#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43157	uniprotkb:O00212	intact:EBI-1111488|uniprotkb:Q6NY20|uniprotkb:Q9UIV7|uniprotkb:Q9UJ92|uniprotkb:Q9UJ93|uniprotkb:A6H8Y2|ensembl:ENSP00000296440|ensembl:ENSP00000351338	intact:EBI-3918631|ensembl:ENSP00000308576	psi-mi:plxb1_human(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym)|uniprotkb:PLXN5(gene name synonym)	psi-mi:rhod_human(display_long)|uniprotkb:RHOD(gene name)|psi-mi:RHOD(display_short)|uniprotkb:ARHD(gene name synonym)|uniprotkb:Rho-related protein HP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6092467|imex:IM-17370-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2JPH|rcsb pdb:2OS6|rcsb pdb:2R2O|rcsb pdb:2REX|rcsb pdb:3HM6|rcsb pdb:3OL2|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:5B4W|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|refseq:NP_001123554.1|refseq:NP_002664.2|ensembl:ENSG00000164050(gene)|ensembl:ENST00000296440(transcript)|ensembl:ENST00000358536(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:O43157|refseq:XP_016862120.1|dip:DIP-36742N	ensembl:ENSG00000173156(gene)|ensembl:ENST00000308831(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR027417|rcsb pdb:2J1L|reactome:R-HSA-5663220|reactome:R-HSA-9013405|interpro:IPR005225(Small GTP-binding protein)|refseq:NP_055393.1	-	-	-	figure legend:fig.1a|comment:"Interactions were observed only using constitutively active (G26V)  RhoD-myc."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/13	2014/10/16	rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606	rogid:tfbt/6dhQwIrWhNcSRuDwIVjYbA9606	intact-crc:1ACE245B450C4567|rigid:K2br4hBzu+IciXFZe4H0200l0ro	false	sufficient binding region:1512-2135|glutathione s tranferase tag:?-?|mutation increasing interaction:1795-1795|mutation increasing interaction:1697-1697	myc tag:?-?|mutation disrupting interaction:31-31|mutation:26-26	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8C6B2	uniprotkb:P61586	intact:EBI-1162441|uniprotkb:Q61192|uniprotkb:Q8VIG7|uniprotkb:E9QM24|ensembl:ENSMUSP00000065571	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	psi-mi:rtkn_mouse(display_long)|uniprotkb:Rtkn(gene name)|psi-mi:Rtkn(display_short)	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6128863|imex:IM-17370-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0031106"(septin ring organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR012966(Protein of unknown function DUF1709, fungi)|interpro:IPR030471|reactome:R-MMU-5666185|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|ensembl:ENSMUSG00000034930(gene)|ensembl:ENSMUST00000065512(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005826"(actomyosin contractile ring)|refseq:NP_001129699.1|refseq:NP_033132.2|refseq:NP_598396.2|dip:DIP-29983N	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	-	-	-	figure legend:fig. 3b|comment:Thr1697Ala or Thr1795Ala or Leu1815Pro mutant forms of Plexin B1 activate Rho to a similar extent as the WT form of PlexinB1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/13	2016/08/15	rogid:O0Nil3ml3d/RyrJzS/4fu1G/KYI10090	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	intact-crc:B9FA06E9C0629EC7	false	sufficient binding region:36..36-99..99(IPR011072)|glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:15996"	uniprotkb:Q8C6B2	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-1162441|uniprotkb:Q61192|uniprotkb:Q8VIG7|uniprotkb:E9QM24|ensembl:ENSMUSP00000065571	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rtkn_mouse(display_long)|uniprotkb:Rtkn(gene name)|psi-mi:Rtkn(display_short)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6128863|imex:IM-17370-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0031106"(septin ring organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR012966(Protein of unknown function DUF1709, fungi)|interpro:IPR030471|reactome:R-MMU-5666185|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|ensembl:ENSMUSG00000034930(gene)|ensembl:ENSMUST00000065512(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005826"(actomyosin contractile ring)|refseq:NP_001129699.1|refseq:NP_033132.2|refseq:NP_598396.2|dip:DIP-29983N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:fig. 3b|comment:Thr1697Ala or Thr1795Ala or Leu1815Pro mutant forms of Plexin B1 activate Rho to a similar extent as the WT form of PlexinB1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/13	2016/08/15	-	rogid:O0Nil3ml3d/RyrJzS/4fu1G/KYI10090	intact-crc:B9FA06E9C0629EC7	false	-	sufficient binding region:36..36-99..99(IPR011072)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43157	uniprotkb:O09126	intact:EBI-1111488|uniprotkb:Q6NY20|uniprotkb:Q9UIV7|uniprotkb:Q9UJ92|uniprotkb:Q9UJ93|uniprotkb:A6H8Y2|ensembl:ENSP00000296440|ensembl:ENSP00000351338	intact:EBI-6092508|uniprotkb:Q6GTM9|ensembl:ENSMUSP00000021900|ensembl:ENSMUSP00000105666|ensembl:ENSMUSP00000105667	psi-mi:plxb1_human(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym)|uniprotkb:PLXN5(gene name synonym)	psi-mi:sem4d_mouse(display_long)|uniprotkb:Sema4d(gene name)|psi-mi:Sema4d(display_short)|uniprotkb:Semacl2(gene name synonym)|uniprotkb:Semaj(gene name synonym)|uniprotkb:M-Sema G(gene name synonym)|uniprotkb:Semaphorin-C-like 2(gene name synonym)|uniprotkb:Semaphorin-J(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6092506|imex:IM-17370-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2JPH|rcsb pdb:2OS6|rcsb pdb:2R2O|rcsb pdb:2REX|rcsb pdb:3HM6|rcsb