go:"GO:0030133"(transport vesicle)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097734"(extracellular exosome biogenesis)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902047"(polyamine transmembrane transport)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903710"(spermine transmembrane transport)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905103"(integral component of lysosomal membrane)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:1990938"(peptidyl-aspartic acid autophosphorylation)|go:"GO:2000152"(regulation of ubiquitin-specific protease activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|go:"GO:0043202"(lysosomal lumen)|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001135445.1|refseq:NP_001135446.1|refseq:NP_071372.1	-	-	-	figure legend:Fig 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2012/10/02	2014/10/16	rogid:+CTVzAL9y1B3+JIg6PHsj8QXIjE9606	rogid:xihAMPfmGM47iGclPPhGk3P4I309606	intact-crc:92E53975B89D140A|rigid:evh8qLEZfoPOBL50nWh7upj1mpE	false	enhanced green fluorescent protein tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)