#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6XVN8	uniprotkb:Q9ULZ3	intact:EBI-6253160|ensembl:ENSRNOP00000032429	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:mlp3a_rat(display_long)|uniprotkb:Map1lc3a(gene name)|psi-mi:Map1lc3a(display_short)|uniprotkb:Autophagy-related protein LC3 A(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 A(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 1(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 A(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 alpha(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253158|imex:IM-17612-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000025443(gene)|ensembl:ENSRNOT00000035060(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043278"(response to morphine)|go:"GO:0044754"(autolysosome)|go:"GO:0045202"(synapse)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0005776"(autophagosome)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|reactome:R-RNO-1632852|reactome:R-RNO-5205685|reactome:R-RNO-8934903|rgd:735183|refseq:NP_955794.1	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:Fig. 2C.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:qtZ3YM26FhxTs/gW+KFMllsVhn410116	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:A4C1A4FC1D8C657F|rigid:UJSXchk47bPzTsaYxmYQw18mix4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9ULZ3	uniprotkb:P11279	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253186|imex:IM-17612-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	-	-	-	figure legend:Fig. 2D.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	intact-crc:DF5847EE67233BC2|rigid:QLRzvQfaThOnCz3uWP6T1/invOk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6XVN8	uniprotkb:O14862	intact:EBI-6253160|ensembl:ENSRNOP00000032429	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	psi-mi:mlp3a_rat(display_long)|uniprotkb:Map1lc3a(gene name)|psi-mi:Map1lc3a(display_short)|uniprotkb:Autophagy-related protein LC3 A(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 A(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 1(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 A(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 alpha(gene name synonym)	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253191|imex:IM-17612-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000025443(gene)|ensembl:ENSRNOT00000035060(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043278"(response to morphine)|go:"GO:0044754"(autolysosome)|go:"GO:0045202"(synapse)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0005776"(autophagosome)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|reactome:R-RNO-1632852|reactome:R-RNO-5205685|reactome:R-RNO-8934903|rgd:735183|refseq:NP_955794.1	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	-	-	-	figure legend:Fig. 3A.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:qtZ3YM26FhxTs/gW+KFMllsVhn410116	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	intact-crc:B573010E6430C52E|rigid:GZ8SZUXUWVZ8xmsp0xS9QkgulfE	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P11279	uniprotkb:O14862	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253225|imex:IM-17612-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	-	-	-	figure legend:Fig. 3B.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	intact-crc:32675EA2E1A2C76A|rigid:AHxU/xrN0fQUJ6qlhfdlG5rnPKY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96P20	uniprotkb:Q9H492	intact:EBI-6253230|uniprotkb:B2RC97|uniprotkb:B7ZKS9|uniprotkb:A0A024R5Q0|uniprotkb:B7ZKT2|uniprotkb:B7ZKT3|uniprotkb:O75434|uniprotkb:Q17RS2|uniprotkb:Q59H68|uniprotkb:Q5JQS8|uniprotkb:Q5JQS9|uniprotkb:Q6TG35|uniprotkb:Q8TCW0|uniprotkb:Q8TEU9|uniprotkb:Q8WXH9	intact:EBI-720768|intact:EBI-28977435|ensembl:ENSP00000353886|ensembl:ENSP00000380821|uniprotkb:Q9BXW5|uniprotkb:E1P5P4|uniprotkb:E1P5P5	psi-mi:nlrp3_human(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)	psi-mi:mlp3a_human(display_long)|uniprotkb:Microtubule-associated protein 1 light chain 3 alpha(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 A(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 1(gene name synonym)|uniprotkb:Autophagy-related protein LC3 A(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 A(gene name synonym)|uniprotkb:MAP1LC3A(gene name)|psi-mi:MAP1LC3A(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253295|imex:IM-17612-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|go:"GO:0042834"(peptidoglycan