#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880721|mint:MINT-8375120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375122(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375126(identity)	-	-	-	figure legend:t1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:2E82B66BEAE134FB|rigid:6B0DBE/CvuH+H1gqYfA6RT1Kqrs	false	fusion protein:?-?(MINT-8375123)	binding-associated region:483-592(MINT-8375127)|fusion protein:?-?(MINT-8375130)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880653|mint:MINT-8375104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375107(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375106(identity)	-	-	-	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:8676CC636F98E15D|rigid:6B0DBE/CvuH+H1gqYfA6RT1Kqrs	false	fusion protein:?-?(MINT-8375113)|binding-associated region:1-318(MINT-8375116)	fusion protein:?-?(MINT-8375109)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880741|mint:MINT-8375135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375137(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375141(identity)	-	-	-	figure legend:t1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:E00A327FFB8FE796|rigid:6B0DBE/CvuH+H1gqYfA6RT1Kqrs	false	binding-associated region:483-592(MINT-8375148)|fusion protein:?-?(MINT-8375138)	binding-associated region:483-592(MINT-8375144)|fusion protein:?-?(MINT-8375142)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880770|mint:MINT-8375154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375156(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375156(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	figure legend:f2|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:5373BCC20CAB7031|rigid:FldaqeheFk4aC9cHjkG4iQ6UDf0	false	binding-associated region:483-592(MINT-8375157)	binding-associated region:483-592(MINT-8375157)	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880804|mint:MINT-8375190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375192(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375192(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	figure legend:f3|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:F4407A2C66ECEAB4|rigid:FldaqeheFk4aC9cHjkG4iQ6UDf0	false	binding-associated region:?-?(MINT-8375206)	binding-associated region:?-?(MINT-8375206)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32455	uniprotkb:P32455	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Syguda et al. (2012)	pubmed:22607347|mint:MINT-8375097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7880819|mint:MINT-8375198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375200(identity)	refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8375200(identity)	-	comment:"Stoichiometry: 4.0"	comment:"Stoichiometry: 4.0"	figure legend:f3a|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/14	2014/10/16	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606	intact-crc:365E30F6A8A888C0|rigid:FldaqeheFk4aC9cHjkG4iQ6UDf0	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)