pdb:3OL2|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:5B4W|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|refseq:NP_001123554.1|refseq:NP_002664.2|ensembl:ENSG00000164050(gene)|ensembl:ENST00000296440(transcript)|ensembl:ENST00000358536(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:O43157|refseq:XP_016862120.1|dip:DIP-36742N	refseq:NP_001268809.1|refseq:NP_038688.2|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031344"(regulation of cell projection organization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0070486"(leukocyte aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1905704"(positive regulation of inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|reactome:R-MMU-416550|reactome:R-MMU-416572|reactome:R-MMU-416700|ensembl:ENSMUSG00000021451(gene)|ensembl:ENSMUST00000021900(transcript)|ensembl:ENSMUST00000110039(transcript)|ensembl:ENSMUST00000110040(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)	-	-	-	figure legend:fig. 2d|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/04/13	2014/10/16	rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606	rogid:/CPfiejOa7dBlIs4aS0bAqpuvBI10090	intact-crc:72C4F3D4CA7DA5B0|rigid:ogi7CYyxWQRU8ou+BaUfIkafXMM	false	vsv tag:?-?	fc-igg tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43157	uniprotkb:O15085	intact:EBI-1111488|uniprotkb:Q6NY20|uniprotkb:Q9UIV7|uniprotkb:Q9UJ92|uniprotkb:Q9UJ93|uniprotkb:A6H8Y2|ensembl:ENSP00000296440|ensembl:ENSP00000351338	intact:EBI-311099|intact:EBI-28988539|ensembl:ENSP00000354644|uniprotkb:Q5VY40|uniprotkb:D3DVD0|uniprotkb:Q6PFW2	psi-mi:plxb1_human(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym)|uniprotkb:PLXN5(gene name synonym)	psi-mi:arhgb_human(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6092556|imex:IM-17370-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2JPH|rcsb pdb:2OS6|rcsb pdb:2R2O|rcsb pdb:2REX|rcsb pdb:3HM6|rcsb pdb:3OL2|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:5B4W|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|refseq:NP_001123554.1|refseq:NP_002664.2|ensembl:ENSG00000164050(gene)|ensembl:ENST00000296440(transcript)|ensembl:ENST00000358536(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:O43157|refseq:XP_016862120.1|dip:DIP-36742N	ensembl:ENSG00000132694(gene)|ensembl:ENST00000361409(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_055599.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|rcsb pdb:1HTJ|rcsb pdb:1XCG|rcsb pdb:2DLS|rcsb pdb:3KZ1|rcsb pdb:3T06|rcsb pdb:5E6P|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5TYT|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_937879.1|ensembl:ENSP00000354644|ensembl:ENST00000368194|ensembl:ENSP00000357177|dip:DIP-31622N	-	-	-	figure legend:fig. 3a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/04/13	2014/10/16	rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606	rogid:1xhgHWC/U14RFSWNJmZudD2/DdQ9606	intact-crc:D6A3A45BF5CFEA72|rigid:uBb12BABeT0+2oRE/3P9xPQ5SNg	false	vsv tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43157	uniprotkb:P04626	intact:EBI-1111488|uniprotkb:Q6NY20|uniprotkb:Q9UIV7|uniprotkb:Q9UJ92|uniprotkb:Q9UJ93|uniprotkb:A6H8Y2|ensembl:ENSP00000296440|ensembl:ENSP00000351338	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:plxb1_human(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym)|uniprotkb:PLXN5(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6092574|imex:IM-17370-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2JPH|rcsb pdb:2OS6|rcsb pdb:2R2O|rcsb pdb:2REX|rcsb pdb:3HM6|rcsb pdb:3OL2|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:5B4W|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|refseq:NP_001123554.1|refseq:NP_002664.2|ensembl:ENSG00000164050(gene)|ensembl:ENST00000296440(transcript)|ensembl:ENST00000358536(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:O43157|refseq:XP_016862120.1|dip:DIP-36742N	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	-	-	-	figure legend:fig. 4a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/04/13	2014/10/16	rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:3A4F62A1435D752A|rigid:CZAj9puVbUlPS2mhDPOXoDtvBmI	false	vsv tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43157	uniprotkb:P08581	intact:EBI-1111488|uniprotkb:Q6NY20|uniprotkb:Q9UIV7|uniprotkb:Q9UJ92|uniprotkb:Q9UJ93|uniprotkb:A6H8Y2|ensembl:ENSP00000296440|ensembl:ENSP00000351338	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	psi-mi:plxb1_human(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym)|uniprotkb:PLXN5(gene name synonym)	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2012)	pubmed:22404908|imex:IM-17370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-6092580|imex:IM-17370-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2JPH|rcsb pdb:2OS6|rcsb pdb:2R2O|rcsb pdb:2REX|rcsb pdb:3HM6|rcsb pdb:3OL2|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:5B4W|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|refseq:NP_001123554.1|refseq:NP_002664.2|ensembl:ENSG00000164050(gene)|ensembl:ENST00000296440(transcript)|ensembl:ENST00000358536(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:O43157|refseq:XP_016862120.1|dip:DIP-36742N	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N	-	-	-	figure legend:fig. 4b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/04/13	2014/10/16	rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	intact-crc:1ECF7D3CD8BC43E2|rigid:hIFwywrlfd6R9gv5USlRjAjHNGE	false	vsv tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)