#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BXC9 uniprotkb:Q8IWZ6 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127594|imex:IM-17327-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1D|comment:Knockdown of BBS9 greatly decreases the association of BBS1, BBS4, and BBS8 with BBS2, but does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:48C931DC4E63F32D|rigid:XGjqdXpGASTzd07elc+agUwxPHI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q96RK4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127594|imex:IM-17327-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1D|comment:Knockdown of BBS9 greatly decreases the association of BBS1, BBS4, and BBS8 with BBS2, but does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:48C931DC4E63F32D|rigid:XGjqdXpGASTzd07elc+agUwxPHI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8TAM2 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127594|imex:IM-17327-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 - - - figure legend:Fig 1D|comment:Knockdown of BBS9 greatly decreases the association of BBS1, BBS4, and BBS8 with BBS2, but does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 intact-crc:48C931DC4E63F32D|rigid:XGjqdXpGASTzd07elc+agUwxPHI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8NFJ9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127594|imex:IM-17327-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1D|comment:Knockdown of BBS9 greatly decreases the association of BBS1, BBS4, and BBS8 with BBS2, but does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:48C931DC4E63F32D|rigid:XGjqdXpGASTzd07elc+agUwxPHI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q3SYG4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127594|imex:IM-17327-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig 1D|comment:Knockdown of BBS9 greatly decreases the association of BBS1, BBS4, and BBS8 with BBS2, but does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:48C931DC4E63F32D|rigid:XGjqdXpGASTzd07elc+agUwxPHI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9BXC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127485|imex:IM-17327-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1A|comment:The mutant BBS7T211I has a decreased ability to interact with endogenous BBSome subunits compared with WT BBS7, however it pulls down relatively more BBS2 than other BBSome proteins.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:02432724BF27988D|rigid:UyNiu4zQ//goTdgBhq5cxd1+sYk false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:Q8NFJ9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127485|imex:IM-17327-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1A|comment:The mutant BBS7T211I has a decreased ability to interact with endogenous BBSome subunits compared with WT BBS7, however it pulls down relatively more BBS2 than other BBSome proteins.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:02432724BF27988D|rigid:UyNiu4zQ//goTdgBhq5cxd1+sYk false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:Q96RK4 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127485|imex:IM-17327-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1A|comment:The mutant BBS7T211I has a decreased ability to interact with endogenous BBSome subunits compared with WT BBS7, however it pulls down relatively more BBS2 than other BBSome proteins.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:02432724BF27988D|rigid:UyNiu4zQ//goTdgBhq5cxd1+sYk false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8IWZ6 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8TAM2 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q3SYG4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q96RK4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8NFJ9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:Q8N3I7 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128046|imex:IM-17327-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 intact-crc:1D2C1DE11E86569D|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:P78371 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128106|imex:IM-17327-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig 6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 intact-crc:D06BB237D454B73A|rigid:47XgxmsD9zsdyqlFV6FDak+GVAQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:Q8TAM1 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-6128013|uniprotkb:Q96CW2|uniprotkb:Q9H5D2|ensembl:ENSP00000497413 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs10_human(display_long)|uniprotkb:BBS10(gene name)|psi-mi:BBS10(display_short)|uniprotkb:C12orf58(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128004|imex:IM-17327-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_078961.3|dip:DIP-60347N|ensembl:ENSG00000179941(gene)|ensembl:ENST00000650064(transcript)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042619|reactome:R-HSA-5620922|go:"GO:0005524"(ATP binding) - - - figure legend:Fig 5B|comment:Overexpression of BBS10 promotes the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:sf8+0h7FqnC3Cv2gfRfdr50+JQ89606 intact-crc:780E2DB06D3915B8|rigid:2THh9Jz8ZObEMtZUB15R7PXSlDw false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:Q8IWZ6 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128004|imex:IM-17327-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 5B|comment:Overexpression of BBS10 promotes the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:780E2DB06D3915B8|rigid:2THh9Jz8ZObEMtZUB15R7PXSlDw false myc tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:P17987 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128004|imex:IM-17327-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Fig 5B|comment:Overexpression of BBS10 promotes the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 intact-crc:780E2DB06D3915B8|rigid:2THh9Jz8ZObEMtZUB15R7PXSlDw false myc tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:P78371 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128004|imex:IM-17327-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig 5B|comment:Overexpression of BBS10 promotes the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 intact-crc:780E2DB06D3915B8|rigid:2THh9Jz8ZObEMtZUB15R7PXSlDw false myc tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BXC9 uniprotkb:P78371 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128121|imex:IM-17327-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig 6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 intact-crc:F0C97CBA2AC363CB|rigid:2R8SdlYbMz9fP/fvcJP3oqQDzyQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:Q8IWZ6 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128035|imex:IM-17327-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:233AF9CB60512A42|rigid:gT+rXi8P6Nyn8A6y2cCCX7LO9og false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:Q9BXC9 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128035|imex:IM-17327-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 6A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:233AF9CB60512A42|rigid:gT+rXi8P6Nyn8A6y2cCCX7LO9og false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:P78371 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127989|imex:IM-17327-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig 5A|comment:Absence of BBS10 decreases the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 intact-crc:407A102E6233A7C8|rigid:ty+HcAua+dhAHVan/YGNU/bf4HM false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:P17987 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127989|imex:IM-17327-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Fig 5A|comment:Absence of BBS10 decreases the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 intact-crc:407A102E6233A7C8|rigid:ty+HcAua+dhAHVan/YGNU/bf4HM false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NPJ1 uniprotkb:Q8IWZ6 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127989|imex:IM-17327-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 5A|comment:Absence of BBS10 decreases the interaction of BBS6 with TCPalpha and TCPbeta.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:407A102E6233A7C8|rigid:ty+HcAua+dhAHVan/YGNU/bf4HM false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TAM2 uniprotkb:Q9BXC9 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127585|imex:IM-17327-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:94AA507611E96CA0|rigid:WrCwNo+BLYaVuB+g2FAnGQb9fnI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TAM2 uniprotkb:Q96RK4 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127585|imex:IM-17327-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:94AA507611E96CA0|rigid:WrCwNo+BLYaVuB+g2FAnGQb9fnI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TAM2 uniprotkb:Q8NFJ9 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127585|imex:IM-17327-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:94AA507611E96CA0|rigid:WrCwNo+BLYaVuB+g2FAnGQb9fnI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TAM2 uniprotkb:Q8IWZ6 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127585|imex:IM-17327-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:94AA507611E96CA0|rigid:WrCwNo+BLYaVuB+g2FAnGQb9fnI false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q9BXC9 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127563|imex:IM-17327-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:2977DCC844DAF4CF|rigid:ErSdS7dVmv1QKwwBlEMbKzlo0E8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q8IWZ6 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127563|imex:IM-17327-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:2977DCC844DAF4CF|rigid:ErSdS7dVmv1QKwwBlEMbKzlo0E8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q8NFJ9 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127563|imex:IM-17327-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:2977DCC844DAF4CF|rigid:ErSdS7dVmv1QKwwBlEMbKzlo0E8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127563|imex:IM-17327-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:2977DCC844DAF4CF|rigid:ErSdS7dVmv1QKwwBlEMbKzlo0E8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3I7 uniprotkb:Q96RK4 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127575|imex:IM-17327-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:F2B4FFB3D6941B4E|rigid:cNEI8U9wpCWetew+Ak2BaSBuY+I false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3I7 uniprotkb:Q8NFJ9 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127575|imex:IM-17327-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:F2B4FFB3D6941B4E|rigid:cNEI8U9wpCWetew+Ak2BaSBuY+I false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3I7 uniprotkb:Q9BXC9 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127575|imex:IM-17327-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:F2B4FFB3D6941B4E|rigid:cNEI8U9wpCWetew+Ak2BaSBuY+I false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3I7 uniprotkb:Q8IWZ6 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127575|imex:IM-17327-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:F2B4FFB3D6941B4E|rigid:cNEI8U9wpCWetew+Ak2BaSBuY+I