binding)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2NAQ|rcsb pdb:3QF2|rcsb pdb:6NPY|refseq:XP_011542350.1|reactome:R-HSA-9707564|reactome:R-HSA-844456|refseq:NP_001073289.1|refseq:NP_001120933.1|refseq:NP_001120934.1|refseq:NP_001230062.1|refseq:NP_004886.3|refseq:NP_899632.1|reactome:R-HSA-5689901|refseq:XP_016855670.1|refseq:XP_016855671.1|refseq:XP_016855672.1|refseq:XP_016855673.1|dip:DIP-41153N|reactome:R-HSA-9660826	ensembl:ENSG00000101460(gene)|ensembl:ENST00000360668(transcript)|ensembl:ENST00000397709(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0044754"(autolysosome)|go:"GO:0045202"(synapse)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9H492|rcsb pdb:3ECI|rcsb pdb:3WAL|rcsb pdb:3WAN|rcsb pdb:4ZDV|rcsb pdb:5CX3|rcsb pdb:5DPR|rcsb pdb:6TBE|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|refseq:NP_115903.1|refseq:NP_852610.1|ensembl:ENSP00000353886|ensembl:ENST00000374837|ensembl:ENSP00000363970|ensembl:ENSP00000380821|dip:DIP-49052N	-	-	-	figure legend:Fig. 3C.|agonist:LPS and ATP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:qtZ3YM26FhxTs/gW+KFMllsVhn49606	intact-crc:CD2414CCFC25E1C4|rigid:bK8yyCl+9WMsqyKUpzj5q+JqgFo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9ULZ3	uniprotkb:Q13501	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253300|imex:IM-17612-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:Fig. 5A, 5C, 5D.|antagonist:nigericin|agonist:"poly(dA:dT) or (LPS and ATP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	intact-crc:0ECB3F6E0E7FA980|rigid:5XBQ0ZsMFcvWGYAuDhKQXJA3HzM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O14862	uniprotkb:Q13501	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253306|imex:IM-17612-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:Fig. S4A.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	intact-crc:93C2CC39A860F41F|rigid:j+SpkeuSfqB01Jyn0m12gCEuGdA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P11234	uniprotkb:Q9ULZ3	intact:EBI-752162|uniprotkb:Q53T32|intact:EBI-4324693|uniprotkb:B4E040|uniprotkb:Q6ZS74|ensembl:ENSP00000272519|ensembl:ENSP00000414224	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:ralb_human(display_long)|uniprotkb:RALB(gene name)|psi-mi:RALB(display_short)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253311|imex:IM-17612-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002872.1|refseq:XP_016860111.1|refseq:XP_005263781.1|refseq:XP_005263784.1|refseq:XP_005263785.1|refseq:XP_005263786.1|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:2KE5|rcsb pdb:2KWI|rcsb pdb:6ZQT|rcsb pdb:6ZRN|reactome:R-HSA-171007|ensembl:ENSG00000144118(gene)|ensembl:ENST00000272519(transcript)|ensembl:ENST00000420510(transcript)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:Fig. S6.|agonist:"poly(dA:dT) or (LPS and ATP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:vw59HFSN8liew1tYF7x9fgdeFCU9606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:5553589ADB5EAB7F|rigid:hNO46CJBESCOykWQtX6s7dezbgs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9ULZ3	uniprotkb:Q13501	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253324|imex:IM-17612-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:Fig. 5A.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	intact-crc:751594242DEB57E3|rigid:aE/ut6Op/ISWiGulX1siSrCGou8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9ULZ3	uniprotkb:Q14457	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253324|imex:IM-17612-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	-	-	-	figure legend:Fig. 5A.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	intact-crc:751594242DEB57E3|rigid:aE/ut6Op/ISWiGulX1siSrCGou8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14862	uniprotkb:Q9ULZ3	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253330|imex:IM-17612-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:Fig. S4B.|agonist:"poly(dA:dT)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:2FFBA404CD0F24AA|rigid:+M556/PQD6SqT5ADopg3og9qbfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14862	uniprotkb:Q14457	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253330|imex:IM-17612-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	-	-	-	figure legend:Fig. S4B.