#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BQB4	uniprotkb:P46462	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-399011|ensembl:ENSRNOP00000040121	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:tera_rat(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621595|refseq:NP_446316.1|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|ensembl:ENSRNOG00000034242(gene)|ensembl:ENSRNOT00000046102(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|reactome:R-RNO-9013407|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P46462|reactome:R-RNO-110320|reactome:R-RNO-3371511|reactome:R-RNO-382556|reactome:R-RNO-532668|reactome:R-RNO-5358346|reactome:R-RNO-5689877|reactome:R-RNO-5689896|reactome:R-RNO-6798695	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:U39+QQfgVQlS+3gjtwc3IDz0VME10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P01830	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2255860|ensembl:ENSRNOP00000008685	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:thy1_rat(display_long)|uniprotkb:Thy1(gene name)|psi-mi:Thy1(display_short)|uniprotkb:Thy-1(gene name synonym)|uniprotkb:Thy-1 antigen(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3860|refseq:NP_036805.1|dip:DIP-1031N|ensembl:ENSRNOG00000006604(gene)|ensembl:ENSRNOT00000008685(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033292|interpro:IPR036179|mint:P01830|reactome:R-RNO-163125	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:P4seZqeNePRK65KZGl6CVdenFHk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O35763	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-915533	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:moes_rat(display_long)|uniprotkb:Msn(gene name)|psi-mi:Msn(display_short)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR008954(Moesin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019747|rgd:621260|refseq:NP_110490.1|interpro:IPR019749|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR029071|mint:O35763|interpro:IPR035963|interpro:IPR041789|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031143"(pseudopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|reactome:R-RNO-437239	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5JGEl/oxEgX4eh5kE9+J394ontE10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P05964	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-931557|uniprotkb:Q9R2B7|ensembl:ENSRNOP00000015612	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:s10a6_rat(display_long)|uniprotkb:S100a6(gene name)|psi-mi:S100a6(display_short)|uniprotkb:Cacy(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:620264|refseq:NP_445937.1|refseq:XP_006232841.1|ensembl:ENSRNOG00000011647(gene)|ensembl:ENSRNOT00000015612(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:1MFclfNLGNtd1K+hbvXDWMJ2DiM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P20760	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-1031206	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:igg2a_rat(display_long)|uniprotkb:Igg-2a(gene name)|psi-mi:Igg-2a(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003597(Immunoglobulin C1-set)|rgd:1359626|rcsb pdb:1FN4|rcsb pdb:1I1A|rcsb pdb:1I1C|go:"GO:0003823"(antigen binding)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4UAO|interpro:IPR036179	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:a1v/77eIoDQCvcxyiAtzQg3l0tw10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P70490	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-918012|ensembl:ENSRNOP00000024253	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:mfgm_rat(display_long)|uniprotkb:Milk fat globule-EGF factor 8(gene name synonym)|uniprotkb:O-acetyl GD3 ganglioside synthase(gene name synonym)|uniprotkb:MFGM(gene name synonym)|uniprotkb:Mfge8(gene name)|psi-mi:Mfge8(display_short)|uniprotkb:Ags(gene name synonym)|uniprotkb:SED1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:NP_001035276.1|rgd:3083|refseq:NP_036943.1|ensembl:ENSRNOG00000017510(gene)|ensembl:ENSRNOT00000024253(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007338"(single fertilization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043627"(response to estrogen)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR008979(Galactose-binding like)|reactome:R-RNO-381426|reactome:R-RNO-8957275	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:C7LHVOlzuI6C53Fk14AV5MF4FAc10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q2PS20	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-920772|ensembl:ENSRNOP00000010938	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:jph2_rat(display_long)|uniprotkb:Junctophilin type 2(gene name synonym)|uniprotkb:Jph2(gene name)|psi-mi:Jph2(display_short)|uniprotkb:Jp2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1305196|refseq:NP_001033063.1|refseq:XP_006235588.1|ensembl:ENSRNOG00000008170(gene)|ensembl:ENSRNOT00000010939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0055024"(regulation of cardiac muscle tissue development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR003409(MORN motif)|interpro:IPR017191(Junctophilin)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:apKBpIYBZU2b8QRoq6Og+xCmQwg10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P04692	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-1374736|uniprotkb:P06469|uniprotkb:P18342|uniprotkb:P18343|uniprotkb:P18344|uniprotkb:P19354|uniprotkb:Q53X09|uniprotkb:Q63582|uniprotkb:Q63608|uniprotkb:Q63609|ensembl:ENSRNOP00000048499	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:tpm1_rat(display_long)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Alpha-tm(gene name synonym)|uniprotkb:Tpma(gene name synonym)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3898|refseq:NP_001029241.1|refseq:NP_001029244.1|refseq:NP_001029245.1|refseq:NP_001029246.1|refseq:NP_001029247.1|refseq:NP_062004.1|refseq:NP_001288265.1|refseq:NP_001288665.1|dip:DIP-29020N|ensembl:ENSRNOG00000018184(gene)|ensembl:ENSRNOT00000048044(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0003065"(positive regulation of heart rate by epinephrine)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032059"(bleb)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051693"(actin filament capping)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000533(Tropomyosin)|rcsb pdb:1IHQ|rcsb pdb:1MV4|rcsb pdb:1TMZ|rcsb pdb:2B9C|rcsb pdb:2G9J|rcsb pdb:3AZD|reactome:R-RNO-390522|reactome:R-RNO-445355	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:d/imATvus0XZvr7i//2MtbXZ7Pw10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q71SA3	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2465723	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q71sa3_rat(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1588455|refseq:NP_001013080.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:dNQya6QHTyXBcMb7aBwQmhRFJoI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q62812	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747325	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:myh9_rat(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3140|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR002928(Myosin tail)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|mint:Q62812|interpro:IPR027417|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042641"(actomyosin)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070650"(actin filament bundle distribution)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905684"(regulation of plasma membrane repair)|reactome:R-RNO-2029482|reactome:R-RNO-5627123	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:6JXGCXNFsQdsUBb5t+ubhweRA8Y10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q64361	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747294|ensembl:ENSRNOP00000018402	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lxn_rat(display_long)|uniprotkb:Lxn(gene name)|psi-mi:Lxn(display_short)|uniprotkb:Endogenous carboxypeptidase inhibitor(gene name synonym)|uniprotkb:Tissue carboxypeptidase inhibitor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:68361|refseq:NP_113843.1|ensembl:ENSRNOG00000013572(gene)|ensembl:ENSRNOT00000018402(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|interpro:IPR009684(Proteinase inhibitor I47, latexin)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:2Sual/9o4hs/W9qz1eiv1NvhwJg10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9R1S9	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747419|ensembl:ENSRNOP00000036207	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:mk_rat(display_long)|uniprotkb:Mdk(gene name)|psi-mi:Mdk(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:69073|refseq:NP_110486.1|refseq:XP_006234654.1|refseq:XP_006234655.1|ensembl:ENSRNOG00000017560(gene)|ensembl:ENSRNOT00000033978(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007614"(short-term memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009725"(response to hormone)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021681"(cerebellar granular layer development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030421"(defecation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048477"(oogenesis)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:0106091"(glial cell projection elongation)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:eU6JR73nWEwaBOuP3+wvhJyR3w810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q63518	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747307	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:mypc1_rat(display_long)|uniprotkb:Mybpc1(gene name)|psi-mi:Mybpc1(display_short)|uniprotkb:C-protein, skeletal muscle slow isoform(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:735102|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036116|interpro:IPR036179|refseq:NP_001094228.2|go:"GO:0003779"(actin binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0032982"(myosin filament)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:T1Csdx6ixYqpz71yPItALAnayx010116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9R1J4	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747260|uniprotkb:Q9Z2Y4	