#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14965	uniprotkb:O15350	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651304|imex:IM-17320-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig  S1C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:BE5988D720EB979D|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	flag tag:?-?	ha tag:?-?|mutation increasing interaction strength:235-235	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14965	uniprotkb:O15350	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5605204|imex:IM-17320-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 1H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:9A4B8E54F43DB0C0|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650983|imex:IM-17320-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig 4F|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:1AD37F597EFB71AD|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650983|imex:IM-17320-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 4F|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:1AD37F597EFB71AD|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14965	uniprotkb:O15350	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5604073|imex:IM-17320-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 1E, 1F, S1A|resulting-ptm:p73 is phosphorylated by Aurora-A.|comment:The N terminally truncated isoform Delta Np73 showed minimal loss of phosphorylation in the SA mutant.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/22	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:1EB7690456670766|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	flag tag:?-?|mutation disrupting interaction rate:162-162	glutathione s tranferase tag:?-?|mutation decreasing interaction rate:235-235	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-5650878	uniprotkb:Q9XSK8	-	intact:EBI-5605763|uniprotkb:Q9TSQ9	psi-mi:grp75_chlae(display_short)|psi-mi:EBI-5650878(display_long)	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650899|imex:IM-17320-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	-	-	-	figure legend:Fig 4E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	-	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	intact-crc:B0B3A4B25868BF73	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-5650878	uniprotkb:Q9XSK8	-	intact:EBI-5605763|uniprotkb:Q9TSQ9	psi-mi:grp75_chlae(display_short)|psi-mi:EBI-5650878(display_long)	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5605906|imex:IM-17320-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	-	-	-	figure legend:Fig 4D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	-	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	intact-crc:3DF9086D6C241DD2	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9XSK8	intact:EBI-5605875	intact:EBI-5605763|uniprotkb:Q9TSQ9	-	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_chlae(display_short)|psi-mi:EBI-5605875(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5605656|imex:IM-17320-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	-	-	-	-	figure legend:Fig 1I,1J,1K.|comment:The amount of Aurora-A bound to p73 progressively increased, peaking at mitosis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	-	intact-crc:B171F32B4C5150CF	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651775|imex:IM-17320-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig S3C|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:7050F93E57C3CA79|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651775|imex:IM-17320-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig S3C|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:7050F93E57C3CA79|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	flag tag:?-?|necessary binding region:235-282	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651324|imex:IM-17320-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig  S1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:A3EBA8AD4E582509|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651342|imex:IM-17320-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig  S1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:33E7833020F25149|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9XSK8	uniprotkb:O14965	intact:EBI-5605763|uniprotkb:Q9TSQ9	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650918|imex:IM-17320-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 4E|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:C87BDBB2886022BA	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9XSK8	intact:EBI-5650878	intact:EBI-5605763|uniprotkb:Q9TSQ9	-	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_chlae(display_short)|psi-mi:EBI-5650878(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650918|imex:IM-17320-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	-	-	-	-	figure legend:Fig 4E|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	-	intact-crc:C87BDBB2886022BA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14965	uniprotkb:O15350	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651355|imex:IM-17320-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig  S1E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2012/02/22	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:8679E1349240F0AE|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14965	uniprotkb:O15350	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651357|imex:IM-17320-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig  S1E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2012/02/22	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:B07B98AB8D5C0088|rigid:+Jg42FcgZVFVSrGClmnS3q8Wtaw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:Q13257	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651170|imex:IM-17320-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig 7G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-saos-2)|taxid:9606(Homo sapiens SAOS-2 cell line established from primary osteogenic sarcoma)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:808D4EAEE7FE997C|rigid:h1x3VA9eT1oACTTE9TAc1+FVOK0	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q12834	uniprotkb:O15350	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651143|imex:IM-17320-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 7F|comment:There was a marked reduction in the interaction of both S235D mutant and MAD2 with CDC20, compared with that in empty vector and S235A mutant cells.