#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5S006	uniprotkb:Q9EPJ9	intact:EBI-2693710|uniprotkb:E9QNJ2|uniprotkb:Q8BWG7|uniprotkb:Q8BZJ6|uniprotkb:Q8CI84|uniprotkb:Q8K062|ensembl:ENSMUSP00000052584	intact:EBI-6288020|ensembl:ENSMUSP00000029092|uniprotkb:A8WIR9|uniprotkb:A8WIS1|uniprotkb:Q3TI52|uniprotkb:Q8BMM6|uniprotkb:Q8BMQ7	psi-mi:lrrk2_mouse(display_long)|uniprotkb:Lrrk2(gene name)|psi-mi:Lrrk2(display_short)	psi-mi:arfg1_mouse(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288697|imex:IM-17740-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080006.3|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|reactome:R-MMU-8857538|ensembl:ENSMUSG00000036273(gene)|ensembl:ENSMUST00000060642(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043204"(perikaryon)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000719(Protein kinase, core)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|interpro:IPR001611(Leucine-rich repeat)|dip:DIP-58648N	refseq:XP_017173503.1|ensembl:ENSMUSG00000027575(gene)|ensembl:ENSMUST00000029092(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-8856828|refseq:NP_001171177.1|refseq:NP_001171178.1|refseq:NP_001171179.1|refseq:NP_001171180.1|refseq:NP_665703.2	go:"GO:0097060"(synaptic membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034592"(synaptic vesicle lumen)	-	-	figure legend:5A/B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2012/09/07	2014/10/16	rogid:MuGbs5uGeIhAtSCm8gFyG8JbOjI10090	rogid:fQX6d9zdbSnh6r3Kv3+7dxfehdo10090	intact-crc:BEB5F71C6292F4F8|rigid:GYuTz5qrAzCvX4763L1ynzzAgvk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N6T3-2	uniprotkb:Q5S007	intact:EBI-6288865|ensembl:ENSP00000314615	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289300|imex:IM-17740-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005829"(cytosol)	isoform-comment:No experimental confirmation available.	-	figure legend:S1C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:16B53D7909086EDD|rigid:ScTgbRSyuhGLrUZS/ikT9QcPox4	false	glutathione s tranferase tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5S007	uniprotkb:Q62848	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-4398879|ensembl:ENSRNOP00000013900	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288663|imex:IM-17740-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0005829"(cytosol)|go:"GO:0000139"(Golgi membrane)|go:"GO:0031966"(mitochondrial membrane)	-	-	figure legend:2C -1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	intact-crc:21547061E43D1636|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	flag tag:n-n	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62848	uniprotkb:Q5S007	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288068|imex:IM-17740-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005737"(cytoplasm)|go:"GO:0030660"(Golgi-associated vesicle membrane)	-	-	figure legend:2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:D2DDD6ADE59800A2|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	yellow fluorescent protein tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
chebi:"CHEBI:15996"	uniprotkb:Q62848	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-4398879|ensembl:ENSRNOP00000013900	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289111|imex:IM-17740-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0005829"(cytosol)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:6E, S2A.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2016/08/15	-	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	intact-crc:FAD544932CBC72EB	false	-	sufficient binding region:65-415|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62848	uniprotkb:Q5S007	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289111|imex:IM-17740-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005829"(cytosol)	-	-	figure legend:6E, S2A.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2016/08/15	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:FAD544932CBC72EB	false	sufficient binding region:65-415|yellow fluorescent protein tag:c-c	mutation increasing interaction rate:1398-1398|mutation decreasing interaction rate:1348-1348|flag tag:n-n|sufficient binding region:895-1503	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q62848	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-4398879|ensembl:ENSRNOP00000013900	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289085|imex:IM-17740-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0005829"(cytosol)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:6D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2016/08/15	-	