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:myoc_rat(display_long)|uniprotkb:Myoc(gene name)|psi-mi:Myoc(display_short)|uniprotkb:Tigr(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:620430|refseq:NP_110492.1|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097453"(mesaxon)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:vpwo07n5BY8gpsHuGwCG2hirOR010116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q03626	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747364|uniprotkb:Q03310|uniprotkb:Q63018|uniprotkb:Q63020|uniprotkb:Q63023|uniprotkb:Q78DZ4|uniprotkb:Q9JMK7	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:mug1_rat(display_long)|uniprotkb:Mug1(gene name)|psi-mi:Mug1(display_short)|uniprotkb:A1i3(gene name synonym)|uniprotkb:Alpha-1 inhibitor 3 variant I(gene name synonym)|uniprotkb:Alpha-X protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621366|refseq:NP_075591.1|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR019742|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR036595|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007566"(embryo implantation)|go:"GO:0030414"(peptidase inhibitor activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:1BhEWtUfSDIhdpgN5Obt6oJ7O0s10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q29RW1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747273	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:myh4_rat(display_long)|uniprotkb:Myh4(gene name)|psi-mi:Myh4(display_short)|uniprotkb:Myosin heavy chain 2b(gene name synonym)|uniprotkb:Myosin heavy chain 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3139|refseq:NP_062198.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR002928(Myosin tail)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0009629"(response to gravity)|go:"GO:0014823"(response to activity)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0032982"(myosin filament)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0051015"(actin filament binding)|go:"GO:0061061"(muscle structure development)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:UV5t/lx6v6BAdPSuSzpxloJxGdo10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02564	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747394	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:myh7_rat(display_long)|uniprotkb:Myh7(gene name)|psi-mi:Myh7(display_short)|uniprotkb:Myosin heavy chain 7(gene name synonym)|uniprotkb:Myosin heavy chain slow isoform(gene name synonym)|uniprotkb:Myosin heavy chain, cardiac muscle beta isoform(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:62030|refseq:NP_058936.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR002928(Myosin tail)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0014728"(regulation of the force of skeletal muscle contraction)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031449"(regulation of slow-twitch skeletal muscle fiber contraction)|go:"GO:0032982"(myosin filament)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5yuax0/FEYDLarpz6uX9wZB4njI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P07092	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747067	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:gdn_rat(display_long)|uniprotkb:Serpine2(gene name)|psi-mi:Serpine2(display_short)|uniprotkb:Pi7(gene name synonym)|uniprotkb:Pn1(gene name synonym)|uniprotkb:Peptidase inhibitor 7(gene name synonym)|uniprotkb:Protease nexin 1(gene name synonym)|uniprotkb:Protease nexin I(gene name synonym)|uniprotkb:Serpin E2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3748|refseq:NP_062070.1|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007566"(embryo implantation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009611"(response to wounding)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021683"(cerebellar granular layer morphogenesis)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|reactome:R-RNO-140837|reactome:R-RNO-140875|reactome:R-RNO-75205|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032940"(secretion by cell)|go:"GO:0033363"(secretory granule organization)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042628"(mating plug formation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061108"(seminal vesicle epithelium development)|go:"GO:0061110"(dense core granule biogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090331"(negative regulation of platelet aggregation)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:gExxbLXtLo1XkqNxSGwVFG9wt5E10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P23785	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747034	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:grn_rat(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:Proepithelin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:61983|refseq:NP_058809.2|interpro:IPR000118(Granulin)|interpro:IPR039036|interpro:IPR037277|reactome:R-RNO-6798695|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:6+kYQ/CNWr23o2lEazsbcBdIck810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P49864	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747053	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:grak_rat(display_long)|uniprotkb:Gzmk(gene name)|psi-mi:Gzmk(display_short)|uniprotkb:NK-tryptase-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:68401|refseq:NP_058815.1|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR033116|interpro:IPR043504|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0008236"(serine-type peptidase activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5BlWGpsKwZQizQVI+vF8kbYAlYA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q03238	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747134	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:gram_rat(display_long)|uniprotkb:Gzmm(gene name)|psi-mi:Gzmm(display_short)|uniprotkb:Met-ase(gene name synonym)|uniprotkb:Natural killer cell granular protease(gene name synonym)|uniprotkb:RNK-Met-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|rgd:620022|interpro:IPR033040|interpro:IPR033116|interpro:IPR043504|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:GqCU9JDMlita43y+oOyoWJrs2Qk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O35793	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747113|ensembl:ENSRNOP00000035888	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:grem1_rat(display_long)|uniprotkb:Grem1(gene name)|psi-mi:Grem1(display_short)|uniprotkb:Cktsf1b1(gene name synonym)|uniprotkb:Drm(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2359|refseq:NP_062155.1|ensembl:ENSRNOG00000026053(gene)|ensembl:ENSRNOT00000037895(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ql/djXIZMkwZFv3FrQWD1eKxo/I10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P11962	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747094|uniprotkb:P70516|ensembl:ENSRNOP00000012385	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:glha_rat(display_long)|uniprotkb:Cga(gene name)|psi-mi:Cga(display_short)|uniprotkb:Cga1(gene name synonym)|uniprotkb:Anterior pituitary glycoprotein hormones common subunit alpha(gene name synonym)|uniprotkb:Follicle-stimulating hormone alpha chain(gene name synonym)|uniprotkb:Follitropin alpha chain(gene name synonym)|uniprotkb:Luteinizing hormone alpha chain(gene name synonym)|uniprotkb:Lutropin alpha chain(gene name synonym)|uniprotkb:Thyroid-stimulating hormone alpha chain(gene name synonym)|uniprotkb:Thyrotropin alpha chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:620436|refseq:XP_017448612.1|ensembl:ENSRNOG00000009269(gene)|ensembl:ENSRNOT00000012385(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008406"(gonad development)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0016913"(follicle-stimulating hormone activity)|go:"GO:0016914"(follicle-stimulating hormone complex)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032275"(luteinizing hormone secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046884"(follicle-stimulating hormone secretion)|go:"GO:0048589"(developmental growth)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR029034|reactome:R-RNO-193048|reactome:R-RNO-193993|reactome:R-RNO-209822|reactome:R-RNO-209968|reactome:R-RNO-375281|reactome:R-RNO-8866910|reactome:R-RNO-975578	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:g3pcVLGimysPP7qxcIJBCCfdDGk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O70598	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5849605	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:o70598_rat(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR000885(Fibrillar collagen, C-terminal)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:vPBPXyxyqEvZW/HJUiNe1aY0Eus10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q5XIH1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754300|ensembl:ENSRNOP00000020704|ensembl:ENSRNOP00000064616|ensembl:ENSRNOP00000076216	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q5xih1_rat(display_long)|uniprotkb:Aspn(gene name)|psi-mi:Aspn(display_short)|uniprotkb:LOC306805(gene name synonym)|uniprotkb:NEWGENE_1549776(gene name synonym)|uniprotkb:rCG_43984(orf name)|uniprotkb:Aspnl1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:XP_008769779.1|rgd:1549776|refseq:NP_001014030.1|rgd:9278606|refseq:XP_006253757.1|refseq:XP_006253769.1|ensembl:ENSRNOG00000015410(gene)|ensembl:ENSRNOG00000050431(gene)|ensembl:ENSRNOT00000020704(transcript)|ensembl:ENSRNOT00000074041(transcript)|ensembl:ENSRNOT00000093577(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0015288"(porin activity)|go:"GO:0030282"(bone mineralization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0046930"(pore complex)|go:"GO:0070171"(negative regulation of tooth mineralization)|go:"GO:1902617"(response to fluoride)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028548|interpro:IPR032675	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:KB9LAOFFYqa2xTV8yRbnJYyfYiU10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754503	