#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30038	uniprotkb:P30038	intact:EBI-3926971|uniprotkb:Q9UDI6|uniprotkb:Q53HU4|uniprotkb:A8K1Q7|uniprotkb:Q16882|uniprotkb:Q8IZ38|uniprotkb:Q5JNV6|uniprotkb:Q96IF0|ensembl:ENSP00000290597|ensembl:ENSP00000364490|uniprotkb:B4DGE4|uniprotkb:D2D4A3	intact:EBI-3926971|uniprotkb:Q9UDI6|uniprotkb:Q53HU4|uniprotkb:A8K1Q7|uniprotkb:Q16882|uniprotkb:Q8IZ38|uniprotkb:Q5JNV6|uniprotkb:Q96IF0|ensembl:ENSP00000290597|ensembl:ENSP00000364490|uniprotkb:B4DGE4|uniprotkb:D2D4A3	psi-mi:al4a1_human(display_long)|uniprotkb:ALDH4A1(gene name)|psi-mi:ALDH4A1(display_short)|uniprotkb:ALDH4(gene name synonym)|uniprotkb:P5CDH(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:al4a1_human(display_long)|uniprotkb:ALDH4A1(gene name)|psi-mi:ALDH4A1(display_short)|uniprotkb:ALDH4(gene name synonym)|uniprotkb:P5CDH(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Srivastava et al. (2012)	pubmed:22516612	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6288635|pdbe:3V9G|pdbe:3V9H|pdbe:3V9I	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154976.1|refseq:NP_003739.2|refseq:NP_733844.1|ensembl:ENSG00000159423(gene)|ensembl:ENST00000290597(transcript)|ensembl:ENST00000375341(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006560"(proline metabolic process)|go:"GO:0006562"(proline catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0019470"(4-hydroxyproline catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:3V9H|rcsb pdb:3V9I|rcsb pdb:4OE5|reactome:R-HSA-389661|reactome:R-HSA-70688|rcsb pdb:3V9G|refseq:NP_001306147.1	refseq:NP_001154976.1|refseq:NP_003739.2|refseq:NP_733844.1|ensembl:ENSG00000159423(gene)|ensembl:ENST00000290597(transcript)|ensembl:ENST00000375341(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006560"(proline metabolic process)|go:"GO:0006562"(proline catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0019470"(4-hydroxyproline catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:3V9H|rcsb pdb:3V9I|rcsb pdb:4OE5|reactome:R-HSA-389661|reactome:R-HSA-70688|rcsb pdb:3V9G|refseq:NP_001306147.1	-	-	-	3d-r-factors:"R-factor: 20.48%, Free R-factor: 23.85% for 3v9g  R-factor: 21.07%, Free R-factor: 25.08%  for 3v9h  R-factor: 21.06%, Free R-factor: 26.4% for 3v9i"|3d-resolution:2.5 A for 3V9G,   2.4 A 3V9H,   2.85 A for 3V9I|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/11	2014/10/16	rogid:EffeJikoazdZ3SwYfhTdzZJ3FDw9606	rogid:EffeJikoazdZ3SwYfhTdzZJ3FDw9606	intact-crc:24CD1A6F9F37849E|rigid:NBYr6WHnfNGVbwxDPUAeuCjeMgI	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CHT0	uniprotkb:Q8CHT0	intact:EBI-6306263|ensembl:ENSMUSP00000043821|uniprotkb:B1AXW8|uniprotkb:Q7TND0|uniprotkb:Q8BXM3|uniprotkb:Q8R0N1|uniprotkb:Q8R1S2	intact:EBI-6306263|ensembl:ENSMUSP00000043821|uniprotkb:B1AXW8|uniprotkb:Q7TND0|uniprotkb:Q8BXM3|uniprotkb:Q8R0N1|uniprotkb:Q8R1S2	psi-mi:al4a1_mouse(display_long)|uniprotkb:Aldh4a1(gene name)|psi-mi:Aldh4a1(display_short)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:al4a1_mouse(display_long)|uniprotkb:Aldh4a1(gene name)|psi-mi:Aldh4a1(display_short)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Srivastava et al. (2012)	pubmed:22516612	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6306291|pdbe:3V9K|pdbe:3V9L|pdbe:3V9J	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028737(gene)|ensembl:ENSMUST00000039818(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:Q8CHT0|rcsb