#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y572	uniprotkb:Q13546	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5380227|imex:IM-16647-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|comment:The interaction between RIP1 and RIP3  was enhanced by Necrosulfonamide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht_29)|taxid:9606(Homo sapiens HT-29 caucasian women with colon adenocarcinoma)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:0F1C27497ECB57D2|rigid:t2uKW9OOdS6fNdNbzxnEEckIQ4w	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y572	uniprotkb:Q8NB16	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5380629|imex:IM-16647-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht_29)|taxid:9606(Homo sapiens HT-29 caucasian women with colon adenocarcinoma)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:55B80641DC33CDD9|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q8NB16	intact:EBI-5381094	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0096"(pull down)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5381393|imex:IM-16647-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	-	-	-	figure legend:Figs. 3D, 4B, 4D, Supp. Figs. 4C, 5E|comment:Mouse MLKL does not bind necrosulfonamide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:AEF4F3E0DB4ECC8A	false	biotin tag:?-?	myc tag:n-n|mutation disrupting interaction:86-86|sufficient binding region:1-178	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q8NB16	intact:EBI-5381094	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0096"(pull down)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5394736|imex:IM-16647-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	-	-	-	figure legend:Supp. Fig. 3B|comment:Non-biotin-labeled necrosulfonamide competed off MLKL and RIP3 binding to the beads. endogenous RIP3 was also pulled down with MLKL before necrosis induction, confirming there was a basal level of MLKL/RIP3 interaction in living cells. As necrosis progressed, less MLKL/RIP3 bound to the biotin-NSA/streptavidin-conjugated beads.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:ED832AA1D59D8C81	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q9Y572	intact:EBI-5381094	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5394736|imex:IM-16647-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	-	-	-	figure legend:Supp. Fig. 3B|comment:Non-biotin-labeled necrosulfonamide competed off MLKL and RIP3 binding to the beads. endogenous RIP3 was also pulled down with MLKL before necrosis induction, confirming there was a basal level of MLKL/RIP3 interaction in living cells. As necrosis progressed, less MLKL/RIP3 bound to the biotin-NSA/streptavidin-conjugated beads.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:ED832AA1D59D8C81	false	biotin tag:?-?	flag tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q8NB16	intact:EBI-5381094	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0096"(pull down)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5381172|imex:IM-16647-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	-	-	-	figure legend:Fig. 3C|comment:Non-biotin-labeled necrosulfonamide competed off MLKL and RIP3 binding to the beads. endogenous RIP3 was also pulled down with MLKL before necrosis induction, confirming there was a basal level of MLKL/RIP3 interaction in living cells. As necrosis progressed, less MLKL/RIP3 bound to the biotin-NSA/streptavidin-conjugated beads.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:35C1A59200E11736	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q9Y572	intact:EBI-5381094	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5381172|imex:IM-16647-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	-	-	-	figure legend:Fig. 3C|comment:Non-biotin-labeled necrosulfonamide competed off MLKL and RIP3 binding to the beads. endogenous RIP3 was also pulled down with MLKL before necrosis induction, confirming there was a basal level of MLKL/RIP3 interaction in living cells. As necrosis progressed, less MLKL/RIP3 bound to the biotin-NSA/streptavidin-conjugated beads.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:35C1A59200E11736	false	biotin tag:?-?	ha tag:?-?|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:63770"	uniprotkb:Q8NB16	intact:EBI-5381094	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:necrosulfonamide(display_short)|psi-mi:"CHEBI:63770"(display_long)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5381708|imex:IM-16647-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	-	-	-	figure legend:Fig. 3E|comment:Non-biotin-labeled necrosulfonamide competed off MLKL and RIP3 binding to the beads.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	-	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:746BE521782B33D5	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y572	uniprotkb:Q8NB16	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5380664|imex:IM-16647-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|antagonist:Necrostatin-1|agonist:Necrosulfonamide|comment:MLKL knockdown enhanced RIP1/RIP3 interaction,  but  this interaction was not further enhanced by necrosulfonamide treatment after MLKL knockdown.