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pgbm_rat_protein(display_short)|psi-mi:EBI-5754503(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754497	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pere_rat_protein(display_short)|psi-mi:EBI-5754497(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754515	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:vita2_rat_protein(display_short)|psi-mi:EBI-5754515(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754491	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pedf_rat_protein(display_short)|psi-mi:EBI-5754491(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754484	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:nacam_rat_protein(display_short)|psi-mi:EBI-5754484(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754430	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:bt3l4_rat_protein(display_short)|psi-mi:EBI-5754430(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754509	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ibiq_rat_protein(display_short)|psi-mi:EBI-5754509(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754460	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:h14_rat_protien(display_short)|psi-mi:EBI-5754460(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754467	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lysc_rat_protein(display_short)|psi-mi:EBI-5754467(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754436	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:csk22_rat_protein(display_short)|psi-mi:EBI-5754436(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754443	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:elne_rat_protein(display_short)|psi-mi:EBI-5754443(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754455	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:graa_rat_protein(display_short)|psi-mi:EBI-5754455(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	intact:EBI-5754448	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	-	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:esyt2_rat_protein(display_short)|psi-mi:EBI-5754448(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	-	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:D3ZQ55	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754315|ensembl:ENSRNOP00000008153|ensembl:ENSRNOP00000075672	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:d3zq55_rat(display_long)|uniprotkb:Jph1(gene name)|psi-mi:Jph1(display_short)|uniprotkb:Jph1_predicted(gene name synonym)|uniprotkb:rCG_30477(orf name)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:XP_008761697.1|rgd:1308789|refseq:NP_001100100.1|refseq:XP_006237781.1|refseq:XP_006237782.1|refseq:XP_006237783.1|refseq:XP_006237784.1|refseq:XP_006237785.1|ensembl:ENSRNOG00000006110(gene)|ensembl:ENSRNOT00000008153(transcript)|ensembl:ENSRNOT00000085564(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007517"(muscle organ development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|interpro:IPR003409(MORN motif)|interpro:IPR017191(Junctophilin)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:JFYv39+egNGkLqclYZRN+1NO5kI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q5XIH1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754300|ensembl:ENSRNOP00000020704|ensembl:ENSRNOP00000064616|ensembl:ENSRNOP00000076216	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q5xih1_rat(display_long)|uniprotkb:Aspn(gene name)|psi-mi:Aspn(display_short)|uniprotkb:LOC306805(gene name synonym)|uniprotkb:NEWGENE_1549776(gene name synonym)|uniprotkb:rCG_43984(orf name)|uniprotkb:Aspnl1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:XP_008769779.1|rgd:1549776|refseq:NP_001014030.1|rgd:9278606|refseq:XP_006253757.1|refseq:XP_006253769.1|ensembl:ENSRNOG00000015410(gene)|ensembl:ENSRNOG00000050431(gene)|ensembl:ENSRNOT00000020704(transcript)|ensembl:ENSRNOT00000074041(transcript)|ensembl:ENSRNOT00000093577(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0015288"(porin activity)|go:"GO:0030282"(bone mineralization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0046930"(pore complex)|go:"GO:0070171"(negative regulation of tooth mineralization)|go:"GO:1902617"(response to fluoride)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028548|interpro:IPR032675	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:KB9LAOFFYqa2xTV8yRbnJYyfYiU10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O35812	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754239	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:o35812_rat(display_long)|uniprotkb:Phex(gene name)|psi-mi:Phex(display_short)|uniprotkb:PHEX(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3323|refseq:NP_037136.1|interpro:IPR024079|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR018497|interpro:IPR008753(Peptidase M13)|interpro:IPR042089|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019637"(organophosphate metabolic process)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042476"(odontogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060348"(bone development)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1990418"(response to insulin-like growth factor stimulus)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:3vyF42qpGfSK7ZaB3z2Z715afAA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q0GC39	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754254	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q0gc39_rat(display_long)|uniprotkb:Myh1(gene name)|psi-mi:Myh1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR036961|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016459"(myosin complex)|go:"GO:0051015"(actin filament binding)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:hZdDVqwloMnooYHhqqaz4KRS1UM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q0GC40	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754229	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q0gc40_rat(display_long)|uniprotkb:Myh2(gene name)|psi-mi:Myh2(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR036961|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016459"(myosin complex)|go:"GO:0051015"(actin filament binding)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:DdE9I3XTkntIJ0a9smQbbNg6NuA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q6QI48	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754181|uniprotkb:F7F3K6|ensembl:ENSRNOP00000015466	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q6qi48_rat(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Podn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3642|interpro:IPR036527|interpro:IPR032675|ensembl:ENSRNOG00000011413(gene)|ensembl:ENSRNOT00000015466(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030336"(negative regulation of cell migration)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003033(Sterol-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:rmw6xYUNnTX5ViQwogogdxrv+8410116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q4FZS3	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754195	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:q4fzs3_rat(display_long)|uniprotkb:Prpf8(gene name)|psi-mi:Prpf8(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR021983|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR027652|interpro:IPR037518|interpro:IPR043173|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0070122"(isopeptidase activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:7N4I98EPt/rY9KfEY9WfpSnm17o10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P85125	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747462	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:cavn1_rat(display_long)|uniprotkb:Cavin1(gene name)|psi-mi:Cavin1(display_short)|uniprotkb:Cavin-1(gene name synonym)|uniprotkb:Polymerase I and transcript release factor(gene name synonym)|uniprotkb:Ptrf(gene name synonym)|uniprotkb:cav-p60(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1307685|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|interpro:IPR033297|interpro:IPR026752|reactome:R-RNO-73863|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009306"(protein secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:2000147"(positive regulation of cell motility)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:WqWZmOkbrRNwM7/EzRMp1sl5kYM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:F1LT30	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754151|ensembl:ENSRNOP00000003834	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:f1lt30_rat(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	ensembl:ENSRNOG00000002874(gene)|ensembl:ENSRNOT00000003834(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR036483	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:YCbND/UvQNb34q1ysf2m0xJ5TqY10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P09812	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747480	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pygm_rat(display_long)|uniprotkb:Pygm(gene name)|psi-mi:Pygm(display_short)|uniprotkb:Myophosphorylase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3461|interpro:IPR011833(Glycogen/starch/alpha-glucan phosphorylase)|interpro:IPR000811(Glycosyl transferase, family 35)|interpro:IPR035090|reactome:R-RNO-70221|go:"GO:0001666"(response to hypoxia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008184"(glycogen phosphorylase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0016208"(AMP binding)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0102250"(linear malto-oligosaccharide phosphorylase activity)|go:"GO:0102499"(SHG alpha-glucan phosphorylase activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:rE+AGEZLw4j9RmP7LtMlCzuV4Vk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02262	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747219	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:h2a1_rat(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR002119(Histone H2A)|mint:P02262|interpro:IPR032454|interpro:IPR032458|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:yNvHACh66Sn9zW5OVCHxC5BdNKA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P0C169	