#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23443	uniprotkb:P08151	intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6092649|imex:IM-17321-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig 2A|agonist:TNF-alpha,  no interactions were found between Gli1 and mTOR pathway components in the absence of TNFalpha.|antagonist:Rapamycin|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skgt4)|taxid:9606(Human SKGT4)	-	2012/04/12	2014/10/16	rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:8740C1A48366B1AE|rigid:2SVJrI3OQaNB4jDUO9FuZ+3PziU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23443	uniprotkb:P08151	intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6092655|imex:IM-17321-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig   S2A|agonist:TNF-alpha,  no interactions were found between Gli1 and mTOR pathway components in the absence of TNFalpha.|antagonist:Rapamycin|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skgt4)|taxid:9606(Human SKGT4)	-	2012/04/12	2014/10/16	rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:0F4AFC283A00573C|rigid:2SVJrI3OQaNB4jDUO9FuZ+3PziU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23443-2	uniprotkb:P08151	intact:EBI-6093204	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:p23443-2(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6092675|imex:IM-17321-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1775921(isoform-parent)|uniprotkb:P23443-2(isoform-parent)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig  2B|antagonist:"Rapamycin could inhibit the activity of S6K1, but not that of  (constitutively activated) S6K1T389E."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:94A65Rjqrfodwc+1my5vsEwCvVc9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:105CE11F69A14C65|rigid:MSceaj9k6QchsrnkposB+YFn1QI	false	ha tag:?-?|mutation disrupting interaction:389-389|mutation increasing interaction:389-389	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08151	uniprotkb:Q9UMX1	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093362|imex:IM-17321-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Fig S5K|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:C5ACC3ED5B0F428E|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08151	uniprotkb:Q9UMX1	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093346|imex:IM-17321-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Fig  5F|agonist:Rapamycin|antagonist:TNF-alpha  and S6K1.|comment:Both TNF-a  treatment and S6K1 ectopic expression decreased the binding between SuFu and Gli1, which was fully reversed by rapamycin.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:52BE203D9BEB91AF|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UMX1	uniprotkb:P08151	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093334|imex:IM-17321-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig  5E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:8D5B50D2527A5E4D|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	-	mutation decreasing interaction:84-84	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23443	uniprotkb:P08151	intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6092661|imex:IM-17321-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig  S2A|agonist:TNF-alpha,  no interactions were found between Gli1 and mTOR pathway components in the absence of TNFalpha.|antagonist:Rapamycin|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:EED60C80D54B8020|rigid:2SVJrI3OQaNB4jDUO9FuZ+3PziU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23443	uniprotkb:P08151	intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6092634|imex:IM-17321-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig 2A|agonist:TNF-alpha,  no interactions were found between Gli1 and mTOR pathway components in the absence of TNFalpha.|antagonist:Rapamycin|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:35C141F87592A752|rigid:2SVJrI3OQaNB4jDUO9FuZ+3PziU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08151	uniprotkb:Q9UMX1	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093326|imex:IM-17321-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Fig  5E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:5EC8C342165A5C8F|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UMX1	uniprotkb:P08151	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093355|imex:IM-17321-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig S5K|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-be3)|taxid:9606(Human BE3-esophageal adenocarcinoma cell line)	-	2012/04/12	2014/10/16	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:9F5AC72EB291538B|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	-	mutation decreasing interaction:84-84|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08151	uniprotkb:P23443-2	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-6093204	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:p23443-2(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2012)	imex:IM-17321|pubmed:22439934	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6093306|imex:IM-17321-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	intact:EBI-1775921(isoform-parent)|uniprotkb:P23443-2(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig  3B, 3D|antagonist:"Rapamycin could inhibit the activity of S6K1, but not that of  (constitutively activated) S6K1T389E."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/12	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:94A65Rjqrfodwc+1my5vsEwCvVc9606	intact-crc:D5DA7FD435651532|rigid:MSceaj9k6QchsrnkposB+YFn1QI	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:84-84|sufficient binding region:1-500	mutation disrupting interaction:389-389|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)