#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7644897|mint:MINT-8385974|imex:IM-18523-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8385976(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8385976(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	comment:mint|figure legend:sf1i st1 f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:C4110CA677056500|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	binding-associated region:106-206(MINT-8385990)	binding-associated region:106-206(MINT-8385990)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7644975|mint:MINT-8386059|imex:IM-18523-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386063(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386061(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf1f sf1g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:337D7C937C968ADB|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	glutathione s tranferase tag:?-?(MINT-8386066)|binding-associated region:148-206(MINT-8386064)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645034|mint:MINT-8386280|imex:IM-18523-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386282(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386282(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:AFC981A25FC0AD86|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	mutation disrupting interaction:166-166(MINT-8386294)|binding-associated region:106-206(MINT-8386283)	mutation disrupting interaction:166-166(MINT-8386294)|binding-associated region:106-206(MINT-8386283)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645092|mint:MINT-8386299|imex:IM-18523-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386301(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386301(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:1BA92C38CB8C4F3D|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	mutation disrupting interaction:172-172(MINT-8386302)|binding-associated region:106-206(MINT-8386304)	mutation disrupting interaction:172-172(MINT-8386302)|binding-associated region:106-206(MINT-8386304)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645185|mint:MINT-8386319|imex:IM-18523-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386321(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386321(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:F97F5EC95F39E05D|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	mutation disrupting interaction:190-190(MINT-8386325)|binding-associated region:106-206(MINT-8386322)	mutation disrupting interaction:190-190(MINT-8386325)|binding-associated region:106-206(MINT-8386322)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645202|mint:MINT-8386363|imex:IM-18523-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386365(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386365(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:4C039F2E7108A521|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	binding-associated region:106-206(MINT-8386368)|mutation disrupting interaction:185-185(MINT-8386366)	binding-associated region:106-206(MINT-8386368)|mutation disrupting interaction:185-185(MINT-8386366)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645228|mint:MINT-8386375|imex:IM-18523-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386377(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386377(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint|comment:"Stoichiometry: 2.0"	figure legend:sf3a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:AAEF819C32377FFE|rigid:eSWsA/OpvvRslO3srpRhhE8Bxe8	false	binding-associated region:106-206(MINT-8386378)	binding-associated region:106-206(MINT-8386378)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645250|mint:MINT-8386657|imex:IM-18523-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386663(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386659(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3d|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.22x10^-6(molar)	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:88BAD906BD7F9C4D|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	binding-associated region:106-206(MINT-8386674)	binding-associated region:749-761(MINT-8386671)|phosphorylated residue:754-754(MINT-8386678)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q9JIY2	uniprotkb:Q99704	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:"MI:0405"(competition binding)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645406|mint:MINT-8386934|imex:IM-18523-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386936(identity)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|mint:MINT-8386940(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	intact-crc:F5BC75F95D903928|rigid:QUoKCliAdQpSmCjRg/S/wdSxq0A	false	flag tag:?-?(MINT-8386937)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645462|mint:MINT-8386956|imex:IM-18523-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386965(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386959(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:domino|comment:mint|figure legend:f5a f5b f5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:984C131D27BB078F|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	binding-associated region:106-206(MINT-8386966)	phosphorylated residue:754-754(MINT-8386960)|binding-associated region:749-761(MINT-8386962)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645611|mint:MINT-8385996|imex:IM-18523-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8385999(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8385998(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf1a f3g f6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:920932A6683B5AB2|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386028)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645626|mint:MINT-8386032|imex:IM-18523-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386036(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386034(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf1b sf1c sf1d sf1e sf1g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:95A97976C5F16B05|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	binding-associated region:148-206(MINT-8386056)|ha tag:?