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747192	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:h2a1c_rat(display_long)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR002119(Histone H2A)|rgd:1566374|interpro:IPR032454|interpro:IPR032458|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:m00IdooZksbNGKHSsaVvGFVpcko10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P03994	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747169|ensembl:ENSRNOP00000040553|ensembl:ENSRNOP00000045959	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:hpln1_rat(display_long)|uniprotkb:Hapln1(gene name)|psi-mi:Hapln1(display_short)|uniprotkb:Crtl1(gene name synonym)|uniprotkb:Cartilage-linking protein 1(gene name synonym)|uniprotkb:Proteoglycan link protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2412|refseq:XP_006231810.1|ensembl:ENSRNOG00000032002(gene)|ensembl:ENSRNOT00000042958(transcript)|ensembl:ENSRNOT00000043196(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|interpro:IPR000538(Link)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036179|mint:P03994|reactome:R-RNO-3000178	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:TQ7UE3ZsSgesM1DKbMig4A1kCYQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P20761	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747204|ensembl:ENSRNOP00000044037	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:igg2b_rat(display_long)|uniprotkb:Igh-1a(gene name)|psi-mi:Igh-1a(display_short)|uniprotkb:Immunoglobulin heavy chain 1a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1305720|ensembl:ENSRNOG00000048402(gene)|ensembl:ENSRNOT00000045874(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P20761|rcsb pdb:1C5D|rcsb pdb:2ARJ|rcsb pdb:3B9K|rcsb pdb:1BFO	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:YP3+ZkBaG+Trma6Rnzpb8qwV8xg10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P40615	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746997|uniprotkb:Q499M9	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P21674	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746973|uniprotkb:Q80XW7|ensembl:ENSRNOP00000015680	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:fst_rat(display_long)|uniprotkb:Fst(gene name)|psi-mi:Fst(display_short)|uniprotkb:Activin-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2633|refseq:NP_036693.1|ensembl:ENSRNOG00000011631(gene)|ensembl:ENSRNOT00000015680(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046882"(negative regulation of follicle-stimulating hormone secretion)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:1LR7|rcsb pdb:1LR8|rcsb pdb:1LR9|rcsb pdb:2ARP|reactome:R-RNO-2473224	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:gxXggD5o3Asz0l8DhQVUxIqusnA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02680	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746951|uniprotkb:Q68FY3	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:fibg_rat(display_long)|uniprotkb:Fgg(gene name)|psi-mi:Fgg(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	reactome:R-RNO-114608|reactome:R-RNO-140875|reactome:R-RNO-216083|interpro:IPR037581|reactome:R-RNO-354192|reactome:R-RNO-354194|reactome:R-RNO-372708|reactome:R-RNO-5674135|rgd:2613|refseq:NP_036691.2|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR020837|refseq:XP_006232587.1|interpro:IPR036056|reactome:R-RNO-381426|reactome:R-RNO-8957275|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:CsN9NToE+VFaDt9W3oGSUHSQ7QQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P09656	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747230|ensembl:ENSRNOP00000017969	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:isk1l_rat(display_long)|uniprotkb:Spink1l(gene name)|psi-mi:Spink1l(display_short)|uniprotkb:Calcium transport inhibitor(gene name synonym)|uniprotkb:Caltrin(gene name synonym)|uniprotkb:Pancreatic secretory trypsin inhibitor II(gene name synonym)|uniprotkb:Spink3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:708468|refseq:NP_690919.1|ensembl:ENSRNOG00000013410(gene)|ensembl:ENSRNOT00000017969(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007568"(aging)|interpro:IPR001239(Proteinase inhibitor I1, Kazal metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:8iP8gF7OAKEU8yLmHNP93zZPwMQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q5U2V4	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747586|ensembl:ENSRNOP00000011930	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:plbl1_rat(display_long)|uniprotkb:Plbd1(gene name)|psi-mi:Plbd1(display_short)|uniprotkb:LAMA-like protein 1(gene name synonym)|uniprotkb:Lamina ancestor homolog 1(gene name synonym)|uniprotkb:Phospholipase B domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1308734|refseq:NP_001013949.1|ensembl:ENSRNOG00000008933(gene)|ensembl:ENSRNOT00000011930(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0009395"(phospholipid catabolic process)|interpro:IPR007000(Laminin A)|interpro:IPR043040|interpro:IPR043041|interpro:IPR043042|reactome:R-RNO-1482788|reactome:R-RNO-1482839|reactome:R-RNO-1482922|reactome:R-RNO-1483115	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:UzmnrXsbbeMbpe5D5DmNYgPzj6810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9JLN4	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747546	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pgrp1_rat(display_long)|uniprotkb:Pglyrp1(gene name)|psi-mi:Pglyrp1(display_short)|uniprotkb:Pglyrp(gene name synonym)|uniprotkb:Pgrp(gene name synonym)|uniprotkb:Peptidoglycan recognition protein short(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621429|refseq:NP_445825.1|interpro:IPR002502(N-acetylmuramoyl-L-alanine amidase, family 2)|interpro:IPR017331(Peptidoglycan recognition protein, PGRP-S)|interpro:IPR015510(Peptidoglycan recognition protein)|interpro:IPR006619(Peptidoglycan recognition protein, metazoa/bacteria)|interpro:IPR036505|reactome:R-RNO-6798695|reactome:R-RNO-6803157|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008745"(N-acetylmuramoyl-L-alanine amidase activity)|go:"GO:0009253"(peptidoglycan catabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0016045"(detection of bacterium)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032827"(negative regulation of natural killer cell differentiation involved in immune response)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:9Tf0w4cj8g+IP1O/WBmkA4f+gZ810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9R0I8	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747601	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pi42a_rat(display_long)|uniprotkb:Pip4k2a(gene name)|psi-mi:Pip4k2a(display_short)|uniprotkb:Pip5k2a(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:PIPK2 alpha(gene name synonym)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:Pip4ka(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR023610|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|rgd:621708|refseq:NP_446378.1|interpro:IPR027484|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:O13XSbwKhTaJsZ48YLN7eRv9MXE10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O88377	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747507|ensembl:ENSRNOP00000017989	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pi42b_rat(display_long)|uniprotkb:Pip4k2b(gene name)|psi-mi:Pip4k2b(display_short)|uniprotkb:Pip5k2b(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-beta(gene name synonym)|uniprotkb:Phosphatidylinositol-phosphate kinase IIgamma(gene name synonym)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-beta"(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-beta(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621710|refseq:NP_446002.1|ensembl:ENSRNOG00000013030(gene)|ensembl:ENSRNOT00000017989(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-RNO-1660499|reactome:R-RNO-6811555|reactome:R-RNO-6811558|reactome:R-RNO-8847453	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:35r8imhw/saR5/MXqXZjNRNVvO810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q63189	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747568	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:prg2_rat(display_long)|uniprotkb:Prg2(gene name)|psi-mi:Prg2(display_short)|uniprotkb:Mbp(gene name synonym)|uniprotkb:Proteoglycan 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:69336|refseq:NP_113807.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR002352(Eosinophil major basic protein)|interpro:IPR033816|reactome:R-RNO-6798695|go:"GO:0002215"(defense response to nematode)|go:"GO:0008201"(heparin binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042742"(defense response to bacterium)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:VYpeqfedmXKCgpRwkKKllgxLtnE10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q924Z9	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747529	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:net1_rat(display_long)|uniprotkb:Ntn1(gene name)|psi-mi:Ntn1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:619809|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR018933|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR008979(Galactose-binding like)|reactome:R-RNO-373752|reactome:R-RNO-418885|go:"GO:0031012"(extracellular matrix)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:0001764"(neuron migration)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030879"(mammary gland development)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:nu4mcwzWPMXZHkL++3QPjuh/JYw10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q5HZV9	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747643	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pp1r7_rat(display_long)|uniprotkb:Ppp1r7(gene name)|psi-mi:Ppp1r7(display_short)|uniprotkb:Sds22(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1308169|refseq:NP_001009825.