#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:G5EBV0	uniprotkb:Q93244	intact:EBI-2004151|intact:EBI-2316422|uniprotkb:G5ECV8|uniprotkb:G5EE79|uniprotkb:G5EEP8|uniprotkb:Q56W01|ensemblmetazoa:F22E12.4a.1|ensemblmetazoa:F22E12.4a.2	intact:EBI-2413537|ensemblmetazoa:C17G1.7.1	psi-mi:egl9_caeel(display_long)|uniprotkb:egl-9(gene name)|psi-mi:egl-9(display_short)|uniprotkb:Egg-laying defective protein 9(gene name synonym)|uniprotkb:Hypoxia-inducible factor-proline dioxygenase(gene name synonym)|uniprotkb:F22E12.4(orf name)	psi-mi:cysk1_caeel(display_long)|uniprotkb:cysl-1(gene name)|psi-mi:cysl-1(display_short)|uniprotkb:"O-acetylserine (thiol)-lyase 1"(gene name synonym)|uniprotkb:C17G1.7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2012)	pubmed:22405203|imex:IM-18011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6391190|imex:IM-18011-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023832.1|refseq:NP_001023833.1|refseq:NP_001023834.1|refseq:NP_001041105.1|uniprotkb:Q565A4(uniprot-removed-ac)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|refseq:NP_741621.1|wormbase:F22E12.4a|wormbase:F22E12.4b|wormbase:F22E12.4c|wormbase:F22E12.4e|wormbase:F22E12.4d|reactome:R-CEL-1234176|ensemblmetazoa:F22E12.4a.1(transcript)|ensemblmetazoa:F22E12.4a.2(transcript)|ensemblmetazoa:WBGene00001178(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071456"(cellular response to hypoxia)	refseq:NP_509670.2|wormbase:C17G1.7|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|ensemblmetazoa:C17G1.7.1(transcript)|ensemblmetazoa:WBGene00007653(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055120"(striated muscle dense body)	-	-	-	figure legend:Figure 6.|agonist:Hydrogen sulphide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2012/11/14	2015/07/17	rogid:a4HDpatGkHrKY66dCfsWuAsoOw46239	rogid:4TucT8+ATkVzBI/Ir0Hfs9OGRqU6239	intact-crc:0CD20F3FCE9D22B6|rigid:rzibT4o1uuf9iudPOUNZIsSwgiA	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93244	uniprotkb:G5EBV0	intact:EBI-2413537|ensemblmetazoa:C17G1.7.1	intact:EBI-2004151|intact:EBI-2316422|uniprotkb:G5ECV8|uniprotkb:G5EE79|uniprotkb:G5EEP8|uniprotkb:Q56W01|ensemblmetazoa:F22E12.4a.1|ensemblmetazoa:F22E12.4a.2	psi-mi:cysk1_caeel(display_long)|uniprotkb:cysl-1(gene name)|psi-mi:cysl-1(display_short)|uniprotkb:"O-acetylserine (thiol)-lyase 1"(gene name synonym)|uniprotkb:C17G1.7(orf name)	psi-mi:egl9_caeel(display_long)|uniprotkb:egl-9(gene name)|psi-mi:egl-9(display_short)|uniprotkb:Egg-laying defective protein 9(gene name synonym)|uniprotkb:Hypoxia-inducible factor-proline dioxygenase(gene name synonym)|uniprotkb:F22E12.4(orf name)	psi-mi:"MI:0018"(two hybrid)	Ma et al. (2012)	pubmed:22405203|imex:IM-18011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6391340|imex:IM-18011-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_509670.2|wormbase:C17G1.7|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|ensemblmetazoa:C17G1.7.1(transcript)|ensemblmetazoa:WBGene00007653(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055120"(striated muscle dense body)	refseq:NP_001023832.1|refseq:NP_001023833.1|refseq:NP_001023834.1|refseq:NP_001041105.1|uniprotkb:Q565A4(uniprot-removed-ac)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|refseq:NP_741621.1|wormbase:F22E12.4a|wormbase:F22E12.4b|wormbase:F22E12.4c|wormbase:F22E12.4e|wormbase:F22E12.4d|reactome:R-CEL-1234176|ensemblmetazoa:F22E12.4a.1(transcript)|ensemblmetazoa:F22E12.4a.2(transcript)|ensemblmetazoa:WBGene00001178(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071456"(cellular response to hypoxia)	-	-	-	figure legend:"Figure 6. CYSL-1 Interaction with EGL-9 Mediates H2S Signaling to HIF-1 and Behavioral Plasticity..........