#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60629	uniprotkb:P35546-2	intact:EBI-1267609|uniprotkb:E9QPV2|ensembl:ENSMUSP00000060646	intact:EBI-5548911|ensembl:ENSMUSP00000086169	psi-mi:epha5_mouse(display_long)|uniprotkb:Epha5(gene name)|psi-mi:Epha5(display_short)|uniprotkb:Bsk(gene name synonym)|uniprotkb:Ehk1(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym)|uniprotkb:CEK-7(gene name synonym)	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5549247|imex:IM-17021-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031963.2|ensembl:ENSMUSG00000029245(gene)|ensembl:ENSMUST00000053733(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR036116|mint:Q60629|rcsb pdb:5ZRZ|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|go:"GO:0043025"(neuronal cell body)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	-	-	-	figure legend:Fig. 5A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:G8F8gmooXB4JL3Vsfr2c732xdW010090	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	intact-crc:08C60C0BC09A41B3|rigid:2KmYKVrx7masTTaOY/vHe2QZMjw	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35546-2	uniprotkb:P07174	intact:EBI-5548911|ensembl:ENSMUSP00000086169	intact:EBI-1038810	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:tnr16_rat(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5549129|imex:IM-17021-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	rgd:3177|refseq:NP_036742.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009986"(cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|rcsb pdb:1NGR|rcsb pdb:1SG1|rcsb pdb:2MIC|rcsb pdb:2MJO|rcsb pdb:3BUK|rcsb pdb:3IJ2|rcsb pdb:4F42|rcsb pdb:4F44|reactome:R-RNO-193634|reactome:R-RNO-193692|reactome:R-RNO-205017|reactome:R-RNO-205025|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-209563|go:"GO:0051897"(positive regulation of protein kinase B signaling)|mint:P07174|dip:DIP-5715N	-	-	-	figure legend:Fig. 3F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	rogid:lscumOKfwxDCsoAs1EZfp6iFwz410116	intact-crc:AAEEED5FAEA2AF39|rigid:UYt/ra1mDOhkbrS1T5iiBTsBPn0	false	ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35546-2	uniprotkb:Q03145	intact:EBI-5548911|ensembl:ENSMUSP00000086169	intact:EBI-529701|uniprotkb:Q60633|uniprotkb:Q62212|uniprotkb:Q3UNI2|ensembl:ENSMUSP00000006614	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:epha2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-2(gene name synonym)|uniprotkb:Epha2(gene name)|psi-mi:Epha2(display_short)|uniprotkb:Eck(gene name synonym)|uniprotkb:Sek2(gene name synonym)|uniprotkb:Myk2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5549061|imex:IM-17021-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	refseq:NP_034269.2|dip:DIP-829N|ensembl:ENSMUSG00000006445(gene)|ensembl:ENSMUST00000006614(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:Q03145|rcsb pdb:5ZRX|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273	-	-	-	figure legend:Fig. 3F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	rogid:PppTcjFTGU5TuCWNmeqK9NVjb5w10090	intact-crc:EA67D8B7D79EA9EA|rigid:kely/76ymS/YeOv7i6LmbrDPVrg	false	ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60629	uniprotkb:P35546-2	intact:EBI-1267609|uniprotkb:E9QPV2|ensembl:ENSMUSP00000060646	intact:EBI-5548911|ensembl:ENSMUSP00000086169	psi-mi:epha5_mouse(display_long)|uniprotkb:Epha5(gene name)|psi-mi:Epha5(display_short)|uniprotkb:Bsk(gene name synonym)|uniprotkb:Ehk1(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym)|uniprotkb:CEK-7(gene name synonym)	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5548919|imex:IM-17021-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031963.2|ensembl:ENSMUSG00000029245(gene)|ensembl:ENSMUST00000053733(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR036116|mint:Q60629|rcsb pdb:5ZRZ|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|go:"GO:0043025"(neuronal cell body)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	-	-	-	figure legend:Fig. 3F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:G8F8gmooXB4JL3Vsfr2c732xdW010090	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	intact-crc:18917DA561C9A5BC|rigid:2KmYKVrx7masTTaOY/vHe2QZMjw	false	v5 tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35546-2	uniprotkb:P97785	intact:EBI-5548911|ensembl:ENSMUSP00000086169	intact:EBI-5549349|uniprotkb:O35246|uniprotkb:O35252|ensembl:ENSMUSP00000026076|ensembl:ENSMUSP00000120333|ensembl:ENSMUSP00000130128	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:gfra1_mouse(display_long)|uniprotkb:Gfra1(gene name)|psi-mi:Gfra1(display_short)|uniprotkb:Gdnfra(gene name synonym)|uniprotkb:Trnr1(gene name synonym)|uniprotkb:TGF-beta-related neurotrophic