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	intact-crc:D5EECD247E02A6AB	false	-	sufficient binding region:65-415|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62848	uniprotkb:Q9Y6X8	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-948566|ensembl:ENSP00000314709	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289085|imex:IM-17740-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1	go:"GO:0005829"(cytosol)	-	-	figure legend:6D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2016/08/15	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606	intact-crc:D5EECD247E02A6AB	false	sufficient binding region:65-415|yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q5S007	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289025|imex:IM-17740-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005829"(cytosol)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:6A/B/C|comment:ArfGAP1 expression fails to appreciably influence the levels of GTP-bound WT or mutant LRRK2.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2016/08/15	-	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:0D18FAE678DAD107	false	-	mutation increasing interaction:1699-1699|mutation disrupting interaction:1348-1348|mutation increasing interaction:2019-2019|flag tag:n-n|mutation increasing interaction:1441-1441	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62848	uniprotkb:Q5S007	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6287995|imex:IM-17740-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:1B|comment:The reverse IP gave a much less robust positive result.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:440CEF160DF7AD3A|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	yellow fluorescent protein tag:c-c|sufficient binding region:65-415	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5S007	uniprotkb:Q62848	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-4398879|ensembl:ENSRNOP00000013900	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6287985|imex:IM-17740-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0005829"(cytosol)	-	-	figure legend:1A, 1C, 2C-2, 4A/B.|comment:Familial and functional mutations which impair GTP hydrolysis and increase the levels of GTP-bound LRRK2 increase the interaction of LRRK2 with ArfGAP1.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	intact-crc:9B563F96043475DB|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	flag tag:n-n|mutation increasing interaction:1699-1699|necessary binding region:480-895|mutation decreasing interaction:1348-1348|mutation increasing interaction:1441-1441|mutation decreasing interaction:1398-1398|mutation increasing interaction:2019-2019	sufficient binding region:65-415|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5S007	uniprotkb:Q5S007	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289461|imex:IM-17740-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:S2B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:CA67A55DFC82E38D|rigid:gzU7rxq8Ua2EeIKBjQwuGiBGDTU	false	flag tag:n-n|sufficient binding region:895-1503	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62848	uniprotkb:Q5S007	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288178|imex:IM-17740-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2B-2|comment:The reverse IP gave a much less robust positive result.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2012/09/07	2014/10/16	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:796EE84EC8F80D80|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	yellow fluorescent protein tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q5S007	-	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	-	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289516|imex:IM-17740-20	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:S4-2|comment:Autophosphorylation of LRRK2 in the absence of ArfGAP1.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	intact-crc:9B3A70FB70B51110	false	mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:1441-1441|mutation increasing interaction rate:2019-2019|myc tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q5S007	-	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	-	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289214|imex:IM-17740-15	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:7A-3|comment:Autophosphorylation of LRRK2 in the absence of ArfGAP1.