false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:Q8NFJ9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127519|imex:IM-17327-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1B|comment:Knockdown of BBS2 decreases the association of BBS7 with BBS1, while knockdown of BBS1 does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:D84321D1456F7730|rigid:3mTUJtufneYyic/LZMcFsYudN38 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9BXC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127519|imex:IM-17327-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1B|comment:Knockdown of BBS2 decreases the association of BBS7 with BBS1, while knockdown of BBS1 does not affect the association of BBS7 with BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:D84321D1456F7730|rigid:3mTUJtufneYyic/LZMcFsYudN38 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127531|imex:IM-17327-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:445EE8A7EDD0D421|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3SYG4 uniprotkb:Q8IWZ6 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127531|imex:IM-17327-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:445EE8A7EDD0D421|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3SYG4 uniprotkb:Q8IWZ6 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128171|imex:IM-17327-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig S2B -2|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:99E4434F28AD5974|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128171|imex:IM-17327-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S2B -2|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:99E4434F28AD5974|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false myc tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFJ9 uniprotkb:Q3SYG4 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127872|imex:IM-17327-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig 2D|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:8BC86CC290A15B7F|rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96RK4 uniprotkb:Q8NFJ9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127867|imex:IM-17327-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 2D|comment:BBS1 M390R mutant protein has greatly reduced interaction with BBS4, but normal interactions with BBS9 and BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:F25E40F07CBA7666|rigid:UNyTE2rjOXZ5UJZkVdq0mqK/eQQ false flag tag:?-? mutation decreasing interaction:390-390|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q8NFJ9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128146|imex:IM-17327-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S2A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:017FCA3B5F92CA26|rigid:8keXDkF2eF1U/w0yv5tYJSDfVq4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9BXC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128134|imex:IM-17327-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S2A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:EC8392E27C783FCC|rigid:+iU0m/P2fcr+u6c7QCVYJuLtESA false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9BXC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128195|imex:IM-17327-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S2B -4|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:D4AD71BBBEFB2A23|rigid:+iU0m/P2fcr+u6c7QCVYJuLtESA false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9BXC9 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128159|imex:IM-17327-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S2B -1|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:F4AEB076A3293AC2|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q3SYG4 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128159|imex:IM-17327-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig S2B -1|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:F4AEB076A3293AC2|rigid:0Y3r9K2s+v+8hxUHWhvtIq0+GH4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFJ9 uniprotkb:Q9BXC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127860|imex:IM-17327-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 2D|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:9250782BAF24B350|rigid:Ad/z+aqXwfkzo5EvsXHipdMOihY false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128183|imex:IM-17327-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S2B -3|comment:BBS7 and BBS9 do not directly interact, rather they only interact in the presence of BBS2.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:054A43C2E7EC1BD3|rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false myc tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15154 uniprotkb:Q96RK4 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127959|imex:IM-17327-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 4A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:BF93ACB43D73BAEF|rigid:CUCLhh2NOYPyZ8s28XrgxkoVDOA false sufficient binding region:1913..1913-2024..2024|ha tag:?-? mutation disrupting interaction:295-295|mutation disrupting interaction:277-277|green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15154 uniprotkb:Q96RK4 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127973|imex:IM-17327-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 4A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:320EFA75EE626437|rigid:CUCLhh2NOYPyZ8s28XrgxkoVDOA false ha tag:?-?