|agonist:"poly(dA:dT)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	intact-crc:2FFBA404CD0F24AA|rigid:+M556/PQD6SqT5ADopg3og9qbfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14862	uniprotkb:Q13501	intact:EBI-6253193|ensembl:ENSP00000357112|uniprotkb:A8K7M7|uniprotkb:Q5T3V9|uniprotkb:Q96FG9	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:aim2_human(display_long)|uniprotkb:AIM2(gene name)|psi-mi:AIM2(display_short)|uniprotkb:Absent in melanoma 2(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253330|imex:IM-17612-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4O7Q|rcsb pdb:6MB2|rcsb pdb:7K3R|reactome:R-HSA-844615|rcsb pdb:3VD8|ensembl:ENSG00000163568(gene)|ensembl:ENST00000368130(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:O14862|rcsb pdb:3RN2|rcsb pdb:3RN5|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004824.1|refseq:XP_016858337.1|dip:DIP-59741N	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:Fig. S4B.|agonist:"poly(dA:dT)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2012/07/25	2014/10/16	rogid:3TN0Sqyw7NrquK9pax1srmuEEJk9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	intact-crc:2FFBA404CD0F24AA|rigid:+M556/PQD6SqT5ADopg3og9qbfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPB4	uniprotkb:O88597	intact:EBI-6253348|ensembl:ENSMUSP00000033056|uniprotkb:Q9D2W9	intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369	psi-mi:asc_mouse(display_long)|uniprotkb:Pycard(gene name)|psi-mi:Pycard(display_short)|uniprotkb:Asc(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)	psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253346|imex:IM-17612-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030793(gene)|ensembl:ENSMUST00000033056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:2N1F|refseq:NP_075747.3|dip:DIP-27619N	refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N	-	-	-	figure legend:Fig. 8D.|agonist:"poly(dA:dT) or (LPS and ATP)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:voh/LYBzHC1ZM83VF91HJfILfGU10090	rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090	intact-crc:84C5C44192AFCB78|rigid:bKTVU11WJBL3XhObUPRt9F85V18	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPB4	uniprotkb:Q9JIW9	intact:EBI-6253348|ensembl:ENSMUSP00000033056|uniprotkb:Q9D2W9	intact:EBI-3956329|uniprotkb:Q3TVS5|ensembl:ENSMUSP00000004565	psi-mi:asc_mouse(display_long)|uniprotkb:Pycard(gene name)|psi-mi:Pycard(display_short)|uniprotkb:Asc(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)	psi-mi:ralb_mouse(display_long)|uniprotkb:Ralb(gene name)|psi-mi:Ralb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253346|imex:IM-17612-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030793(gene)|ensembl:ENSMUST00000033056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:2N1F|refseq:NP_075747.3|dip:DIP-27619N	ensembl:ENSMUSG00000004451(gene)|ensembl:ENSMUST00000004565(transcript)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|go:"GO:0005886"(plasma membrane)|refseq:NP_071722.1|refseq:XP_006529845.1	-	-	-	figure legend:Fig. 8D.|agonist:"poly(dA:dT) or (LPS and ATP)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:voh/LYBzHC1ZM83VF91HJfILfGU10090	rogid:uZ5/RHOTMzhPtySfh5q+CHi1jXo10090	intact-crc:84C5C44192AFCB78|rigid:bKTVU11WJBL3XhObUPRt9F85V18	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91VJ1	uniprotkb:Q9JIW9	intact:EBI-6253384|ensembl:ENSMUSP00000119465|ensembl:ENSMUSP00000132253	intact:EBI-3956329|uniprotkb:Q3TVS5|ensembl:ENSMUSP00000004565	psi-mi:aim2_mouse(display_long)|uniprotkb:Aim2(gene name)|psi-mi:Aim2(display_short)|uniprotkb:Gm1313(gene name synonym)|uniprotkb:Ifi210(gene name synonym)|uniprotkb:Interferon-inducible protein 210(gene name synonym)|uniprotkb:Interferon-inducible protein p210(gene name synonym)	psi-mi:ralb_mouse(display_long)|uniprotkb:Ralb(gene name)|psi-mi:Ralb(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253382|imex:IM-17612-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037860(gene)|ensembl:ENSMUST00000147604(transcript)|ensembl:ENSMUST00000166137(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|rcsb pdb:2N00|rcsb pdb:4JBM|reactome:R-MMU-844615|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:XP_011237133.1|refseq:XP_011237137.1|refseq:XP_011237144.1|refseq:XP_006496982.1|refseq:XP_006496989.1|refseq:NP_001013801.2|refseq:XP_017176969.1|refseq:XP_017176971.1|refseq:XP_017176972.1|refseq:XP_017176975.1|refseq:XP_017176976.1|refseq:XP_017176977.1|refseq:XP_017176981.1|refseq:XP_017176983.1|refseq:XP_017176985.1|refseq:XP_017176987.1|refseq:XP_017176990.1|refseq:XP_017176994.1|refseq:XP_017176996.1|refseq:XP_017176999.1	ensembl:ENSMUSG00000004451(gene)|ensembl:ENSMUST00000004565(transcript)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|go:"GO:0005886"(plasma membrane)|refseq:NP_071722.1|refseq:XP_006529845.1	-	-	-	figure legend:Fig. 8E.