-?(MINT-8386037)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q9JIY2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645644|mint:MINT-8386395|imex:IM-18523-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386406(identity)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386397(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	intact-crc:F312A70A1CF9F572|rigid:61zYHpdXz8Mihmg55X27mMgEkaQ	false	ha tag:?-?(MINT-8386407)	flag tag:?-?(MINT-8386411)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645662|mint:MINT-8386415|imex:IM-18523-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386419(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386417(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:44C0B4A23A59EA67|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386420)|mutation disrupting interaction:166-166(MINT-8386427)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645681|mint:MINT-8386430|imex:IM-18523-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386434(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386432(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:63012E07473D7083|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	mutation disrupting interaction:172-172(MINT-8386435)|flag tag:?-?(MINT-8386437)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645700|mint:MINT-8386444|imex:IM-18523-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386448(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386446(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:DF595B409E228094|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386451)|mutation disrupting interaction:185-185(MINT-8386449)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645753|mint:MINT-8386456|imex:IM-18523-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386460(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386458(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:F7C770A0ED5CBA61|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386461)|mutation disrupting interaction:190-190(MINT-8386463)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645772|mint:MINT-8386468|imex:IM-18523-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386472(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386470(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:72AC0F15401419C6|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386475)	mutation disrupting interaction:754-754(MINT-8386481)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645850|mint:MINT-8386485|imex:IM-18523-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386491(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386487(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:9181403DD5452E23|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386492)	mutation disrupting interaction:754-754(MINT-8386488)|mutation disrupting interaction:753-753(MINT-8386496)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645892|mint:MINT-8386500|imex:IM-18523-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386508(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386502(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:880FFBDB05955D10|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386509)	mutation disrupting interaction:754-754(MINT-8386505)|mutation disrupting interaction:755-755(MINT-8386503)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7645981|mint:MINT-8386515|imex:IM-18523-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386523(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386517(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f3c f3f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:6753DC19A47E2A8E|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386524)	mutation disrupting interaction:754-754(MINT-8386518)|mutation disrupting interaction:753-753(MINT-8386529)|mutation disrupting interaction:755-755(MINT-8386520)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646027|mint:MINT-8386534|imex:IM-18523-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386544(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386536(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:89D39451DE6DCA06|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386545)	mutation disrupting interaction:757-757(MINT-8386539)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646065|mint:MINT-8386552|imex:IM-18523-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386558(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386554(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:F229329254457B45|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386559)	mutation disrupting interaction:756-756(MINT-8386555)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646084|mint:MINT-8386565|imex:IM-18523-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386571(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386567(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:5A36E41B68B6DCCE|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386572)	mutation disrupting interaction:750-750(MINT-8386568)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646173|mint:MINT-8386578|imex:IM-18523-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386584(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386580(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f3f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:ADC3A99C7CE7BE48|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8386585)	mutation disrupting interaction:752-752(MINT-8386581)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q60598	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646211|mint:MINT-8386591|imex:IM-18523-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386597(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-8386593(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f3h f3j f3l f4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:3ED7726097884B0B|rigid:v0tskFtDByRx18pgzeK1x1j67Uw	false	flag tag:?