#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00749	uniprotkb:P05121	intact:EBI-3905042|uniprotkb:Q15844|uniprotkb:B4DPZ2|uniprotkb:Q53XS3|uniprotkb:Q16618|uniprotkb:Q5SWW9|uniprotkb:Q969W6|ensembl:ENSP00000361850	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	psi-mi:urok_human(display_long)|uniprotkb:PLAU(gene name)|psi-mi:PLAU(display_short)	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	D'Amico et al. (2012)	pubmed:22449964|mint:MINT-8309289	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7800864|mint:MINT-8309294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138503.1|refseq:NP_002649.1|dip:DIP-46387N|refseq:NP_001306120.1|rcsb pdb:4MNX|rcsb pdb:4MNY|rcsb pdb:4OS1|rcsb pdb:4OS2|rcsb pdb:4OS4|rcsb pdb:4OS5|rcsb pdb:4OS6|rcsb pdb:4OS7|rcsb pdb:4X0W|rcsb pdb:4X1N|rcsb pdb:4X1P|rcsb pdb:4X1Q|rcsb pdb:4X1R|rcsb pdb:4X1S|rcsb pdb:4XSK|rcsb pdb:4ZHL|rcsb pdb:4ZHM|rcsb pdb:4ZKN|rcsb pdb:4ZKO|rcsb pdb:4ZKR|rcsb pdb:4ZKS|ensembl:ENSG00000122861(gene)|ensembl:ENST00000372764(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042730"(fibrinolysis)|go:"GO:0061041"(regulation of wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:2000097"(regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000001(Kringle)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR033116|interpro:IPR034814|interpro:IPR038178|interpro:IPR043504|rcsb pdb:1C5W|rcsb pdb:1C5X|rcsb pdb:1C5Y|rcsb pdb:1C5Z|rcsb pdb:1EJN|rcsb pdb:1F5K|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1F5L|rcsb pdb:1F92|rcsb pdb:5ZAH|rcsb pdb:5ZAJ|rcsb pdb:5ZC5|rcsb pdb:6AG2|rcsb pdb:6AG3|rcsb pdb:6AG7|rcsb pdb:6AG9|rcsb pdb:6JYP|rcsb pdb:6JYQ|rcsb pdb:6L04|rcsb pdb:6L05|rcsb pdb:6NMB|rcsb pdb:6XVD|reactome:R-HSA-6798695|reactome:R-HSA-75205|rcsb pdb:5HGG|rcsb pdb:5WXF|rcsb pdb:5WXO|rcsb pdb:5WXP|rcsb pdb:5WXQ|rcsb pdb:5WXR|rcsb pdb:5WXS|rcsb pdb:5WXT|rcsb pdb:5XG4|rcsb pdb:5YC6|rcsb pdb:5YC7|rcsb pdb:5Z1C|rcsb pdb:5ZA7|rcsb pdb:5ZA8|rcsb pdb:5ZA9|rcsb pdb:5ZAE|rcsb pdb:5ZAF|rcsb pdb:5ZAG|rcsb pdb:1O5A|rcsb pdb:1O5B|rcsb pdb:1O5C|rcsb pdb:1OWD|rcsb pdb:1OWE|rcsb pdb:1OWH|rcsb pdb:1OWI|rcsb pdb:1OWJ|rcsb pdb:1OWK|rcsb pdb:1SC8|rcsb pdb:1SQA|rcsb pdb:1SQO|rcsb pdb:1SQT|rcsb pdb:1U6Q|rcsb pdb:1URK|rcsb pdb:1VJ9|rcsb pdb:1VJA|rcsb pdb:1W0Z|rcsb pdb:1W10|rcsb pdb:1W11|rcsb pdb:1W12|rcsb pdb:1W13|rcsb pdb:1W14|rcsb pdb:1FV9|rcsb pdb:1GI7|rcsb pdb:1GI8|rcsb pdb:1GI9|rcsb pdb:1GJ7|rcsb pdb:1GJ8|rcsb pdb:1GJ9|rcsb pdb:1GJA|rcsb pdb:1GJB|rcsb pdb:1GJC|rcsb pdb:1GJD|rcsb pdb:1KDU|rcsb pdb:1LMW|rcsb pdb:1O3P|rcsb pdb:2FD6|rcsb pdb:2I9A|rcsb pdb:2I9B|rcsb pdb:2NWN|rcsb pdb:2O8T|rcsb pdb:2O8U|rcsb pdb:2O8W|rcsb pdb:2R2W|rcsb pdb:2VIN|rcsb pdb:2VIO|rcsb pdb:2VIP|rcsb pdb:2VIQ|rcsb pdb:2VIV|rcsb pdb:2VIW|rcsb pdb:2VNT|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:3IG6|rcsb pdb:3KGP|rcsb pdb:3KHV|rcsb pdb:3KID|rcsb