#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529414|imex:IM-16689-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b left|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:B9E24146186735F1|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	sufficient binding region:95-281|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:O15519-2	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-5529416|ensembl:ENSP00000339335|ensembl:ENSP00000406775	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:o15519-2(display_long)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:FLIP-S(isoform synonym)|uniprotkb:CLARP2(isoform synonym)|uniprotkb:MRIT beta-1(isoform synonym)|uniprotkb:CASH beta(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529414|imex:IM-16689-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000341222(transcript)|ensembl:ENST00000440180(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b left|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:2iA2neNSXROh9irtfQSPvoqvL/E9606	intact-crc:B9E24146186735F1|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	sufficient binding region:95-281|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:O15519-1	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529414|imex:IM-16689-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b left|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:B9E24146186735F1|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	sufficient binding region:95-281|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:Q13158	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529414|imex:IM-16689-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b left|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:B9E24146186735F1|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	sufficient binding region:95-281|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:Q14790	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529414|imex:IM-16689-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b left|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	intact-crc:B9E24146186735F1|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	sufficient binding region:95-281|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:O15519-1	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529470|imex:IM-16689-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b right|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:8F73C893D86B8DCF|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	flag tag:n-n|sufficient binding region:95-281	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:Q13158	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529470|imex:IM-16689-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b right|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:8F73C893D86B8DCF|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	flag tag:n-n|sufficient binding region:95-281	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:O15519-2	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-5529416|ensembl:ENSP00000339335|ensembl:ENSP00000406775	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:o15519-2(display_long)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:FLIP-S(isoform synonym)|uniprotkb:CLARP2(isoform synonym)|uniprotkb:MRIT beta-1(isoform synonym)|uniprotkb:CASH beta(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529470|imex:IM-16689-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000341222(transcript)|ensembl:ENST00000440180(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b right|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:2iA2neNSXROh9irtfQSPvoqvL/E9606	intact-crc:8F73C893D86B8DCF|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	flag tag:n-n|sufficient binding region:95-281	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529470|imex:IM-16689-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b right|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:8F73C893D86B8DCF|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	flag tag:n-n|sufficient binding region:95-281	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50591	uniprotkb:Q14790	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529470|imex:IM-16689-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3b right|antagonist:"Co-immunoprecipitation of cFlip-L (O15519-1) is diminished by treatment with histone deacetylase inhibitor MS275. The same treatment abolished the co-immunoprecipitation of cFlip-S (O15519-2)."|agonist:Co-immunoprecipitation of casp8, fadd and tr10b was increased by treatment with histone deacetylase inhibitor MS275.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	intact-crc:8F73C893D86B8DCF|rigid:A1c4w5ZCfPBpHbEOHkwKX2iCJ70	false	flag tag:n-n|sufficient binding region:95-281	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01106	ensembl:ENSG00000177606	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	intact:EBI-5840729	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:jun_human_gene(display_short)|psi-mi:ENSG00000177606(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5529505|imex:IM-16689-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	-	-	-	-	figure legend:4e|agonist:The interaction requires the treatment with histone deacetylase inhibitor MS275 to happen.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	-	intact-crc:90188459192ED21B	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P01106	ensembl:ENSG00000003402	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	intact:EBI-5840810	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:cflar_human_gene(display_short)|psi-mi:ENSG00000003402(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bangert et al. (2012)	pubmed:22266862|imex:IM-16689	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5840817|imex:IM-16689-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	-	-	-	-	figure legend:4e|agonist:The interaction requires the treatment with histone deacetylase inhibitor MS275 to happen.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a172)|taxid:9606(Human A172 glioblastoma cell line)	-	2012/02/15	2014/10/16	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	-	intact-crc:603188F51E3682D8	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)