|sufficient binding region:1913..1913-2024..2024 mutation disrupting interaction:277-277|mutation disrupting interaction:295-295|green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128252|imex:IM-17327-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S3A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:2EC0FB8ED2CF6C1B|rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false myc tag:?-? green fluorescent protein tag:n-n|necessary binding region:236-439 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128267|imex:IM-17327-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S3B|comment:PCM1 can interact with BBIP10 only when BBS4 is present.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:03A4600768033F66|rigid:cNlwgGo/pNMzQHVZKPffMHwyl58 false myc tag:?-? green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A8MTZ0 uniprotkb:Q15154 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128267|imex:IM-17327-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N - - - figure legend:Fig S3B|comment:PCM1 can interact with BBIP10 only when BBS4 is present.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 intact-crc:03A4600768033F66|rigid:cNlwgGo/pNMzQHVZKPffMHwyl58 false myc tag:?-? sufficient binding region:1913..1913-2024..2024|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15154 uniprotkb:Q96RK4 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128330|imex:IM-17327-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S3B|comment:PCM1 can interact with BBIP10 only when BBS4 is present.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:E61E7BF928A536F0|rigid:cNlwgGo/pNMzQHVZKPffMHwyl58 false ha tag:?-?|sufficient binding region:1913..1913-2024..2024 green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15154 uniprotkb:A8MTZ0 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128330|imex:IM-17327-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 - - - figure legend:Fig S3B|comment:PCM1 can interact with BBIP10 only when BBS4 is present.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 intact-crc:E61E7BF928A536F0|rigid:cNlwgGo/pNMzQHVZKPffMHwyl58 false ha tag:?-?|sufficient binding region:1913..1913-2024..2024 myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15154 uniprotkb:Q96RK4 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128242|imex:IM-17327-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S3A|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2018/04/06 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:33C31AD4A34692D9|rigid:CUCLhh2NOYPyZ8s28XrgxkoVDOA false sufficient binding region:1913..1913-2024..2024|ha tag:?-? necessary binding region:51-372|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q6ZW61 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128382|imex:IM-17327-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 - - - figure legend:S4B|caution:"Although the text states:-\"The interaction of BBS7 with BBS12 requires BBS6.\" - however there is a clearly visible band when the antibody used for IP is anti-myc, even when BBS6-siRNA is present."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 intact-crc:D88F5D9ABA46791E|rigid:RMfs0Ya/FgUJimbKt+AuxkZqh2w false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q8IWZ6 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128394|imex:IM-17327-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:S4B -2|comment:The interaction of BBS7 with BBS12 requires BBS6.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:8E7073C6521D1514|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q9NPJ1 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128394|imex:IM-17327-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 - - - figure legend:S4B -2|comment:The interaction of BBS7 with BBS12 requires BBS6.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 intact-crc:8E7073C6521D1514|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q8IWZ6 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128507|imex:IM-17327-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:S4C-2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:A4343A71D13CA5A6|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q9NPJ1 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128507|imex:IM-17327-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 - - - figure legend:S4C-2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 intact-crc:A4343A71D13CA5A6|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? ha tag:?-?|mutation decreasing interaction:57-57 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q9NPJ1 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128486|imex:IM-17327-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 - - - figure legend:S4C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 intact-crc:8615F0360DBC1C2D|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false myc tag:?-? ha tag:?-?|mutation decreasing interaction:57-57 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IWZ6 uniprotkb:Q6ZW61 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128486|imex:IM-17327-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 - - - figure legend:S4C|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 intact-crc:8615F0360DBC1C2D|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NPJ1 uniprotkb:Q6ZW61 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128347|imex:IM-17327-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 - - - figure legend:S4A|comment:The interaction of BBS6 with BBS12 requires BBS7.