pdb:3M61|rcsb pdb:3MHW|rcsb pdb:3MWI|rcsb pdb:3OX7|rcsb pdb:3OY5|rcsb pdb:3OY6|rcsb pdb:3PB1|rcsb pdb:3QN7|rcsb pdb:3U73|rcsb pdb:4DVA|rcsb pdb:4DW2|rcsb pdb:4FU7|rcsb pdb:4FU8|rcsb pdb:4FU9|rcsb pdb:4FUB|rcsb pdb:4FUC|rcsb pdb:4FUD|rcsb pdb:4FUE|rcsb pdb:4FUF|rcsb pdb:4FUG|rcsb pdb:4FUH|rcsb pdb:4FUI|rcsb pdb:4FUJ|rcsb pdb:4GLY|rcsb pdb:4H42|rcsb pdb:4JK5|rcsb pdb:4JK6|rcsb pdb:4K24|rcsb pdb:4MNV|rcsb pdb:4MNW|mint:MINT-8309297(identity)	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1|mint:MINT-8309296(identity)	-	-	-	figure legend:f5|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/09	2014/10/16	rogid:UgdiI+n26oe/Pa7q8Le493SlNE89606	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	intact-crc:69BBFA551D91891D|rigid:f3Xi5+lROkvyaKV5KKXcWB+ajjs	false	polyprotein fragment:21-177(MINT-8309304)	his tag:?-?(MINT-8309307)	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P00750	uniprotkb:P05121	intact:EBI-5605520|uniprotkb:A8K022|uniprotkb:B2R8E8|uniprotkb:Q15103|uniprotkb:Q503B0|uniprotkb:Q6PJA5|uniprotkb:Q7Z7N2|uniprotkb:Q86YK8|uniprotkb:Q9BU99|uniprotkb:Q9BZW1|ensembl:ENSP00000220809|ensembl:ENSP00000392045|ensembl:ENSP00000504311	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	psi-mi:tpa_human(display_long)|uniprotkb:PLAT(gene name)|psi-mi:PLAT(display_short)	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	D'Amico et al. (2012)	pubmed:22449964|mint:MINT-8309289	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7800882|mint:MINT-8309311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306118.1|refseq:NP_000921.1|refseq:NP_127509.1|ensembl:ENSG00000104368(gene)|ensembl:ENST00000220809(transcript)|ensembl:ENST00000429089(transcript)|ensembl:ENST00000679151(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0030141"(secretory granule)|go:"GO:0031639"(plasminogen activation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045177"(apical part of cell)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|interpro:IPR000001(Kringle)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR026280|interpro:IPR033116|interpro:IPR034811|interpro:IPR038178|interpro:IPR043504|rcsb pdb:1A5H|rcsb pdb:1BDA|rcsb pdb:1PK2|rcsb pdb:1PML|rcsb pdb:1RTF|rcsb pdb:1TPG|rcsb pdb:1TPK|rcsb pdb:1TPM|rcsb pdb:1TPN|rcsb pdb:5BRR|rcsb pdb:5ZLZ|reactome:R-HSA-186797|reactome:R-HSA-75205|mint:MINT-8309317(identity)	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1|mint:MINT-8309313(identity)	-	comment:"Stoichiometry: 1.6"	comment:"Stoichiometry: 6.1"	figure legend:f5|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/09	2022/01/21	rogid:YG0q3fS8FWhr/g9xuRyMM+oYcXo9606	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	intact-crc:36B650CD1A01B53E|rigid:h6L0F/N0E5jgDSaiAVgrqWRwlvU	false	-	his tag:?-?(MINT-8309314)	1	6	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)