#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02994 uniprotkb:P16521 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-6338|uniprotkb:O93815|uniprotkb:Q06558|uniprotkb:D6VYP7|ensemblfungi:YLR249W psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:ef3a_yeast(display_long)|uniprotkb:YEF3(gene name)|psi-mi:YEF3(display_short)|uniprotkb:EFC1(gene name synonym)|uniprotkb:TEF3(gene name synonym)|uniprotkb:Translation elongation factor 3A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 3(gene name synonym)|uniprotkb:Yeast elongation factor 3(gene name synonym)|uniprotkb:YEF3A(gene name synonym)|uniprotkb:L9672.5(orf name)|uniprotkb:YLR249W(locus name) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) refseq:NP_013350.1|sgd:S000004239|mint:P16521|dip:DIP-2249N|ensemblfungi:YLR249W(gene)|ensemblfungi:YLR249W_mRNA(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005840"(ribosome)|go:"GO:0006414"(translational elongation)|go:"GO:0006415"(translational termination)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015688(Elongation Factor 3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017871|interpro:IPR021133|interpro:IPR027417|interpro:IPR040533|rcsb pdb:2IW3|rcsb pdb:2IWH|rcsb pdb:2IX3|rcsb pdb:2IX8|rcsb pdb:7B7D|mint:MINT-8309454(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 crc64:41E40B8BDD7A4C33 figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:k0wEVxeuDrrQ2RFCCu+qMtiSvA8559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:P33892 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-7442|uniprotkb:D6VTV8|ensemblfungi:YGL195W psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:gcn1_yeast(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:General control non-derepressible protein 1(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)|uniprotkb:G1318(orf name)|uniprotkb:YGL195W(locus name) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) sgd:S000003163|refseq:NP_011320.3|mint:P33892|dip:DIP-2344N|ensemblfungi:YGL195W(gene)|ensemblfungi:YGL195W_mRNA(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR022716|interpro:IPR033173|interpro:IPR034085|mint:MINT-8309452(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 crc64:980FDD03753E9D1C figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:WPYtEB/xjy4g2cJFwhe+2teVYVk559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:P15442 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-330|uniprotkb:D6VSR3|ensemblfungi:YDR283C psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:gcn2_yeast(display_long)|uniprotkb:GCN2(gene name)|psi-mi:GCN2(display_short)|uniprotkb:AAS1(gene name synonym)|uniprotkb:General control non-derepressible protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase GCN2(gene name synonym)|uniprotkb:YDR283C(locus name) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) sgd:S000002691|refseq:NP_010569.3|dip:DIP-2346N|ensemblfungi:YDR283C(gene)|ensemblfungi:YDR283C_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|mint:P15442|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043621"(protein