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR025875|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0007059"(chromosome segregation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:aB3rvJzH/q4yZwDyw+HbtweCvrI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9QWJ9	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747656|ensembl:ENSRNOP00000014492|ensembl:ENSRNOP00000075034	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:nrp1_rat(display_long)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Vascular endothelial cell growth factor 165 receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621588|refseq:NP_659566.1|refseq:XP_006255887.1|dip:DIP-44935N|ensembl:ENSRNOG00000010744(gene)|ensembl:ENSRNOT00000014492(transcript)|ensembl:ENSRNOT00000080465(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|rcsb pdb:2ORX|rcsb pdb:2ORZ|reactome:R-RNO-194306|reactome:R-RNO-399954|reactome:R-RNO-399955|reactome:R-RNO-399956|reactome:R-RNO-445144	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:oJzPYHrqKTqPas+piky5vQDLdJU10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P06765	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747686|ensembl:ENSRNOP00000032276	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:plf4_rat(display_long)|uniprotkb:Pf4(gene name)|psi-mi:Pf4(display_short)|uniprotkb:Cxcl4(gene name synonym)|uniprotkb:Scyb4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3305|refseq:NP_001007730.1|ensembl:ENSRNOG00000028015(gene)|ensembl:ENSRNOT00000033406(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|reactome:R-RNO-114608|reactome:R-RNO-140875|reactome:R-RNO-202733|reactome:R-RNO-380108|reactome:R-RNO-418594	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:jE+L7X3Epn/8UyYjjcq0erVC7aY10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P15399	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747622|uniprotkb:Q53Z30|ensembl:ENSRNOP00000042730|ensembl:ENSRNOP00000075719	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pbas_rat(display_long)|uniprotkb:Pbsn(gene name)|psi-mi:Pbsn(display_short)|uniprotkb:Prbs(gene name synonym)|uniprotkb:M-40(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:708571|refseq:NP_061998.1|refseq:XP_008771461.1|ensembl:ENSRNOG00000003713(gene)|ensembl:ENSRNOG00000061715(gene)|ensembl:ENSRNOT00000046768(transcript)|ensembl:ENSRNOT00000080431(transcript)|go:"GO:0005549"(odorant binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0036094"(small molecule binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR002448(Odour-binding protein)|interpro:IPR012674(Calycin)|interpro:IPR022272	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:zGH9G6/cmQ+OYlAHOtM3MwKkoEk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:D3ZZQ0	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5754120|ensembl:ENSRNOP00000016799	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:d3zzq0_rat(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:RGD1561817_predicted(gene name synonym)|uniprotkb:rCG_41596(orf name)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1561817|refseq:NP_001099892.1|ensembl:ENSRNOG00000012422(gene)|ensembl:ENSRNOT00000016799(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:7dnNZXaTyA9zP3+vPhWlMPXPgCE10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9WUL0	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5748034	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:top1_rat(display_long)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:DNA topoisomerase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621246|refseq:NP_072137.1|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR018521|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR036202|interpro:IPR025834|reactome:R-RNO-4615885|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009303"(rRNA transcription)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0097100"(supercoiled DNA binding)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:4EwmplCBZcDyvFkQg0mOLWmCUzE10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P12346	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5748069|uniprotkb:Q63602|uniprotkb:Q64628|uniprotkb:Q64630|uniprotkb:Q7TNX0|ensembl:ENSRNOP00000045637	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:trfe_rat(display_long)|uniprotkb:Tf(gene name)|psi-mi:Tf(display_short)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRG03(gene name synonym)|uniprotkb:Siderophilin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3845|refseq:NP_001013128.1|ensembl:ENSRNOG00000030625(gene)|ensembl:ENSRNOT00000045628(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0055037"(recycling endosome)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P12346|reactome:R-RNO-114608|reactome:R-RNO-381426|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8957275|reactome:R-RNO-917937|reactome:R-RNO-917977	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:9b+8HnYQbOkvBtuNUgHzhq2+cQ010116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9R168	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747950	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:sfrp1_rat(display_long)|uniprotkb:Sfrp1(gene name)|psi-mi:Sfrp1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621074|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR018933|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR026559|interpro:IPR036790|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046546"(development of primary male sexual characteristics)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0008201"(heparin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090175"(regulation of establishment of planar polarity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:JZwt3wdZE0jrgpbklXGb81lw1is10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q3B7T9	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747832|ensembl:ENSRNOP00000073557	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:rfip1_rat(display_long)|uniprotkb:Rab11fip1(gene name)|psi-mi:Rab11fip1(display_short)|uniprotkb:Rcp(gene name synonym)|uniprotkb:Rab-coupling protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1562965|refseq:NP_001178484.1|refseq:NP_001184170.1|ensembl:ENSRNOG00000058940(gene)|ensembl:ENSRNOT00000086082(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070164"(negative regulation of adiponectin secretion)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR019018|interpro:IPR035892|interpro:IPR037245|interpro:IPR037789	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ciTRpve52fY7+jUom3bl2ZhtY+c10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9WVC1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747914	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:slit2_rat(display_long)|uniprotkb:Slit2(gene name)|psi-mi:Slit2(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:69310|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR002272(Follicle-stimulating hormone receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR032675|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0004963"(follicle-stimulating hormone receptor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0098609"(cell-cell adhesion)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:DsEt075EWTxYlIZJlnr4tIxmb6o10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O88280	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747884	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:slit3_rat(display_long)|uniprotkb:Slit3(gene name)|psi-mi:Slit3(display_short)|uniprotkb:Megf5(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:69311|refseq:NP_112611.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR001791(Laminin G)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|interpro:IPR032675|interpro:IPR009030(Growth factor, receptor)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:AEGjFxjh9BKhIyM66N6syA9eXcw10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q8VHQ7	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747970|uniprotkb:Q8VHQ6	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:sytl4_rat(display_long)|uniprotkb:Sytl4(gene name)|psi-mi:Sytl4(display_short)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:620204|refseq:NP_536335.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR043567|interpro:IPR035892|interpro:IPR028694|interpro:IPR037303|interpro:IPR041282|reactome:R-RNO-114608|interpro:IPR044134|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1905684"(regulation of plasma membrane repair)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5G0GemOsEp3+YowTbguopZXwg3k10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q6BDS1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747937|uniprotkb:Q5BK69|ensembl:ENSRNOP00000016306	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:spi1_rat(display_long)|uniprotkb:Spi1(gene name)|psi-mi:Spi1(display_short)|uniprotkb:Sfpi1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:1359607|refseq:NP_001005892.1|ensembl:ENSRNOG00000012172(gene)|ensembl:ENSRNOT00000016306(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001944"(vasculature development)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1905036"(positive regulation of antifungal innate immune response)|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:4ow1fZZ14imfwd94d5wsv6ZhliA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P05545	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747806|uniprotkb:P14281|uniprotkb:Q64254|uniprotkb:Q6P6G8	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:spa3k_rat(display_long)|uniprotkb:Serpina3k(gene name)|psi-mi:Serpina3k(display_short)|uniprotkb:Spin2b(gene name synonym)|uniprotkb:CPI-21(gene name synonym)|uniprotkb:Contrapsin-like protease inhibitor 1(gene name synonym)|uniprotkb:GHR-P63(gene name synonym)|uniprotkb:Growth hormone-regulated proteinase inhibitor(gene name synonym)|uniprotkb:Kallikrein-binding protein(gene name synonym)|uniprotkb:SPI-2.3(gene name synonym)|uniprotkb:Serine protease inhibitor 2(gene name synonym)|uniprotkb:Thyroid hormone-regulated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3746|refseq:NP_036789.2|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0010951"(negative regulation of endopeptidase activity)|interpro:IPR036186|refseq:XP_006240520.1|interpro:IPR042178|interpro:IPR042185	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:JVQQzNrZItfJJN3+lxTBqW4AjNg10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q63396	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747768|uniprotkb:Q5M805|ensembl:ENSRNOP00000067467	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:tcp4_rat(display_long)|uniprotkb:Sub1(gene name)|psi-mi:Sub1(display_short)|uniprotkb:Pc4(gene name synonym)|uniprotkb:Rpo2tc1(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:p14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621582|refseq:NP_001009618.