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:26D74F0813007EB1|rigid:kBz7AHgyLqHzTIXqohFxiVBuKcw	false	-	ha tag:?-?|mutation decreasing interaction strength:235-235	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651143|imex:IM-17320-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig 7F|comment:There was a marked reduction in the interaction of both S235D mutant and MAD2 with CDC20, compared with that in empty vector and S235A mutant cells.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:26D74F0813007EB1|rigid:kBz7AHgyLqHzTIXqohFxiVBuKcw	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12834	uniprotkb:O15350	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651126|imex:IM-17320-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:72C96CA3355A3DFB|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:O14965	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651126|imex:IM-17320-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:72C96CA3355A3DFB|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651126|imex:IM-17320-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:72C96CA3355A3DFB|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:Q13257	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651114|imex:IM-17320-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:9E250B988DF922ED|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651114|imex:IM-17320-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:9E250B988DF922ED|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:Q12834	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651114|imex:IM-17320-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:Fig 7E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	intact-crc:9E250B988DF922ED|rigid:DnrIqmnYPl2QgeHgRqmJSHc8T9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651001|imex:IM-17320-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig 4F|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:9CC56DF920A8C7B5|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O14965	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651001|imex:IM-17320-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 4F|comment:Less mortalin bound to p73 in Aurora-A inhibitor MLN8054  treated cells,  than in untreated cells.|antagonist:MLN8054|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:9CC56DF920A8C7B5|rigid:CZ15jS0UMj9/fRdmthF1/R/I4SU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-5608604	uniprotkb:O15350	-	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p53/p73_binding _consensus_site_probe(display_short)|psi-mi:EBI-5608604(display_long)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5608067|imex:IM-17320-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/22	2014/10/16	-	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:BFB16AB7FB833F07	false	32p radiolabel:?-?	ha tag:?-?|mutation disrupting interaction strength:235-235|mutation decreasing interaction strength:235-235	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O15350	uniprotkb:O15350	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5614002|imex:IM-17320-5	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:CFD91951C5ECF67B|rigid:OdU5/lVUUkIb6LHyiKByXrUL5+M	false	green fluorescent protein tag:?-?	green fluorescent protein tag:?-?	4	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651095|imex:IM-17320-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 5F|comment:"Nuclear staining was detected in 36% of mortalin mutant MCF-7 and Panc-1 cells (n = 100) versus 2% of empty vector cells."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:3E8C83C64C4716C6|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	-	necessary binding region:253-282|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P38646	uniprotkb:O15350	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651070|imex:IM-17320-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 5F|comment:"Nuclear staining was detected in 36% of mortalin mutant MCF-7 and Panc-1 cells (n = 100) versus 2% of empty vector cells."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2012/02/22	2014/10/16	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:FC3572D0D58AFCE9|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	green fluorescent protein tag:?-?|necessary binding region:253-282	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P38646	uniprotkb:O15350	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651032|imex:IM-17320-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 5A/B|comment:In cells with mutant mortalin, the p73 S235D mutant translocated into the nucleus more than in the empty-vector-transfected cells|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:01E9238140FCA203|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	necessary binding region:253-282|green fluorescent protein tag:?-?	mutation increasing interaction strength:235-235|ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9XSK8	uniprotkb:O14965	intact:EBI-5605763|uniprotkb:Q9TSQ9	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:p73_chlae(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5614241|imex:IM-17320-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|interpro:IPR037612|interpro:IPR032646|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig 3E, 3F.|comment:Cells overexpressing Aurora-A showed evenly diffused endogenous p73 staining in the cytoplasm and nucleus, which were reversed with Aurora-A inhibitor MLN8054.