self-association)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071232"(cellular response to histidine)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1903833"(positive regulation of cellular response to amino acid starvation)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR000719(Protein kinase, core)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:1ZXE|rcsb pdb:1ZY4|rcsb pdb:1ZY5|rcsb pdb:1ZYC|rcsb pdb:1ZYD|rcsb pdb:2YZ0|rcsb pdb:4OTM|mint:MINT-8309453(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 crc64:1F56E4B046D52325 figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:d8fcrr70iKA6pK9Z4yqMQsPTAWI559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:Q03768 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-7618|uniprotkb:D6VSD4|ensemblfungi:YDR152W psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:gir2_yeast(display_long)|uniprotkb:GIR2(gene name)|psi-mi:GIR2(display_short)|uniprotkb:YDR152W(locus name)|uniprotkb:YD8358.08(orf name)|uniprotkb:DFRP2(gene name synonym)|uniprotkb:DRG family-regulatory protein 2(gene name synonym)|uniprotkb:Genetically interacts with ribosomal genes protein 2(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) sgd:S000002559|refseq:NP_010436.3|mint:Q03768|dip:DIP-1751N|ensemblfungi:YDR152W(gene)|ensemblfungi:YDR152W_mRNA(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1903833"(positive regulation of cellular response to amino acid starvation)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR040213|mint:MINT-8309456(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 crc64:CE09A067388638ED figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:2gb8Bf2IGl8RoOmNcIvEMlmgeTE559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:P20459 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2 psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N|mint:MINT-8309460(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 crc64:AF4F1C80303A4E98 figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:9/iGImP9/c8HSYwgmItME27z7lE559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:P04650 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-15360|uniprotkb:D6VW02|ensemblfungi:YJL189W psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:rl39_yeast(display_long)|uniprotkb:RPL39(gene name)|psi-mi:RPL39(display_short)|uniprotkb:RPL46(gene name synonym)|uniprotkb:SPB2(gene name synonym)|uniprotkb:YJL189W(locus name)|uniprotkb:J0360(orf name)|uniprotkb:L46(gene name synonym)|uniprotkb:YL40(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL39(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) refseq:NP_012346.1|sgd:S000003725|reactome:R-SCE-156827|reactome:R-SCE-72689|reactome:R-SCE-72706|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-1799339|ensemblfungi:YJL189W(gene)|ensemblfungi:YJL189W_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000077(Ribosomal protein L39e)|interpro:IPR020083|interpro:IPR023626|rcsb pdb:2WW9|rcsb pdb:2WWA|rcsb pdb:2WWB|rcsb pdb:3J6X|rcsb pdb:3J6Y|rcsb pdb:3J77|rcsb pdb:3J78|rcsb