factor receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5549376|imex:IM-17021-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	refseq:NP_034409.1|refseq:NP_001272386.1|refseq:XP_006526744.1|refseq:XP_006526745.1|refseq:XP_006526746.1|refseq:XP_006526747.1|ensembl:ENSMUSG00000025089(gene)|ensembl:ENSMUST00000026076(transcript)|ensembl:ENSMUST00000152507(transcript)|ensembl:ENSMUST00000169850(transcript)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0016477"(cell migration)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003438(Glial cell line-derived neurotrophic factor receptor)|interpro:IPR003503(Glial cell line-derived neurotrophic factor receptor, alpha 1)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR017372(Glial cell line-derived neurotrophic factor receptor, alpha 1/2)|interpro:IPR037193|reactome:R-MMU-5673001|reactome:R-MMU-8853659	-	-	-	figure legend:Fig. 5A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	rogid:kWBJK9F1m2QXPP+uBIV3TehnE1w10090	intact-crc:6761F44EB404F758|rigid:Z1n7mJaXLSjwrIe6MBANcEk9/y8	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35546-2	uniprotkb:Q60629	intact:EBI-5548911|ensembl:ENSMUSP00000086169	intact:EBI-1267609|uniprotkb:E9QPV2|ensembl:ENSMUSP00000060646	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:epha5_mouse(display_long)|uniprotkb:Epha5(gene name)|psi-mi:Epha5(display_short)|uniprotkb:Bsk(gene name synonym)|uniprotkb:Ehk1(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym)|uniprotkb:CEK-7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5549376|imex:IM-17021-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	refseq:NP_031963.2|ensembl:ENSMUSG00000029245(gene)|ensembl:ENSMUST00000053733(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR036116|mint:Q60629|rcsb pdb:5ZRZ|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Fig. 5A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/02/16	2014/10/16	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	rogid:G8F8gmooXB4JL3Vsfr2c732xdW010090	intact-crc:6761F44EB404F758|rigid:Z1n7mJaXLSjwrIe6MBANcEk9/y8	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60629	uniprotkb:P35546-2	intact:EBI-1267609|uniprotkb:E9QPV2|ensembl:ENSMUSP00000060646	intact:EBI-5548911|ensembl:ENSMUSP00000086169	psi-mi:epha5_mouse(display_long)|uniprotkb:Epha5(gene name)|psi-mi:Epha5(display_short)|uniprotkb:Bsk(gene name synonym)|uniprotkb:Ehk1(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym)|uniprotkb:CEK-7(gene name synonym)	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6095846|imex:IM-17021-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031963.2|ensembl:ENSMUSG00000029245(gene)|ensembl:ENSMUST00000053733(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR036116|mint:Q60629|rcsb pdb:5ZRZ|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|go:"GO:0043025"(neuronal cell body)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 3I, 4W.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick-neuron)|taxid:9031(Chick neuron)	-	2012/02/16	2014/10/16	rogid:G8F8gmooXB4JL3Vsfr2c732xdW010090	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	intact-crc:013720753BB9A57E|rigid:2KmYKVrx7masTTaOY/vHe2QZMjw	false	green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P35546-2	uniprotkb:Q60629	intact:EBI-5548911|ensembl:ENSMUSP00000086169	intact:EBI-1267609|uniprotkb:E9QPV2|ensembl:ENSMUSP00000060646	psi-mi:p35546-2(display_long)|uniprotkb:Ret9(isoform synonym)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:epha5_mouse(display_long)|uniprotkb:Epha5(gene name)|psi-mi:Epha5(display_short)|uniprotkb:Bsk(gene name synonym)|uniprotkb:Ehk1(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym)|uniprotkb:CEK-7(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Bonanomi et al. (2012)	pubmed:22304922|imex:IM-17021	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6095855|imex:IM-17021-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000088790(transcript)|intact:EBI-2480800(isoform-parent)	refseq:NP_031963.2|ensembl:ENSMUSG00000029245(gene)|ensembl:ENSMUST00000053733(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR036116|mint:Q60629|rcsb pdb:5ZRZ|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|go:"GO:0043025"(neuronal cell body)	go:"GO:0044297"(cell body)|go:"GO:0033267"(obsolete axon part)|go:"GO:0009986"(cell surface)	-	-	figure legend:Fig.  S3V-Y|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick-neuron)|taxid:9031(Chick neuron)	-	2012/02/16	2014/10/16	rogid:h2NifU5tjXstIkUwhEl1H/e7Ux410090	rogid:G8F8gmooXB4JL3Vsfr2c732xdW010090	intact-crc:F7071C8F93B8AF54|rigid:2KmYKVrx7masTTaOY/vHe2QZMjw	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)