#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22216	uniprotkb:P43601	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	intact:EBI-22968|uniprotkb:D6VTQ1|ensemblfungi:YFR021W	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:atg18_yeast(display_long)|uniprotkb:NMR1(gene name synonym)|uniprotkb:YFR021W(locus name)|uniprotkb:ATG18(gene name)|psi-mi:ATG18(display_short)|uniprotkb:AUT10(gene name synonym)|uniprotkb:CVT18(gene name synonym)|uniprotkb:SVP1(gene name synonym)|uniprotkb:Cytoplasm to vacuole targeting protein 18(gene name synonym)|uniprotkb:Swollen vacuole phenotype protein 1(gene name synonym)|uniprotkb:Needed for premeiotic replication protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Travesa et al. (2012)	doi:10.1038/emboj.2012.28|pubmed:22333915|imex:IM-17571|mint:MINT-8381613	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7697252|mint:MINT-8381621|imex:IM-17571-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216|mint:MINT-8381623(identity)	refseq:NP_444297.1|sgd:S000001917|dip:DIP-5185N|mint:P43601|ensemblfungi:YFR021W(gene)|ensemblfungi:YFR021W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0061908"(phagophore)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070772"(PAS complex)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:6KYB|reactome:R-SCE-1632852|mint:MINT-8381624(identity)	-	crc64:84A9612229CA72D1	crc64:06B2DFAF842AE933	comment:homomint|comment:mint|figure legend:f5c f6d f6e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/29	2014/10/16	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rogid:dUJPRtNzoRFY/sp9LSteu2xC13A559292	intact-crc:B95CF176D74E1DEB|rigid:gor/FT3XyodQwA1Pi5udy3E/zIY	false	glutathione s tranferase tag:?-?(MINT-8381627)	phosphorylated residue:47-47(MINT-8381638)|phosphorylated residue:42-42(MINT-8381636)|mutation decreasing interaction:47-47(MINT-8381648)|mutation decreasing interaction:42-42(MINT-8381645)|mutation decreasing interaction:240-240(MINT-8381654)|phosphorylated residue:240-240(MINT-8381640)|mutation decreasing interaction:145-145(MINT-8381651)|glutathione s tranferase tag:?-?(MINT-8381633)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)