pdb:3V9J|rcsb pdb:3V9K|rcsb pdb:3V9L|rcsb pdb:4E3X|rcsb pdb:4LGZ|rcsb pdb:4LH0|rcsb pdb:4LH1|rcsb pdb:4LH2|rcsb pdb:4LH3|rcsb pdb:7MER|rcsb pdb:7MES|reactome:R-MMU-389661|reactome:R-MMU-70688|refseq:NP_780647.3	ensembl:ENSMUSG00000028737(gene)|ensembl:ENSMUST00000039818(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:Q8CHT0|rcsb pdb:3V9J|rcsb pdb:3V9K|rcsb pdb:3V9L|rcsb pdb:4E3X|rcsb pdb:4LGZ|rcsb pdb:4LH0|rcsb pdb:4LH1|rcsb pdb:4LH2|rcsb pdb:4LH3|rcsb pdb:7MER|rcsb pdb:7MES|reactome:R-MMU-389661|reactome:R-MMU-70688|refseq:NP_780647.3	-	-	-	3d-resolution:1.30 A for 3V9J;  1.50 A for 3V9K  1.50 A for 3V9L|3d-r-factors:"R-Value: 0.133 (obs.) for 3V9J, R-Free: 0.160 for 3V9J, R-Value: 0.159 (obs.) for 3V9L, R-Free: 0.176 for 3V9L, R-Value: 0.152 (obs.) for 3V9K, R-Free: 0.169 for 3V9K"|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/11	2014/10/16	rogid:cOK/nEjmVFweQmsJorTlgFhpGPA10090	rogid:cOK/nEjmVFweQmsJorTlgFhpGPA10090	intact-crc:29D75C88D9CE2A50|rigid:gxkcDRY7cXsxiSIk6IXkYhgbuZ0	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30038	uniprotkb:P30038	intact:EBI-3926971|uniprotkb:Q9UDI6|uniprotkb:Q53HU4|uniprotkb:A8K1Q7|uniprotkb:Q16882|uniprotkb:Q8IZ38|uniprotkb:Q5JNV6|uniprotkb:Q96IF0|ensembl:ENSP00000290597|ensembl:ENSP00000364490|uniprotkb:B4DGE4|uniprotkb:D2D4A3	intact:EBI-3926971|uniprotkb:Q9UDI6|uniprotkb:Q53HU4|uniprotkb:A8K1Q7|uniprotkb:Q16882|uniprotkb:Q8IZ38|uniprotkb:Q5JNV6|uniprotkb:Q96IF0|ensembl:ENSP00000290597|ensembl:ENSP00000364490|uniprotkb:B4DGE4|uniprotkb:D2D4A3	psi-mi:al4a1_human(display_long)|uniprotkb:ALDH4A1(gene name)|psi-mi:ALDH4A1(display_short)|uniprotkb:ALDH4(gene name synonym)|uniprotkb:P5CDH(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:al4a1_human(display_long)|uniprotkb:ALDH4A1(gene name)|psi-mi:ALDH4A1(display_short)|uniprotkb:ALDH4(gene name synonym)|uniprotkb:P5CDH(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Srivastava et al. (2012)	pubmed:22516612	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6288648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154976.1|refseq:NP_003739.2|refseq:NP_733844.1|ensembl:ENSG00000159423(gene)|ensembl:ENST00000290597(transcript)|ensembl:ENST00000375341(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006560"(proline metabolic process)|go:"GO:0006562"(proline catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0019470"(4-hydroxyproline catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:3V9H|rcsb pdb:3V9I|rcsb pdb:4OE5|reactome:R-HSA-389661|reactome:R-HSA-70688|rcsb pdb:3V9G|refseq:NP_001306147.1	refseq:NP_001154976.1|refseq:NP_003739.2|refseq:NP_733844.1|ensembl:ENSG00000159423(gene)|ensembl:ENST00000290597(transcript)|ensembl:ENST00000375341(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006560"(proline metabolic process)|go:"GO:0006562"(proline catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0019470"(4-hydroxyproline catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:3V9H|rcsb pdb:3V9I|rcsb pdb:4OE5|reactome:R-HSA-389661|reactome:R-HSA-70688|rcsb pdb:3V9G|refseq:NP_001306147.1	-	-	-	figure legend:Fig 3.|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/11	2014/10/16	rogid:EffeJikoazdZ3SwYfhTdzZJ3FDw9606	rogid:EffeJikoazdZ3SwYfhTdzZJ3FDw9606	intact-crc:252BA583DBB7D95D|rigid:NBYr6WHnfNGVbwxDPUAeuCjeMgI	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)