-?(MINT-8386598)	mutation disrupting interaction:482-482(MINT-8386594)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q60598	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646250|mint:MINT-8386610|imex:IM-18523-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386612(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-8386616(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f3l|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:5B4C1B1FBF44BF8C|rigid:v0tskFtDByRx18pgzeK1x1j67Uw	false	flag tag:?-?(MINT-8386613)	mutation decreasing interaction:478-478(MINT-8386617)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q60598	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646298|mint:MINT-8386625|imex:IM-18523-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386627(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-8386631(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f3l|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:2BB43CE107F61E95|rigid:v0tskFtDByRx18pgzeK1x1j67Uw	false	flag tag:?-?(MINT-8386628)	mutation disrupting interaction:486-486(MINT-8386632)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q60598	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646340|mint:MINT-8386641|imex:IM-18523-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386643(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-8386647(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f3l|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:880E9C2C08785325|rigid:v0tskFtDByRx18pgzeK1x1j67Uw	false	flag tag:?-?(MINT-8386644)	mutation decreasing interaction:480-480(MINT-8386648)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q99704	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646360|mint:MINT-8386850|imex:IM-18523-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386852(identity)	refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659|mint:MINT-8386863(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606	intact-crc:48F8164F0FE54920|rigid:QUoKCliAdQpSmCjRg/S/wdSxq0A	false	flag tag:?-?(MINT-8386853)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646376|mint:MINT-8386981|imex:IM-18523-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8386987(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8386983(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:F3E8D5D99C9D50E0|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	mutation disrupting interaction:127-127(MINT-8386994)|flag tag:?-?(MINT-8386988)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646415|mint:MINT-8386998|imex:IM-18523-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387002(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8387000(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:0DD3F5BB22C4F082|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8387005)|mutation disrupting interaction:185-185(MINT-8387003)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646434|mint:MINT-8387010|imex:IM-18523-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387014(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8387012(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:8CF545E8C3B180D1|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	mutation disrupting interaction:176-176(MINT-8387017)|flag tag:?-?(MINT-8387015)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P12830	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646453|mint:MINT-8387022|imex:IM-18523-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387026(identity)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N|mint:MINT-8387024(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:4A50BA876A7B704E|rigid:MIFesqS9CKtzoZ99QqSkcDcnS48	false	flag tag:?-?(MINT-8387029)|mutation disrupting interaction:189-189(MINT-8387027)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646472|mint:MINT-8387035|imex:IM-18523-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387039(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387037(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f5f f6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:DB0B265D7906B0CF|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	mutation disrupting interaction:127-127(MINT-8387040)|flag tag:?-?(MINT-8387042)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646491|mint:MINT-8387047|imex:IM-18523-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387049(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387055(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f5f f5g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:48C717D4E73D90A9|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	flag tag:?-?(MINT-8387050)|mutation disrupting interaction:185-185(MINT-8387052)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646510|mint:MINT-8387059|imex:IM-18523-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387061(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387067(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f5f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:D851504D85C660ED|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	flag tag:?-?(MINT-8387064)|mutation disrupting interaction:176-176(MINT-8387062)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646529|mint:MINT-8387071|imex:IM-18523-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387073(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387079(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f5f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:1EF4AF222C0C9072|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	mutation disrupting interaction:189-189(MINT-8387076)|flag tag:?