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:Q63396|ensembl:ENSRNOG00000050563(gene)|ensembl:ENSRNOT00000074446(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|refseq:XP_006232105.1	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:EGzXl7sYJsbVGWy0h/NRe+4lvwY10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P50904	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747849	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:rasa1_rat(display_long)|uniprotkb:Rasa1(gene name)|psi-mi:Rasa1(display_short)|uniprotkb:Rasa(gene name synonym)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:3537|refseq:NP_037267.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR023152|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR028554|mint:P50904|interpro:IPR039360|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030539"(male genitalia development)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051020"(GTPase binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1990782"(protein tyrosine kinase binding)|reactome:R-RNO-186763|reactome:R-RNO-3928662|reactome:R-RNO-5218921|reactome:R-RNO-5658442|reactome:R-RNO-8849471|go:"GO:0048514"(blood vessel morphogenesis)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:bPQVnB+sC99xPSbNxpVjvlPg3Xs10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9EQS0	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5747785|uniprotkb:Q6PCV1|ensembl:ENSRNOP00000024863	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:taldo_rat(display_long)|uniprotkb:Taldo1(gene name)|psi-mi:Taldo1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:620674|refseq:NP_113999.2|ensembl:ENSRNOG00000018367(gene)|ensembl:ENSRNOT00000024863(transcript)|go:"GO:0004801"(transaldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019682"(glyceraldehyde-3-phosphate metabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR001585(Transaldolase)|interpro:IPR004730(Transaldolase AB)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR018225|reactome:R-RNO-163754|reactome:R-RNO-71336	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ullVwXSLqrGsyB3moWYiqASuWuc10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P27274	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746872|ensembl:ENSRNOP00000060967	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:cd59_rat(display_long)|uniprotkb:Cd59(gene name)|psi-mi:Cd59(display_short)|uniprotkb:MAC-inhibitory protein(gene name synonym)|uniprotkb:Membrane attack complex inhibition factor(gene name synonym)|uniprotkb:Protectin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2311|refseq:NP_037057.1|ensembl:ENSRNOG00000042821(gene)|ensembl:ENSRNOT00000067085(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043218"(compact myelin)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR018363|interpro:IPR027101|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6798695|reactome:R-RNO-6807878|reactome:R-RNO-977606	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:dP0We0mch9vvdjis+B7CccrhHIM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P13635	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746846|uniprotkb:Q64719	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ceru_rat(display_long)|uniprotkb:Cp(gene name)|psi-mi:Cp(display_short)|uniprotkb:Ferroxidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR033138|rgd:2387|interpro:IPR001117(Multicopper oxidase, type 1)|interpro:IPR011706(Multicopper oxidase, type 2)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR002355(Multicopper oxidase, copper-binding site)|interpro:IPR008972(Cupredoxin)|interpro:IPR024715|rcsb pdb:5N0K|rcsb pdb:5N4L|reactome:R-RNO-381426|reactome:R-RNO-425410|reactome:R-RNO-8957275|reactome:R-RNO-917937|go:"GO:0001889"(liver development)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007595"(lactation)|go:"GO:0015679"(plasma membrane copper ion transport)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046688"(response to copper ion)|go:"GO:0051087"(chaperone binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:M/76X5xvjFYHuDV69kOoY21xQaM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P05539	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746904|uniprotkb:Q63123|uniprotkb:Q63565|uniprotkb:Q78DY3	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:co2a1_rat(display_long)|uniprotkb:Col2a1(gene name)|psi-mi:Col2a1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2375|refseq:NP_037061.1|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR000885(Fibrillar collagen, C-terminal)|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-186797|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-216083|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-419037|reactome:R-RNO-8874081|reactome:R-RNO-8948216|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010165"(response to X-ray)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060348"(bone development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:VmiGnOFLmUHtLiUmKFc4N4QnSYI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9ES72	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746820	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ccn1_rat(display_long)|uniprotkb:Ccn1(gene name)|psi-mi:Ccn1(display_short)|uniprotkb:Cellular communication network factor 1(gene name synonym)|uniprotkb:Cyr61(gene name synonym)|uniprotkb:Cysteine-rich angiogenic inducer 61(gene name synonym)|uniprotkb:Igfbp10(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 10(gene name synonym)|uniprotkb:Protein CYR61(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR043973|rgd:620763|refseq:NP_112617.2|interpro:IPR006208(Cystine knot)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR036383|interpro:IPR009030(Growth factor, receptor)|reactome:R-RNO-381426|reactome:R-RNO-8957275|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002041"(intussusceptive angiogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008201"(heparin binding)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:AGqbGYIna2R4N/6VIBaeHyUmNi010116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q9JI03	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746921	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:co5a1_rat(display_long)|uniprotkb:Col5a1(gene name)|psi-mi:Col5a1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:70920|refseq:NP_604447.1|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-186797|reactome:R-RNO-2022090|reactome:R-RNO-216083|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-419037|reactome:R-RNO-8874081|reactome:R-RNO-8948216|go:"GO:0001568"(blood vessel development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005588"(collagen type V trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0016477"(cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035989"(tendon development)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0045112"(integrin biosynthetic process)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0051128"(regulation of cellular component organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:1903225"(negative regulation of endodermal cell differentiation)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:7HHQCaxNhaCqkGmTVkCsD3fVlCk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P20909	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:B0BNN3	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746802|ensembl:ENSRNOP00000014267	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:cah1_rat(display_long)|uniprotkb:Ca1(gene name)|psi-mi:Ca1(display_short)|uniprotkb:Car1(gene name synonym)|uniprotkb:Carbonate dehydratase I(gene name synonym)|uniprotkb:Carbonic anhydrase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:XP_008759064.1|rgd:1309780|refseq:NP_001101130.1|refseq:XP_006232173.1|ensembl:ENSRNOG00000010698(gene)|ensembl:ENSRNOT00000014267(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016836"(hydro-lyase activity)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018442|interpro:IPR023561|interpro:IPR036398|reactome:R-RNO-1237044|reactome:R-RNO-1247673|reactome:R-RNO-1475029	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:hh001bHba5O7MiKBFxKwEcs5lwQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q63041	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746765|uniprotkb:Q63332|ensembl:ENSRNOP00000009467	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:a1m_rat(display_long)|uniprotkb:A1m(gene name)|psi-mi:A1m(display_short)|uniprotkb:Pzp(gene name synonym)|uniprotkb:Alpha-1-macroglobulin 165 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:628643|refseq:NP_665722.2|ensembl:ENSRNOG00000006709(gene)|ensembl:ENSRNOT00000009467(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|rcsb pdb:1EDY|go:"GO:0007566"(embryo implantation)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:gDclxOxSgV18Xvt3Mrg7hKUaJLM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P15684	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746713|uniprotkb:Q9JHP4	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ampn_rat(display_long)|uniprotkb:Anpep(gene name)|psi-mi:Anpep(display_short)|uniprotkb:Alanyl aminopeptidase(gene name synonym)|uniprotkb:Aminopeptidase M(gene name synonym)|uniprotkb:Kidney Zn peptidase(gene name synonym)|uniprotkb:Microsomal aminopeptidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2991|refseq:NP_112274.1|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|go:"GO:0001525"(angiogenesis)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031526"(brush border