pdb:3JCT|rcsb pdb:4U3M|rcsb pdb:5MEI|rcsb pdb:5NDG|rcsb pdb:5NDV|rcsb pdb:5NDW|rcsb pdb:5OBM|rcsb pdb:5MC6|rcsb pdb:5ON6|rcsb pdb:5T62|rcsb pdb:5T6R|rcsb pdb:5TBW|rcsb pdb:5TGA|rcsb pdb:5TGM|rcsb pdb:6FT6|rcsb pdb:6GQ1|rcsb pdb:6GQB|rcsb pdb:6GQV|rcsb pdb:6HD7|rcsb pdb:6HHQ|rcsb pdb:6I7O|rcsb pdb:6M62|rcsb pdb:6N8J|rcsb pdb:6N8K|rcsb pdb:6N8L|rcsb pdb:6N8M|rcsb pdb:6N8N|rcsb pdb:6N8O|rcsb pdb:4U3U|rcsb pdb:4U4N|rcsb pdb:4U4O|rcsb pdb:4U4Q|rcsb pdb:4U4R|rcsb pdb:4U4U|rcsb pdb:4U4Y|rcsb pdb:4U4Z|rcsb pdb:4U50|rcsb pdb:4U51|rcsb pdb:4U52|rcsb pdb:4U53|rcsb pdb:4U55|rcsb pdb:4U56|rcsb pdb:4U6F|rcsb pdb:4V6I|rcsb pdb:4V7F|rcsb pdb:4V7R|rcsb pdb:4V88|rcsb pdb:4V8T|rcsb pdb:4V8Y|rcsb pdb:4V8Z|rcsb pdb:4V91|rcsb pdb:5APN|rcsb pdb:5APO|rcsb pdb:5DAT|rcsb pdb:5DC3|rcsb pdb:5DGE|rcsb pdb:5DGF|rcsb pdb:5DGV|rcsb pdb:5FCI|rcsb pdb:5FCJ|rcsb pdb:5FL8|rcsb pdb:5GAK|rcsb pdb:5H4P|rcsb pdb:5I4L|rcsb pdb:5IT7|rcsb pdb:5JCS|rcsb pdb:5JUO|rcsb pdb:5JUP|rcsb pdb:5JUS|rcsb pdb:5JUT|rcsb pdb:5JUU|rcsb pdb:5LYB|rcsb pdb:5M1J|rcsb pdb:4U3N|rcsb pdb:6OIG|rcsb pdb:6Q8Y|rcsb pdb:6QIK|rcsb pdb:6QT0|rcsb pdb:6QTZ|rcsb pdb:6R84|rcsb pdb:6R86|rcsb pdb:6R87|rcsb pdb:6RI5|rcsb pdb:6RZZ|rcsb pdb:6S05|rcsb pdb:6S47|rcsb pdb:6SNT|rcsb pdb:6SV4|rcsb pdb:6T4Q|rcsb pdb:6T7I|rcsb pdb:6T7T|rcsb pdb:6T83|rcsb pdb:6TB3|rcsb pdb:6TNU|rcsb pdb:6WOO|rcsb pdb:6XIQ|rcsb pdb:6XIR|rcsb pdb:6YLG|rcsb pdb:6YLH|rcsb pdb:6YLX|rcsb pdb:6YLY|rcsb pdb:6Z6J|rcsb pdb:6Z6K|rcsb pdb:7AZY|rcsb pdb:7B7D|rcsb pdb:7NRC|rcsb pdb:7NRD|dip:DIP-4522N|mint:MINT-8309457(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 - figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:IGlHTwfe8Zo174p/ay3cB8Sh7Ug559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02994 uniprotkb:P25637 intact:EBI-6314|uniprotkb:Q7Z7U8|uniprotkb:Q7Z8Q8|uniprotkb:Q7Z8Q9|uniprotkb:D6VQB6|ensemblfungi:YBR118W|ensemblfungi:YPR080W intact:EBI-21951|uniprotkb:D6VR64|ensemblfungi:YCR059C psi-mi:ef1a_yeast(display_long)|uniprotkb:TEF1(gene name)|psi-mi:TEF1(display_short)|uniprotkb:YPR080W(locus name)|uniprotkb:P9513.7(orf name)|uniprotkb:TEF2(gene name)|psi-mi:TEF2(display_short)|uniprotkb:YBR118W(locus name)|uniprotkb:YBR0913(orf name)|uniprotkb:Translation elongation factor 1A(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1A(gene name synonym) psi-mi:yih1_yeast(display_long)|uniprotkb:YCR59C(orf name)|uniprotkb:YCR059C(locus name)|uniprotkb:YIH1(gene name)|psi-mi:YIH1(display_short) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784027|mint:MINT-8309449|imex:IM-16828-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009676.1|refseq:NP_015405.1|sgd:S000006284|sgd:S000000322|mint:P02994|dip:DIP-2250N|ensemblfungi:YBR118W(gene)|ensemblfungi:YBR118W_mRNA(transcript)|ensemblfungi:YPR080W(gene)|ensemblfungi:YPR080W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:1904408"(melatonin binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1F60|rcsb pdb:1G7C|rcsb pdb:1IJE|rcsb pdb:1IJF|rcsb pdb:2B7B|rcsb pdb:2B7C|rcsb