(C) Yeast two-hybrid assays with colony growth on selective plates (SD/-LEU/-TRP, or SD/-LEU/-TRP/-HIS3/-ADE) after cotransformation of cysl-1 prey constructs and various egl-9 bait constructs. The growth with vector-only control group, i.e., pGADT7 with egl-9-C-terminal, indicates non-specific reporter activation. All egl-9 constructs lack the N-terminal domain, which conferred moderate non-specific reporter activation. Note the specific association of CYSL-1 with EGL-9 with an intact C terminus but not with n5535 or n5539 mutant EGL-9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/11/14	2015/07/17	rogid:4TucT8+ATkVzBI/Ir0Hfs9OGRqU6239	rogid:a4HDpatGkHrKY66dCfsWuAsoOw46239	intact-crc:9904C5223020945E|rigid:rzibT4o1uuf9iudPOUNZIsSwgiA	false	-	mutation disrupting interaction strength:720-720|necessary binding region:719-723	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q93244	uniprotkb:G5EBV0	intact:EBI-2413537|ensemblmetazoa:C17G1.7.1	intact:EBI-2004151|intact:EBI-2316422|uniprotkb:G5ECV8|uniprotkb:G5EE79|uniprotkb:G5EEP8|uniprotkb:Q56W01|ensemblmetazoa:F22E12.4a.1|ensemblmetazoa:F22E12.4a.2	psi-mi:cysk1_caeel(display_long)|uniprotkb:cysl-1(gene name)|psi-mi:cysl-1(display_short)|uniprotkb:"O-acetylserine (thiol)-lyase 1"(gene name synonym)|uniprotkb:C17G1.7(orf name)	psi-mi:egl9_caeel(display_long)|uniprotkb:egl-9(gene name)|psi-mi:egl-9(display_short)|uniprotkb:Egg-laying defective protein 9(gene name synonym)|uniprotkb:Hypoxia-inducible factor-proline dioxygenase(gene name synonym)|uniprotkb:F22E12.4(orf name)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Ma et al. (2012)	pubmed:22405203|imex:IM-18011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6393995|imex:IM-18011-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0495"(experimental role)	psi-mi:"MI:0495"(experimental role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_509670.2|wormbase:C17G1.7|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|ensemblmetazoa:C17G1.7.1(transcript)|ensemblmetazoa:WBGene00007653(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055120"(striated muscle dense body)	refseq:NP_001023832.1|refseq:NP_001023833.1|refseq:NP_001023834.1|refseq:NP_001041105.1|uniprotkb:Q565A4(uniprot-removed-ac)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|refseq:NP_741621.1|wormbase:F22E12.4a|wormbase:F22E12.4b|wormbase:F22E12.4c|wormbase:F22E12.4e|wormbase:F22E12.4d|reactome:R-CEL-1234176|ensemblmetazoa:F22E12.4a.1(transcript)|ensemblmetazoa:F22E12.4a.2(transcript)|ensemblmetazoa:WBGene00001178(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071456"(cellular response to hypoxia)	-	-	-	figure legend:Figures S7A–S7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/14	2015/07/17	rogid:4TucT8+ATkVzBI/Ir0Hfs9OGRqU6239	rogid:a4HDpatGkHrKY66dCfsWuAsoOw46239	intact-crc:DF47C6424267EF0D|rigid:rzibT4o1uuf9iudPOUNZIsSwgiA	false	-	sufficient binding region:720-723|mutation decreasing interaction strength:723-723|mutation decreasing interaction strength:720-720	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q93244	uniprotkb:Q93244	intact:EBI-2413537|ensemblmetazoa:C17G1.7.1	intact:EBI-2413537|ensemblmetazoa:C17G1.7.1	psi-mi:cysk1_caeel(display_long)|uniprotkb:cysl-1(gene name)|psi-mi:cysl-1(display_short)|uniprotkb:"O-acetylserine (thiol)-lyase 1"(gene name synonym)|uniprotkb:C17G1.7(orf name)	psi-mi:cysk1_caeel(display_long)|uniprotkb:cysl-1(gene name)|psi-mi:cysl-1(display_short)|uniprotkb:"O-acetylserine (thiol)-lyase 1"(gene name synonym)|uniprotkb:C17G1.7(orf name)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Ma et al. (2012)	pubmed:22405203|imex:IM-18011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6394421|imex:IM-18011-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_509670.2|wormbase:C17G1.7|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|ensemblmetazoa:C17G1.7.1(transcript)|ensemblmetazoa:WBGene00007653(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055120"(striated muscle dense body)	refseq:NP_509670.2|wormbase:C17G1.7|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|ensemblmetazoa:C17G1.7.1(transcript)|ensemblmetazoa:WBGene00007653(gene)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055120"(striated muscle dense body)	-	-	-	figure legend:Supp. Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2012/11/14	2014/10/16	rogid:4TucT8+ATkVzBI/Ir0Hfs9OGRqU6239	rogid:4TucT8+ATkVzBI/Ir0Hfs9OGRqU6239	intact-crc:E774F0A4107C954C|rigid:Ot0e1UpX2lL9k4X7Io9QGJZSXDw	false	-	-	2	0	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)