#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q16620 uniprotkb:Q16620 intact:EBI-3904881|uniprotkb:B1ANZ4|uniprotkb:Q8WXJ6|uniprotkb:Q16675|uniprotkb:Q8WXJ5|uniprotkb:Q8WXJ7|uniprotkb:B4DFV9|uniprotkb:Q59GJ1|ensembl:ENSP00000314586|ensembl:ENSP00000365386 intact:EBI-3904881|uniprotkb:B1ANZ4|uniprotkb:Q8WXJ6|uniprotkb:Q16675|uniprotkb:Q8WXJ5|uniprotkb:Q8WXJ7|uniprotkb:B4DFV9|uniprotkb:Q59GJ1|ensembl:ENSP00000314586|ensembl:ENSP00000365386 psi-mi:ntrk2_human(display_long)|uniprotkb:Tropomyosin-related kinase B(gene name synonym)|uniprotkb:NTRK2(gene name)|psi-mi:NTRK2(display_short)|uniprotkb:TRKB(gene name synonym)|uniprotkb:GP145-TrkB(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym) psi-mi:ntrk2_human(display_long)|uniprotkb:Tropomyosin-related kinase B(gene name synonym)|uniprotkb:NTRK2(gene name)|psi-mi:NTRK2(display_short)|uniprotkb:TRKB(gene name synonym)|uniprotkb:GP145-TrkB(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Shen et al. (2012) pubmed:22269274|imex:IM-20551 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5650732|imex:IM-20551-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011517020.1|refseq:XP_011517022.1|refseq:NP_001007098.1|refseq:NP_001018074.1|refseq:NP_001018076.1|dip:DIP-5720N|refseq:NP_001018075.1|refseq:NP_006171.2|ensembl:ENSG00000148053(gene)|ensembl:ENST00000323115(transcript)|ensembl:ENST00000376213(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|rcsb pdb:1HCF|rcsb pdb:1WWB|rcsb pdb:2MFQ|rcsb pdb:4ASZ|rcsb pdb:4AT3|rcsb pdb:4AT4|rcsb pdb:4AT5|rcsb pdb:5MO9|reactome:R-HSA-187024|reactome:R-HSA-9024909|reactome:R-HSA-9025046|reactome:R-HSA-9026357|reactome:R-HSA-9026519|reactome:R-HSA-9026527|reactome:R-HSA-9028335|reactome:R-HSA-9028731|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-9032845|refseq:XP_005252058.1|refseq:XP_005252060.1|refseq:XP_005252061.1|refseq:XP_005252063.1|refseq:XP_016870240.1|refseq:XP_016870241.1|refseq:XP_016870242.1|refseq:XP_016870243.1|refseq:XP_016870244.1|refseq:XP_016870245.1|refseq:XP_016870246.1|refseq:XP_016870249.1|refseq:XP_005252064.1|refseq:XP_016870247.1|refseq:XP_016870248.1|refseq:XP_016870250.1 refseq:XP_011517020.1|refseq:XP_011517022.1|refseq:NP_001007098.1|refseq:NP_001018074.1|refseq:NP_001018076.1|dip:DIP-5720N|refseq:NP_001018075.1|refseq:NP_006171.2|ensembl:ENSG00000148053(gene)|ensembl:ENST00000323115(transcript)|ensembl:ENST00000376213(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|rcsb pdb:1HCF|rcsb pdb:1WWB|rcsb pdb:2MFQ|rcsb pdb:4ASZ|rcsb pdb:4AT3|rcsb pdb:4AT4|rcsb pdb:4AT5|rcsb pdb:5MO9|reactome:R-HSA-187024|reactome:R-HSA-9024909|reactome:R-HSA-9025046|reactome:R-HSA-9026357|reactome:R-HSA-9026519|reactome:R-HSA-9026527|reactome:R-HSA-9028335|reactome:R-HSA-9028731|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-9032845|refseq:XP_005252058.1|refseq:XP_005252060.1|refseq:XP_005252061.1|refseq:XP_005252063.1|refseq:XP_016870240.1|refseq:XP_016870241.1|refseq:XP_016870242.1|refseq:XP_016870243.1|refseq:XP_016870244.1|refseq:XP_016870245.1|refseq:XP_016870246.1|refseq:XP_016870249.1|refseq:XP_005252064.1|refseq:XP_016870247.1|refseq:XP_016870248.1|refseq:XP_016870250.1 go:"GO:0005783"(endoplasmic reticulum) - - figure legend:fig. 2a, 2b, 2c, 2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/02/27 2014/10/16 rogid:ozPO6HfbJO55U7b6EYTBBsbux6A9606 rogid:ozPO6HfbJO55U7b6EYTBBsbux6A9606 intact-crc:C10BE55F39036A94|rigid:pMOh+sa/wCPloznzYoFEEE4UnEA false necessary binding region:455..455-822..822|venus c-terminal fragment:c-c venus c-terminal fragment:c-c|necessary binding region:455..455-822..822 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16620 