pdb:5O8W|reactome:R-SCE-156842|reactome:R-SCE-3371511|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-8309455(identity) refseq:NP_009985.1|sgd:S000000655|mint:P25637|dip:DIP-1846N|ensemblfungi:YCR059C(gene)|ensemblfungi:YCR059C_mRNA(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1905538"(polysome binding)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|rcsb pdb:6BQI|rcsb pdb:6U1L|rcsb pdb:6U1O|mint:MINT-8309451(identity) go:"GO:0005844"(polysome) crc64:411C66D830716576 - figure legend:f1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:u3vFHdbpfo8w7GJh4nHkx/KQRAk559292 rogid:aAbGir3o4M0LUpwOv6YBC25KpQQ559292 intact-crc:F91FEC43B02869AA|rigid:qV9s/G6oaQOLdSr1ANmbTGRE/pU false - glutathione s tranferase tag:?-?(MINT-8309466) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P25637 uniprotkb:P04650 intact:EBI-21951|uniprotkb:D6VR64|ensemblfungi:YCR059C intact:EBI-15360|uniprotkb:D6VW02|ensemblfungi:YJL189W psi-mi:yih1_yeast(display_long)|uniprotkb:YCR59C(orf name)|uniprotkb:YCR059C(locus name)|uniprotkb:YIH1(gene name)|psi-mi:YIH1(display_short) psi-mi:rl39_yeast(display_long)|uniprotkb:RPL39(gene name)|psi-mi:RPL39(display_short)|uniprotkb:RPL46(gene name synonym)|uniprotkb:SPB2(gene name synonym)|uniprotkb:YJL189W(locus name)|uniprotkb:J0360(orf name)|uniprotkb:L46(gene name synonym)|uniprotkb:YL40(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL39(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7784061|mint:MINT-8309485|imex:IM-16828-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009985.1|sgd:S000000655|mint:P25637|dip:DIP-1846N|ensemblfungi:YCR059C(gene)|ensemblfungi:YCR059C_mRNA(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1905538"(polysome binding)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|rcsb pdb:6BQI|rcsb pdb:6U1L|rcsb pdb:6U1O|mint:MINT-8309487(identity) refseq:NP_012346.1|sgd:S000003725|reactome:R-SCE-156827|reactome:R-SCE-72689|reactome:R-SCE-72706|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-1799339|ensemblfungi:YJL189W(gene)|ensemblfungi:YJL189W_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000077(Ribosomal protein L39e)|interpro:IPR020083|interpro:IPR023626|rcsb pdb:2WW9|rcsb pdb:2WWA|rcsb pdb:2WWB|rcsb pdb:3J6X|rcsb pdb:3J6Y|rcsb pdb:3J77|rcsb pdb:3J78|rcsb pdb:3JCT|rcsb pdb:4U3M|rcsb pdb:5MEI|rcsb pdb:5NDG|rcsb pdb:5NDV|rcsb pdb:5NDW|rcsb pdb:5OBM|rcsb pdb:5MC6|rcsb pdb:5ON6|rcsb pdb:5T62|rcsb pdb:5T6R|rcsb pdb:5TBW|rcsb pdb:5TGA|rcsb pdb:5TGM|rcsb pdb:6FT6|rcsb pdb:6GQ1|rcsb pdb:6GQB|rcsb pdb:6GQV|rcsb pdb:6HD7|rcsb pdb:6HHQ|rcsb pdb:6I7O|rcsb pdb:6M62|rcsb pdb:6N8J|rcsb pdb:6N8K|rcsb pdb:6N8L|rcsb pdb:6N8M|rcsb pdb:6N8N|rcsb pdb:6N8O|rcsb pdb:4U3U|rcsb pdb:4U4N|rcsb pdb:4U4O|rcsb pdb:4U4Q|rcsb pdb:4U4R|rcsb pdb:4U4U|rcsb pdb:4U4Y|rcsb pdb:4U4Z|rcsb pdb:4U50|rcsb pdb:4U51|rcsb pdb:4U52|rcsb pdb:4U53|rcsb pdb:4U55|rcsb pdb:4U56|rcsb pdb:4U6F|rcsb pdb:4V6I|rcsb pdb:4V7F|rcsb pdb:4V7R|rcsb pdb:4V88|rcsb pdb:4V8T|rcsb pdb:4V8Y|rcsb pdb:4V8Z|rcsb pdb:4V91|rcsb pdb:5APN|rcsb pdb:5APO|rcsb pdb:5DAT|rcsb pdb:5DC3|rcsb pdb:5DGE|rcsb pdb:5DGF|rcsb pdb:5DGV|rcsb pdb:5FCI|rcsb pdb:5FCJ|rcsb pdb:5FL8|rcsb pdb:5GAK|rcsb pdb:5H4P|rcsb