membrane)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|interpro:IPR027268|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR024571|interpro:IPR034016|interpro:IPR042097|reactome:R-RNO-6798695	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:8IEqzW1ewby6Beqdgh0a6jr43EA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P50123	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746740|uniprotkb:Q64200|uniprotkb:Q9JLQ7|uniprotkb:Q9JLQ9|uniprotkb:Q9QV24	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ampe_rat(display_long)|uniprotkb:Enpep(gene name)|psi-mi:Enpep(display_short)|uniprotkb:Aminopeptidase A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621228|refseq:NP_071587.2|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|go:"GO:0001525"(angiogenesis)|interpro:IPR027268|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031526"(brush border membrane)|go:"GO:0032835"(glomerulus development)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR033508|interpro:IPR024571|interpro:IPR034016|interpro:IPR042097|reactome:R-RNO-2022377	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:EifpK3wackR9IkPgLDxYIkAv1q410116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P14046	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-5746688|uniprotkb:Q4G042|uniprotkb:Q63266|uniprotkb:Q6LDP2|uniprotkb:Q6LDR8	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:a1i3_rat(display_long)|uniprotkb:A1i3(gene name)|psi-mi:A1i3(display_short)|uniprotkb:Alpha-1-inhibitor 3 variant II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR019742|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR010916(TonB box, conserved site)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036595|interpro:IPR014756(Immunoglobulin E-set)|rgd:1584999|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:axwrnCrzifXcC7Zh82r0oXWLFDk10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02650	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-1638221|ensembl:ENSRNOP00000050968|ensembl:ENSRNOP00000068937	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:apoe_rat(display_long)|uniprotkb:Apoe(gene name)|psi-mi:Apoe(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2138|refseq:NP_620183.2|refseq:NP_001257610.1|refseq:NP_001257611.1|refseq:NP_001257612.1|refseq:NP_001257613.1|ensembl:ENSRNOG00000018454(gene)|ensembl:ENSRNOT00000041891(transcript)|ensembl:ENSRNOT00000091574(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046848"(hydroxyapatite binding)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0097006"(regulation of plasma lipoprotein particle levels)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1904421"(response to D-galactosamine)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|reactome:R-RNO-3000480|reactome:R-RNO-381426|reactome:R-RNO-8957275|reactome:R-RNO-8963888|reactome:R-RNO-8963901|reactome:R-RNO-8964026|reactome:R-RNO-8964058|reactome:R-RNO-975634	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ERgpYnyTQFwZp5c5F1hi5oSwg0I10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q07936	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-918209|ensembl:ENSRNOP00000038428	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:anxa2_rat(display_long)|uniprotkb:Anxa2(gene name)|psi-mi:Anxa2(display_short)|uniprotkb:Anx2(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621170|refseq:NP_063970.1|ensembl:ENSRNOG00000010362(gene)|ensembl:ENSRNOT00000038677(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044147"(negative regulation of formation of structure involved in a symbiotic process)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0052362"(obsolete catabolism by host of symbiont protein)|go:"GO:0052405"|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|reactome:R-RNO-6798695|reactome:R-RNO-75205	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:SOUcyxKVc0YRMNALClXoYKomQT810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P67874	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-348189|ensembl:ENSRNOP00000001123|ensembl:ENSRNOP00000068429|uniprotkb:P07312|uniprotkb:P13862	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:csk2b_rat(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Csnk2b(gene name)|psi-mi:Csnk2b(display_short)|uniprotkb:Ck2n(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	reactome:R-RNO-8939243|reactome:R-RNO-8948751|reactome:R-RNO-8934903|ensembl:ENSRNOG00000000847(gene)|ensembl:ENSRNOT00000001123(transcript)|ensembl:ENSRNOT00000076528(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67874|rcsb pdb:2R6M|go:"GO:0031519"(PcG protein complex)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0061154"(endothelial tube morphogenesis)|reactome:R-RNO-1483191|reactome:R-RNO-201688|reactome:R-RNO-2514853|reactome:R-RNO-445144|reactome:R-RNO-6798695|reactome:R-RNO-6804756|reactome:R-RNO-6814122|rgd:619978|refseq:NP_001030315.1|refseq:NP_112283.1	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P07150	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-916045|uniprotkb:Q64664|ensembl:ENSRNOP00000023664	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:anxa1_rat(display_long)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:NP_037036.1|rgd:2118|refseq:XP_008758517.1|ensembl:ENSRNOG00000017469(gene)|ensembl:ENSRNOT00000023664(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-444473	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:stwhnd4HyVtBxO/rvSW2UZKYmmA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P27139	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-522217|ensembl:ENSRNOP00000013354	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:cah2_rat(display_long)|uniprotkb:Carbonic anhydrase II(gene name synonym)|uniprotkb:Carbonate dehydratase II(gene name synonym)|uniprotkb:Ca2(gene name)|psi-mi:Ca2(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2240|refseq:NP_062164.1|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009268"(response to pH)|go:"GO:0010033"(response to organic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043209"(myelin sheath)|ensembl:ENSRNOG00000009629(gene)|ensembl:ENSRNOT00000013354(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0004064"(arylesterase activity)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045177"(apical part of cell)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046903"(secretion)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2001150"(positive regulation of dipeptide transmembrane transport)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR023561|interpro:IPR036398|reactome:R-RNO-1237044|reactome:R-RNO-1247673|reactome:R-RNO-1475029	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:/w7Mjwnj7SvksMoIbVcq++U9acA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P24090	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-1187298|uniprotkb:Q5BKD2	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:fetua_rat(display_long)|uniprotkb:Fetuin-A(gene name synonym)|uniprotkb:Glycoprotein PP63(gene name synonym)|uniprotkb:59 kDa bone sialic acid-containing protein(gene name synonym)|uniprotkb:Ahsg(gene name)|psi-mi:Ahsg(display_short)|uniprotkb:Fetua(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2075|refseq:NP_037030.1|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR025760|go:"GO:0001503"(ossification)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008584"(male gonad development)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030294"(receptor signaling protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0006953"(acute-phase response)	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:NwNdomt3sxkAeX/mKrvaghPW9e810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q6P6V0	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-918999|ensembl:ENSRNOP00000029515	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:g6pi_rat(display_long)|uniprotkb:Gpi(gene name)|psi-mi:Gpi(display_short)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)|uniprotkb:Autocrine motility factor(gene name synonym)|uniprotkb:Neuroleukin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2727|refseq:NP_997475.1|ensembl:ENSRNOG00000023150(gene)|ensembl:ENSRNOT00000032613(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0060170"(ciliary membrane)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|reactome:R-RNO-5628897|reactome:R-RNO-6798695|reactome:R-RNO-70171|reactome:R-RNO-70263	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:PVOR/rmNkZatD6rcScBNvyOk6HY10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P63018	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-433431|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q4FZY7|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:hsp7c_rat(display_long)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621725|refseq:NP_077327.