#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46379	uniprotkb:Q8TEK3	intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wakeman et al. (2012)	doi:10.1038/emboj.2012.50|pubmed:22373577|imex:IM-17755|mint:MINT-8380886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7776967|mint:MINT-8380894|imex:IM-17755-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86|mint:MINT-8380896(identity)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N|mint:MINT-8380897(identity)	-	-	-	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2012/05/28	2018/09/18	rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	intact-crc:581D2D71D6CC8434|rigid:MZVCrVMGbZS0vSnJ9LEpeM7MIio	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46379	uniprotkb:Q8TEK3	intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wakeman et al. (2012)	doi:10.1038/emboj.2012.50|pubmed:22373577|imex:IM-17755|mint:MINT-8380886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7776998|mint:MINT-8380903|imex:IM-17755-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86|mint:MINT-8380905(identity)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N|mint:MINT-8380907(identity)	-	-	-	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2012/05/28	2018/09/18	rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	intact-crc:0FBD219F299781C5|rigid:MZVCrVMGbZS0vSnJ9LEpeM7MIio	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)