#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z0F8	uniprotkb:P08887	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-299383|ensembl:ENSP00000357470|uniprotkb:Q16202|uniprotkb:Q53EQ7|uniprotkb:Q5FWG2|uniprotkb:Q5VZ23|uniprotkb:B2R6V4|uniprotkb:A8KAE8	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:il6ra_human(display_long)|uniprotkb:IL6R(gene name)|psi-mi:IL6R(display_short)|uniprotkb:IL-6R 1(gene name synonym)|uniprotkb:Membrane glycoprotein 80(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lorenzen et al. (2012)	pubmed:22575642|mint:MINT-8329485	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7848563|mint:MINT-8329490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N|mint:MINT-8329493(identity)	go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|ensembl:ENSG00000160712(gene)|ensembl:ENST00000368485(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070119"(ciliary neurotrophic factor binding)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1N26|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2ARW|rcsb pdb:5FUC|rcsb pdb:7DC8|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6785807|reactome:R-HSA-9616222|reactome:R-HSA-9679191|refseq:NP_000556.1|refseq:NP_001193795.1|refseq:NP_852004.1|dip:DIP-162N|mint:MINT-8329492(identity)	-	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	figure legend:f2a|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/03/08	2014/10/16	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:qV0FIgWdLU9dOASd1U1jOhFFdt09606	intact-crc:A020DA8E1551AB8B|rigid:3ejSRTv7XYidnSaGH4xDKn2A4yY	false	flag tag:?-?(MINT-8329497)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z0F8	uniprotkb:P27930	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-2831568|uniprotkb:Q9UE68|uniprotkb:D3DVJ5|ensembl:ENSP00000330959|ensembl:ENSP00000377066|uniprotkb:Q6LCE6	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:il1r2_human(display_long)|uniprotkb:IL1R2(gene name)|psi-mi:IL1R2(display_short)|uniprotkb:IL1RB(gene name synonym)|uniprotkb:CD121 antigen-like family member B(gene name synonym)|uniprotkb:CDw121b(gene name synonym)|uniprotkb:Interleukin-1 receptor beta(gene name synonym)|uniprotkb:Interleukin-1 receptor type II(gene name synonym)|uniprotkb:IL-1 type II receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lorenzen et al. (2012)	pubmed:22575642|mint:MINT-8329485	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7848617|mint:MINT-8329502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N|mint:MINT-8329504(identity)	refseq:XP_011510106.1|ensembl:ENST00000332549(transcript)|ensembl:ENST00000393414(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004910"(interleukin-1, type II, blocking receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004077(Interleukin-1 receptor, type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|ensembl:ENSG00000115590(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|reactome:R-HSA-6783783|reactome:R-HSA-9020702|refseq:NP_004624.1|refseq:NP_001248348.1|refseq:XP_006712797.1|dip:DIP-61267N|mint:MINT-8329508(identity)	-	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	figure legend:f3a|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/03/08	2014/10/16	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:dbXLqsJM7HjQKDnuuUlyGcwp/Tc9606	intact-crc:A0274DC4C48D64DA|rigid:Fta//ElTIAxtE00jn5raPGZvlBw	false	ha tag:?-?(MINT-8329505)	myc tag:?-?(MINT-8329516)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)