#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P22336 uniprotkb:P26754 intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700450|mint:MINT-8388359|imex:IM-17761-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388363(identity) refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754|mint:MINT-8388361(identity) - crc64:7EB8DFA6910EF8A8 crc64:F6087501E4E28CC1 figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292 intact-crc:64DBE005A1663BA9|rigid:gbDWyPxAFWISm+WFoEeTmf1AXW8 false myc tag:?-?(MINT-8388364) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:P26754 uniprotkb:Q04437 intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W intact:EBI-8224|uniprotkb:Q0P737|uniprotkb:Q0P738|uniprotkb:Q0P741|uniprotkb:Q0P749|uniprotkb:D6VZS9|ensemblfungi:YMR106C psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym) psi-mi:ku80_yeast(display_long)|uniprotkb:YKU80(gene name)|psi-mi:YKU80(display_short)|uniprotkb:HDF2(gene name synonym)|uniprotkb:YMR106C(locus name)|uniprotkb:YM9718.05C(orf name)|uniprotkb:Yeast Ku80(gene name synonym)|uniprotkb:High affinity DNA-binding factor subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II subunit Ku80(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700436|mint:MINT-8388346|imex:IM-17761-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754|mint:MINT-8388348(identity) refseq:NP_013824.1|sgd:S000004712|mint:Q04437|dip:DIP-2757N|ensemblfungi:YMR106C(gene)|ensemblfungi:YMR106C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007535"(donor selection)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|rcsb pdb:5Y58|rcsb pdb:5Y59|reactome:R-SCE-6798695|mint:MINT-8388349(identity) - crc64:F6087501E4E28CC1 crc64:58126164EE375643 figure legend:f2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292 rogid:/N3a9q2fCKmobRCO3NKX0AACMTY559292 intact-crc:F3DE993B9D9B73D1|rigid:p3BWL8/lrc3I3DvCcTgeQRYgsjY false - myc tag:?-?(MINT-8388354) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26754 uniprotkb:P32797 intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym) psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700480|mint:MINT-8388380|imex:IM-17761-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754|mint:MINT-8388382(identity) refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE|mint:MINT-8388384(identity) - crc64:F6087501E4E28CC1 crc64:9FE0AD08520A6F8A figure legend:f2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292 rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292 intact-crc:E9560F0C4725A5BF|rigid:ZX9KuNpV/6tmaLn65YqbxQLtqTo false - myc tag:?-?(MINT-8388385) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26754 uniprotkb:Q06163 intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W intact:EBI-3764464|uniprotkb:D6VYW1|ensemblfungi:YLR318W psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym) psi-mi:tert_yeast(display_long)|uniprotkb:EST2(gene name)|psi-mi:EST2(display_short)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:L8543.12(orf name)|uniprotkb:YLR318W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700465|mint:MINT-8388370|imex:IM-17761-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754|mint:MINT-8388372(identity) refseq:NP_013422.2|sgd:S000004310|dip:DIP-7548N|ensemblfungi:YLR318W(gene)|ensemblfungi:YLR318W_mRNA(transcript)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070034"(telomerase RNA binding)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|mint:MINT-8388374(identity) - crc64:F6087501E4E28CC1 crc64:84540735E3CD40F5 figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292 rogid:DaX8x7PaQFAD7ZXlPC+8C7/N3uY559292 intact-crc:B25193DE794AAB56|rigid:Ws5OFnlqR/jH0ASoOF/W2zUGVcg false - myc tag:?-?(MINT-8388375) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06163 uniprotkb:P22336 intact:EBI-3764464|uniprotkb:D6VYW1|ensemblfungi:YLR318W intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C psi-mi:tert_yeast(display_long)|uniprotkb:EST2(gene name)|psi-mi:EST2(display_short)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:L8543.12(orf name)|uniprotkb:YLR318W(locus name) psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700526|mint:MINT-8388400|imex:IM-17761-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013422.2|sgd:S000004310|dip:DIP-7548N|ensemblfungi:YLR318W(gene)|ensemblfungi:YLR318W_mRNA(transcript)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070034"(telomerase RNA binding)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|mint:MINT-8388402(identity) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388406(identity) - crc64:84540735E3CD40F5 crc64:7EB8DFA6910EF8A8 figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:DaX8x7PaQFAD7ZXlPC+8C7/N3uY559292 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 intact-crc:46F88D194ECDB7A0|rigid:jMwPmi6Brc1U7LmVBczbG2w7szs false myc tag:?-?(MINT-8388403) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:P32797 uniprotkb:P22336 intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name) psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700511|mint:MINT-8388390|imex:IM-17761-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE|mint:MINT-8388394(identity) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388392(identity) - crc64:9FE0AD08520A6F8A crc64:7EB8DFA6910EF8A8 figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 intact-crc:15B555807DD8C05C|rigid:UGjMFU2sffi3tCxEBiwUblhLWKw false myc tag:?