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	intact-crc:95C682DF24166A76	false	sufficient binding region:970-2527|mutation increasing interaction rate:2019-2019|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q5S007	uniprotkb:Q8N6T3-2	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-6288865|ensembl:ENSP00000314615	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288833|imex:IM-17740-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	isoform-comment:No experimental confirmation available.	figure legend:7A/B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:9.3x10^-9(molar)	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	intact-crc:6416550DFEBCF4F6|rigid:ScTgbRSyuhGLrUZS/ikT9QcPox4	false	sufficient binding region:970-2527|mutation disrupting interaction rate:1994-1994|glutathione s tranferase tag:?-?|mutation increasing interaction rate:1441-1441|mutation increasing interaction rate:2019-2019	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:P26038	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289249|imex:IM-17740-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:7C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:0701B42F9773203F|rigid:c4zGS+Er7HF3IoP+6SmiUMJt0po	false	glutathione s tranferase tag:?-?|mutation increasing interaction rate:1441-1441|mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:2019-2019|sufficient binding region:970-2527	sufficient binding region:550-564	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:Q8N6T3-2	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-6288865|ensembl:ENSP00000314615	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289249|imex:IM-17740-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	isoform-comment:No experimental confirmation available.	figure legend:7C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	intact-crc:0701B42F9773203F|rigid:c4zGS+Er7HF3IoP+6SmiUMJt0po	false	glutathione s tranferase tag:?-?|mutation increasing interaction rate:1441-1441|mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:2019-2019|sufficient binding region:970-2527	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:Q8N6T3-2	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-6288865|ensembl:ENSP00000314615	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289471|imex:IM-17740-19	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	isoform-comment:No experimental confirmation available.	figure legend:S4-1|comment:Autophosphorylation of LRRK2.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	intact-crc:48A9A5348FA90376|rigid:ScTgbRSyuhGLrUZS/ikT9QcPox4	false	mutation increasing interaction rate:2019-2019|mutation decreasing interaction rate:1994-1994|myc tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8N6T3-2	uniprotkb:Q5S007	intact:EBI-6288865|ensembl:ENSP00000314615	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289542|imex:IM-17740-21	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	isoform-comment:No experimental confirmation available.	-	figure legend:S4-3|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:76003B13B4294872|rigid:ScTgbRSyuhGLrUZS/ikT9QcPox4	false	glutathione s tranferase tag:n-n	mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:1441-1441|myc tag:?-?|mutation increasing interaction rate:2019-2019	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:Q8N6T3-2	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-6288865|ensembl:ENSP00000314615	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:q8n6t3-2(display_long)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6289182|imex:IM-17740-14	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	intact:EBI-716933(isoform-parent)|ensembl:ENSG00000101199(gene)|ensembl:ENST00000353546(transcript)|uniprotkb:Q8N6T3-2(isoform-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	isoform-comment:No experimental confirmation available.	figure legend:7A-2|comment:Autophosphorylation of LRRK2.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:u+yn46US/e/Uc45ydi8QOL5Hjuk9606	intact-crc:690F23CA30B0240E|rigid:ScTgbRSyuhGLrUZS/ikT9QcPox4	false	sufficient binding region:970-2527|mutation increasing interaction rate:2019-2019|glutathione s tranferase tag:?-?|mutation increasing interaction rate:1994-1994	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q62848	uniprotkb:Q5S007	intact:EBI-4398879|ensembl:ENSRNOP00000013900	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_rat(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288113|imex:IM-17740-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659558.1|rgd:708452|refseq:XP_017446953.1|ensembl:ENSRNOG00000043150(gene)|ensembl:ENSRNOT00000013900(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q62848|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2B|comment:The reverse IP gave a much less robust positive result.