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:lqcVQoV02gCTc42dYGBpJf8k4v89534	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:F4847CD6BAB88685|rigid:bWOmzFSi+K4HdWixlF6MSr92ZR0	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650682|imex:IM-17320-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig 4B|comment:The S235D mutant and mortalin-containing complexes were significantly more enriched at >2-megadalton-sized fractions than were the p73-WT and mortalin complexes.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:DBE0FBE1B42A3DE1|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	flag tag:?-?|mutation increasing interaction strength:235-235	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38646	uniprotkb:P04637	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651739|imex:IM-17320-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:Fig S3B|comment:WT and mutant p53 did not interact with the mortalin deletion mutant, but full-length mortalin's interaction was enhanced with S215D.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:8E52EADFA2401D86|rigid:QuQnL366uWx2RnqzMltnbOs6als	false	flag tag:?-?|necessary binding region:253-282	mutation increasing interaction strength:215-215|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P38646	uniprotkb:O15350	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5650800|imex:IM-17320-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:Fig 4C|comment:WT and mutant p73 did not interact with the mortalin deletion mutant, but full-length mortalin's interaction was enhanced with S235D.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:88A12D7A5CA7DF46|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	necessary binding region:253-282|flag tag:?-?	green fluorescent protein tag:?-?|mutation increasing interaction strength:235-235	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5614920|imex:IM-17320-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig 4A|comment:A protein band of approximately 80 kD MW was detected only in the immune complex of the S235D mutant but not the WT.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:28AE4F7D3DAA75A3|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	flag tag:?-?|mutation increasing interaction strength:235-235	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O15350-8	uniprotkb:O15350	intact:EBI-5651259|intact:EBI-7471341|intact:MINT-97811|intact:EBI-7471173|intact:EBI-7471309|intact:EBI-7471260|ensembl:ENSP00000367537	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:o15350-8(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651246|imex:IM-17320-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-389606(isoform-parent)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378288(transcript)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	isoform-comment:Produced by alternative promoter usage.	-	figure legend:S1B|comment:"Isoform Delta Np73 appeared  to bind the WT and the phosphor-mimetic (S235D) mutant of p73 with similar efficiency."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2012/02/22	2014/10/16	rogid:6NnGpApC39PxLvdbY/GJ03RMtEs9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:D3433732BF68479C|rigid:Zy20nNXBCfo00IClaNqPFgPGPEE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651665|imex:IM-17320-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:S3A -RHS|comment:Enrichment of S235D mutant and mortalin in the higher molecular complex was also evident.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:4CD9C7E8A2D7FBEE|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	mutation increasing interaction strength:235-235|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:P38646	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651387|imex:IM-17320-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:S3A -RHS|comment:Enrichment of S235D mutant and mortalin in the higher molecular complex was also evident.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:EC833EFAFC95A79A|rigid:5ZKmnJiViiKK01gyCPnKlS8uCpY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15350	uniprotkb:O15350	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651674|imex:IM-17320-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:S3A -LHS|comment:Enrichment of S235D mutant and mortalin in the higher molecular complex was also evident.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:F34D934840E640B8|rigid:OdU5/lVUUkIb6LHyiKByXrUL5+M	false	green fluorescent protein tag:?-?	green fluorescent protein tag:?-?	4	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:O15350	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651373|imex:IM-17320-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:S3A -LHS|comment:Enrichment of S235D mutant and mortalin in the higher molecular complex was also evident.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:01A913A6EE6258AB|rigid:BYvZdraTJw4d6m+6QJSCov9lrNE	false	green fluorescent protein tag:?-?|mutation increasing interaction strength:235-235	mutation:235-235|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:O15350	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651708|imex:IM-17320-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:S3A -LHS mmm|comment:Enrichment of S235D mutant and mortalin in the higher molecular complex was also evident.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:C2AD11AAD65BC92A|rigid:OdU5/lVUUkIb6LHyiKByXrUL5+M	false	green fluorescent protein tag:?-?|mutation:235-235	green fluorescent protein tag:?-?|mutation:235-235	4	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15350	uniprotkb:O15350	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Katayama et al. (2012)	pubmed:22340593|imex:IM-17320	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5651698|imex:IM-17320-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	-	-	-	figure legend:S3A LHS|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/02/22	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	intact-crc:C85DDA0C4B77ECE0|rigid:BYvZdraTJw4d6m+6QJSCov9lrNE	false	green fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)