#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q63053	uniprotkb:P08413	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	intact:EBI-916155	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162029|imex:IM-17367-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	-	-	-	figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/06/21	2014/10/16	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	intact-crc:48BD9C758C74A886|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08413	uniprotkb:Q63053	intact:EBI-916155	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162015|imex:IM-17367-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/06/21	2014/10/16	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	intact-crc:ABDB773E67960871|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08413	uniprotkb:Q63053	intact:EBI-916155	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162048|imex:IM-17367-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	go:"GO:0043197"(dendritic spine)	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell)	-	2012/06/21	2014/10/16	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	intact-crc:D75FDFA15CAE643F|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P28652	uniprotkb:Q9WV31	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162063|imex:IM-17367-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	-	-	-	figure legend:Fig. 1B, Supp. Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2012/06/21	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	intact-crc:1E9755056B290DB2|rigid:HyQO6erD+uj5BUL79aM3cLMA71Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11275	uniprotkb:Q63053	intact:EBI-2640645	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	psi-mi:kcc2a_rat(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162082|imex:IM-17367-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2261|refseq:NP_037052.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:5U6Y|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-4086398|reactome:R-RNO-438066|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|dip:DIP-29639N|mint:P11275	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	-	-	-	figure legend:Fig. 1D, Supp. Figs. 1E, 1F|comment:interaction was observed only in the presence of Ca2+/CaM.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-5(molar)	2012/06/21	2014/10/16	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10116	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	intact-crc:21C1FA6EAD4AF7AF|rigid:9UW/b1DQUMjkyGYTVoERSR4aUPo	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08413	uniprotkb:Q63053	intact:EBI-916155	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162077|imex:IM-17367-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	-	-	-	figure legend:Fig. 1C, 1D, 6B, C, D, Supp. Fig. 1F|comment:"This interaction was strong in the absence of Ca2+ and calmodulin (CaM) but was attenuated when Ca2+/CaM was present. Inhibition of CaM activation by W-7 (100 uM) in the presence of Ca2+/CaM restored Arc binding to CaMKIIB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-7(molar)	2012/06/21	2014/10/16	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	intact-crc:2C41C209CDF7E8CC|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	mutation decreasing interaction strength:287-287	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63053	uniprotkb:P08413	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	intact:EBI-916155	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162100|imex:IM-17367-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	go:"GO:0043197"(dendritic spine)	-	-	figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell)	-	2012/06/21	2014/10/16	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	intact-crc:C290F8622DAFCAEC|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	cyan fluorescent protein tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P28652	uniprotkb:Q9WV31	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6162122|imex:IM-17367-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	-	-	-	figure legend:Supp. Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2012/06/21	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	intact-crc:CF93B8AECE33CEB4|rigid:HyQO6erD+uj5BUL79aM3cLMA71Q	false	-	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08413	uniprotkb:Q63053	intact:EBI-916155	intact:EBI-5275794|uniprotkb:Q62743|ensembl:ENSRNOP00000063719|ensembl:ENSRNOP00000068090	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:arc_rat(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Okuno et al. (2012)	pubmed:22579289|imex:IM-17367	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6265412|imex:IM-17367-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	rgd:62037|refseq:NP_062234.1|refseq:XP_017450553.1|ensembl:ENSRNOG00000043465(gene)|ensembl:ENSRNOT00000067442(transcript)|ensembl:ENSRNOT00000076998(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|rcsb pdb:4X3H|rcsb pdb:4X3I|rcsb pdb:4X3X|rcsb pdb:6GSE	go:"GO:0043197"(dendritic spine)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell)	-	2012/06/21	2014/10/16	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	rogid:rlHU9lDjMpnl4JNl5HKQBpOziYo10116	intact-crc:1597E5C2C3A13ABE|rigid:eWNdhGBFOF4LHoB5bTCjWiki2oE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)