#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WTS6	uniprotkb:Q9WVH4	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782502|mint:MINT-8375746|imex:IM-20825-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375749(identity)	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638|mint:MINT-8375748(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/05/16	2014/10/16	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	intact-crc:15A8C248DA80D66B|rigid:VsldY86VunEh1sbH9t+aehB/ock	false	flag tag:?-?(MINT-8375758)	green fluorescent protein tag:?-?(MINT-8375762)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:D4ADE5	uniprotkb:D3ZBQ1	intact:EBI-7782545|ensembl:ENSRNOP00000017736|intact:MINT-8375872	intact:EBI-7782569|ensembl:ENSRNOP00000000327|intact:MINT-8375868	psi-mi:d4ade5_rat(display_long)|uniprotkb:Setd7(gene name)|psi-mi:Setd7(display_short)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:rCG_49977(orf name)	psi-mi:d3zbq1_rat(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Foxo3a_predicted(gene name synonym)|uniprotkb:rCG_58542(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782564|mint:MINT-8375955|imex:IM-20825-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013045(gene)|ensembl:ENSRNOT00000017736(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006479"(protein methylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018022"(peptidyl-lysine methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|reactome:R-RNO-3214841|refseq:NP_001103028.1|rgd:1586346|mint:MINT-8375958(identity)	ensembl:ENSRNOG00000000299(gene)|ensembl:ENSRNOT00000000327(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-RNO-1181150|reactome:R-RNO-198693|reactome:R-RNO-5687128|reactome:R-RNO-9607240|reactome:R-RNO-9614399|reactome:R-RNO-9617629|reactome:R-RNO-9617828|reactome:R-RNO-9634638|rgd:1309196|refseq:NP_001099865.1|mint:MINT-8375957(identity)	-	comment:mint	comment:mint	comment:mint|figure legend:f1b f2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cgnp)|taxid:10116(Rattus norvegicus)	-	2012/05/16	2014/10/16	rogid:grC92wZvFmKuvlN6O4rRVSPnKjg10116	rogid:KreB5LlYU6W49YmDMud6Dq1S2E410116	intact-crc:60263F0BF08667BB|rigid:ANX3rzlfTipAIuoTf+9obAzKrpU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVH4	uniprotkb:Q8WTS6	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782643|mint:MINT-8375889|imex:IM-20825-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638|mint:MINT-8375892(identity)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375891(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/16	2014/10/16	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	intact-crc:9311EDEC1B5E3A2F|rigid:VsldY86VunEh1sbH9t+aehB/ock	false	his tag:?-?(MINT-8375896)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R1E0	uniprotkb:Q8WTS6	intact:EBI-1371343|uniprotkb:Q9JJW4|ensembl:ENSMUSP00000055308	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	psi-mi:foxo1_mouse(display_long)|uniprotkb:Foxo1(gene name)|psi-mi:Foxo1(display_short)|uniprotkb:Fkhr(gene name synonym)|uniprotkb:Foxo1a(gene name synonym)|uniprotkb:Forkhead box protein O1A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma(gene name synonym)	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782698|mint:MINT-8375923|imex:IM-20825-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062713.2|ensembl:ENSMUSG00000044167(gene)|ensembl:ENSMUST00000053764(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030154"(cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|reactome:R-MMU-5687128|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-211163|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1902617"(response to fluoride)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|mint:Q9R1E0|reactome:R-MMU-198693|mint:MINT-8375925(identity)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375929(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/16	2014/10/16	rogid:FZARINw0mWPO0HuwqULfIigXL2M10090	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	intact-crc:AC78ACB2F7735B59|rigid:HSXts69HvFjVKCUu+4txlyMFrlY	false	glutathione s tranferase tag:?-?(MINT-8375926)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WTS6	uniprotkb:Q9WVH4	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782676|mint:MINT-8375905|imex:IM-20825-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375913(identity)	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638|mint:MINT-8375907(identity)	-	-	-	figure legend:f1f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/16	2014/10/16	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	intact-crc:62E8259C72741BC7|rigid:VsldY86VunEh1sbH9t+aehB/ock	false	-	his tag:?-?(MINT-8375908)|binding-associated region:154-409(MINT-8375910)|methylated residue:270-270(MINT-8375917)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9WVH4	uniprotkb:Q8WTS6	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782713|mint:MINT-8375933|imex:IM-20825-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638|mint:MINT-8375935(identity)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375939(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1d f1e f1g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/16	2014/10/16	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	intact-crc:5953F9F4A797383C|rigid:VsldY86VunEh1sbH9t+aehB/ock	false	glutathione s tranferase tag:?-?(MINT-8375936)|mutation disrupting interaction:270-270(MINT-8375948)|binding-associated region:154-409(MINT-8375943)	mutation disrupting interaction:297-297(MINT-8375952)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WVH4	uniprotkb:Q8WTS6	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Xie et al. (2012)	pubmed:22402663|imex:IM-20825|mint:MINT-8375350	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7782757|mint:MINT-8375976|imex:IM-20825-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638|mint:MINT-8375978(identity)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841|mint:MINT-8375986(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf1 f1g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/16	2014/10/16	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	intact-crc:D627D3EFD252A506|rigid:VsldY86VunEh1sbH9t+aehB/ock	false	glutathione s tranferase tag:?-?(MINT-8375981)|binding-associated region:154-409(MINT-8375983)	mutation disrupting interaction:297-297(MINT-8375987)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)