#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P21462 uniprotkb:O15264 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-2116951|uniprotkb:O14739|uniprotkb:O15124|uniprotkb:Q9UNU0|uniprotkb:Q6FI46|uniprotkb:Q5U4A5|ensembl:ENSP00000211287 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:mk13_human(display_long)|uniprotkb:MAPK13(gene name)|psi-mi:MAPK13(display_short)|uniprotkb:PRKM13(gene name synonym)|uniprotkb:SAPK4(gene name synonym)|uniprotkb:Stress-activated protein kinase 4(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 delta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253863|imex:IM-17613-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_002745.1|ensembl:ENSG00000156711(gene)|ensembl:ENST00000211287(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0072740"(cellular response to anisomycin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038785|rcsb pdb:3COI|rcsb pdb:4EYJ|rcsb pdb:4EYM|rcsb pdb:4MYG|rcsb pdb:4YNO|rcsb pdb:5EKN|rcsb pdb:5EKO|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-376172|reactome:R-HSA-4420097 - - - figure legend:Fig. 7C.|agonist:SB203580 and stimulated with fMLF|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:ESdnKcoE9u2TK5ixHx7fr2p3MFc9606 intact-crc:82B8390D3104828C|rigid:Ct7Ea1XF+ylv8AqAYNzVRvZRf/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:P25098 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253868|imex:IM-17613-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse) - - - figure legend:Fig. 7F.|agonist:fMLF|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606 intact-crc:EB818B4E2CEB6C19|rigid:QoiiN/EmqMTFZAzfsEgok7GecPE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:O15264 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-2116951|uniprotkb:O14739|uniprotkb:O15124|uniprotkb:Q9UNU0|uniprotkb:Q6FI46|uniprotkb:Q5U4A5|ensembl:ENSP00000211287 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:mk13_human(display_long)|uniprotkb:MAPK13(gene name)|psi-mi:MAPK13(display_short)|uniprotkb:PRKM13(gene name synonym)|uniprotkb:SAPK4(gene name synonym)|uniprotkb:Stress-activated protein kinase 4(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 delta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253881|imex:IM-17613-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_002745.1|ensembl:ENSG00000156711(gene)|ensembl:ENST00000211287(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0072740"(cellular response to anisomycin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038785|rcsb pdb:3COI|rcsb pdb:4EYJ|rcsb pdb:4EYM|rcsb pdb:4MYG|rcsb pdb:4YNO|rcsb pdb:5EKN|rcsb pdb:5EKO|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-376172|reactome:R-HSA-4420097 - - - figure legend:Fig. 7G.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:ESdnKcoE9u2TK5ixHx7fr2p3MFc9606 intact-crc:80A8BAEA3181DC72|rigid:JtONBaGEBIZV8Bcs40Jz6HHX06g false mutation disrupting interaction:342-342|flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:P25098 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253881|imex:IM-17613-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse) - - - figure legend:Fig. 7G.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606 intact-crc:80A8BAEA3181DC72|rigid:JtONBaGEBIZV8Bcs40Jz6HHX06g false mutation disrupting interaction:342-342|flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:P27361 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253890|imex:IM-17613-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species) - - - figure legend:Fig. S8C.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606 intact-crc:0CDF3DB0016AFDE3|rigid:9HyB1sa/lIhEwJ3gXUmtw7VOHUw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:P25098 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253907|imex:IM-17613-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse) - - - figure legend:Fig. S7C.|agonist:fMLF|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606 intact-crc:CEB2E8D273E5A110|rigid:QoiiN/EmqMTFZAzfsEgok7GecPE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21462 uniprotkb:O15264 intact:EBI-2869495|uniprotkb:Q14939|uniprotkb:Q7Z6A4|uniprotkb:Q86U52|uniprotkb:Q9NS48|ensembl:ENSP00000302707|ensembl:ENSP00000471493 intact:EBI-2116951|uniprotkb:O14739|uniprotkb:O15124|uniprotkb:Q9UNU0|uniprotkb:Q6FI46|uniprotkb:Q5U4A5|ensembl:ENSP00000211287 psi-mi:fpr1_human(display_long)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:N-formyl peptide receptor(gene name synonym)|uniprotkb:N-formylpeptide chemoattractant receptor(gene name synonym) psi-mi:mk13_human(display_long)|uniprotkb:MAPK13(gene name)|psi-mi:MAPK13(display_short)|uniprotkb:PRKM13(gene name synonym)|uniprotkb:SAPK4(gene name synonym)|uniprotkb:Stress-activated protein kinase 4(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 delta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2012) imex:IM-17613|pubmed:22447027 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0974"(InnateDB) intact:EBI-6253902|imex:IM-17613-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180235.1|refseq:NP_002020.1|ensembl:ENSG00000171051(gene)|ensembl:ENST00000304748(transcript)|ensembl:ENST00000595042(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004982"(N-formyl peptide receptor activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027345|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-6783783|reactome:R-HSA-6798695|interpro:IPR000826(Formyl/methionyl peptide receptor) refseq:NP_002745.1|ensembl:ENSG00000156711(gene)|ensembl:ENST00000211287(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0072740"(cellular response to anisomycin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038785|rcsb pdb:3COI|rcsb pdb:4EYJ|rcsb pdb:4EYM|rcsb pdb:4MYG|rcsb pdb:4YNO|rcsb pdb:5EKN|rcsb pdb:5EKO|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-376172|reactome:R-HSA-4420097 - - - figure legend:Fig. S7B.|agonist:fMLF|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2012/07/25 2014/10/16 rogid:x2eLQFr7xe8Y0Vt7g55kMwqV/9o9606 rogid:ESdnKcoE9u2TK5ixHx7fr2p3MFc9606 intact-crc:EB92CCA318B26AFB|rigid:Ct7Ea1XF+ylv8AqAYNzVRvZRf/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)