-?(MINT-8387074)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646548|mint:MINT-8387083|imex:IM-18523-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387085(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387091(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f5g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:6AF37BFE17CD2A4A|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	mutation disrupting interaction:190-190(MINT-8387086)|flag tag:?-?(MINT-8387088)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646567|mint:MINT-8387096|imex:IM-18523-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387098(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387104(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f5g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:FE352559BDACE0A8|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	mutation disrupting interaction:172-172(MINT-8387101)|flag tag:?-?(MINT-8387099)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646586|mint:MINT-8387108|imex:IM-18523-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387110(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387116(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	figure legend:f5g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2014/10/16	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:D9F4BFFCC0C87A4C|rigid:Ac+TOSz+BS1n17aVM9hoow0myxg	false	mutation disrupting interaction:166-166(MINT-8387111)|flag tag:?-?(MINT-8387113)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JIY2	uniprotkb:P35813	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972|mint:MINT-8387190(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P10644	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY|mint:MINT-8387194(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q9Y2A7-1	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7646633|intact:MINT-7382832|ensembl:ENSP00000355348	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:q9y2a7-1(display_long)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	intact:EBI-389845(isoform-parent)|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|mint:MINT-8387199(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	comment:mint|comment:homomint	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:O75688-1	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7646621|ensembl:ENSP00000282412|intact:MINT-4844080	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:o75688-1(display_long)|uniprotkb:PPM1B(gene name)|psi-mi:PPM1B(display_short)|uniprotkb:PP2CB(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform beta(gene name synonym)|uniprotkb:Beta-X(isoform synonym)|uniprotkb:PPM1B2(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	ensembl:ENSG00000138032(gene)|ensembl:ENST00000282412(transcript)|intact:EBI-1047039(isoform-parent)|mint:MINT-8387189(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	comment:mint|comment:homomint	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:cwwfGSSTv9pR/XNLa9UxQ/6hpD89606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P51617-3	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-7646611|intact:MINT-97128	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:p51617-3(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	intact:EBI-358664(isoform-parent)|mint:MINT-8387197(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	comment:mint|isoform-comment:No experimental confirmation available.|comment:homomint	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uXrepYbQ89pl4q9VPZUMMyTFJRo9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q12905	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-357925|uniprotkb:A6NDB0|uniprotkb:Q5SR10|uniprotkb:Q5SR11|uniprotkb:Q7L7R3|uniprotkb:Q9BWD4|uniprotkb:Q9P1N0|uniprotkb:B2R8G7|ensembl:ENSP00000355011	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:ilf2_human(display_long)|uniprotkb:PRO3063(orf name)|uniprotkb:NF45(gene name synonym)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_004506.2|refseq:NP_001254738.1|ensembl:ENSG00000143621(gene)|ensembl:ENST00000361891(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q12905|reactome:R-HSA-6798695|mint:MINT-8387195(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q99570	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N|mint:MINT-8387208(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:CjToF5FvjyANBQtA1wuWQxC82889606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P48730	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-751621|uniprotkb:Q96KZ6|uniprotkb:Q9BTN5|uniprotkb:A2I2P2|ensembl:ENSP00000324464	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:kc1d_human(display_long)|uniprotkb:CSNK1D(gene name)|psi-mi:CSNK1D(display_short)|uniprotkb:HCKID(gene name synonym)|uniprotkb:Tau-protein kinase CSNK1D(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001884.2|refseq:NP_620693.1|dip:DIP-39735N|ensembl:ENSG00000141551(gene)|ensembl:ENST00000314028(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48730|rcsb pdb:3UYS|rcsb pdb:3UYT|rcsb pdb:3UZP|rcsb pdb:4HGT|rcsb pdb:4HNF|rcsb pdb:4KB8|rcsb pdb:4KBA|rcsb pdb:4KBC|rcsb pdb:4KBK|rcsb pdb:4TN6|rcsb pdb:4TW9|rcsb pdb:4TWC|rcsb pdb:5IH4|rcsb pdb:5IH5|rcsb pdb:5IH6|rcsb pdb:5MQV|rcsb pdb:5OKT|rcsb pdb:5W4W|rcsb pdb:6F1W|rcsb pdb:6F26|rcsb pdb:6GZM|rcsb pdb:6HMP|rcsb pdb:6HMR|rcsb pdb:6PXN|rcsb pdb:6PXO|rcsb pdb:6PXP|rcsb pdb:6RCG|rcsb pdb:6RCH|rcsb pdb:6RU6|rcsb pdb:6RU7|rcsb pdb:6RU8|reactome:R-HSA-204005|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-400253|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|mint:MINT-8387192(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:Rz5aON17Bfduv29izmgHa/FR1/49606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P50395	