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:/oQtebkbkx5ypHAM8LCTgo/gmew10090	rogid:uZ5/RHOTMzhPtySfh5q+CHi1jXo10090	intact-crc:66BD605324764F3E|rigid:YwAG5Nzg7i8NzpMnK05poDdMM84	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6PGF7	uniprotkb:Q91VJ1	intact:EBI-775347|ensembl:ENSMUSP00000095915	intact:EBI-6253384|ensembl:ENSMUSP00000119465|ensembl:ENSMUSP00000132253	psi-mi:exoc8_mouse(display_long)|uniprotkb:Exocyst complex 84 kDa subunit(gene name synonym)|uniprotkb:Exoc8(gene name)|psi-mi:Exoc8(display_short)	psi-mi:aim2_mouse(display_long)|uniprotkb:Aim2(gene name)|psi-mi:Aim2(display_short)|uniprotkb:Gm1313(gene name synonym)|uniprotkb:Ifi210(gene name synonym)|uniprotkb:Interferon-inducible protein 210(gene name synonym)|uniprotkb:Interferon-inducible protein p210(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253412|imex:IM-17612-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932771.1|ensembl:ENSMUSG00000074030(gene)|ensembl:ENSMUST00000098312(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR032403|interpro:IPR033961|interpro:IPR042560|interpro:IPR042561|reactome:R-MMU-264876|reactome:R-MMU-5620916	ensembl:ENSMUSG00000037860(gene)|ensembl:ENSMUST00000147604(transcript)|ensembl:ENSMUST00000166137(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:1904270"(pyroptosome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|rcsb pdb:2N00|rcsb pdb:4JBM|reactome:R-MMU-844615|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:XP_011237133.1|refseq:XP_011237137.1|refseq:XP_011237144.1|refseq:XP_006496982.1|refseq:XP_006496989.1|refseq:NP_001013801.2|refseq:XP_017176969.1|refseq:XP_017176971.1|refseq:XP_017176972.1|refseq:XP_017176975.1|refseq:XP_017176976.1|refseq:XP_017176977.1|refseq:XP_017176981.1|refseq:XP_017176983.1|refseq:XP_017176985.1|refseq:XP_017176987.1|refseq:XP_017176990.1|refseq:XP_017176994.1|refseq:XP_017176996.1|refseq:XP_017176999.1	-	-	-	figure legend:Fig. S5.|agonist:"poly(dA:dT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:XrVr7L9gZRmW22kNUpaBVVga6QY10090	rogid:/oQtebkbkx5ypHAM8LCTgo/gmew10090	intact-crc:66FAE923F27146E9|rigid:lYlJckESM/zw/bEAQM4bY6Qc/48	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O88597	uniprotkb:Q9EPB4	intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369	intact:EBI-6253348|ensembl:ENSMUSP00000033056|uniprotkb:Q9D2W9	psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short)	psi-mi:asc_mouse(display_long)|uniprotkb:Pycard(gene name)|psi-mi:Pycard(display_short)|uniprotkb:Asc(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253417|imex:IM-17612-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N	ensembl:ENSMUSG00000030793(gene)|ensembl:ENSMUST00000033056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:2N1F|refseq:NP_075747.3|dip:DIP-27619N	-	-	-	agonist:uric acid crystals|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090	rogid:voh/LYBzHC1ZM83VF91HJfILfGU10090	intact-crc:83B2DF4409EB2AF4|rigid:YU+h8zu7z5t3L990xjReE8eSB6U	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9EPB4	uniprotkb:Q6PGF7	intact:EBI-6253348|ensembl:ENSMUSP00000033056|uniprotkb:Q9D2W9	intact:EBI-775347|ensembl:ENSMUSP00000095915	psi-mi:asc_mouse(display_long)|uniprotkb:Pycard(gene name)|psi-mi:Pycard(display_short)|uniprotkb:Asc(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)	psi-mi:exoc8_mouse(display_long)|uniprotkb:Exocyst complex 84 kDa subunit(gene name synonym)|uniprotkb:Exoc8(gene name)|psi-mi:Exoc8(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shi et al. (2012)	imex:IM-17612|pubmed:22286270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6253421|imex:IM-17612-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030793(gene)|ensembl:ENSMUST00000033056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:2N1F|refseq:NP_075747.3|dip:DIP-27619N	refseq:NP_932771.1|ensembl:ENSMUSG00000074030(gene)|ensembl:ENSMUST00000098312(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR032403|interpro:IPR033961|interpro:IPR042560|interpro:IPR042561|reactome:R-MMU-264876|reactome:R-MMU-5620916	-	-	-	agonist:uric acid crystals|figure legend:Fig. S5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2012/07/25	2014/10/16	rogid:voh/LYBzHC1ZM83VF91HJfILfGU10090	rogid:XrVr7L9gZRmW22kNUpaBVVga6QY10090	intact-crc:5409D48131044D72|rigid:WqeVEXOHIFzvOjKC3rCoTEWSgdA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)