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008380"(RNA splicing)|go:"GO:0009408"(response to heat)|go:"GO:0009986"(cell surface)|go:"GO:0010045"(response to nickel cation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0044849"(estrous cycle)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990834"(response to odorant)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1CKR|rcsb pdb:1Q2G|rcsb pdb:1UD0|rcsb pdb:2V7Z|rcsb pdb:7HSC|mint:P63018|dip:DIP-33262N	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P53534	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2696349	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pygb_rat(display_long)|uniprotkb:Pygb(gene name)|psi-mi:Pygb(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	interpro:IPR035090|rgd:3460|refseq:NP_037320.1|interpro:IPR011833(Glycogen/starch/alpha-glucan phosphorylase)|interpro:IPR000811(Glycosyl transferase, family 35)|mint:P53534|go:"GO:0005737"(cytoplasm)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0008184"(glycogen phosphorylase activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0042802"(identical protein binding)|go:"GO:0102250"(linear malto-oligosaccharide phosphorylase activity)|go:"GO:0102499"(SHG alpha-glucan phosphorylase activity)|reactome:R-RNO-6798695	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:WcV4oiXMS78KKpVSzVnziBt5uD810116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P19139	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-1373494|uniprotkb:Q5BKC1|ensembl:ENSRNOP00000007558	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:csk21_rat(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621663|refseq:NP_446276.1|refseq:XP_006235282.1|refseq:XP_006235283.1|reactome:R-RNO-6804756|reactome:R-RNO-6814122|reactome:R-RNO-8934903|reactome:R-RNO-8939243|reactome:R-RNO-8948751|ensembl:ENSRNOG00000005276(gene)|ensembl:ENSRNOT00000007558(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19139|rcsb pdb:2R7I|reactome:R-RNO-1483191|reactome:R-RNO-201688|reactome:R-RNO-2514853|reactome:R-RNO-445144	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:igJEbVxBh30nMZF6jfiISzpHEMQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P47853	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-917563|ensembl:ENSRNOP00000072449	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:pgs1_rat(display_long)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:Bgn(gene name)|psi-mi:Bgn(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2207|refseq:NP_058783.1|ensembl:ENSRNOG00000055962(gene)|ensembl:ENSRNOT00000085201(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|reactome:R-RNO-1971475|reactome:R-RNO-2022870|reactome:R-RNO-2022923|reactome:R-RNO-2024101|reactome:R-RNO-3000178	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:y5uL0GPot1EHpM1UIKRfmWJXdEI10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P08289	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2255876|uniprotkb:P14055|uniprotkb:P70707|ensembl:ENSRNOP00000019004	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ppbt_rat(display_long)|uniprotkb:Alpl(gene name)|psi-mi:Alpl(display_short)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2100|refseq:NP_037191.1|refseq:XP_017448654.1|refseq:XP_006239198.1|ensembl:ENSRNOG00000013954(gene)|ensembl:ENSRNOT00000019004(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0065010"(extracellular membrane-bounded organelle)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-RNO-163125	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:UmaR+Pnr0kr3PzsURLAfUlChXlM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02793	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2925566|ensembl:ENSRNOP00000028315|ensembl:ENSRNOP00000064683|uniprotkb:Q6P7T1	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:fril1_rat(display_long)|uniprotkb:Ftl1(gene name)|psi-mi:Ftl1(display_short)|uniprotkb:Ftl(gene name synonym)|uniprotkb:Ferritin L subunit 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	ensembl:ENSRNOG00000020843(gene)|ensembl:ENSRNOG00000031506(gene)|ensembl:ENSRNOT00000028315(transcript)|ensembl:ENSRNOT00000044711(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0042802"(identical protein binding)|go:"GO:0044754"(autolysosome)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|reactome:R-RNO-6798695|reactome:R-RNO-917937|go:"GO:0008199"(ferric iron binding)|rgd:61813|refseq:NP_071945.3|refseq:XP_002726683.1|refseq:XP_002729599.1	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:ZIRr0ZoKDP4C8UGE1MX73rzV/+U10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P06761	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-916036|ensembl:ENSRNOP00000025064	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P31977	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-917242|uniprotkb:Q5WQV4|uniprotkb:Q66H97|uniprotkb:Q8VHK3|ensembl:ENSRNOP00000046593	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:ezri_rat(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621161|refseq:NP_062230.1|ensembl:ENSRNOG00000018524(gene)|ensembl:ENSRNOT00000046746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|reactome:R-RNO-373752|reactome:R-RNO-437239	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:2udcesOWgp+JEk1HN7Ss0qo+1TQ10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:Q6P7S1	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-919850|uniprotkb:Q9EQJ6|ensembl:ENSRNOP00000013463	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:asah1_rat(display_long)|uniprotkb:Asah1(gene name)|psi-mi:Asah1(display_short)|uniprotkb:Acylsphingosine deacylase(gene name synonym)|uniprotkb:N-acylsphingosine amidohydrolase(gene name synonym)|uniprotkb:N-acylethanolamine hydrolase ASAH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:621568|refseq:NP_445859.2|ensembl:ENSRNOG00000010034(gene)|ensembl:ENSRNOT00000013463(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0017040"(N-acylsphingosine amidohydrolase activity)|go:"GO:0017064"(fatty acid amide hydrolase activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046514"(ceramide catabolic process)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0062098"(regulation of programmed necrotic cell death)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0102121"(ceramidase activity)|interpro:IPR016699(Acid ceramidase-like)|interpro:IPR029130|interpro:IPR029132|reactome:R-RNO-1660662|reactome:R-RNO-6798695	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:P7I8EZHrqVDvJBzzLA7MzYBj0hY10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P04762	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-915842|ensembl:ENSRNOP00000011230	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:cata_rat(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	go:"GO:0009060"(aerobic respiration)|go:"GO:0009314"(response to radiation)|go:"GO:0009411"(response to UV)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|ensembl:ENSRNOG00000008364(gene)|ensembl:ENSRNOT00000011230(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|rgd:2279|refseq:NP_036652.1|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|reactome:R-RNO-3299685|reactome:R-RNO-6798695|reactome:R-RNO-9033241	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:dvt8S8neDN5cx0C+L0THuo00/BA10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P05065	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-522118|uniprotkb:Q63038|ensembl:ENSRNOP00000068764|ensembl:ENSRNOP00000069507|ensembl:ENSRNOP00000069540	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:aldoa_rat(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2089|refseq:NP_001170776.1|refseq:NP_036627.1|ensembl:ENSRNOG00000052802(gene)|ensembl:ENSRNOT00000080988(transcript)|ensembl:ENSRNOT00000087928(transcript)|ensembl:ENSRNOT00000088473(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035094"(response to nicotine)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043627"(response to estrogen)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P05065|reactome:R-RNO-114608|reactome:R-RNO-6798695|reactome:R-RNO-70171|reactome:R-RNO-70263|refseq:XP_006230273.1|refseq:NP_001258465.1	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:dUcYtyffbl8dC/1SD/ZtEtiFyB010116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P00507	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-915723|uniprotkb:Q64551|uniprotkb:Q9QV50|ensembl:ENSRNOP00000015956	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:aatm_rat(display_long)|uniprotkb:Plasma membrane-associated fatty acid-binding protein(gene name synonym)|uniprotkb:Transaminase A(gene name synonym)|uniprotkb:Glutamate oxaloacetate transaminase 2(gene name synonym)|uniprotkb:Fatty acid-binding protein(gene name synonym)|uniprotkb:Got2(gene name)|psi-mi:Got2(display_short)|uniprotkb:Maat(gene name synonym)|uniprotkb:Kynurenine aminotransferase 4(gene name synonym)|uniprotkb:Kynurenine aminotransferase IV(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase 4(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase IV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:2722|refseq:NP_037309.1|reactome:R-RNO-70263|reactome:R-RNO-8963693|reactome:R-RNO-8964539|ensembl:ENSRNOG00000011782(gene)|ensembl:ENSRNOT00000015956(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006533"(aspartate catabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0016212"(kynurenine-oxoglutarate transaminase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0019550"(glutamate catabolic process to aspartate)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030315"(T-tubule)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0045471"(response to ethanol)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P00507|reactome:R-RNO-389661	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:DmuLdUQ/Ak7zSKqE7Viztf5O1CM10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:P02454	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-915744|uniprotkb:P02455|uniprotkb:Q63079|ensembl:ENSRNOP00000005311|uniprotkb:A3KNA1	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:co1a1_rat(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)	psi-mi:"MI:0096"(pull down)	Devarajan-Ketha et al. (2012)	pubmed:22206666|imex:IM-17213	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5746499|imex:IM-17213-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	rgd:61817|refseq:NP_445756.1|ensembl:ENSRNOG00000003897(gene)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|ensembl:ENSRNOT00000005311(transcript)|go:"GO:0030141"(secretory granule)|go:"GO:0001501"(skeletal system development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007584"(response to nutrient)|go:"GO:0007601"(visual perception)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|rcsb pdb:3HQV|rcsb pdb:3HR2|reactome:R-RNO-114604|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2243919|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-430116|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902617"(response to fluoride)|dip:DIP-36887N|reactome:R-RNO-75892|reactome:R-RNO-76009|reactome:R-RNO-8874081|reactome:R-RNO-8948216	-	-	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/06	2014/10/16	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:eng4MkFnf/zWoFkxosROYXl6VuU10116	intact-crc:742E344E117AD5F5	false	maltose binding protein tag:?-?|sufficient binding region:24-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)