uniprotkb:Q16620 intact:EBI-3904881|uniprotkb:B1ANZ4|uniprotkb:Q8WXJ6|uniprotkb:Q16675|uniprotkb:Q8WXJ5|uniprotkb:Q8WXJ7|uniprotkb:B4DFV9|uniprotkb:Q59GJ1|ensembl:ENSP00000314586|ensembl:ENSP00000365386 intact:EBI-3904881|uniprotkb:B1ANZ4|uniprotkb:Q8WXJ6|uniprotkb:Q16675|uniprotkb:Q8WXJ5|uniprotkb:Q8WXJ7|uniprotkb:B4DFV9|uniprotkb:Q59GJ1|ensembl:ENSP00000314586|ensembl:ENSP00000365386 psi-mi:ntrk2_human(display_long)|uniprotkb:Tropomyosin-related kinase B(gene name synonym)|uniprotkb:NTRK2(gene name)|psi-mi:NTRK2(display_short)|uniprotkb:TRKB(gene name synonym)|uniprotkb:GP145-TrkB(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym) psi-mi:ntrk2_human(display_long)|uniprotkb:Tropomyosin-related kinase B(gene name synonym)|uniprotkb:NTRK2(gene name)|psi-mi:NTRK2(display_short)|uniprotkb:TRKB(gene name synonym)|uniprotkb:GP145-TrkB(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym) psi-mi:"MI:1204"(split firefly luciferase complementation) Shen et al. (2012) pubmed:22269274|imex:IM-20551 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5650880|imex:IM-20551-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011517020.1|refseq:XP_011517022.1|refseq:NP_001007098.1|refseq:NP_001018074.1|refseq:NP_001018076.1|dip:DIP-5720N|refseq:NP_001018075.1|refseq:NP_006171.2|ensembl:ENSG00000148053(gene)|ensembl:ENST00000323115(transcript)|ensembl:ENST00000376213(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|rcsb pdb:1HCF|rcsb pdb:1WWB|rcsb pdb:2MFQ|rcsb pdb:4ASZ|rcsb pdb:4AT3|rcsb pdb:4AT4|rcsb pdb:4AT5|rcsb pdb:5MO9|reactome:R-HSA-187024|reactome:R-HSA-9024909|reactome:R-HSA-9025046|reactome:R-HSA-9026357|reactome:R-HSA-9026519|reactome:R-HSA-9026527|reactome:R-HSA-9028335|reactome:R-HSA-9028731|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-9032845|refseq:XP_005252058.1|refseq:XP_005252060.1|refseq:XP_005252061.1|refseq:XP_005252063.1|refseq:XP_016870240.1|refseq:XP_016870241.1|refseq:XP_016870242.1|refseq:XP_016870243.1|refseq:XP_016870244.1|refseq:XP_016870245.1|refseq:XP_016870246.1|refseq:XP_016870249.1|refseq:XP_005252064.1|refseq:XP_016870247.1|refseq:XP_016870248.1|refseq:XP_016870250.1 refseq:XP_011517020.1|refseq:XP_011517022.1|refseq:NP_001007098.1|refseq:NP_001018074.1|refseq:NP_001018076.1|dip:DIP-5720N|refseq:NP_001018075.1|refseq:NP_006171.2|ensembl:ENSG00000148053(gene)|ensembl:ENST00000323115(transcript)|ensembl:ENST00000376213(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|rcsb pdb:1HCF|rcsb pdb:1WWB|rcsb pdb:2MFQ|rcsb pdb:4ASZ|rcsb pdb:4AT3|rcsb pdb:4AT4|rcsb pdb:4AT5|rcsb pdb:5MO9|reactome:R-HSA-187024|reactome:R-HSA-9024909|reactome:R-HSA-9025046|reactome:R-HSA-9026357|reactome:R-HSA-9026519|reactome:R-HSA-9026527|reactome:R-HSA-9028335|reactome:R-HSA-9028731|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-9032845|refseq:XP_005252058.1|refseq:XP_005252060.1|refseq:XP_005252061.1|refseq:XP_005252063.1|refseq:XP_016870240.1|refseq:XP_016870241.1|refseq:XP_016870242.1|refseq:XP_016870243.1|refseq:XP_016870244.1|refseq:XP_016870245.1|refseq:XP_016870246.1|refseq:XP_016870249.1|refseq:XP_005252064.1|refseq:XP_016870247.1|refseq:XP_016870248.1|refseq:XP_016870250.1 - - - figure legend:fig. 3a, b and c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/02/27 2014/10/16 rogid:ozPO6HfbJO55U7b6EYTBBsbux6A9606 rogid:ozPO6HfbJO55U7b6EYTBBsbux6A9606 intact-crc:8605A70DE8A23788|rigid:pMOh+sa/wCPloznzYoFEEE4UnEA false necessary binding region:455..455-822..822|C-terminal firefly luciferase tag:c-c necessary binding region:455..455-822..822|N-terminal fragment of firefly luciferase:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)