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 intact-crc:01E295A624C51BE2|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NPJ1 uniprotkb:Q8IWZ6 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128347|imex:IM-17327-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:S4A|comment:The interaction of BBS6 with BBS12 requires BBS7.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:01E295A624C51BE2|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q9NPJ1 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-721319|uniprotkb:A8K7B0|uniprotkb:D3DW18|ensembl:ENSP00000246062|ensembl:ENSP00000382008|ensembl:ENSP00000498849 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:mkks_human(display_long)|uniprotkb:Bardet-Biedl syndrome 6 protein(gene name synonym)|uniprotkb:MKKS(gene name)|psi-mi:MKKS(display_short)|uniprotkb:BBS6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128421|imex:IM-17327-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_061336.1|refseq:NP_740754.1|dip:DIP-60349N|ensembl:ENSG00000125863(gene)|ensembl:ENST00000347364(transcript)|ensembl:ENST00000399054(transcript)|ensembl:ENST00000651692(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008406"(gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032502"(developmental process)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035176"(social behavior)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046907"(intracellular transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051216"(cartilage development)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902636"(kinociliary basal body)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR028790|reactome:R-HSA-5620922 - - - figure legend:S4A -2|comment:The interaction of BBS6 with BBS12 requires BBS7.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:L2xnUng1MXSDE+PQJpgcLP4T7CQ9606 intact-crc:CABAA4DB4639A95F|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZW61 uniprotkb:Q8IWZ6 intact:EBI-6128352|uniprotkb:D3DNX5|uniprotkb:Q7Z342|uniprotkb:Q7Z482|uniprotkb:Q8NAB8|ensembl:ENSP00000319062|ensembl:ENSP00000438273 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs12_human(display_long)|uniprotkb:BBS12(gene name)|psi-mi:BBS12(display_short)|uniprotkb:C4orf24(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128421|imex:IM-17327-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529982.1|refseq:NP_001171478.1|refseq:NP_689831.2|refseq:XP_016863320.1|dip:DIP-60348N|ensembl:ENSG00000181004(gene)|ensembl:ENST00000314218(transcript)|ensembl:ENST00000542236(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005929"(cilium)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042755"(eating behavior)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|interpro:IPR042984|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:S4A -2|comment:The interaction of BBS6 with BBS12 requires BBS7.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/05/15 2014/10/16 rogid:n1x/po4b7gFRhkpkNylETKP7fBE9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:CABAA4DB4639A95F|rigid:HnoqwdNe/IxQUzBB7c8vb4JwxM4 false myc tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFJ9 uniprotkb:Q9BXC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q96RK4 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q8N3I7 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q8IWZ6 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q3SYG4 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q8TAM2 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128693|imex:IM-17327-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 - - - figure legend:Fig S6B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 intact-crc:676BDC802FA297A1|rigid:jkD1CuVj29HaIpa2SgrL+0yhBHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q9BXC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128664|imex:IM-17327-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig S6B -2|comment:Absence of BBS10 lowers BBS2 protein levels and inhibits BBSome formation.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:325EAB8469E72DDB|rigid:I06wtxde5Z0gVyLqP4x1Nxek0vc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFJ9 uniprotkb:Q8N3I7 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128664|imex:IM-17327-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Fig S6B -2|comment:Absence of BBS10 lowers BBS2 protein levels and inhibits BBSome formation.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2012/05/15 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 intact-crc:325EAB8469E72DDB|rigid:I06wtxde5Z0gVyLqP4x1Nxek0vc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8K2G4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127946|imex:IM-17327-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig 3B.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:4459852430FB1756|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8VD72 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127946|imex:IM-17327-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - - - figure legend:Fig 3B.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:4459852430FB1756|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q811G0 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127691|uniprotkb:P97498|uniprotkb:Q3UMR2|uniprotkb:Q7TQH9|uniprotkb:Q8BKD7|uniprotkb:Q8K0T5|ensembl:ENSMUSP00000120927 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:pthb1_mouse(display_long)|uniprotkb:Bbs9(gene name)|psi-mi:Bbs9(display_short)|uniprotkb:Pthb1(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein homolog(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127946|imex:IM-17327-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:XP_006510478.1|refseq:XP_006510479.1|refseq:XP_006510480.1|refseq:XP_006510481.1|refseq:XP_006510482.1|refseq:NP_848502.1|refseq:NP_851833.2|ensembl:ENSMUSG00000035919(gene)|ensembl:ENSMUST00000147405(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|reactome:R-MMU-5620922 - - - figure legend:Fig 3B.