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2012/09/07	2014/10/16	rogid:zGVo6jKRj3KWSXtp93bNvxnWdgY10116	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:C84F25505DC59CFB|rigid:WhqyvkAGs5TQmGUzuVeojhoseVc	false	-	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8N6T3	uniprotkb:Q5S007	intact:EBI-716933|uniprotkb:Q6PK71|uniprotkb:Q96KC4|uniprotkb:Q96T02|uniprotkb:Q9NSU3|uniprotkb:Q9NVF6|uniprotkb:Q9UIL0|uniprotkb:B7ZBI3|uniprotkb:E1P5I9|ensembl:ENSP00000359306|uniprotkb:B7Z3U0|uniprotkb:E7EV62|uniprotkb:B7Z8H8	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:arfg1_human(display_long)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288151|imex:IM-17740-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060679.1|refseq:NP_783202.1|refseq:NP_001268411.1|refseq:NP_001268412.1|refseq:NP_001268413.1|ensembl:ENSG00000101199(gene)|ensembl:ENST00000370283(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q8N6T3|rcsb pdb:3DWD|rcsb pdb:3O47|reactome:R-HSA-381038|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8856828	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005737"(cytoplasm)|go:"GO:0000139"(Golgi membrane)	-	-	figure legend:2A-2|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/07	2014/10/16	rogid:vAIMUqWHtBQzZYe5JJp6WEMXQdo9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:4D540E1CA4FE6810|rigid:/AY9p1/rCVYkIAg3b3M53sNMYtA	false	-	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9EPJ9	uniprotkb:Q5S006	intact:EBI-6288020|ensembl:ENSMUSP00000029092|uniprotkb:A8WIR9|uniprotkb:A8WIS1|uniprotkb:Q3TI52|uniprotkb:Q8BMM6|uniprotkb:Q8BMQ7	intact:EBI-2693710|uniprotkb:E9QNJ2|uniprotkb:Q8BWG7|uniprotkb:Q8BZJ6|uniprotkb:Q8CI84|uniprotkb:Q8K062|ensembl:ENSMUSP00000052584	psi-mi:arfg1_mouse(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_mouse(display_long)|uniprotkb:Lrrk2(gene name)|psi-mi:Lrrk2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288054|imex:IM-17740-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173503.1|ensembl:ENSMUSG00000027575(gene)|ensembl:ENSMUST00000029092(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-8856828|refseq:NP_001171177.1|refseq:NP_001171178.1|refseq:NP_001171179.1|refseq:NP_001171180.1|refseq:NP_665703.2	refseq:NP_080006.3|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|reactome:R-MMU-8857538|ensembl:ENSMUSG00000036273(gene)|ensembl:ENSMUST00000060642(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043204"(perikaryon)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000719(Protein kinase, core)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|interpro:IPR001611(Leucine-rich repeat)|dip:DIP-58648N	-	-	-	figure legend:1F|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2012/09/07	2014/10/16	rogid:fQX6d9zdbSnh6r3Kv3+7dxfehdo10090	rogid:MuGbs5uGeIhAtSCm8gFyG8JbOjI10090	intact-crc:74309D6F098E6366|rigid:GYuTz5qrAzCvX4763L1ynzzAgvk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPJ9	uniprotkb:Q5S006	intact:EBI-6288020|ensembl:ENSMUSP00000029092|uniprotkb:A8WIR9|uniprotkb:A8WIS1|uniprotkb:Q3TI52|uniprotkb:Q8BMM6|uniprotkb:Q8BMQ7	intact:EBI-2693710|uniprotkb:E9QNJ2|uniprotkb:Q8BWG7|uniprotkb:Q8BZJ6|uniprotkb:Q8CI84|uniprotkb:Q8K062|ensembl:ENSMUSP00000052584	psi-mi:arfg1_mouse(display_long)|uniprotkb:Arfgap1(gene name)|psi-mi:Arfgap1(display_short)|uniprotkb:Arf1gap(gene name synonym)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)	psi-mi:lrrk2_mouse(display_long)|uniprotkb:Lrrk2(gene name)|psi-mi:Lrrk2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stafa et al. (2012)	imex:IM-17740|pubmed:22363216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6288018|imex:IM-17740-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173503.1|ensembl:ENSMUSG00000027575(gene)|ensembl:ENSMUST00000029092(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-8856828|refseq:NP_001171177.1|refseq:NP_001171178.1|refseq:NP_001171179.1|refseq:NP_001171180.1|refseq:NP_665703.2	refseq:NP_080006.3|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|reactome:R-MMU-8857538|ensembl:ENSMUSG00000036273(gene)|ensembl:ENSMUST00000060642(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043204"(perikaryon)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000719(Protein kinase, core)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|interpro:IPR001611(Leucine-rich repeat)|dip:DIP-58648N	-	-	-	figure legend:1E|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2012/09/07	2014/10/16	rogid:fQX6d9zdbSnh6r3Kv3+7dxfehdo10090	rogid:MuGbs5uGeIhAtSCm8gFyG8JbOjI10090	intact-crc:1429B1E0927716C6|rigid:GYuTz5qrAzCvX4763L1ynzzAgvk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)