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N|mint:MINT-8387202(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P41743	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029|mint:MINT-8387198(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q05655	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU|mint:MINT-8387289(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:BR/lNGg6f55rGP91akTf8BLkX449606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q14247	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|mint:MINT-8387184(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:O14654	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-356594|ensembl:ENSP00000505547	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|mint:MINT-8387196(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P23458	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1383438|uniprotkb:Q59GQ2|uniprotkb:Q9UD26|ensembl:ENSP00000343204|ensembl:ENSP00000499884|ensembl:ENSP00000499900|ensembl:ENSP00000500296|ensembl:ENSP00000500485|ensembl:ENSP00000500841	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:jak1_human(display_long)|uniprotkb:JAK1(gene name)|psi-mi:JAK1(display_short)|uniprotkb:JAK1A(gene name synonym)|uniprotkb:JAK1B(gene name synonym)|uniprotkb:Janus kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001308785.1|refseq:NP_002218.2|refseq:NP_001307852.1|refseq:NP_001308781.1|refseq:NP_001308782.1|refseq:NP_001308783.1|refseq:NP_001308784.1|dip:DIP-133N|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-909733|ensembl:ENSG00000162434(gene)|ensembl:ENST00000342505(transcript)|ensembl:ENST00000671929(transcript)|ensembl:ENST00000671954(transcript)|ensembl:ENST00000672179(transcript)|ensembl:ENST00000672247(transcript)|ensembl:ENST00000672434(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P23458|rcsb pdb:3EYG|rcsb pdb:3EYH|rcsb pdb:4E4L|rcsb pdb:4E4N|rcsb pdb:4E5W|rcsb pdb:4EHZ|rcsb pdb:4EI4|rcsb pdb:4FK6|rcsb pdb:4GS0|rcsb pdb:4I5C|rcsb pdb:4IVB|rcsb pdb:4IVC|rcsb pdb:4IVD|rcsb pdb:4K6Z|rcsb pdb:4K77|rcsb pdb:4L00|rcsb pdb:4L01|rcsb pdb:5E1E|rcsb pdb:5HX8|rcsb pdb:5IXD|rcsb pdb:5IXI|rcsb pdb:5KHW|rcsb pdb:5KHX|rcsb pdb:5L04|rcsb pdb:5WO4|rcsb pdb:6AAH|rcsb pdb:6BBU|rcsb pdb:6C7Y|rcsb pdb:6DBN|rcsb pdb:6ELR|rcsb pdb:6GGH|rcsb pdb:6HZU|rcsb pdb:6N77|rcsb pdb:6N78|rcsb pdb:6N79|rcsb pdb:6N7A|rcsb pdb:6N7B|rcsb pdb:6N7C|rcsb pdb:6N7D|rcsb pdb:6RSB|rcsb pdb:6RSC|rcsb pdb:6RSD|rcsb pdb:6RSE|rcsb pdb:6RSH|rcsb pdb:6SM8|rcsb pdb:6SMB|rcsb pdb:6TPE|rcsb pdb:6TPF|rcsb pdb:6W8L|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1169408|reactome:R-HSA-1266695|reactome:R-HSA-449836|reactome:R-HSA-5673001|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020591|reactome:R-HSA-9020956|reactome:R-HSA-9020958|mint:MINT-8387292(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:gEEiBAxwXnGGFWwO7OC0l0KjmSY9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P49674	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|mint:MINT-8387193(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P60228	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|mint:MINT-8387200(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:s09LicCa0mb9WwO7esZvVdvUonY9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q5T5U3	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-1642518|uniprotkb:Q8NI19|uniprotkb:Q0VF98|uniprotkb:Q7Z3P7|uniprotkb:Q8N3A2|uniprotkb:Q8TBV5|uniprotkb:Q9P2C3|ensembl:ENSP00000379709	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:rhg21_human(display_long)|uniprotkb:ARHGAP21(gene name)|psi-mi:ARHGAP21(display_short)|uniprotkb:ARHGAP10(gene name synonym)|uniprotkb:KIAA1424(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 21(gene name synonym)|uniprotkb:Rho GTPase-activating protein 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_065875.3|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9696264|reactome:R-HSA-9013148|ensembl:ENSG00000107863(gene)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051645"(Golgi localization)|ensembl:ENST00000396432(transcript)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR000198(RhoGAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036034|interpro:IPR041489|mint:Q5T5U3|rcsb pdb:2DHJ|rcsb pdb:2J59|rcsb pdb:2YUY|reactome:R-HSA-8980692|reactome:R-HSA-9013026|go:"GO:0005794"(Golgi apparatus)|reactome:R-HSA-9013106|refseq:XP_005252599.1|refseq:XP_016871948.1|mint:MINT-8387201(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:oXBGm9w5FjXr9jPDxzrx856rtck9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:P42356	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3|mint:MINT-8387211(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:O14974	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|mint:MINT-8387191(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q9UGP4	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176|mint:MINT-8387203(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:Q5VTR2	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422|mint:MINT-8387221(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9JIY2	uniprotkb:O75150	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mukherjee et al. (2012)	doi:10.1038/emboj.2011.496|pubmed:22252131|imex:IM-18523|mint:MINT-8385947	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7646605|mint:MINT-8387176|imex:IM-18523-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1|mint:MINT-8387178(identity)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|mint:MINT-8387216(identity)	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/07/10	2019/02/20	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:B2FA9F1C235952E7|rigid:7KQODvfU5wfZp37BJTJHQByEUJk	false	flag tag:?-?(MINT-8387181)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)