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:sZIkJkIaNYEhrEujD3WS4KO76Yw10090 intact-crc:4459852430FB1756|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q3V3N7 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892836|ensembl:ENSMUSP00000055321 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127946|imex:IM-17327-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 - - crc64:322E9DD4DD554813 figure legend:Fig 3B.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 intact-crc:4459852430FB1756|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q9CZQ9 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127679|uniprotkb:A2AUC7|ensembl:ENSMUSP00000074494 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs5_mouse(display_long)|uniprotkb:Bbs5(gene name)|psi-mi:Bbs5(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127946|imex:IM-17327-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_082560.1|ensembl:ENSMUSG00000063145(gene)|ensembl:ENSMUST00000074963(transcript)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|mint:Q9CZQ9|reactome:R-MMU-5620922 - - - figure legend:Fig 3B.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:tpfXPd3gpQIC6+kp3OOpwiXrZe810090 intact-crc:4459852430FB1756|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q9CZQ9 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127679|uniprotkb:A2AUC7|ensembl:ENSMUSP00000074494 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs5_mouse(display_long)|uniprotkb:Bbs5(gene name)|psi-mi:Bbs5(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_082560.1|ensembl:ENSMUSG00000063145(gene)|ensembl:ENSMUST00000074963(transcript)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|mint:Q9CZQ9|reactome:R-MMU-5620922 - - - figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:tpfXPd3gpQIC6+kp3OOpwiXrZe810090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8C1Z7 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892887|ensembl:ENSMUSP00000026265|uniprotkb:Q3UYF0|uniprotkb:Q562E1|uniprotkb:Q5EBJ7|uniprotkb:Q8CA57 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs4_mouse(display_long)|uniprotkb:Bbs4(gene name)|psi-mi:Bbs4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000025235(gene)|ensembl:ENSMUST00000026265(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035176"(social behavior)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0060613"(fat pad development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902855"(regulation of non-motile cilium assembly)|go:"GO:1903546"(protein localization to photoreceptor outer segment)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|reactome:R-MMU-5620922|refseq:NP_780534.1|dip:DIP-60352N - - - figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:ypTOupyEotNCkm/1dQKmxoUv0VU10090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8VD72 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - - - figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8K2G4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q811G0 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127691|uniprotkb:P97498|uniprotkb:Q3UMR2|uniprotkb:Q7TQH9|uniprotkb:Q8BKD7|uniprotkb:Q8K0T5|ensembl:ENSMUSP00000120927 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:pthb1_mouse(display_long)|uniprotkb:Bbs9(gene name)|psi-mi:Bbs9(display_short)|uniprotkb:Pthb1(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein homolog(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:XP_006510478.1|refseq:XP_006510479.1|refseq:XP_006510480.1|refseq:XP_006510481.1|refseq:XP_006510482.1|refseq:NP_848502.1|refseq:NP_851833.2|ensembl:ENSMUSG00000035919(gene)|ensembl:ENSMUST00000147405(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|reactome:R-MMU-5620922 - - - figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:sZIkJkIaNYEhrEujD3WS4KO76Yw10090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q3V3N7 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892836|ensembl:ENSMUSP00000055321 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6127837|imex:IM-17327-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 - - crc64:322E9DD4DD554813 figure legend:Fig 2C, 3B.|comment:Using Bbs1 M390R/M390R mutant mice, BBS1 is missing from the complex along with BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 intact-crc:341CED3A43178A59|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false - mutation disrupting interaction:390-390 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q9CWF6 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-2892863|ensembl:ENSMUSP00000034206 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127934|imex:IM-17327-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N - crc64:322E9DD4DD554813 - figure legend:Fig 3A.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 intact-crc:F5B1374FC262F208|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q9CZQ9 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127679|uniprotkb:A2AUC7|ensembl:ENSMUSP00000074494 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs5_mouse(display_long)|uniprotkb:Bbs5(gene name)|psi-mi:Bbs5(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127934|imex:IM-17327-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:NP_082560.1|ensembl:ENSMUSG00000063145(gene)|ensembl:ENSMUST00000074963(transcript)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|mint:Q9CZQ9|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 3A.