pdb:5I4L|rcsb pdb:5IT7|rcsb pdb:5JCS|rcsb pdb:5JUO|rcsb pdb:5JUP|rcsb pdb:5JUS|rcsb pdb:5JUT|rcsb pdb:5JUU|rcsb pdb:5LYB|rcsb pdb:5M1J|rcsb pdb:4U3N|rcsb pdb:6OIG|rcsb pdb:6Q8Y|rcsb pdb:6QIK|rcsb pdb:6QT0|rcsb pdb:6QTZ|rcsb pdb:6R84|rcsb pdb:6R86|rcsb pdb:6R87|rcsb pdb:6RI5|rcsb pdb:6RZZ|rcsb pdb:6S05|rcsb pdb:6S47|rcsb pdb:6SNT|rcsb pdb:6SV4|rcsb pdb:6T4Q|rcsb pdb:6T7I|rcsb pdb:6T7T|rcsb pdb:6T83|rcsb pdb:6TB3|rcsb pdb:6TNU|rcsb pdb:6WOO|rcsb pdb:6XIQ|rcsb pdb:6XIR|rcsb pdb:6YLG|rcsb pdb:6YLH|rcsb pdb:6YLX|rcsb pdb:6YLY|rcsb pdb:6Z6J|rcsb pdb:6Z6K|rcsb pdb:7AZY|rcsb pdb:7B7D|rcsb pdb:7NRC|rcsb pdb:7NRD|dip:DIP-4522N|mint:MINT-8309488(identity) - - - figure legend:f3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:aAbGir3o4M0LUpwOv6YBC25KpQQ559292 rogid:IGlHTwfe8Zo174p/ay3cB8Sh7Ug559292 intact-crc:8481AB09A7CB336E|rigid:7KjFJKgZuc2p2eSy6Rr6jodAl/Q false glutathione s tranferase tag:?-?(MINT-8309490) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O55091 uniprotkb:P04650 intact:EBI-7784102|ensembl:ENSMUSP00000025290|uniprotkb:Q9EQH0|intact:MINT-4129020|uniprotkb:Q3UUR6 intact:EBI-15360|uniprotkb:D6VW02|ensemblfungi:YJL189W psi-mi:impct_mouse(display_long)|uniprotkb:Impact(gene name)|psi-mi:Impact(display_short)|uniprotkb:Imprinted and ancient gene protein(gene name synonym) psi-mi:rl39_yeast(display_long)|uniprotkb:RPL39(gene name)|psi-mi:RPL39(display_short)|uniprotkb:RPL46(gene name synonym)|uniprotkb:SPB2(gene name synonym)|uniprotkb:YJL189W(locus name)|uniprotkb:J0360(orf name)|uniprotkb:L46(gene name synonym)|uniprotkb:YL40(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL39(gene name synonym) psi-mi:"MI:0096"(pull down) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784124|mint:MINT-8309499|imex:IM-16828-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024423(gene)|ensembl:ENSMUST00000025290(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|mint:O55091|refseq:NP_032404.1|mint:MINT-8309501(identity) refseq:NP_012346.1|sgd:S000003725|reactome:R-SCE-156827|reactome:R-SCE-72689|reactome:R-SCE-72706|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-1799339|ensemblfungi:YJL189W(gene)|ensemblfungi:YJL189W_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000077(Ribosomal protein L39e)|interpro:IPR020083|interpro:IPR023626|rcsb pdb:2WW9|rcsb pdb:2WWA|rcsb pdb:2WWB|rcsb pdb:3J6X|rcsb pdb:3J6Y|rcsb pdb:3J77|rcsb pdb:3J78|rcsb pdb:3JCT|rcsb pdb:4U3M|rcsb pdb:5MEI|rcsb pdb:5NDG|rcsb pdb:5NDV|rcsb pdb:5NDW|rcsb pdb:5OBM|rcsb pdb:5MC6|rcsb pdb:5ON6|rcsb pdb:5T62|rcsb pdb:5T6R|rcsb pdb:5TBW|rcsb pdb:5TGA|rcsb pdb:5TGM|rcsb pdb:6FT6|rcsb pdb:6GQ1|rcsb pdb:6GQB|rcsb pdb:6GQV|rcsb pdb:6HD7|rcsb pdb:6HHQ|rcsb pdb:6I7O|rcsb pdb:6M62|rcsb pdb:6N8J|rcsb pdb:6N8K|rcsb pdb:6N8L|rcsb pdb:6N8M|rcsb pdb:6N8N|rcsb pdb:6N8O|rcsb pdb:4U3U|rcsb pdb:4U4N|rcsb pdb:4U4O|rcsb pdb:4U4Q|rcsb pdb:4U4R|rcsb pdb:4U4U|rcsb pdb:4U4Y|rcsb pdb:4U4Z|rcsb pdb:4U50|rcsb pdb:4U51|rcsb pdb:4U52|rcsb pdb:4U53|rcsb pdb:4U55|rcsb pdb:4U56|rcsb pdb:4U6F|rcsb pdb:4V6I|rcsb pdb:4V7F|rcsb pdb:4V7R|rcsb pdb:4V88|rcsb pdb:4V8T|rcsb pdb:4V8Y|rcsb