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:23933629BDDB7384|rigid:bN+sXpivsEqFqN9C4B8MrG8MBbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y572	uniprotkb:Q13546	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5380664|imex:IM-16647-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|antagonist:Necrostatin-1|agonist:Necrosulfonamide|comment:MLKL knockdown enhanced RIP1/RIP3 interaction,  but  this interaction was not further enhanced by necrosulfonamide treatment after MLKL knockdown.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:23933629BDDB7384|rigid:bN+sXpivsEqFqN9C4B8MrG8MBbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y572	uniprotkb:Q8NB16	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5395061|imex:IM-16647-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:7328B4F053F2ADC3|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	flag tag:?-?|mutation decreasing interaction:50-50	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y572	uniprotkb:Q8NB16	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5401960|imex:IM-16647-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:489C04A64C85B4F9|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NB16	uniprotkb:Q9Y572	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5394230|imex:IM-16647-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B,  7C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:75C71F32987E24D4|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	myc tag:?-?|sufficient binding region:179-471	sufficient binding region:1-323(IPR000719)|mutation disrupting interaction:227-227|mutation disrupting interaction:142-142|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y572	uniprotkb:Q8NB16	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5394247|imex:IM-16647-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	intact-crc:6C1D39CFFFAEFDF3|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	sufficient binding region:1-323(IPR000719)|flag tag:?-?	myc tag:?-?|sufficient binding region:179-471(IPR000719)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9D2Y4	uniprotkb:Q9QZL0	intact:EBI-5401970|uniprotkb:Q8CIJ5|ensembl:ENSMUSP00000055521	intact:EBI-2367423|intact:EBI-6116401|uniprotkb:G3X8V8|uniprotkb:Q3U3Z9|uniprotkb:Q8K2Y2|ensembl:ENSMUSP00000022830	psi-mi:mlkl_mouse(display_long)|uniprotkb:Mlkl(gene name)|psi-mi:Mlkl(display_short)	psi-mi:ripk3_mouse(display_long)|uniprotkb:Ripk3(gene name)|psi-mi:Ripk3(display_short)|uniprotkb:Rip3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5401968|imex:IM-16647-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083281.1|refseq:NP_001297542.1|refseq:XP_006531505.1|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|rcsb pdb:4BTF|rcsb pdb:4M68|rcsb pdb:4M69|reactome:R-MMU-3295583|reactome:R-MMU-5213460|reactome:R-MMU-5675482|ensembl:ENSMUSG00000012519(gene)|ensembl:ENSMUST00000056157(transcript)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)	refseq:NP_064339.2|dip:DIP-54883N|ensembl:ENSMUSG00000022221(gene)|ensembl:ENSMUST00000022830(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|rcsb pdb:4M66|rcsb pdb:4M69|rcsb pdb:6JPD|rcsb pdb:6OKO|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-5213460|reactome:R-MMU-5675482|reactome:R-MMU-937041	psi-mi:"MI:0469"(intact)	-	-	figure legend:S6|comment:Mouse RIP3 only binds to mouse MLKL, but not the human homolog.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:psAtDkJEqy995YtXIt+xgMVYHWI10090	rogid:zl7TnLWZPUSq1KtKfpsUKJq57X810090	intact-crc:137EE134649AD9C7|rigid:tcAaNVucDdwEVp/mb9MRQcqGPCk	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NB16	uniprotkb:Q9Y572	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5380393|imex:IM-16647-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/27	2014/10/16	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:1B68D9D983406293|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	-	flag tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NB16	uniprotkb:Q9Y572	intact:EBI-1055040|uniprotkb:A6NCE4|uniprotkb:Q8N6V0|ensembl:ENSP00000308351	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:mlkl_human(display_long)|uniprotkb:MLKL(gene name)|psi-mi:MLKL(display_short)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sun et al. (2012)	pubmed:22265413|imex:IM-16647	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5394271|imex:IM-16647-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135969.1|refseq:NP_689862.1|refseq:XP_005255891.1|ensembl:ENSG00000168404(gene)|ensembl:ENST00000308807(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR036537|mint:Q8NB16|rcsb pdb:2MSV|rcsb pdb:4M67|rcsb pdb:4MWI|rcsb pdb:5KNJ|rcsb pdb:5KO1|rcsb pdb:6BWK|rcsb pdb:6D74|rcsb pdb:6LK5|rcsb pdb:6LK6|rcsb pdb:6O5Z|rcsb pdb:6UX8|rcsb pdb:6ZPR|rcsb pdb:6ZVO|rcsb pdb:6ZZ1|rcsb pdb:7JW7|rcsb pdb:7JXU|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9686347|rcsb pdb:6ZLE|dip:DIP-41782N	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5E, 6A, 6C, Supp. Fig. 5A|resulting-ptm:Tandem mass spectrometry of MLKL unambiguously identified threonine 357 and serine 358 as being phosphorylated|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/27	2014/10/16	rogid:xpqkgVEYtiqCJEVp3mmNVyprRQQ9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:E995D5043753A72D|rigid:s3iEmfJwRNh6LLNKHBr5li9HT1U	false	mutation disrupting interaction:357-358|mutation decreasing interaction:357-358|sufficient binding region:179-471(IPR000719)	ha tag:?-?|flag tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)