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:tpfXPd3gpQIC6+kp3OOpwiXrZe810090 intact-crc:F5B1374FC262F208|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q8K2G4 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127934|imex:IM-17327-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - crc64:322E9DD4DD554813 - figure legend:Fig 3A.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:F5B1374FC262F208|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q811G0 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127691|uniprotkb:P97498|uniprotkb:Q3UMR2|uniprotkb:Q7TQH9|uniprotkb:Q8BKD7|uniprotkb:Q8K0T5|ensembl:ENSMUSP00000120927 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:pthb1_mouse(display_long)|uniprotkb:Bbs9(gene name)|psi-mi:Bbs9(display_short)|uniprotkb:Pthb1(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein homolog(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein homolog(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127934|imex:IM-17327-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:XP_006510478.1|refseq:XP_006510479.1|refseq:XP_006510480.1|refseq:XP_006510481.1|refseq:XP_006510482.1|refseq:NP_848502.1|refseq:NP_851833.2|ensembl:ENSMUSG00000035919(gene)|ensembl:ENSMUST00000147405(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 3A.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:sZIkJkIaNYEhrEujD3WS4KO76Yw10090 intact-crc:F5B1374FC262F208|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q8VD72 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127934|imex:IM-17327-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 3A.|comment:"Loss of BBS4 does not affect the incorporation of other BBSome subunits (including BBS1) into the BBSome."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:F5B1374FC262F208|rigid:CMwBMmlsmKs9bnjtUABit+vm6c0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q9CWF6 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-2892863|ensembl:ENSMUSP00000034206 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q8C1Z7 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-2892887|ensembl:ENSMUSP00000026265|uniprotkb:Q3UYF0|uniprotkb:Q562E1|uniprotkb:Q5EBJ7|uniprotkb:Q8CA57 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs4_mouse(display_long)|uniprotkb:Bbs4(gene name)|psi-mi:Bbs4(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 ensembl:ENSMUSG00000025235(gene)|ensembl:ENSMUST00000026265(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035176"(social behavior)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0060324"(face development)|go:"GO:0060613"(fat pad development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902855"(regulation of non-motile cilium assembly)|go:"GO:1903546"(protein localization to photoreceptor outer segment)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|reactome:R-MMU-5620922|refseq:NP_780534.1|dip:DIP-60352N - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:ypTOupyEotNCkm/1dQKmxoUv0VU10090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q9CZQ9 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127679|uniprotkb:A2AUC7|ensembl:ENSMUSP00000074494 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs5_mouse(display_long)|uniprotkb:Bbs5(gene name)|psi-mi:Bbs5(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:NP_082560.1|ensembl:ENSMUSG00000063145(gene)|ensembl:ENSMUST00000074963(transcript)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|mint:Q9CZQ9|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:tpfXPd3gpQIC6+kp3OOpwiXrZe810090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q8K2G4 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q811G0 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127691|uniprotkb:P97498|uniprotkb:Q3UMR2|uniprotkb:Q7TQH9|uniprotkb:Q8BKD7|uniprotkb:Q8K0T5|ensembl:ENSMUSP00000120927 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:pthb1_mouse(display_long)|uniprotkb:Bbs9(gene name)|psi-mi:Bbs9(display_short)|uniprotkb:Pthb1(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein homolog(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein homolog(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:XP_006510478.1|refseq:XP_006510479.1|refseq:XP_006510480.1|refseq:XP_006510481.1|refseq:XP_006510482.1|refseq:NP_848502.1|refseq:NP_851833.2|ensembl:ENSMUSG00000035919(gene)|ensembl:ENSMUST00000147405(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:sZIkJkIaNYEhrEujD3WS4KO76Yw10090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3V3N7 uniprotkb:Q8VD72 intact:EBI-2892836|ensembl:ENSMUSP00000055321 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Zhang et al. (2012) pubmed:22500027|imex:IM-17327 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6127677|imex:IM-17327-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - crc64:322E9DD4DD554813 - figure legend:Fig 2B, 3A.|comment:The BBS1 M390R mutation associates normally with all BBSome proteins, except for BBS4.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/05/15 2014/10/16 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:D4502F0CD92A1C5A|rigid:+8uqSznFxCPKyJbMr+9hI3qebW0 false mutation decreasing interaction strength:390-390 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)