pdb:4V8Z|rcsb pdb:4V91|rcsb pdb:5APN|rcsb pdb:5APO|rcsb pdb:5DAT|rcsb pdb:5DC3|rcsb pdb:5DGE|rcsb pdb:5DGF|rcsb pdb:5DGV|rcsb pdb:5FCI|rcsb pdb:5FCJ|rcsb pdb:5FL8|rcsb pdb:5GAK|rcsb pdb:5H4P|rcsb pdb:5I4L|rcsb pdb:5IT7|rcsb pdb:5JCS|rcsb pdb:5JUO|rcsb pdb:5JUP|rcsb pdb:5JUS|rcsb pdb:5JUT|rcsb pdb:5JUU|rcsb pdb:5LYB|rcsb pdb:5M1J|rcsb pdb:4U3N|rcsb pdb:6OIG|rcsb pdb:6Q8Y|rcsb pdb:6QIK|rcsb pdb:6QT0|rcsb pdb:6QTZ|rcsb pdb:6R84|rcsb pdb:6R86|rcsb pdb:6R87|rcsb pdb:6RI5|rcsb pdb:6RZZ|rcsb pdb:6S05|rcsb pdb:6S47|rcsb pdb:6SNT|rcsb pdb:6SV4|rcsb pdb:6T4Q|rcsb pdb:6T7I|rcsb pdb:6T7T|rcsb pdb:6T83|rcsb pdb:6TB3|rcsb pdb:6TNU|rcsb pdb:6WOO|rcsb pdb:6XIQ|rcsb pdb:6XIR|rcsb pdb:6YLG|rcsb pdb:6YLH|rcsb pdb:6YLX|rcsb pdb:6YLY|rcsb pdb:6Z6J|rcsb pdb:6Z6K|rcsb pdb:7AZY|rcsb pdb:7B7D|rcsb pdb:7NRC|rcsb pdb:7NRD|dip:DIP-4522N|mint:MINT-8309503(identity) - function:"Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate tranlation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis"|comment:mint|comment:homomint - figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:lorhSSIZdtsYZD1He3u6ryC643g10090 rogid:IGlHTwfe8Zo174p/ay3cB8Sh7Ug559292 intact-crc:D5D6A2B2DE904C06|rigid:kYU/n86Qa3CfBaz/NpO2IkMOAi4 false glutathione s tranferase tag:?-?(MINT-8309505) - - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0113"(western blot) uniprotkb:O55091 uniprotkb:P33892 intact:EBI-7784102|ensembl:ENSMUSP00000025290|uniprotkb:Q9EQH0|intact:MINT-4129020|uniprotkb:Q3UUR6 intact:EBI-7442|uniprotkb:D6VTV8|ensemblfungi:YGL195W psi-mi:impct_mouse(display_long)|uniprotkb:Impact(gene name)|psi-mi:Impact(display_short)|uniprotkb:Imprinted and ancient gene protein(gene name synonym) psi-mi:gcn1_yeast(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:General control non-derepressible protein 1(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)|uniprotkb:G1318(orf name)|uniprotkb:YGL195W(locus name) psi-mi:"MI:0096"(pull down) Waller et al. (2012) pubmed:22404850|imex:IM-16828|mint:MINT-8308497 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7784124|mint:MINT-8309499|imex:IM-16828-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024423(gene)|ensembl:ENSMUST00000025290(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|mint:O55091|refseq:NP_032404.1|mint:MINT-8309501(identity) sgd:S000003163|refseq:NP_011320.3|mint:P33892|dip:DIP-2344N|ensemblfungi:YGL195W(gene)|ensemblfungi:YGL195W_mRNA(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR022716|interpro:IPR033173|interpro:IPR034085|mint:MINT-8309502(identity) - function:"Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate tranlation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis"|comment:mint|comment:homomint crc64:980FDD03753E9D1C figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/10 2014/10/16 rogid:lorhSSIZdtsYZD1He3u6ryC643g10090 rogid:WPYtEB/xjy4g2cJFwhe+2teVYVk559292 intact-crc:D5D6A2B2DE904C06|rigid:kYU/n86Qa3CfBaz/NpO2IkMOAi4 false glutathione s tranferase tag:?-?(MINT-8309505) - - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0113"(western blot)