#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UNA0	uniprotkb:P13608	intact:EBI-2808663|ensembl:ENSP00000284987|uniprotkb:Q9UKP2|uniprotkb:Q52LV4	intact:EBI-6259246|uniprotkb:P79117|uniprotkb:Q28159|uniprotkb:Q6XL66	psi-mi:ats5_human(display_long)|uniprotkb:ADAMTS5(gene name)|psi-mi:ADAMTS5(display_short)|uniprotkb:ADAMTS11(gene name synonym)|uniprotkb:ADMP2(gene name synonym)|uniprotkb:A disintegrin and metalloproteinase with thrombospondin motifs 11(gene name synonym)|uniprotkb:ADMP-2(gene name synonym)|uniprotkb:Aggrecanase-2(gene name synonym)	psi-mi:pgca_bovin(display_long)|uniprotkb:ACAN(gene name)|psi-mi:ACAN(display_short)|uniprotkb:AGC1(gene name synonym)|uniprotkb:Cartilage-specific proteoglycan core protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Lo et al. (2012)	pubmed:22406378|imex:IM-17886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6259245|imex:IM-17886-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154736(gene)|ensembl:ENST00000284987(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0044691"(tooth eruption)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR013276(Peptidase M12B, ADAM-TS5)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2RJQ|rcsb pdb:3B8Z|rcsb pdb:3HY7|rcsb pdb:3HY9|rcsb pdb:3HYG|rcsb pdb:3LJT|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|rcsb pdb:6YJM|refseq:NP_008969.2	go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|refseq:NP_776406.1|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179	go:"GO:0004222"(metalloendopeptidase activity)	-	-	figure legend:1A, 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/01	2014/10/16	rogid:J+ZTdYjh2OrzLQM4ZUXxbyKaPHo9606	rogid:N8c0q0eezpnE88oNvhte/CjBm1Y9913	intact-crc:F720413B55DDD847|rigid:bbUIYOXi5zrimqv4z1fUOqi0N5E	false	sufficient binding region:17-863|flag tag:c-c	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9UNA0	uniprotkb:P13608	intact:EBI-2808663|ensembl:ENSP00000284987|uniprotkb:Q9UKP2|uniprotkb:Q52LV4	intact:EBI-6259246|uniprotkb:P79117|uniprotkb:Q28159|uniprotkb:Q6XL66	psi-mi:ats5_human(display_long)|uniprotkb:ADAMTS5(gene name)|psi-mi:ADAMTS5(display_short)|uniprotkb:ADAMTS11(gene name synonym)|uniprotkb:ADMP2(gene name synonym)|uniprotkb:A disintegrin and metalloproteinase with thrombospondin motifs 11(gene name synonym)|uniprotkb:ADMP-2(gene name synonym)|uniprotkb:Aggrecanase-2(gene name synonym)	psi-mi:pgca_bovin(display_long)|uniprotkb:ACAN(gene name)|psi-mi:ACAN(display_short)|uniprotkb:AGC1(gene name synonym)|uniprotkb:Cartilage-specific proteoglycan core protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Lo et al. (2012)	pubmed:22406378|imex:IM-17886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6259296|imex:IM-17886-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154736(gene)|ensembl:ENST00000284987(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0044691"(tooth eruption)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR013276(Peptidase M12B, ADAM-TS5)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2RJQ|rcsb pdb:3B8Z|rcsb pdb:3HY7|rcsb pdb:3HY9|rcsb pdb:3HYG|rcsb pdb:3LJT|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|rcsb pdb:6YJM|refseq:NP_008969.2	go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|refseq:NP_776406.1|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179	go:"GO:0008191"(metalloendopeptidase inhibitor activity)	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/01	2014/10/16	rogid:J+ZTdYjh2OrzLQM4ZUXxbyKaPHo9606	rogid:N8c0q0eezpnE88oNvhte/CjBm1Y9913	intact-crc:D36D03A2BE2D47B9|rigid:3Vbxg6hVbRScDKq24vi6yrUV86k	false	flag tag:c-c|sufficient binding region:17-863	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9UNA0	uniprotkb:P35625	intact:EBI-2808663|ensembl:ENSP00000284987|uniprotkb:Q9UKP2|uniprotkb:Q52LV4	intact:EBI-1748085|uniprotkb:Q5THV4|uniprotkb:Q9UC74|uniprotkb:Q9UGS2|uniprotkb:B2RBY9|ensembl:ENSP00000266085	psi-mi:ats5_human(display_long)|uniprotkb:ADAMTS5(gene name)|psi-mi:ADAMTS5(display_short)|uniprotkb:ADAMTS11(gene name synonym)|uniprotkb:ADMP2(gene name synonym)|uniprotkb:A disintegrin and metalloproteinase with thrombospondin motifs 11(gene name synonym)|uniprotkb:ADMP-2(gene name synonym)|uniprotkb:Aggrecanase-2(gene name synonym)	psi-mi:timp3_human(display_long)|uniprotkb:TIMP3(gene name)|psi-mi:TIMP3(display_short)|uniprotkb:Tissue inhibitor of metalloproteinases 3(gene name synonym)|uniprotkb:Protein MIG-5(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Lo et al. (2012)	pubmed:22406378|imex:IM-17886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6259296|imex:IM-17886-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154736(gene)|ensembl:ENST00000284987(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0044691"(tooth eruption)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR013276(Peptidase M12B, ADAM-TS5)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2RJQ|rcsb pdb:3B8Z|rcsb pdb:3HY7|rcsb pdb:3HY9|rcsb pdb:3HYG|rcsb pdb:3LJT|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|rcsb pdb:6YJM|refseq:NP_008969.2	refseq:NP_000353.1|ensembl:ENSG00000100234(gene)|ensembl:ENST00000266085(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007601"(visual perception)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0046872"(metal ion binding)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015612(Tissue inhibitor of metalloprotease 3)|interpro:IPR027465|interpro:IPR030490|rcsb pdb:3CKI|reactome:R-HSA-114608	go:"GO:0008191"(metalloendopeptidase inhibitor activity)	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/01	2014/10/16	rogid:J+ZTdYjh2OrzLQM4ZUXxbyKaPHo9606	rogid:PlxF7dY2tocdVIVz1s5j14mViqY9606	intact-crc:D36D03A2BE2D47B9|rigid:3Vbxg6hVbRScDKq24vi6yrUV86k	false	flag tag:c-c|sufficient binding region:17-863	his tag:c-c|sufficient binding region:1-121	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)