-?(MINT-8388395) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:P22336 uniprotkb:P26754 intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C intact:EBI-14976|uniprotkb:P38905|uniprotkb:D6W0N3|ensemblfungi:YNL312W psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:rfa2_yeast(display_long)|uniprotkb:RFA2(gene name)|psi-mi:RFA2(display_short)|uniprotkb:BUF1(gene name synonym)|uniprotkb:YNL312W(locus name)|uniprotkb:N0368(orf name)|uniprotkb:Replication protein A 36 kDa subunit(gene name synonym)|uniprotkb:DNA-binding protein BUF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700582|mint:MINT-8388446|imex:IM-17761-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388450(identity) refseq:NP_014087.1|sgd:S000005256|ensemblfungi:YNL312W(gene)|ensemblfungi:YNL312W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|go:"GO:0000781"(chromosome, telomeric region)|dip:DIP-2518N|mint:P26754|mint:MINT-8388448(identity) - crc64:7EB8DFA6910EF8A8 crc64:F6087501E4E28CC1 figure legend:f5c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 rogid:CsitdDua0N9AQdlJn9I0RNmz3Ts559292 intact-crc:24B97AFBEF142145|rigid:gbDWyPxAFWISm+WFoEeTmf1AXW8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q04437 uniprotkb:P22336 intact:EBI-8224|uniprotkb:Q0P737|uniprotkb:Q0P738|uniprotkb:Q0P741|uniprotkb:Q0P749|uniprotkb:D6VZS9|ensemblfungi:YMR106C intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C psi-mi:ku80_yeast(display_long)|uniprotkb:YKU80(gene name)|psi-mi:YKU80(display_short)|uniprotkb:HDF2(gene name synonym)|uniprotkb:YMR106C(locus name)|uniprotkb:YM9718.05C(orf name)|uniprotkb:Yeast Ku80(gene name synonym)|uniprotkb:High affinity DNA-binding factor subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II subunit Ku80(gene name synonym) psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700562|mint:MINT-8388413|imex:IM-17761-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013824.1|sgd:S000004712|mint:Q04437|dip:DIP-2757N|ensemblfungi:YMR106C(gene)|ensemblfungi:YMR106C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007535"(donor selection)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|rcsb pdb:5Y58|rcsb pdb:5Y59|reactome:R-SCE-6798695|mint:MINT-8388417(identity) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388415(identity) - crc64:58126164EE375643 crc64:7EB8DFA6910EF8A8 comment:mint|figure legend:f3a f3b f3c f5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:/N3a9q2fCKmobRCO3NKX0AACMTY559292 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 intact-crc:E6E750BD27C3D67F|rigid:uVO/nENPr41UPxDtjnpVOc5HX6M false myc tag:?-?(MINT-8388418) mutation decreasing interaction:228-228(MINT-8388442) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22336 uniprotkb:Q04437 intact:EBI-14971|uniprotkb:P38906|uniprotkb:D6VPL9|ensemblfungi:YAR007C intact:EBI-8224|uniprotkb:Q0P737|uniprotkb:Q0P738|uniprotkb:Q0P741|uniprotkb:Q0P749|uniprotkb:D6VZS9|ensemblfungi:YMR106C psi-mi:rfa1_yeast(display_long)|uniprotkb:RFA1(gene name)|psi-mi:RFA1(display_short)|uniprotkb:BUF2(gene name synonym)|uniprotkb:YAR007C(locus name)|uniprotkb:FUN3(orf name)|uniprotkb:Replication protein A 69 kDa DNA-binding subunit(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:DNA-binding protein BUF2(gene name synonym)|uniprotkb:RPA1(gene name synonym) psi-mi:ku80_yeast(display_long)|uniprotkb:YKU80(gene name)|psi-mi:YKU80(display_short)|uniprotkb:HDF2(gene name synonym)|uniprotkb:YMR106C(locus name)|uniprotkb:YM9718.05C(orf name)|uniprotkb:Yeast Ku80(gene name synonym)|uniprotkb:High affinity DNA-binding factor subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II subunit Ku80(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Luciano et al. (2012) doi:10.1038/emboj.2012.40|pubmed:22354040|imex:IM-17761|mint:MINT-8387796 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7700603|mint:MINT-8388425|imex:IM-17761-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009404.1|sgd:S000000065|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5696397|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-68962|reactome:R-SCE-69166|reactome:R-SCE-5655862|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensemblfungi:YAR007C(gene)|ensemblfungi:YAR007C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0006260"(DNA replication)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030491"(heteroduplex formation)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043934"(sporulation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|rcsb pdb:1YNX|rcsb pdb:5M1X|rcsb pdb:5OMB|rcsb pdb:5OMC|rcsb pdb:6I52|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-176187|dip:DIP-2512N|mint:P22336|mint:MINT-8388431(identity) refseq:NP_013824.1|sgd:S000004712|mint:Q04437|dip:DIP-2757N|ensemblfungi:YMR106C(gene)|ensemblfungi:YMR106C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007535"(donor selection)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|rcsb pdb:5Y58|rcsb pdb:5Y59|reactome:R-SCE-6798695|mint:MINT-8388427(identity) - crc64:7EB8DFA6910EF8A8 crc64:58126164EE375643 comment:mint|figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/07/19 2014/10/16 rogid:g7zFw4pOaeYLHSwBeKICZVqA13I559292 rogid:/N3a9q2fCKmobRCO3NKX0AACMTY559292 intact-crc:76C55396FFB10EA4|rigid:uVO/nENPr41UPxDtjnpVOc5HX6M false - myc tag:?-?(MINT-8388428) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot)